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Disodium methylarsonate

PubChem CID
8947
Structure
Disodium methylarsonate_small.png
Molecular Formula
Synonyms
  • Disodium methylarsonate
  • 144-21-8
  • DISODIUM METHANEARSONATE
  • Sodium methylarsonate
  • DSMA
Molecular Weight
183.934 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Dates
  • Create:
    2005-08-08
  • Modify:
    2025-01-11
See also: Monosodium methanearsonate (annotation moved to).

1 Structures

1.1 2D Structure

Chemical Structure Depiction
Disodium methylarsonate.png

1.2 3D Status

Conformer generation is disallowed since MMFF94s unsupported element, mixture or salt

2 Names and Identifiers

2.1 Computed Descriptors

2.1.1 IUPAC Name

disodium;methyl-dioxido-oxo-λ5-arsane
Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)

2.1.2 InChI

InChI=1S/CH5AsO3.2Na/c1-2(3,4)5;;/h1H3,(H2,3,4,5);;/q;2*+1/p-2
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.3 InChIKey

SDIXRDNYIMOKSG-UHFFFAOYSA-L
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.4 SMILES

C[As](=O)([O-])[O-].[Na+].[Na+]
Computed by OEChem 2.3.0 (PubChem release 2024.12.12)

2.2 Molecular Formula

CH3AsNa2O3
Computed by PubChem 2.2 (PubChem release 2021.10.14)

2.3 Other Identifiers

2.3.1 CAS

144-21-8

2.3.3 Deprecated CAS

19444-53-2

2.3.4 European Community (EC) Number

2.3.5 UNII

2.3.6 ChEMBL ID

2.3.7 DSSTox Substance ID

2.3.8 Nikkaji Number

2.3.9 Wikidata

2.3.10 Wikipedia

2.4 Synonyms

2.4.1 MeSH Entry Terms

  • disodium methanearsonate
  • methanearsonic acid
  • methylarsonate
  • methylarsonic acid
  • methylarsonous acid
  • monomethylarsonic acid
  • monomethylarsonic acid, ammonium, iron (3+) salt
  • monomethylarsonic acid, calcium salt (2:1)
  • monomethylarsonic acid, dimercury (1+) salt
  • monomethylarsonic acid, dipotassium salt
  • monomethylarsonic acid, disodium salt
  • monomethylarsonic acid, iron (2+) salt (3:2)
  • monomethylarsonic acid, iron salt
  • monomethylarsonic acid, monoammonium salt
  • monomethylarsonic acid, monocalcium salt
  • monomethylarsonic acid, monosodium salt
  • monomethylarsonic acid, zinc salt
  • monosodium methanearsonate
  • MSMA
  • sodium methanearsonate

2.4.2 Depositor-Supplied Synonyms

3 Chemical and Physical Properties

3.1 Computed Properties

Property Name
Molecular Weight
Property Value
183.934 g/mol
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Donor Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Acceptor Count
Property Value
3
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Rotatable Bond Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Exact Mass
Property Value
183.909352 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Monoisotopic Mass
Property Value
183.909352 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Topological Polar Surface Area
Property Value
63.2 Ų
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Heavy Atom Count
Property Value
7
Reference
Computed by PubChem
Property Name
Formal Charge
Property Value
0
Reference
Computed by PubChem
Property Name
Complexity
Property Value
49.8
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Isotope Atom Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Covalently-Bonded Unit Count
Property Value
3
Reference
Computed by PubChem
Property Name
Compound Is Canonicalized
Property Value
Yes
Reference
Computed by PubChem (release 2021.10.14)

3.2 Experimental Properties

3.2.1 Physical Description

Colorless hygroscopic solid; [Hawley]

3.2.2 Color / Form

Hydrated crystals containing 5H2O or 6H2O
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1018
Monoclinic spear-shaped plates from absolute alcohol
Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 938
White crystalline solid
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 115

3.2.3 Taste

Pleasant acid taste
Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 938

3.2.4 Melting Point

>355 °C
Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 417
Melting point 132-139 °C /Disodium methanearsonate hexahydrate/
Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 417

3.2.5 Solubility

Soluble in methanol; practically insoluble in most organic solvents
Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p. 822
Soluble in water (300 g/l at 25 °C)
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V23 43 (1980)
In water, 4.32X10+5 mg/l @ 25 °C
Shiu WY et al; Rev Environ Contam Toxicol 116: 15-187 (1990)

3.2.6 Density

1.04 g/ml
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 116

3.2.7 Vapor Pressure

0.0000001 [mmHg]
10-7 mm Hg @ 25 °C
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 116

3.2.8 LogP

Kow = <10
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 116

3.2.9 Stability / Shelf Life

DECOMPOSED BY STRONG OXIDIZING & REDUCING AGENTS.
Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p. 684
/Decomposes/ slowly at elevated temperatures. Stable to hydrolysis.
Spencer, E. Y. Guide to the Chemicals Used in Crop Protection. 7th ed. Publication 1093. Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1982., p. 241

3.2.10 Decomposition

When heated to decomposition it emits toxic fumes of /arsenic & sodium oxide/.
Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1425
DECOMPOSED BY STRONG OXIDIZING & REDUCING AGENTS.
Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p. 684

3.2.11 Corrosivity

NON-CORROSIVE TO IRON, RUBBER AND MOST PLASTICS
Worthing, C.R. and S.B. Walker (eds.). The Pesticide Manual - A World Compendium. 8th ed. Thornton Heath, UK: The British Crop Protection Council, 1987., p. 558
Mildly corrosive
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 116

3.2.12 Dissociation Constants

pKa1 = 4.1; pKa2 = 8.94
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 116

3.2.13 Other Experimental Properties

Hydrolysis to MSMA @ pH 6-7; decomposed by strong oxidizing and reducing agents
Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p. 822
Colorless crystals /Hexahydrate/
Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p. 822
Hygroscopic
Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 417

3.3 Chemical Classes

Metals -> Arsenic Compounds, Organic

4 Spectral Information

4.1 IR Spectra

4.1.1 FTIR Spectra

Technique
KBr WAFER
Source of Sample
U.S. Epa Repository, Research Triangle Park, North Carolina
Copyright
Copyright © 1980, 1981-2024 John Wiley & Sons, Inc. All Rights Reserved.
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6 Chemical Vendors

7 Agrochemical Information

7.1 Agrochemical Category

Herbicide

8 Pharmacology and Biochemistry

8.1 MeSH Pharmacological Classification

Teratogens
An agent that causes the production of physical defects in the developing embryo. (See all compounds classified as Teratogens.)
Herbicides
Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. (See all compounds classified as Herbicides.)

8.2 Absorption, Distribution and Excretion

USING (14)C LABELED DSMA, STUDIES SHOWED THAT DSMA .. READILY TAKEN UP BY BERMUDAGRASS FROM ... NUTRIENT SOLN BUT... SLOWLY FROM SOIL. ... ABOUT 25% ... TRANSLOCATED TO ROOTS & RHIZOMES WITHIN 5 DAYS. SMALL AMT OF CARBON DIOXIDE ... DETECTED. ... C-AS BOND REMAINED LARGELY INTACT ... .
Menzie, C. M. Metabolism of Pesticides, An Update. U.S. Department of the Interior, Fish, Wild-life Service, Special Scientific Report - Wildlife No. 184, Washington, DC: U.S. Government Printing Office, l974., p. 38
EARLY REPORTS INDICATED ... DSMA ... NOT TRANSLOCATED IN PLANTS ... HOWEVER ... EXAMINED TRANSLOCATION OF AMMONIUM METHYLARSONATE TO SHOOTS OF SINGLE NUTSEDGE TUBERS & TO TERMINAL TUBER SHOOTS. ARSENIC WAS TRANSLOCATED ... LATERALLY TO TUBERS SEPARATED BY AT LEAST FOUR TUBERS FROM TUBER'S SHOOT ... . /AMMONIUM METHYLARSONATE/
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 765
... STUDIED TRANSLOCATION OF DSMA ... IN PURPLE NUTSEDGE FOLLOWING FOLIAR APPLICATION. ... STUDIES INDICATED ... APOPLASTIC & SYMPLASTIC MOVEMENT ... DSMA MOVED IN ... ACROPETAL & BASIPETAL DIRECTIONS ... ARSENIC ... ACCUMULATED IN TERMINAL TUBERS AFTER REPEATED APPLICATIONS.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 765
... FOUND MOVEMENT OF ARSENIC INTO RHIZOMES AND FOLIAR REGROWTH OF JOHNSONGRASS FOLLOWING FOLIAR APPLICATION OF DSMA. ... FOUND ACROPETAL AND BASIPETAL TRANSLOCATION ... IN COASTAL BERMUDA GRASS. APPROXIMATELY 25% OF ARSENIC INTERCEPTED BY LEAVES ... TRANSLOCATED TO ROOTS AND RHIZOMES ... .
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 765
For more Absorption, Distribution and Excretion (Complete) data for DISODIUM METHANEARSONATE (12 total), please visit the HSDB record page.

8.3 Metabolism / Metabolites

... EXAMINED REACTION PRODUCTS OF DSMA ... IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS L). ... RADIOACTIVITY WAS ... DETECTED IN RESPIRATORY CARBON DIOXIDE FROM (14)C DSMA-TREATED PLANTS, INDICATING C-AS BOND DEGRADATION.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 754
... TREATED ... BERMUDA GRASS (CYNODON DACTYLON LEGUMINOSAE PERS) WITH (14)C DSMA. MOLECULE REMAINED INTACT, BUT ... COMPLEXED. 80% HOT ETHANOL EXTRACT CONTAINED UNKNOWN ... LITTLE (14)C CARBON DIOXIDE (0.1%) ... FOUND IN RESPIRATORY CARBON DIOXIDE 10 DAYS AFTER TREATMENT.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 754
Evolution of gaseous arsenic from DSMA-treated soil was a function of organic matter and moisture content. Greatest loss of arsenic was from soil containing 11% added organic matter and maintained under reduced conditions. The sorbed arsenic was predominantly in the form of iron arsenate. Aluminum arsenate was the next most abundant form.
Menzie, C.M. Metabolism of Pesticides-Update III. Special Scientific Report- Wildlife No. 232. Washington, DC: U.S.Department of the Interior, Fish and Wildlife Service, 1980., p. 40
Studies have identified the compound evolved from cultures of Penicillium brevicaule containing DSMA as trimethylarsine.
Menzie, C.M. Metabolism of Pesticides-Update III. Special Scientific Report- Wildlife No. 232. Washington, DC: U.S.Department of the Interior, Fish and Wildlife Service, 1980., p. 40
VOLUNTEERS INGESTED A SINGLE ORAL DOSE OF 500 MG ARSENIC AS DISODIUM METHANEARSONATE. AFTER 4 DAYS, 78% OF INGESTED ARSENIC WAS EXCRETED IN URINE. METHANEARSONATE IS 13% METHYLATED INTO DIMETHYLARSINATE.
BUCHET ET AL; INT ARCH OCCUP ENVIRON HEALTH 48 (1): 71-9 (1981)

8.4 Mechanism of Action

ARSONIC ACID HERBICIDES ARE NOT GROWTH REGULATORS IN SENSE OF PLANT HORMONES. THEY ... ACT THROUGH ENZYME SYSTEMS TO INHIBIT GROWTH. THEY KILL ... SLOWLY; FIRST SYMPTOMS ARE ... CHLOROSIS, CESSATION OF GROWTH, & GRADUAL YELLOWING, THEN BROWNING FOLLOWED BY DEHYDRATION & DEATH. /ORGANOARSENICAL HERBICIDES/
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 763

9 Use and Manufacturing

9.1 Uses

EPA CPDat Chemical and Product Categories
The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products, Scientific Data, volume 5, Article number: 180125 (2018), DOI:10.1038/sdata.2018.125
Sources/Uses
Used as herbicide for control of grass weeds in turf, cotton, and non-crop areas; Also used in pharmaceuticals; [HSDB]
Industrial Processes with risk of exposure
Farming (Pesticides) [Category: Industry]
For Disodium methanearsonate (USEPA/OPP Pesticide Code: 013802) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
U.S. Environmental Protection Agency/Office of Pesticide Program's Chemical Ingredients Database on Disodium methanearsonate (144-21-8). Available from, as of May 24, 2001: https://npirspublic.ceris.purdue.edu/ppis/
Herbicide; pharmaceuticals
Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 417
Recommended to control grass weeds on non-crop areas; directed spray under trees.
Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p. 822
USEFUL AS DIRECTED APPLICATION ... FOR POST-EMERGENT CONTROL OF WEEDS AND GRASSES, IN ZOYSIA, BLUEGRASS, AND BERMUDA GRASS LAWNS, GENERAL NON-CROP WEED CONTROL ... .
Spencer, E. Y. Guide to the Chemicals Used in Crop Protection. 7th ed. Publication 1093. Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1982., p. 241
For more Uses (Complete) data for DISODIUM METHANEARSONATE (6 total), please visit the HSDB record page.

9.1.1 Use Classification

Hazard Classes and Categories -> Carcinogens

9.2 Methods of Manufacturing

Reaction of methyl chloride with sodium arsenate.
Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 13th ed. New York, NY: John Wiley & Sons, Inc. 1997., p. 417
Prepared from sodium arsenite and methyl iodide.
Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 938
Prepared by the reaction of dimethyl sulfate with a solution of arsenic trioxidein sodium hydroxide.
Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 938
Methanearsonic acid, disodium salt is prepared commercially by the reaction of sodium arsenate with methyl chloride.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V23 55 (1980)

9.3 Formulations / Preparations

USEPA/OPP Pesticide Code 013802; Trade Names: Ansar 8100; Arrhenal; Ansar DSMA Liquid; Dinate; Crab-E-Rad; Chipco Crab Kleen; Arsinyl; Sodar; Methar; Drexel DSMA Liquid; Di-Tac; Ansar 184; Weed-E-Rad; Versar DSMA-LQ; Calar-E-Rad; Dal-E-Rad; Jon-Trol; Namate.
U.S. Environmental Protection Agency/Office of Pesticide Program's Chemical Ingredients Database on Disodium methanearsonate (144-21-8). Available from, as of May 24, 2001: https://npirspublic.ceris.purdue.edu/ppis/
DISODIUM METHYLARSONATE COMBINED WITH EQUIMOLAR AMT OF MERCURY SALICYLATE IS CALLED ENESOL, WHITE POWDER, SOLUBLE IN WATER.
Budavari, S. (ed.). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc., 1989., p. 938
ANSAR 8100--WATER SOLUBLE POWDER 81% ACTIVE INGREDIENT; ANSAR DSMA LIQUID--AQ SOLN 21% ACTIVE INGREDIENT ... .
Spencer, E. Y. Guide to the Chemicals Used in Crop Protection. 7th ed. Publication 1093. Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1982., p. 241
THE PENTAHYDRATE CONTAINS ABOUT 28% ARSENIC, BUT THE COMMERCIAL MATERIAL USUALLY HAS A PURITY OF ONLY 50% (14% ARSENIC).
Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. II-132
For more Formulations/Preparations (Complete) data for DISODIUM METHANEARSONATE (6 total), please visit the HSDB record page.

9.4 General Manufacturing Information

MSMA and DSMA were introduced by Ansul Chemical Co (which no longer exists) ... under US patent as trade mark 'Ansar' ... .
Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium, 11 th ed., British Crop Protection Council, Surrey, England 1997, p. 822
... MAA /METHANEARSONIC ACID/ AND DSMA WERE NOT GOOD SOIL STERILIZERS. ... DSMA CONTROLLED DALLIS GRASS (PASPALUM DILATATUM ... AND GOOSEGRASS (ELEUSINE INDICA (L) GAERTN). ... DSMA GREATLY ENHANCED WEED CONTROL ACTIVITY OF ... DICRYL.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 743
WEEDS CONTROLLED BY ... DSMA: AGERATUM, TROPIC; ANGELTONGRASS; BAMBOO GRASS; BARNYARDGRASS; BINDWEED, FIELD; BLACKSEEDGRASS; BUFFELGRASS; BULRUSH; CARELESS WEED; CHEATGRASS; CHICKWEED, FIELD; CHICKWEED, MOUSEEAR; CHICKWEED, STICKY; CHOMPIPE; COCKLEBUR, COMMON; CRABGRASS, HAIRY ... .
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 744
WEEDS CONTROLLED BY ... DSMA: ... CRABGRASS, LARGE; CRABGRASS, SMALL; CRABGRASS,SMOOTH; DALLISGRASS; DROPSEED, INDIAN; FIDDLENECK; FINGERGRASS, SWOLLEN; FOXTAIL, GIANT; FOXTAIL, GREEN; FOXTAIL, YELLOW; GERMAN WEED; GROMWELL;GROUNDCHERRY, LONGLEAF; HEMPWEED, CLIMBING; HENBIT ... .
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 744
For more General Manufacturing Information (Complete) data for DISODIUM METHANEARSONATE (12 total), please visit the HSDB record page.

10 Identification

10.1 Analytic Laboratory Methods

IN FORMULATED PRODUCTS CONTAINING INTERFERING ACIDS, DETERMINE ARSENIC CONTENT BY STANDARD WET DIGESTION PROCEDURE AND CONVERT TO DSMA CONTENT.
Spencer, E. Y. Guide to the Chemicals Used in Crop Protection. 7th ed. Publication 1093. Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1982., p. 241
METHOD FOR QUANTITATING METHANEARSONATE IONS IN RUNOFF (WATER & SUSPENDED SEDIMENT): FLAMELESS ATOMIC ABSORPTION.
WAUCHOPE RD, YAMAMOTO M; J ENVIRON QUAL 9 (4): 597 (1980)

11 Safety and Hazards

11.1 Hazards Identification

11.1.1 GHS Classification

Pictogram(s)
Acute Toxic
Environmental Hazard
Signal
Danger
GHS Hazard Statements

H301 (97.4%): Toxic if swallowed [Danger Acute toxicity, oral]

H331 (97.4%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (97.4%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

ECHA C&L Notifications Summary

Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

11.1.2 Hazard Classes and Categories

Acute Tox. 3 (97.4%)

Acute Tox. 3 (97.4%)

Aquatic Acute 1 (100%)

Aquatic Chronic 1 (97.4%)

Carcinogens

11.1.3 Hazards Summary

A mild skin and eye irritant; [HSDB] May cause irritation; [MSDSonline] Most excreted unchanged; [Rosenstock, p. 947] For MSMA and DSMA, developmental studies of rats and rabbits along with a two-generation reproductive study show no indication of increased susceptibility; No evidence of carcinogenicity; Target organs are large intestines and kidneys; [Reference #1] See Dimethylarsenic acid.
Rosenstock - Rosenstock L, Cullen MR, Brodkin CA, Redlich CA (eds). Textbook of Clinical Occupational and Environmental Medicine, 2nd Ed. Philadelphia: Elsevier Saunders, 2004., p. 947

11.1.4 Fire Potential

NOT FLAMMABLE
U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
Dangerous fire hazard by spontaneous chemical reaction. Ignites spontaneously in dry air. Can react vigorously with oxidizing materials; e.g. air, /chloride/.
Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1425

11.1.5 Skin, Eye, and Respiratory Irritations

Slight eye, skin irritant.
Farm Chemicals Handbook 1993. Willoughby, OH: Meister Publishing Co., 1993., p. C-131

11.1.6 EPA Hazardous Waste Number

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

11.2 Safety and Hazard Properties

11.2.1 OSHA Standards

Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/
29 CFR 1910.1000 (7/1/2001)

11.3 Fire Fighting

11.3.1 Fire Fighting Procedures

Wear goggles and self contained breathing apparatus
U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
Fire extinguishing media: Dry chemical, carbon dioxide.
Farm Chemicals Handbook 1993. Willoughby, OH: Meister Publishing Co., 1993., p. C-131

11.4 Accidental Release Measures

11.4.1 Disposal Methods

Generators of waste (equal to or greater than 100 kg/mo) containing this contaminant, EPA hazardous waste number D004, must conform with USEPA regulations in storage, transportation, treatment and disposal of waste.
40 CFR 240-280, 300-306, 702-799 (7/1/91)
Arsenic or organo-arsenic containing wastewater treatment sludges from production of veterinary pharmaceuticals are poor candidates for incineration.
USEPA; Engineering Handbook for Hazardous Waste Incineration p.3-18 (1981) EPA 68-03-3025

11.4.2 Preventive Measures

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.
Protective clothing to prevent contact with skin; chemical goggles.
U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.
Avoid skin contact or breathing spray mist. ... Keep children, domestic animals off treated areas until material washes into soil.
Farm Chemicals Handbook 1993. Willoughby, OH: Meister Publishing Co., 1993., p. C-131

11.5 Handling and Storage

11.5.1 Storage Conditions

Do not store near feed, food.
Farm Chemicals Handbook 1993. Willoughby, OH: Meister Publishing Co., 1993., p. C-131

11.6 Exposure Control and Personal Protection

11.6.1 Permissible Exposure Limit (PEL)

0.5 [mg/m3], as As

11.6.2 Other Standards Regulations and Guidelines

... The following countries had adopted the ... TLV of 0.5 mg/cu m: Austria, Belgium, Finland, Japan, and Holland. Czechoslavakia, East Germany, Hungary and Poland ... USSR ... 0.3 mg/cu m; Romania and Switzerland, 0.2 mg/cu m; Sweden 0.05 mg/cu m; and Italy 0.25 mg/cu m. /Arsenic and sol cmpd/
American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 37

11.6.3 Allowable Tolerances

Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruit, 0.35 ppm; cottonseed, 0.7 ppm; and cottonseed hulls, 0.9 ppm.
40 CFR 180.289 (4/1/2000)
Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue; 2 ppm in uncooked edible by-products; & 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney; 0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/
21 CFR 556.60 (4/1/2001)

11.6.4 Personal Protective Equipment (PPE)

Goggles or face shield, rubber or neoprene gloves, rubber apron.
Farm Chemicals Handbook 1993. Willoughby, OH: Meister Publishing Co., 1993., p. C-131

11.7 Stability and Reactivity

11.7.1 Hazardous Reactivities and Incompatibilities

Can react vigorously with oxidizing materials; e.g. air, /chloride/.
Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 1425

11.8 Transport Information

11.8.1 Standard Transportation Number

49 232 11; Arsenical compound nos, solid, (or) arsenical mixture, NOS, solid
49 232 10; Arsenical cmpd, NOS, liquid (or) arsenical mixture, NOS, liquid

11.9 Regulatory Information

REACH Restricted Substance

Restricted substance: Disodium methylarsonate

EC: 205-620-7

Restriction condition document: PDF link

11.9.1 Atmospheric Standards

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Disodium methanearsonate is included on this list.
Clean Air Act as amended in 1990, Sect. 112 (b) (1) Public Law 101-549 Nov. 15, 1990
(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/
40 CFR 61.162(a) (7/1/2001)
(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/
40 CFR 61.162(b) (7/1/2001)
The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/
40 CFR 61.172(b) (7/1/2001)

11.9.2 Federal Drinking Water Standards

10 ug/l /Arsenic/
USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present

11.9.3 State Drinking Water Guidelines

(AZ) ARIZONA 10 ug/L /Arsenic/
USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present
(CT) CONNECTICUT 10 ug/l /Arsenic/
USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present

11.9.4 Clean Water Act Requirements

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/
40 CFR 401.15 (7/1/2001)
For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/
USEPA; Quality Criteria for Water 1986: Arsenic: Human Health Criteria (May 1, 1986) EPA 440/5-86-001
D004; A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.
40 CFR 261.24 (7/1/2001)

11.9.5 FIFRA Requirements

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their future use. Under this pesticide reregistration program, EPA examines health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether they are eligible for reregistration. In addition, all pesticides must meet the new safety standard of the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA, as amended in 1988, were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern and List D pesticides of less concern. Disodium methanearsonate is found on List B. Case No: 2395; Pesticide type: insecticide, herbicide, rodenticide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the Reregistration Eligibility Decision (RED) document.; Active ingredient (AI): Disodium methanearsonate; Data Call-in (DCI) Date(s): 06/14/91, 03/03/95, 10/13/95; AI Status: The producers of the pesticide has made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.
USEPA/OPP; Status of Pesticides in Registration, Reregistration and Special Review p.190 (Spring, 1998) EPA 738-R-98-002
Tolerances are established for residues of the herbicide methanearsonic acid (calculated as As2O3) from application of the disodium and monosodium salts of methanearsonic acid in or on raw agricultural commodities as follows: citrus fruit; cottonseed; and cottonseed hulls.
40 CFR 180.289 (4/1/2000)
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/
Association of American Railroads. Emergency Handling of Hazardous Materials in Surface Transportation. Washington, DC: Association of American Railroads, Bureau of Explosives, 1994., p. 104
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/
Association of American Railroads. Emergency Handling of Hazardous Materials in Surface Transportation. Washington, DC: Association of American Railroads, Bureau of Explosives, 1994., p. 105

11.10 Other Safety Information

Chemical Assessment

IMAP assessments - Arsonic acid, methyl-, disodium salt: Environment tier I assessment

IMAP assessments - Arsonic acid, methyl-, disodium salt: Human health tier I assessment

11.10.1 Other Hazardous Reactions

Poisonous gases are produced when heated
U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.

12 Toxicity

12.1 Toxicological Information

12.1.1 RAIS Toxicity Values

Oral Acute Reference Dose (RfDoa)(mg/kg-day)
0.1
Oral Acute Reference Dose Reference
OPP
Oral Chronic Reference Dose (RfDoc) (mg/kg-day)
0.03
Oral Chronic Reference Dose Reference
OPP

12.1.2 EPA Human Health Benchmarks for Pesticides

Chemical Substance
Acute or One Day PAD (RfD) [mg/kg/day]
0.1
Acute or One Day HHBPs [ppb]
700
Acute HHBP Sensitive Lifestage/Population
Children
Chronic or One Day PAD (RfD) [mg/kg/day]
0.03
Chronic or One Day HHBPs [ppb]
200
Chronic HHBP Sensitive Lifestage/Population
General Population

12.1.3 Evidence for Carcinogenicity

Cancer Classification: Not Likely to be Carcinogenic to Humans
USEPA Office of Pesticide Programs, Health Effects Division, Science Information Management Branch: "Chemicals Evaluated for Carcinogenic Potential" (April 2006)

12.1.4 Acute Effects

12.1.5 Toxicity Data

LC50 (rat) > 6,000 mg/m3

12.1.6 Human Toxicity Excerpts

COMPOUNDS INCLUDED METHANEARSONIC ACID & ITS SODIUM SALTS; 9/34 CASES SHOWED SYSTEMIC SYMPTOMS & REMAINDER HAD EYE & SKIN IRRITATION.
PEOPLES ET AL; VET HUM TOXICOL 21 (6): 417-21 (1979)
ORGANIC ARSENICALS INCLUDE DISODIUM METHYLARSONATE ... AND AMINE METHYLARSONATE. TOXICITY OF THESE CMPD TO HUMANS IS CONSIDERABLY LESS THAN ... INORGANIC ARSENICALS; HOWEVER THEY ARE HARMFUL IF INHALED, SWALLOWED, OR IF THEY COME IN CONTACT WITH EYES OR SKIN.
International Labour Office. Encyclopedia of Occupational Health and Safety. Volumes I and II. New York: McGraw-Hill Book Co., 1971., p. 664
Toxic by ingestion and inhalation.
Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 434

12.1.7 Non-Human Toxicity Excerpts

RATS TOLERATED SUB-LETHAL DOSES WITHOUT APPARENT ILL EFFECTS.
Spencer, E. Y. Guide to the Chemicals Used in Crop Protection. 7th ed. Publication 1093. Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1982., p. 241
... FOUND THAT 100 & 1000 PPM OF ... DSMA ... WERE EXTREMELY TOXIC TO NEWLY EMERGED WORKER BEES (APIS MELLIFERA L). ... HERBICIDES WERE CONTAINED IN 60% SUCROSE SYRUP. TOXICITY ... JUDGED BY DEGREE & RATE OF MORTALITY. NO DIFFERENCES ... OBSERVED BETWEEN PURIFIED & COMMERCIALLY FORMULATED HERBICIDES.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 761
ADULT SWISS-WEBSTER MICE GIVEN UP TO 6.9 MG/L DSMA IN AIR FOR 2 HR CAUSED RESP DISTRESS. IV & IP DOSING: DIFFICULT BREATHING, DECR BODY TEMP, STOMACH LINING IRRITATION, & BLOOD IN INTESTINE. IRRITANCY POTENTIAL MAY PRECLUDE STUDY OF INHALATION TOXICITY.
STEVENS ET AL; BULL ENVIRON CONTAM TOXICOL 21 (3): 304-11 (1979)
TOXICITY OF DISODIUM METHYL ARSENATE TO STONEFLIES, AMPHIPODS, & TROUT, & ITS BIOACCUMULATION WERE STUDIED DURING 28 DAY FLOW-THROUGH TEST. DAPHNIA MAGNA EXPOSED IN 21 DAY STATIC TEST TO DETERMINE LIFE CYCLE EFFECTS. NO EFFECTS WERE SHOWN ON SURVIVAL OR LIFE CYCLE.
SPEHAR ET AL; ARCH ENVIRON CONTAM TOXICOL 9 (1): 53-63 (1980)
For more Non-Human Toxicity Excerpts (Complete) data for DISODIUM METHANEARSONATE (10 total), please visit the HSDB record page.

12.1.8 Non-Human Toxicity Values

LD50 RAT ORAL 8000 MG/KG /21% LIQUID/
Spencer, E. Y. Guide to the Chemicals Used in Crop Protection. 7th ed. Publication 1093. Research Institute, Agriculture Canada, Ottawa, Canada: Information Canada, 1982., p. 241
LD50 MOUSE IV 316 MG/KG
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 760
LD50 MOUSE SC 3350 MG/KG
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 760
LD50 RABBIT IV 1240 MG/KG
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 760
For more Non-Human Toxicity Values (Complete) data for DISODIUM METHANEARSONATE (13 total), please visit the HSDB record page.

12.2 Ecological Information

12.2.1 EPA Ecotoxicity

Pesticide Ecotoxicity Data from EPA

12.2.2 Ecotoxicity Values

LC50 BLUEGILL SUNFISH (LEPOMIS MACROCHIRUS) > 1000 PPM/48 HR/FRESH WATER /CONDITIONS OF BIOASSAY NOT SPECIFIED/
U.S. Coast Guard, Department of Transportation. CHRIS - Hazardous Chemical Data. Volume II. Washington, D.C.: U.S. Government Printing Office, 1984-5.

12.2.3 Environmental Fate

... FOUND RAPID LOSS OF HERBICIDAL ACTIVITY FROM DSMA APPLIED TO BOSKET SILT LOAM. MOST MARKED REDUCTION IN TOXIC RESIDUES OCCURRED BETWEEN INITIAL PLANTING DATE AND 16-WEEK REPLANTING DATE.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 756
TERRESTRIAL FATE: Organoarsenicals, such as dimethylarsinic acid, methanearsonic acid, monosodium and disodium salts, and sodium cacodylate are adsorbed by clay soils. After rapid initial adsorption, changes occur which result in the redistribution of dimethylarsinic acid into a less soluble form associated with aluminium in the soil. Downward leaching of the methanearsonic acid salts has also been reported. The methanearsonic acid salts and dimethylarsinic acid are fixed by iron and aluminium in the soil, although not as strongly as inorganic arsenate.
IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work). Available at: https://monographs.iarc.fr/ENG/Classification/index.php, p. V23 71 (1980)
REACTION OF ... DSMA ... EXAMINED IN ... PLANTS ... SINGLE RADIOACTIVE CMPD ... FOUND /IN PURPLE NUTSEDGE (CYPERUS ROTUNDUS LEGUMINOSAE)/ IN HOT 80% ETHANOL EXTRACT. RF WAS 0.59 COMPARED TO 0.66 FOR STANDARD DSMA. CHEM ANALYSIS REVEALED THAT C-AS BOND REMAINED INTACT.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 754

12.2.4 Environmental Biodegradation

... NORFOLK LOAMY SAND SAMPLES (WITH AND WITHOUT ORGANIC MATTER ADDED) SHOWED INCREASED DSMA DECOMPOSITION RELATIVE TO SOIL ORGANIC MATTER. THIS SUGGESTS ADAPTATION OF MICROBIAL POPULATION TO METABOLIZE METHYL CARBON OF MAA /METHANEARSONIC ACID/.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 757

12.2.5 Environmental Abiotic Degradation

LOSS FROM PHOTODECOMPOSITION IN BASIC SOIL TYPES: NONE.
Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979., p. 254

12.2.6 Environmental Bioconcentration

Leghorn hens (groups of 5) were fed a diet containing 200 ppm of the herbicide Angar 8100 (active principle disodium methylarsenate) for 30 days ... /until/ slaughter; a similar group was fed the same diet containing 2 g sunflower pectin. Considerable residues /were/ found in the former group, the level in tissue being 0.0250 mg/kg; however, addition of pectin to the diet produced a 30-80% decline, the level in tissue being 0.0047 mg/kg.
Kalburov G, Kerkenyakova A; Nauchni Trudove, Vissh Institut po Khranitelna i Vkusova Promyshelnnost 25 (2): 295-7 (1978)

12.2.7 Soil Adsorption / Mobility

TYPE OF CLAY MINERAL MAY BE RESPONSIBLE FOR DIFFERENT FIXATION TENDENCIES ... KAOLINITE REMOVED MUCH MORE DSMA FROM SOLN THAN DID VERMICULITE. SMALLER SIZE FRACTIONS OF AUGUSTA SILT LOAM ... ABSORBED LARGER PERCENTAGES OF MAA /METHANEARSONIC ACID/ PRESENT IN SOLUTION.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 757
PHYTOTOXICITY IS ... AFFECTED BY LEACHING OF DSMA. IF ARSONATE IS APPLIED WITHIN 2 HR OF RAIN, LITTLE ABSORPTION WILL OCCUR AND LEACHING OF MAA /METHANEARSONIC ACID/ PROCEEDS.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 757
... FOUND NO LEACHING OF DSMA IN DECATUR CLAY LOAM, WHILE 52% ... RECOVERED IN THE TWENTY 1 IN INCREMENTS OF LEACHATE FROM NORFOLK LOAMY SAND. MOVEMENT THROUGH NORFOLK LOAMY SAND OCCURRED AS BAND OF HIGH FRONTAL CONCN WHICH ... DECREASED IN DIRECTION OF ZONE OF APPLICATION.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 757

12.2.8 Volatilization from Water / Soil

NONE
Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979., p. 254

12.2.9 Sediment / Soil Concentrations

The sorption of arsenic, phosphate, disodium methanearsonate, and the sodium salt of cacodylic acid by 16 Mississippi river alluvial flood plain soils is measured in a slurry experiment in which initial pH and molar solution concn for all four solutes are identical. Sorption of the two organoarsenical herbicides is strongly correlated with arsenate and phophate sorption, and sorption of all four species is strongly correlated with clay and iron oxide contents of the soils.
Wauchope RD; J Env Quality 4 (3): 355 (1975)

12.2.10 Probable Routes of Human Exposure

CMPD INCL METHANEARSONIC ACID SODIUM SALTS; INJURIES WERE CAUSED PRIMARILY BY USE OF FAULTY EQUIPMENT, CARELESSNESS IN ITS OPERATION, IMPROPER USE OF PROTECTIVE EQUIPMENT. /METHANEARSONIC ACID SODIUM SALTS/
PEOPLES ET AL; VET HUM TOXICOL 21 (6): 417-21 (1979)
The National Occupational Hazard Survey conducted by NIOSH estimated that 1130 workers may be exposed to Disodium Methanearsonate; 100% from observed use of a tradename product known to contain this chemical.
NIOSH National Hazard Exposure Survey (1972-1974)

13 Literature

13.1 Consolidated References

13.2 NLM Curated PubMed Citations

13.3 Springer Nature References

13.4 Chemical Co-Occurrences in Literature

13.5 Chemical-Gene Co-Occurrences in Literature

13.6 Chemical-Disease Co-Occurrences in Literature

14 Patents

14.1 Depositor-Supplied Patent Identifiers

14.2 WIPO PATENTSCOPE

14.3 Chemical Co-Occurrences in Patents

14.4 Chemical-Disease Co-Occurrences in Patents

14.5 Chemical-Gene Co-Occurrences in Patents

15 Biological Test Results

15.1 BioAssay Results

16 Classification

16.1 MeSH Tree

16.2 ChemIDplus

16.3 UN GHS Classification

16.4 EPA CPDat Classification

16.5 NORMAN Suspect List Exchange Classification

16.6 EPA DSSTox Classification

16.7 EPA Substance Registry Services Tree

16.8 MolGenie Organic Chemistry Ontology

17 Information Sources

  1. Australian Industrial Chemicals Introduction Scheme (AICIS)
  2. ChemIDplus
    ChemIDplus Chemical Information Classification
    https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
  3. EPA DSSTox
    CompTox Chemicals Dashboard Chemical Lists
    https://comptox.epa.gov/dashboard/chemical-lists/
  4. EPA Safe Drinking Water Act (SDWA)
  5. European Chemicals Agency (ECHA)
    LICENSE
    Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.
    https://echa.europa.eu/web/guest/legal-notice
  6. FDA Global Substance Registration System (GSRS)
    LICENSE
    Unless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.
    https://www.fda.gov/about-fda/about-website/website-policies#linking
  7. Hazardous Substances Data Bank (HSDB)
  8. NJDOH RTK Hazardous Substance List
  9. Risk Assessment Information System (RAIS)
    LICENSE
    This work has been sponsored by the U.S. Department of Energy (DOE), Office of Environmental Management, Oak Ridge Operations (ORO) Office through a joint collaboration between United Cleanup Oak Ridge LLC (UCOR), Oak Ridge National Laboratory (ORNL), and The University of Tennessee, Ecology and Evolutionary Biology, The Institute for Environmental Modeling (TIEM). All rights reserved.
    https://rais.ornl.gov/
  10. ChEMBL
    LICENSE
    Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).
    http://www.ebi.ac.uk/Information/termsofuse.html
  11. EPA Chemical and Products Database (CPDat)
  12. Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
    LICENSE
    Copyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.
    https://haz-map.com/About
    Disodium methanearsonate
    https://haz-map.com/Agents/5021
  13. EPA Pesticide Ecotoxicity Database
  14. Japan Chemical Substance Dictionary (Nikkaji)
  15. SpectraBase
  16. Springer Nature
  17. Wikidata
  18. Wikipedia
  19. PubChem
  20. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  21. GHS Classification (UNECE)
  22. NORMAN Suspect List Exchange
    LICENSE
    Data: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0
    https://creativecommons.org/licenses/by/4.0/
    NORMAN Suspect List Exchange Classification
    https://www.norman-network.com/nds/SLE/
  23. EPA Substance Registry Services
  24. MolGenie
    MolGenie Organic Chemistry Ontology
    https://github.com/MolGenie/ontology/
  25. PATENTSCOPE (WIPO)
CONTENTS