Amphotericin B, Antibiotic for Culture Media Use Only
- 1397-89-3
- A-7680
- Amphotericin B, Antibiotic for Culture Media Use Only
- Create:2021-09-10
- Modify:2025-01-18
Use (kg; approx.) in Germany (2009): >1000
Use (kg) in USA (2002): 73
Use (kg) in France (2004): 18179
Consumption (g per capita; approx.) in Germany (2009): 0.0122
Consumption (g per capita) in the USA (2002): 0.000258
Consumption (g per capita) in France (2004): 0.301
Excretion rate: 1
Calculated removal (%): 75.1
H315 (97.4%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (96.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (97.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 152 reports by companies from 23 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Skin Irrit. 2 (97.4%)
Eye Irrit. 2 (96.1%)
STOT SE 3 (97.4%)
◉ Summary of Use during Lactation
Although no information exists on the milk excretion of amphotericin B, it is highly protein bound, has a large molecular weight, is virtually unabsorbed orally and has been use directly in the mouths of infants; therefore, most reviewers consider it acceptable to use in nursing mothers.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
- Australian Industrial Chemicals Introduction Scheme (AICIS)
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeAmphotericin B (EC: 215-742-2)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/19204
- Hazardous Substances Data Bank (HSDB)AMPHOTERICIN Bhttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/3008
- New Zealand Environmental Protection Authority (EPA)LICENSEThis work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence.https://www.epa.govt.nz/about-this-site/general-copyright-statement/
- Drugs and Lactation Database (LactMed)Amphotericin Bhttps://www.ncbi.nlm.nih.gov/books/n/lactmed/LM446/
- EU Clinical Trials Register
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/AMPHOTERICIN B
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falseCAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react