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Methylarsonic acid

PubChem CID
8948
Structure
Methylarsonic acid_small.png
Molecular Formula
Synonyms
  • Methylarsonic acid
  • 124-58-3
  • Monomethylarsonic acid
  • Arsonic acid, methyl-
  • METHANEARSONIC ACID
Molecular Weight
139.970 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Dates
  • Create:
    2004-09-16
  • Modify:
    2025-01-11
Description
Methylarsonic acid is a member of arsonic acids, a one-carbon compound and an organoarsonic acid. It is a conjugate acid of a methylarsonate(1-).
Methylarsonic acid, disodium salt is an organoarsenic compound formed from the methylation of inorganic arsenic by living organisms. Arsenic is a chemical element that has the symbol As and atomic number 33. It is a poisonous metalloid that has many allotropic forms: yellow (molecular non-metallic) and several black and grey forms (metalloids) are a few that are seen. Three metalloidal forms of arsenic with different crystal structures are found free in nature (the minerals arsenopyrite and the much rarer arsenolamprite and pararsenolamprite), but it is more commonly found as a compound with other elements. (T3, L389)
L389: Wikipedia. Organoarsenic chemistry. Last Updated 30 April 2009. http://en.wikipedia.org/wiki/Organoarsenic_compound
T3: Emsley, John (2001). Nature's Building Blocks: An A-Z Guide to the Elements. Oxford: Oxford University Press.

1 Structures

1.1 2D Structure

Chemical Structure Depiction
Methylarsonic acid.png

1.2 3D Status

Conformer generation is disallowed since MMFF94s unsupported element

2 Names and Identifiers

2.1 Computed Descriptors

2.1.1 IUPAC Name

methylarsonic acid
Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)

2.1.2 InChI

InChI=1S/CH5AsO3/c1-2(3,4)5/h1H3,(H2,3,4,5)
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.3 InChIKey

QYPPRTNMGCREIM-UHFFFAOYSA-N
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.4 SMILES

C[As](=O)(O)O
Computed by OEChem 2.3.0 (PubChem release 2024.12.12)

2.2 Molecular Formula

CH3AsO(OH)2

CH5AsO3

CH5AsO3
Computed by PubChem 2.2 (PubChem release 2021.10.14)

2.3 Other Identifiers

2.3.1 CAS

2.3.3 European Community (EC) Number

2.3.4 UNII

2.3.5 UN Number

2.3.6 ChEBI ID

2.3.7 ChEMBL ID

2.3.8 DSSTox Substance ID

2.3.9 HMDB ID

2.3.10 ICSC Number

2.3.11 KEGG ID

2.3.12 Nikkaji Number

2.3.13 Wikidata

2.3.14 Wikipedia

2.4 Synonyms

2.4.1 MeSH Entry Terms

  • disodium methanearsonate
  • methanearsonic acid
  • methylarsonate
  • methylarsonic acid
  • methylarsonous acid
  • monomethylarsonic acid
  • monomethylarsonic acid, ammonium, iron (3+) salt
  • monomethylarsonic acid, calcium salt (2:1)
  • monomethylarsonic acid, dimercury (1+) salt
  • monomethylarsonic acid, dipotassium salt
  • monomethylarsonic acid, disodium salt
  • monomethylarsonic acid, iron (2+) salt (3:2)
  • monomethylarsonic acid, iron salt
  • monomethylarsonic acid, monoammonium salt
  • monomethylarsonic acid, monocalcium salt
  • monomethylarsonic acid, monosodium salt
  • monomethylarsonic acid, zinc salt
  • monosodium methanearsonate
  • MSMA
  • sodium methanearsonate

2.4.2 Depositor-Supplied Synonyms

3 Chemical and Physical Properties

3.1 Computed Properties

Property Name
Molecular Weight
Property Value
139.970 g/mol
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Donor Count
Property Value
2
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Acceptor Count
Property Value
3
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Rotatable Bond Count
Property Value
0
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Exact Mass
Property Value
139.945464 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Monoisotopic Mass
Property Value
139.945464 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Topological Polar Surface Area
Property Value
57.5 Ų
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Heavy Atom Count
Property Value
5
Reference
Computed by PubChem
Property Name
Formal Charge
Property Value
0
Reference
Computed by PubChem
Property Name
Complexity
Property Value
61.3
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Isotope Atom Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Covalently-Bonded Unit Count
Property Value
1
Reference
Computed by PubChem
Property Name
Compound Is Canonicalized
Property Value
Yes
Reference
Computed by PubChem (release 2021.10.14)

3.2 Experimental Properties

3.2.1 Physical Description

White hygroscopic solid; [ICSC]
Solid
WHITE HYGROSCOPIC SOLID IN VARIOUS FORMS.

3.2.2 Color / Form

Monoclinic, spear-shaped plates from absolute alcohol
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1018
White, crystalline solid
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 210
LEAVES FROM ALCOHOL
Weast, R.C. (ed.). Handbook of Chemistry and Physics. 64th ed. Boca Raton, Florida: CRC Press Inc., 1983-84., p. C-374

3.2.3 Taste

Pleasant acid taste
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1018

3.2.4 Melting Point

160.5 °C
Lide, DR (ed.). CRC Handbook of Chemistry and Physics. 81st Edition. CRC Press LLC, Boca Raton: FL 2000, p. 3-15
161 °C

3.2.5 Solubility

Soluble in ethanol
Lide, DR (ed.). CRC Handbook of Chemistry and Physics. 81st Edition. CRC Press LLC, Boca Raton: FL 2000, p. 3-15
In water, 2.56X10+5 mg/l @ 20 °C.
Yalkowsky SH, Dannenfelser RM; The AQUASOL dATAbASE of Aqueous Solubility. Fifth Ed, Tucson, AZ: Univ Az, College of Pharmacy (1992)
Solubility in water: very good

3.2.6 Vapor Pressure

0.00162 [mmHg]
<7.5X10-8 mm Hg @ 25 °C
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 210

3.2.7 Stability / Shelf Life

STABLE
Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979., p. 254

3.2.8 Decomposition

WHEN HEATED TO DECOMPOSITION IT EMITS TOXIC FUMES OF /ARSENIC/.
Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2182

3.2.9 Corrosivity

Mildly corrosive
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 210

3.2.10 Dissociation Constants

pKa1= 4.1; pKa2= 9.02
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 210

3.2.11 Other Experimental Properties

Strong dibasic acid.
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1018
Water high in calcium, magnesium and iron may cause precipitation; these cations form insoluble methane arsonate salts.
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 210

3.3 Chemical Classes

Metals -> Arsenic Compounds, Organic

4 Spectral Information

4.1 Mass Spectrometry

4.1.1 GC-MS

1 of 2
NIST Number
117137
Library
Main library
Total Peaks
20
m/z Top Peak
125
m/z 2nd Highest
91
m/z 3rd Highest
107
Thumbnail
Thumbnail
2 of 2
Source of Spectrum
TE-1992-326-0
Copyright
Copyright © 2020-2024 John Wiley & Sons, Inc. All Rights Reserved.
Thumbnail
Thumbnail

4.1.2 MS-MS

NIST Number
1187532
Instrument Type
IT/ion trap
Collision Energy
0
Spectrum Type
MS2
Precursor Type
[M+H]+
Precursor m/z
140.9527
Total Peaks
4
m/z Top Peak
122.8
m/z 2nd Highest
140.9
m/z 3rd Highest
123.8
Thumbnail
Thumbnail

4.2 IR Spectra

IR Spectra
IR: 247 (Coblentz Society Spectral Collection)

6 Chemical Vendors

7 Food Additives and Ingredients

7.1 Associated Foods

8 Pharmacology and Biochemistry

8.1 MeSH Pharmacological Classification

Teratogens
An agent that causes the production of physical defects in the developing embryo. (See all compounds classified as Teratogens.)
Herbicides
Pesticides used to destroy unwanted vegetation, especially various types of weeds, grasses (POACEAE), and woody plants. Some plants develop HERBICIDE RESISTANCE. (See all compounds classified as Herbicides.)

8.2 Absorption, Distribution and Excretion

...DAIRY COWS /WERE FED/ COTTONSEED RATION CONTAINING MAA. THE MAA HAD NO EFFECT ON COWS, WITH VERY LITTLE RESIDUE ACCUMULATING IN TISSUES OR MILK. THE MAA APPEARED TO BE POORLY ABSORBED FROM INTESTINAL TRACT & WAS RAPIDLY EXCRETED IN URINE.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 761
ARSENIC CONTENT OF MILK OR EDIBLE TISSUES OF COWS FED FOR 9 WK WITH 5 LB COTTONSEED MEAL CONTAINING 30 PPM OF ACID WAS NOT SIGNIFICANTLY INCREASED; NOR WAS ARSENIC CONTENT OF EGGS AND MEAT OF HENS RECEIVING DIETS CONTAINING UP TO 3 PPM OF METHANEARSONIC ACID.
Martin, H. and C.R. Worthing (eds.). Pesticide Manual. 4th ed. Worcestershire, England: British Crop Protection Council, 1974., p. 234
/COTTON/ COTYLEDONS ABSORBED MAA /METHANEARSONIC ACID/ & MSMA /MONOSODIUM METHANEARSONIC ACID/ MORE READILY THAN DSMA. ... ABSORPTION OF (14)C DSMA TENDED TO INCREASE WITH TEMPERATURE. /METHANEARSONIC ACID, DISODIUM SALT/
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 766

8.3 Metabolism / Metabolites

AFTER INGESTION /SRP: BY HUMANS/ OF ARSENIC-RICH WINE, APPROX 10% OF THE ARSENIC WAS EXCRETED AS ARSENITE, BUT THE MAJORITY OF ARSENIC WAS METHYLATED TO METHYLARSONIC ACID & DIMETHYLARSINIC ACID & EXCRETED.
CRECELIUS EA; CHANGES IN CHEMICAL SPECIATION OF ARSENIC FOLLOWING INGESTION BY MAN; ENVIRON HEALTH PERSPECT 19: 147-50 (1977)
IN THE PRESENCE OF CECAL CONTENT, BUT NOT SMALL INTESTINE, SMALL AMOUNTS OF METHYLARSONIC ACID & DIMETHYLARSINIC ACID WERE FORMED BY THE RAT IN VITRO.
ROWLAND IR, DAVIES MJ; IN VITRO METABOLISM OF INORGANIC ARSENIC BY THE GASTROINTESTINAL MICROFLORA OF THE RAT; J APPL TOXICOL 1 (5): 278-83 (1981)
IN FIRST VOID URINE SAMPLES FROM COPPER SMELTER WORKERS EXPOSED TO INORG ARSENIC & FROM NONEXPOSED CONTROLS 20% OF TOTAL ARSENIC WAS EXCRETED AS METHYLARSONIC ACID.
SMITH TJ ET AL; AIRBORNE ARSENIC EXPOSURE AND EXCRETION OF METHYLATED ARSENIC COMPOUNDS; ENVIRON HEALTH PERSPECT 19: 89-93 (1977)
THE HUMAN ORGANISM CAN COPE WITH MODERATE DOSES OF ARSENIC BY A RAPID & EFFICIENT METHYLATION PROCESS GIVING MONOMETHYLARSONIC ACID & DIMETHYLARSINIC ACID WHICH ARE RAPIDLY ELIMINATED IN THE URINE.
BUTCHET JP ET AL; INORGANIC ARSENIC METABOLISM IN MAN; ARCH TOXICOL, SUPPL 5: 326-7 (1982)
For more Metabolism/Metabolites (Complete) data for METHANEARSONIC ACID (6 total), please visit the HSDB record page.
Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. (L20)
L20: Wikipedia. Arsenic toxicity. Last Updated 22 February 2009. http://en.wikipedia.org/wiki/Arsenic_toxicity

8.4 Biochemical Reactions

8.5 Transformations

9 Use and Manufacturing

9.1 Uses

Sources/Uses
Used as herbicide in the past; [Merck Index] Not currently registered with the EPA for use in the US; [HSDB]
Merck Index - O'Neil MJ, Heckelman PE, Dobbelaar PH, Roman KJ (eds). The Merck Index, An Encyclopedia of Chemicals, Drugs, and Biologicals, 15th Ed. Cambridge, UK: The Royal Society of Chemistry, 2013.
Industrial Processes with risk of exposure
Farming (Pesticides) [Category: Industry]
For Methanearsonic acid (USEPA/OPP Pesticide Code: 128876) there are 0 labels match. /SRP: Not registered for current use in the U.S., but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./
U.S. Environmental Protection Agency/Office of Pesticide Program's Chemical Ingredients Database on Methanearsonic acid (124-58-3). Available from, as of May 24, 2001: https://npirspublic.ceris.purdue.edu/ppis/
Herbicide /Former use/
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1018
Methylarsonic acid, disodium salt is used as an herbicide and pesticide. (L389)
L389: Wikipedia. Organoarsenic chemistry. Last Updated 30 April 2009. http://en.wikipedia.org/wiki/Organoarsenic_compound

9.2 Methods of Manufacturing

Prepared from sodium arsenite and methyl iodide: Quick, Adams, J Am Chem Soc 44, 809 (1922). The disodium salt is...prepared by treating sodium arsenite with dimethyl sulfate at 85 °C... other routes are by reaction of methyl chloride with sodium arsonate under pressure: Miller et al, US patent 2,442,372 (1948); by the reaction of dimethyl sulfate with soln of arsenic trioxide in sodium hydroxide: Schwerdle, US patent 2,889,347 (1959).
Budavari, S. (ed.). The Merck Index - An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 1996., p. 1018

9.3 General Manufacturing Information

Patent assingments: US Patents: 2,678,265; 3,030,199; 3,035,910; 3,056,670; 3,056,821; 3,068,088.
Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979., p. 255

10 Identification

10.1 Analytic Laboratory Methods

PRODUCT ANALYSIS IS BY ACID-BASE TITRATION; TOTAL ARSENIC IS DETERMINED BY WET OXIDATION. RESIDUES MAY BE DETERMINED BY ESTIMATION OF TOTAL ARSENIC REDUCTION TO ARSINE & COLORIMETRY (EA DIETZ & LO MOORE, ANAL METHODS PESTIC PLANT GROWTH REGUL, 1978, 10 385).
Worthing, C.R., S.B. Walker (eds.). The Pesticide Manual - A World Compendium. 7th ed. Lavenham, Suffolk, Great Britain: The Lavenham Press Limited, 1983., p. 371
METHANEARSONIC ACID WAS DETERMINED BY GAS CHROMATOGRAPHY USING OV-17 ON CHROMOSORB W, HELIUM OR ARGON AS CARRIER GAS, & THE FLAME IONIZATION DETECTOR.
JOHNSON LD ET AL; DETERMINATION OF METHANEARSONIC ACID BY GAS-LIQUID CHROMATOGRAPHY; SCI TOTAL ENVIRON 1 (1): 108-13 (1972)
CHROMATOGRAPHIC SEPARATION USING A STRONG-ACID CATION-EXCHANGE RESIN & WATER AS ELUTING SOLVENT WAS UTILIZED FOR DETERMINING CONCN OF INORG ARSENICALS IN GENERAL SAMPLES.
DIETZ EA JR, PEREZ ME; PURIFICATION AND ANALYSIS METHODS FOR METHYLARSONIC ACID AND HYDROXYDIMETHYLARSINE OXIDE; ANAL CHEM 48 (7): 1088-92 (1976)
METHYLARSONIC ACID IS EST DIRECTLY BY VAPOR GENERATION ATOMIC ABSORPTION SPECTROMETRY WITHOUT PRIOR DIGESTION.
EDMONDS JS, FRANCESCONI KA; ESTIMATION OF METHYLATED ARSENICALS BY VAPOR GENERATION ATOMIC ABSORPTION SPECTROMETRY; ANAL CHEM 48 (13): 2019-20 (1976)
For more Analytic Laboratory Methods (Complete) data for METHANEARSONIC ACID (7 total), please visit the HSDB record page.

10.2 Clinical Laboratory Methods

METHYLARSONIC ACID IS ANALYZED FROM URINE BY SELECTIVE VOLATILIZATION AS ARSINE WITH DETERMINATION OF ARSENIC BY PLASMA EXCITATION EMISSION SPECTROMETRY.
SMITH TJ ET AL; AIRBORNE ARSENIC EXPOSURE AND EXCRETION OF METHYLATED ARSENIC COMPOUNDS; ENVIRON HEALTH PERSPECT 19: 89 (1977)
A SIMPLE CHROMATOGRAPHIC METHOD TO SEPARATE THE ARSENIC METABOLITES IN PLASMA & URINE FOLLOWING IV ADMIN OF ARSENIC TO DOGS IS DESCRIBED. PLASMA & URINE SAMPLES WERE CHROMATOGRAPHED ON CATION-EXCHANGE RESIN COLUMN.
TAM KH ET AL; SEPARATION OF ARSENIC METABOLITES IN DOG PLASMA AND URINE FOLLOWING INTRAVENOUS INJECTION OF (74) ARSENIC; ANAL BIOCHEM 86 (2): 505-11 (1978)
FLAMELESS ATOMIC ABSORPTION & GAS LIQUID CHROMATOGRAPHIC PROCEDURES FOR DETERMINATION OF ARSENIC IN SOFT TISSUES, AS WELL AS MONOMETHYL COMPOUNDS ARE PRESENTED.
MUSHAK P ET AL; FLAMELESS ATOMIC ABSORPTION (FFA) AND GAS-LIQUID CHROMATOGRAPHIC STUDIES IN ARSENIC BIOANALYSIS; ENVIRON HEALTH PERSPECT 19: 5 (1977)

10.3 NIOSH Analytical Methods

11 Safety and Hazards

11.1 Hazards Identification

11.1.1 GHS Classification

Pictogram(s)
Acute Toxic
Environmental Hazard
Signal
Danger
GHS Hazard Statements

H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]

H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]

H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]

H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]

Precautionary Statement Codes

P261, P264, P270, P271, P273, P301+P316, P304+P340, P316, P321, P330, P391, P403+P233, P405, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

ECHA C&L Notifications Summary

Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

11.1.2 Hazard Classes and Categories

Acute Tox. 3 (100%)

Acute Tox. 3 (100%)

Aquatic Acute 1 (100%)

Aquatic Chronic 1 (100%)

11.1.3 Fire Hazards

Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.

11.1.4 Hazards Summary

Oral LD50 (rat) = 961 mg/kg; [Sax] A mild skin, eye, and respiratory tract irritant; May cause kidney and liver injury; [ICSC] After ingestion of arsenic-rich wine, the majority of the arsenic was excreted in the urine in methylated form (methylarsonic acid & dimethylarsinic acid); Methylarsonic acid (MAA) fed to dairy cows in cottonseed ration had no apparent adverse effects; MAA was poorly absorbed and rapidly excreted in the urine; [HSDB] Arsenic is a known teratogen, but the effects of organic arsenicals is less clear. MAA is not likely to be a reproductive hazard at levels currently found in the environment; [REPROTOX] An irritant; [MSDSonline]
REPROTOX - Scialli AR, Lione A, Boyle Padgett GK. Reproductive Effects of Chemical, Physical, and Biological Agents. Baltimore: The Johns Hopkins University Press, 1995.

11.1.5 EPA Hazardous Waste Number

D004; A waste containing arsenic may or may not be characterized as a hazardous waste following testing by the Toxicity Characteristic Leaching Procedure as prescribed by the Resource Conservation and Recovery Act (RCRA) regulations. /Arsenic/

11.2 Safety and Hazard Properties

11.2.1 OSHA Standards

Permissible Exposure Limit: Table Z-1 8-Hr Time Weighted Avg: 0.5 mg/cu m. /Arsenic, organic cmpd (as As)/
29 CFR 1910.1000 (7/1/2001)

11.3 First Aid Measures

Inhalation First Aid
Fresh air, rest. Refer for medical attention.
Skin First Aid
Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eye First Aid
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion First Aid
Rinse mouth. Refer for medical attention .

11.4 Fire Fighting

In case of fire in the surroundings, use appropriate extinguishing media.

11.5 Accidental Release Measures

11.5.1 Spillage Disposal

Personal protection: particulate filter respirator adapted to the airborne concentration of the substance. Sweep spilled substance into covered containers. If appropriate, moisten first to prevent dusting. Carefully collect remainder. Then store and dispose of according to local regulations.

11.5.2 Disposal Methods

At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

11.6 Handling and Storage

11.6.1 Safe Storage

Separated from strong bases and food and feedstuffs. Dry. Store in an area without drain or sewer access.

11.6.2 Storage Conditions

SOLID FORMULATIONS ARE SOMEWHAT HYGROSCOPIC & SHOULD BE STORED IN DRY PLACE.
Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979., p. 254

11.7 Exposure Control and Personal Protection

11.7.1 Permissible Exposure Limit (PEL)

0.5 [mg/m3], as As

11.7.2 Other Standards Regulations and Guidelines

... The following countries had adopted the ... TLV of 0.5 mg/cu m: Austria, Belgium, Finland, Japan, and Holland. Czechoslavakia, East Germany, Hungary and Poland ... USSR ... 0.3 mg/cu m; Romania and Switzerland, 0.2 mg/cu m; Sweden 0.05 mg/cu m; and Italy 0.25 mg/cu m. /Arsenic and sol cmpd/
American Conference of Governmental Industrial Hygienists. Documentation of the Threshold Limit Values and Biological Exposure Indices. 5th ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, 1986., p. 37

11.7.3 Inhalation Risk

A harmful concentration of airborne particles can be reached quickly when dispersed.

11.7.4 Effects of Short Term Exposure

The substance is mildly irritating to the eyes, skin and respiratory tract. Ingestion could cause gastroenteritis. Medical observation is indicated.

11.7.5 Effects of Long Term Exposure

The substance may have effects on the kidneys and liver. This may result in impaired functions. This substance is carcinogenic to humans.

11.7.6 Allowable Tolerances

Tolerances for total residues of combined arsenic (calculated as As) in food are established as follows: (a) In edible tissues & in eggs of chickens & turkeys: 0.5 ppm in uncooked muscle tissue; 2 ppm in uncooked edible by-products; & 0.5 ppm in eggs. (b) In edible tissues of swine: 2 ppm in uncooked liver & kidney; 0.5 ppm in uncooked muscle tissue & by-products other than liver & kidney. /Arsenic/
21 CFR 556.60 (4/1/2001)

11.7.7 Preventions

Exposure Prevention
PREVENT DISPERSION OF DUST! AVOID ALL CONTACT!
Inhalation Prevention
Use local exhaust or breathing protection.
Skin Prevention
Protective gloves.
Eye Prevention
Wear safety goggles or eye protection in combination with breathing protection if powder.
Ingestion Prevention
Do not eat, drink, or smoke during work. Wash hands before eating.

11.8 Transport Information

11.8.1 Packaging and Labelling

Do not transport with food and feedstuffs. Marine pollutant.

11.8.2 EC Classification

Symbol: T, N; R: 23/25-50/53; S: (1/2)-20/21-28-45-60-61; Note: A, 1

11.8.3 UN Classification

UN Hazard Class: 6.1; UN Pack Group: I

11.9 Regulatory Information

California Safe Cosmetics Program (CSCP) Reportable Ingredient

Hazard Traits - Carcinogenicity

Authoritative List - IARC Carcinogens - 2B

Report - regardless of intended function of ingredient in the product

REACH Restricted Substance

Restricted substance: Methylarsonic acid

EC: 204-705-6

Restriction condition document: PDF link

11.9.1 Atmospheric Standards

Listed as a hazardous air pollutant (HAP) generally known or suspected to cause serious health problems. The Clean Air Act, as amended in 1990, directs EPA to set standards requiring major sources to sharply reduce routine emissions of toxic pollutants. EPA is required to establish and phase in specific performance based standards for all air emission sources that emit one or more of the listed pollutants. Methanearsonic acid is included on this list.
Clean Air Act as amended in 1990, Sect. 112 (b) (1) Public Law 101-549 Nov. 15, 1990
(a) The owner or operator of an existing glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (a)(1) or (a)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 2.5 Mg (2.7 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/
40 CFR 61.162(a) (7/1/2001)
(b) The owner or operator of a new or modified glass melting furnace subject to the provisions of this subpart shall comply with either paragraph (b)(1) or (b)(2) of this section ... (1) Uncontrolled total arsenic emissions from the glass melting furnace shall be less than 0.4 Mg (0.44 ton) per year, or ... (2) Total arsenic emissions from glass melting furnace shall be conveyed to a control device and reduced by at least 85%. /Total arsenic/
40 CFR 61.162(b) (7/1/2001)
The owner or operator of each copper converter subject to the provisions of this subpart shall reduce inorganic arsenic emissions to the atmosphere by meeting the following design, equipment, work practice, and operational requirements: (1) Install, operate, and maintain a secondary hood system on each copper converter. Each secondary hood system shall consist of a hood enclosure, air curtain fan(s), exhaust system fan(s), and ductwork that conveys the captured emission to a control device ... (2) Optimize the capture of secondary inorganic arsenic emission by operating the copper converter and secondary hood systems at all times ... . /Inorganic arsenic/
40 CFR 61.172(b) (7/1/2001)

11.9.2 Federal Drinking Water Standards

10 ug/l /Arsenic/
USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present

11.9.3 State Drinking Water Guidelines

(AZ) ARIZONA 10 ug/L /Arsenic/
USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present
(CT) CONNECTICUT 10 ug/l /Arsenic/
USEPA/Office of Water; Federal-State Toxicology and Risk Analysis Committee (FSTRAC). Summary of State and Federal Drinking Water Standards and Guidelines (11/93) To Present

11.9.4 Clean Water Act Requirements

Toxic pollutant designated pursuant to section 307(a)(1) of the Federal Water Pollution Control Act and is subject to effluent limitations. /Arsenic & cmpd/
40 CFR 401.15 (7/1/2001)
For the maximum protection of human health from the potential carcinogenic effects due to exposure of arsenic through ingestion of contaminated water & contaminated aquatic organisms, the ambient water concn should be zero based on the nonthreshold assumption for this chemical. However, zero level may not be attainable at the present time. Therefore, the levels which may result in incremental increase of cancer risk over the lifetime are estimated at 1X10-5, 1X10-6, & 1X10-7. The corresponding criteria are 22 ng/l, 2.2 ng/l, & .22 ng/l, respectively .... For consumption of aquatic organisms only, excluding consumption of water, the levels are 175 ng/ml, 17.5 ng/l, & 1.75 ng/l, respectively. /Arsenic/
USEPA; Quality Criteria for Water 1986: Arsenic: Human Health Criteria (May 1, 1986) EPA 440/5-86-001
D004; A solid waste containing arsenic may or may not become characterized as a hazardous waste when subjected to the Toxicity Characteristic Leaching Procedure listed in 40 CFR 261.24, and if so characterized, must be managed as a hazardous waste.
40 CFR 261.24 (7/1/2001)

11.9.5 FIFRA Requirements

If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, liquid, NOS/
Association of American Railroads. Emergency Handling of Hazardous Materials in Surface Transportation. Washington, DC: Association of American Railroads, Bureau of Explosives, 1994., p. 104
If material involved in fire: Extinguish fire using agent suitable for type of surrounding fire. (Material itself does not burn or burns with difficulty.) Use water in flooding quantities as fog. Use foam, dry chemical, or carbon dioxide. /Arsenical cmpd, solid, NOS/
Association of American Railroads. Emergency Handling of Hazardous Materials in Surface Transportation. Washington, DC: Association of American Railroads, Bureau of Explosives, 1994., p. 105

11.10 Other Safety Information

11.10.1 Special Reports

REVIEW OF THE CHEMICAL, PHYSICAL, & BIOL PROPERTIES & METHODS OF ANALYSIS FOR MONOMETHYLARSONIC ACID, CACODYLIC ACID, & THEIR SODIUM SALTS.[DIETZ EA JR, MOORE LO; MONOMETHYLARSONIC ACID, CACODYLIC ACID, AND THEIR SODIUM SALTS; ANAL METHODS PESTIC PLANT GROWTH REGUL 10: 385-401 (1978)]

12 Toxicity

12.1 Toxicological Information

12.1.1 Toxicity Summary

Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. (T1, A17)
A17: Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. doi: 10.1016/j.jinorgbio.2007.10.021. Epub 2007 Nov 22. PMID:18164070
T1: Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

12.1.2 RAIS Toxicity Values

Oral Chronic Reference Dose (RfDoc) (mg/kg-day)
0.01
Oral Chronic Reference Dose Reference
ATSDR Final
Oral Subchronic Chronic Reference Dose (RfDos) (mg/kg-day)
0.1
Oral Subchronic Chronic Reference Dose Reference
ATSDR Final
Short-term Oral Reference Dose (RfDot) (mg/kg-day)
0.1
Short-term Oral Reference Dose Reference
ATSDR Final

12.1.3 Carcinogen Classification

1 of 2
IARC Carcinogenic Agent
Methylarsonic acid
IARC Carcinogenic Classes
Group 2B: Possibly carcinogenic to humans
IARC Monographs
Volume 100C: (2012) Arsenic, Metals, Fibres, and Dusts
2 of 2
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)

12.1.4 Health Effects

Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. (T1, L20)
L20: Wikipedia. Arsenic toxicity. Last Updated 22 February 2009. http://en.wikipedia.org/wiki/Arsenic_toxicity
T1: Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

12.1.5 Exposure Routes

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.
Oral (L2) ; inhalation (L2); dermal (L2)
L2: ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/toxprofiles/tp2.html

12.1.6 Symptoms

Inhalation Exposure
Cough. Sore throat.
Skin Exposure
Redness.
Ingestion Exposure
Abdominal pain. Diarrhoea. Vomiting.
Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, damage to blood vessels, and a sensation of burn (T1).
T1: Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

12.1.7 Adverse Effects

Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.

IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.

12.1.8 Acute Effects

12.1.9 Minimum Risk Level

Acute Oral: 0.005 mg/kg/day (L134) Chronic Oral: 0.0003 mg/kg/day (L134) Chronic Inhalation: 0.01 mg/m3 (L134)
L134: ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). http://www.atsdr.cdc.gov/mrls/

12.1.10 Treatment

Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (L20)
L20: Wikipedia. Arsenic toxicity. Last Updated 22 February 2009. http://en.wikipedia.org/wiki/Arsenic_toxicity

12.1.11 Human Toxicity Excerpts

SKIN IRRITATION OF THESE VARIOUS ARSENICALS VARY FROM VERY-MILD TO NONE, DEPENDING ON ACIDITY OR ALKALINITY OF EACH PREPN, & SKIN SENSITIVITY OF EXPOSED INDIVIDUAL. SYMPTOMS OF...SUBACUTE POISONING WITH ARSENICALS.../INCL METHANEARSONIC ACID/ SALTY TASTE, BURNING IN THROAT, & COLICKY PAINS IN STOMACH & INTESTINES. GARLICKY ODOR OF BREATH & SKIN IS FREQUENTLY PRESENT. SYMPTOMS OF ACUTE POISONING...HEADACHE, VOMITING, DIARRHEA, DIZZINESS, STUPOR, CONVULSIONS, GENERAL PARALYSIS, & DEATH.
Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979., p. 254

12.1.12 Non-Human Toxicity Excerpts

/INVESTIGATORS/...FOUND THAT 100 & 1000 PPM BY WT OF MAA /METHANEARSONIC ACID/, MSMA /MONOSODIUM SALT/, DAMA /DISODIUM SALT/, & CA /CACODYLIC ACID/ WERE EXTREMELY TOXIC TO NEWLY-EMERGED WORKER BEES (APIS MELLIFERA L). TWO ARSENICALS, MAA & CA, WERE MODERATELY TOXIC AT 10 PPM BY WT. THE HERBICIDES WERE CONTAINED IN A 60% SUCROSE SYRUP.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 761
ONLY A MILD IRRITANT TO SKIN OF RABBITS. IN FEEDING TRIALS DOGS RECEIVING 100 MG ACID/KG DIET SHOWED NO ILL-EFFECT.
Tomlin, C.D.S. (ed.). The Pesticide Manual - World Compendium. 10th ed. Surrey, UK: The British Crop Protection Council, 1994., p. 685
MONOMETHYLARSONIC ACID CAUSED NO CHANGES IN OSMOTIC FRAGILITY OF RAT ERYTHROCYTES WHEN ADMIN ORALLY OR IN VITRO.
TSUZUKI S ET AL; OSMOTIC FRAGILITY OF RAT ERYTHROCYTES CAUSED BY ARSENIC COMPOUNDS; MATSUMOTO SHIGAKU 6 (2): 173-8 (1980)
Oligouria was noted after acute exposure and interstitial nephritis and tubular nephrosis have been noted in rabbits give repeated oral doses of MMA ... . /Dose not specified/
DHHS/ATSDR; Toxicological Profile for Arsenic p. 111 (2000)
Male and female mice dosed with MMA (55 mg As/kg/day) prior to mating and during pregnancy produced fewer litters than normal, an effect that was attributable mainly to decr fertility of the males ... .
DHHS/ATSDR; Toxicological Profile for Arsenic p. 117 (2000)

12.1.13 Non-Human Toxicity Values

LD50 RATS ORAL 1800 MG/KG ACUTE
Weed Science Society of America. Herbicide Handbook. 4th ed. Champaign, IL: Weed Science Society of America, 1979. of America, 1979., p. 254
LD50 MICE ORAL 185 MG/KG
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 760
LD50 MICE INTRAVENOUS 316 MG/KG
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 760
LD50 Rat oral 961 mg/kg
Lewis, R.J. Sax's Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996., p. 2181
For more Non-Human Toxicity Values (Complete) data for METHANEARSONIC ACID (7 total), please visit the HSDB record page.

12.1.14 TSCA Test Submissions

Methylarsenic acid was evaluated for clastogenicity in groups of 20 male Long-Evans rats injected intraperitoneally with total dose levels of 0 or 500 mg/kg bw, in three equal increments at 2 day intervals. Blood and bone marrow samples were obtained from each rat at 1 and 30 days after treatment, for determination of chromosomal abnormalities. The treatment increased the frequency of 1 type of chromosomal aberration (gap/break) in bone marrow cells obtained on day 1, indicating that the test compound was positive for clastogenicity in rats under the conditions of this assay. Positive control treatment with a single intraperitoneal injection of 0.3 mg/kg triethylenemelamine produced a significant increase in the frequency of chromosomal aberrations in bone marrow cells collected on day 1; bone marrow cells collected from positive control rats on day 30 and blood cells collected on day 1 or 30 were similar to negative controls in frequency of chromosomal aberrations.
Toxicology Research Laboratory; Estimation of the Carcinogenicity and Mutagenicity of Some Arsenic Compounds Utilizing Somatic Mutations in Rats(Final Report), (1978), EPA Document No. 8EHQ-0579-0150, Fiche No.OTS0200532

12.2 Ecological Information

12.2.1 US EPA Regional Screening Levels for Chemical Contaminants

Resident Soil (mg/kg)
6.30e+02
Industrial Soil (mg/kg)
8.20e+03
Tapwater (ug/L)
2.00e+02
MCL (ug/L)
4.00e+01
Risk-based SSL (mg/kg)
5.80e-02
Chronic Oral Reference Dose (mg/kg-day)
1.00e-02
Volatile
Volatile
Mutagen
Mutagen
Fraction of Contaminant Absorbed in Gastrointestinal Tract
1
Fraction of Contaminant Absorbed Dermally from Soil
0.1

12.2.2 US EPA Regional Removal Management Levels for Chemical Contaminants

Resident Soil (mg/kg)
1.90e+03
Industrial Soil (mg/kg)
2.50e+04
Tapwater (ug/L)
6.00e+02
MCL (ug/L)
4.00e+01
Chronic Oral Reference Dose (mg/kg-day)
1.00e-02
Volatile
Volatile
Mutagen
Mutagen
Fraction of Contaminant Absorbed in Gastrointestinal Tract
1
Fraction of Contaminant Absorbed Dermally from Soil
0.1

12.2.3 ICSC Environmental Data

The substance is toxic to aquatic organisms. This substance does enter the environment under normal use. Great care, however, should be taken to avoid any additional release, for example through inappropriate disposal.

12.2.4 Environmental Fate

EVOLUTION OF DIMETHYLARSINE & TRIMETHYLARSINE FROM GRASSES TREATED WITH SODIUM ARSENITE, METHYLARSONIC ACID, DIMETHYLARSINIC ACID, OR PHENYLARSONIC ACID CONFIRMED THE IDEA OF NATURAL BIOMETHYLATION.
BRAMAN RS; ARSENIC IN THE ENVIRONMENT; ACS SYMP SER; 7 (ARSENICAL PESTIC, SYMP, 1974): 108-23 (1975)
Strongly adsorbed to soil; fixed by Fe and Al hydrous oxides in soil. Sorption increases as size of clay fraction decreases.
Ahrens, W.H. Herbicide Handbook of the Weed Science Society of America. 7th ed. Champaign, IL: Weed Science Society of America, 1994., p. 210
DECR IN PHYTOTOXICITY IS A RESULT OF FIXATION...MAINLY BY IRON & ALUMINUM HYDROUS OXIDES IN THE SOIL.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 756

12.2.5 Environmental Biodegradation

THE METABOLISM OF MAA TO INORGANIC ARSENIC IS THE MAIN MECHANISM OF HERBICIDE DEGRADATION... THE ASSOC OF HERBICIDAL BREAKDOWN WITH THE GENERAL MICROBIOLOGICAL ACTIVITY SUGGESTS THAT THE OXIDATION OF MAA /METHANEARSONIC ACID/ OCCURRED COINCIDENTALLY WITH THE METAB OF SOIL ORG MATTER. ON THE OTHER HAND, BOTH NORFOLK LOAMY SAND SAMPLES (WITH & WITHOUT ORGANIC MATTER ADDED) SHOWED AN INCREASED DSMA /DISODIUM SALT OF MAA/ DECOMPOSITION RELATIVE TO SOIL ORGANIC MATTER. THIS SUGGESTED AN ADAPTATION OF THE MICROBIAL POPULATION TO METABOLIZE THE METHYL CARBON OF MAA. /INVESTIGATORS/...EXAM THE DEGRADATION OF MSMA /MONOSODIUM SALT OF MAA/ ON 4 SOILS. THEY CONCLUDED THAT SOIL MICROORGANISMS APPEARED TO PLAY SOME ROLE IN THE DECOMPOSITION PROCESS. A FUNGUS, SEVERAL ACTINOMYCETES, & SEVERAL BACTERIA WERE ISOLATED USING SOIL ENRICHMENT TECHNIQUES. THE ORGANISMS DEGRADED 3, 13 OR 9, & 20% OF THE MSMA IN 11 DAYS, RESPECTIVELY. HOWEVER, IN THE ABSENCE OF AN ENERGY SOURCE, MICROBIAL METABOLISM OF THE ORGANIC ARSENICAL WAS NONEXISTENT. THE PRODUCTS OF METABOLISM WERE CARBON DIOXIDE & ARSENATE. NO ARSENITE COULD BE DETECTED.
Kearney, P.C., and D. D. Kaufman (eds.) Herbicides: Chemistry, Degredation and Mode of Action. Volumes 1 and 2. 2nd ed. New York: Marcel Dekker, Inc., 1975., p. 757

12.2.6 Environmental Abiotic Degradation

BEHAVIOR IN OR ON SOILS ... LOSS FROM PHOTODECOMPOSITION ... NONE.
Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983., p. 291

12.2.7 Environmental Bioconcentration

IN AQUATIC MODEL ECOSYSTEM TESTING BIOACCUMULATION & DISTRIBUTION OF (14)C-METHANEARSONIC ACID, BIOACCUMULATION RATIOS FOR DAPHNIDS, GAMBUSIA, ALGAE & CRAYFISH WERE 5, 127, 34, & 5, RESPECTIVELY. BIOACCUMULATION RATIO VALUES DECLINED FOR CRAYFISH & CATFISH WHEN REMOVED FROM (14)C-METHANEARSONIC ACID EXPOSURE TO UNTREATED WATER. (14)C WAS FOUND @ HIGHER % RATE IN RESIDUE OF EXPTL ORGANISMS THAN (74)AS-ARSENATE.
WOOLSON EA ET AL; DISTRIBUTION AND ISOLATION OF RADIOACTIVITY FROM 74AS-ARSENATE AND 14C-METHANEARSONIC ACID IN AN AQUATIC MODEL ECOSYSTEM; PEST BIOCHEM PHYSIOL 6 (3): 261-9 (1976)

12.2.8 Volatilization from Water / Soil

BEHAVIOR IN OR ON SOILS ... LOSS FROM ... VOLATILIZATION: NONE.
Weed Science Society of America. Herbicide Handbook. 5th ed. Champaign, Illinois: Weed Science Society of America, 1983., p. 291

12.2.9 Environmental Water Concentrations

METHANEARSONIC ACID WAS 1 OF THE 4 ARSENIC SPECIES ANALYZED IN SEAWATER SAMPLES OFF SOUTHERN CA & VARIOUS TERRESTRIAL WATERS OF THE USA.
ANDREAE MO; DISTRIBUTION AND SPECIATION OF ARSENIC IN NATURAL WATERS AND SOME MARINE ALGAE; DEEP-SEA RES 25 (4): 391-402 (1978)

12.2.10 Food Survey Values

NINETEEN SAMPLES REPRESENTING 13 VARIETIES OF RED & WHITE DOMESTIC TABLE WINES WERE ANALYZED FOR ARSENITE, ARSENATE, METHYLARSONIC ACID & DIMETHYLARSINIC ACID. THE CONCN OF ARSENITE RANGED FROM LESS THAN 1 TO 420 PPB, & THE CONCN OF ARSENATE RANGED FROM 1 TO 110 PPB. METHYLARSONIC ACID WAS BELOW LIMIT OF DETECTION OF 1 PPB.
CRECELIUS EA; ARSENITE AND ARSENATE LEVELS IN WINE; BULL ENVIRON CONTAM TOXICOL 18 (2): 227-30 (1977)

12.2.11 Probable Routes of Human Exposure

THE SOURCE OF THE HIGH ARSENIC LEVELS IN SOME TO THE WINES APPEARED TO BE THE USE OF ARSENICALS IN GRAPE PRODUCTION.
CRECELIUS EA; ARSENITE AND ARSENATE LEVELS IN WINE; BULL ENVIRON CONTAM TOXICOL 18 (2): 227-30 (1977)

13 Associated Disorders and Diseases

14 Literature

14.1 Consolidated References

14.2 NLM Curated PubMed Citations

14.3 Springer Nature References

14.4 Chemical Co-Occurrences in Literature

14.5 Chemical-Gene Co-Occurrences in Literature

14.6 Chemical-Disease Co-Occurrences in Literature

15 Patents

15.1 Depositor-Supplied Patent Identifiers

15.2 WIPO PATENTSCOPE

15.3 Chemical Co-Occurrences in Patents

15.4 Chemical-Disease Co-Occurrences in Patents

15.5 Chemical-Gene Co-Occurrences in Patents

16 Interactions and Pathways

16.1 Chemical-Target Interactions

16.2 Pathways

17 Biological Test Results

17.1 BioAssay Results

18 Classification

18.1 MeSH Tree

18.2 ChEBI Ontology

18.3 KEGG: Pesticides

18.4 ChemIDplus

18.5 ChEMBL Target Tree

18.6 UN GHS Classification

18.7 NORMAN Suspect List Exchange Classification

18.8 EPA DSSTox Classification

18.9 International Agency for Research on Cancer (IARC) Classification

18.10 EPA Substance Registry Services Tree

18.11 MolGenie Organic Chemistry Ontology

19 Information Sources

  1. California Safe Cosmetics Program (CSCP) Product Database
  2. European Chemicals Agency (ECHA)
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    https://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
  5. EPA DSSTox
    CompTox Chemicals Dashboard Chemical Lists
    https://comptox.epa.gov/dashboard/chemical-lists/
  6. FDA Global Substance Registration System (GSRS)
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    https://www.fda.gov/about-fda/about-website/website-policies#linking
  7. Hazardous Substances Data Bank (HSDB)
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  9. ILO-WHO International Chemical Safety Cards (ICSCs)
  10. Risk Assessment Information System (RAIS)
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    Methylarsonic acid, disodium salt
    http://www.t3db.ca/toxins/T3D0308
  13. ChEMBL
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  15. EPA Regional Screening Levels for Chemical Contaminants at Superfund Sites
  16. FooDB
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  18. IUPAC Digitized pKa Dataset
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    https://publications.iarc.fr/Terms-Of-Use
    IARC Classification
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  20. Japan Chemical Substance Dictionary (Nikkaji)
  21. KEGG
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  22. NIOSH Manual of Analytical Methods
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  23. NIST Mass Spectrometry Data Center
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  24. SpectraBase
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    Methylarsonic acid
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    https://www.norman-network.com/nds/SLE/
  26. Springer Nature
  27. Wikidata
  28. Wikipedia
  29. PubChem
  30. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
  31. GHS Classification (UNECE)
  32. EPA Substance Registry Services
  33. MolGenie
    MolGenie Organic Chemistry Ontology
    https://github.com/MolGenie/ontology/
  34. PATENTSCOPE (WIPO)
CONTENTS