Capreomycin
- capreomycin
- Capreomycin (INN)
- CAPREOMYCIN [INN]
- Capostatin
- Capreomicin
- Create:2005-08-01
- Modify:2025-01-11
- Capastat
- Capreomycin
- Capreomycin Sulfate
- Capromycin
Intramuscular therapy with capreomycin has not been definitely linked to liver injury, either in the form of asymptomatic elevations in serum enzymes or of clinically apparent liver injury. However, the agent is rarely used and is always used in combination with other antituberculosis medications, many of which are well known to cause liver injury. Nevertheless, in the few studies done, capreomycin has not been associated with an increase in the rate of serum enzyme elevations or in episodes of acute liver injury above or beyond what was reported in the comparator arm.
Likelihood score: E (unlikely cause of clinically apparent liver injury).
◉ Summary of Use during Lactation
Developmental problems have been reported in two infants exposed to capreomycin in breastmilk; however, their mothers were also exposed to several drugs during pregnancy and during breastfeeding, so the problems cannot necessarily be attributed to capreomycin. Because capreomycin is not orally absorbed it is unlikely to adversely affect the breastfed infant.
◉ Effects in Breastfed Infants
Capreomycin was used as part of multidrug regimens to treat two pregnant women with multidrug-resistant tuberculosis, one throughout pregnancy and postpartum and the other postpartum only. The infants were breastfed (extent and duration not stated). At age 4.6 and 5.1 years, the children were developing normally except for a mild speech delay in one and hyperactivity in the other.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
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- WikipediaUranyl zinc acetatehttps://en.wikipedia.org/wiki/Uranyl_zinc_acetateCapreomycinhttps://en.wikipedia.org/wiki/Capreomycin
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