Methoxyflurane
- C3H4Cl2F2O
- CH3OCF2CHCl2
- methoxyflurane
- 76-38-0
- Methoxyfluran
- Methoflurane
- Penthrane
- Create:2005-03-25
- Modify:2025-01-18
C3H4Cl2F2O
CH3OCF2CHCl2
- Anecotan
- Methofluranum
- Methoxyflurane
- Penthrane
- Pentrane
- methoxyflurane
- 76-38-0
- Methoxyfluran
- Methoflurane
- Penthrane
- 2,2-Dichloro-1,1-difluoroethyl methyl ether
- Metoxfluran
- Metoxifluran
- Analgizer
- Anecotan
- Inhalan
- Methoxane
- Metofane
- Pentrane
- 2,2-Dichloro-1,1-difluoro-1-methoxyethane
- Methofane
- Pentran
- Methoxiflurane
- Methoxifluranum
- Ingalan
- Methoxyfluoran
- Metoxiflurano
- Methoxyfluorane
- Methoxyfluranum
- Metossiflurano [DCIT]
- Metossiflurano
- Ethane, 2,2-dichloro-1,1-difluoro-1-methoxy-
- Methoxyfluranum [INN-Latin]
- Metoxiflurano [INN-Spanish]
- NSC-110432
- Methyl 1,1-difluoro-2,2-dichloroethyl ether
- Penthrox
- (2,2-dichloro-1,1-difluoroethyl) methyl ether
- CCRIS 5840
- Methoxy flurane
- HSDB 7201
- EINECS 200-956-0
- DA-759
- Ether, 2,2-dichloro-1,1-difluoroethyl methyl
- BRN 1737766
- CHEBI:6843
- DTXSID7025556
- UNII-30905R8O7B
- 30905R8O7B
- DTXCID405556
- Methofluranum
- 2,2-DICHLORO-1,1-DIFLUOROETHYLMETHYLETHER
- Methoxyflurane [USAN:USP:INN:BAN]
- NSC110432
- Penthrane (VAN)
- Metofane (VAN)
- NCGC00168747-01
- Methoxyfluranum (INN-Latin)
- Metoxiflurano (INN-Spanish)
- METHOXYFLURANE (MART.)
- METHOXYFLURANE [MART.]
- METHOXYFLURANE (USP-RS)
- METHOXYFLURANE [USP-RS]
- Methoxyflurane (USAN:USP:INN:BAN)
- METHOXYFLURANE (USP MONOGRAPH)
- METHOXYFLURANE [USP MONOGRAPH]
- Penthrane (TN)
- Methoxyflurane (USP/INN)
- Methoxyflurane [Anaesthetics, volatile]
- WLN: GYGXFFO1
- METHOXYFLURANE [MI]
- CHEMBL1341
- METHOXYFLURANE [INN]
- METHOXYFLURANE [HSDB]
- METHOXYFLURANE [USAN]
- METHOXY FLURANE [JAN]
- METHOXYFLURANE [VANDF]
- SCHEMBL121229
- 2,1-difluoro-1-methoxyethane
- 2,1-difluoroethyl methyl ether
- GTPL7234
- METHOXYFLURANE [WHO-DD]
- N02BG09
- DA759
- METHOXYFLURANE [GREEN BOOK]
- HY-B0718
- Tox21_112626
- MFCD00040144
- AKOS006228995
- DB01028
- KS-5167
- CAS-76-38-0
- Ether,2-dichloro-1,1-difluoroethyl methyl
- DB-019611
- CS-0009624
- Ethane,2-dichloro-1,1-difluoro-1-methoxy-
- NS00041004
- 1,1-Difluoro-2,2-dichloroethyl methyl ether
- C07517
- D00544
- Q411594
- SR-01000944693
- SR-01000944693-1
- BRD-K06152156-001-01-8
- Z1201617823
- Cytoplasm
- Membrane
H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
H315 (16.7%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (16.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H341 (83.3%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
P203, P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 6 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Flam. Liq. 3 (100%)
Skin Irrit. 2 (16.7%)
Eye Irrit. 2 (100%)
STOT SE 3 (16.7%)
Excerpt from NIOSH Pocket Guide for Methoxyflurane:
Exposure Routes: Inhalation, ingestion, skin and/or eye contact
Symptoms: Irritation eyes; central nervous system depression, analgesia, anesthesia, convulsions, resp depression; liver, kidney injury; In Animals: reproductive, teratogenic effects
Target Organs: Eyes, central nervous system, liver, kidneys, reproductive system (NIOSH, 2024)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
(See general first aid procedures)
Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
Skin: Soap wash - If this chemical contacts the skin, wash the contaminated skin with soap and water.
Breathing: Respiratory support
Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area for at least 50 meters (150 feet) in all directions.
LARGE SPILL: Consider initial downwind evacuation for at least 300 meters (1000 feet).
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION. Then, use absorbent paper to pick up all liquid spill material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this material for prolonged exposure to light and store it under ambient temperatures. (NTP, 1992)
N.D.
See: IDLH INDEX
Excerpt from NIOSH Pocket Guide for Methoxyflurane:
Skin: No recommendation is made specifying the need for personal protective equipment for the body.
Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.
Wash skin: No recommendation is made specifying the need for washing the substance from the skin (either immediately or at the end of the work shift).
Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: No recommendation is made specifying the need for the worker to change clothing after the workshift. (NIOSH, 2024)
(See personal protection and sanitation codes)
Skin: No recommendation
Eyes: Prevent eye contact - Wear appropriate eye protection to prevent eye contact.
Wash skin: No recommendation
Remove: When wet or contaminated
Change: No recommendation
Ethers
Halogenated Organic Compounds
Fluorinated Organic Compounds
Neurotoxin - Acute solvent syndrome
Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=RFKMCNOHBTXSMU-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Ethane, 2,2-dichloro-1,1-difluoro-1-methoxy-https://services.industrialchemicals.gov.au/search-inventory/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falseMETHOXYFLURANEhttps://cameochemicals.noaa.gov/chemical/20609CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- ILO-WHO International Chemical Safety Cards (ICSCs)
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Methoxyfluranehttps://commonchemistry.cas.org/detail?cas_rn=76-38-0
- ChemIDplusMethoxyflurane [USAN:USP:INN:BAN]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0000076380ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useMethoxyfluranehttps://www.drugbank.ca/drugs/DB01028
- DTP/NCILICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuse
- EPA DSSToxMethoxyfluranehttps://comptox.epa.gov/dashboard/DTXSID7025556CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeMethoxyflurane (EC: 200-956-0)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/124300
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Hazardous Substances Data Bank (HSDB)METHOXYFLURANEhttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/7201
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citingMethoxyfluranehttp://www.hmdb.ca/metabolites/HMDB0015162
- The National Institute for Occupational Safety and Health (NIOSH)LICENSEThe information provided using CDC Web site is only intended to be general summary information to the public. It is not intended to take the place of either the written law or regulations.https://www.cdc.gov/Other/disclaimer.htmlEther, 2,2-dichloro-1,1-difluoroethyl methylhttps://www.cdc.gov/niosh-rtecs/KN7752E0.htmlMethoxyfluranehttps://www.cdc.gov/niosh/npg/npgd0389.html
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutMethoxyfluranehttps://haz-map.com/Agents/206
- ChEBI
- Open TargetsLICENSEDatasets generated by the Open Targets Platform are freely available for download.https://platform-docs.opentargets.org/licenceMETHOXYFLURANEhttps://platform.opentargets.org/drug/CHEMBL1341
- Toxin and Toxin Target Database (T3DB)LICENSET3DB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (T3DB) and the original publication.http://www.t3db.ca/downloadsMethoxyfluranehttp://www.t3db.ca/toxins/T3D2962
- ChEMBLLICENSEAccess to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).http://www.ebi.ac.uk/Information/termsofuse.htmlChEMBL Protein Target Treehttps://www.ebi.ac.uk/chembl/g/#browse/targets
- ClinicalTrials.govLICENSEThe ClinicalTrials.gov data carry an international copyright outside the United States and its Territories or Possessions. Some ClinicalTrials.gov data may be subject to the copyright of third parties; you should consult these entities for any additional terms of use.https://clinicaltrials.gov/ct2/about-site/terms-conditions#Use
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jspMethoxyfluranehttps://ctdbase.org/detail.go?type=chem&acc=D008733
- Drug Gene Interaction database (DGIdb)LICENSEThe data used in DGIdb is all open access and where possible made available as raw data dumps in the downloads section.http://www.dgidb.org/downloadsMETHOXYFLURANEhttps://www.dgidb.org/drugs/rxcui:6857
- Therapeutic Target Database (TTD)Methoxyfluranehttps://idrblab.net/ttd/data/drug/details/D07SOO
- European Medicines Agency (EMA)LICENSEInformation on the European Medicines Agency's (EMA) website is subject to a disclaimer and copyright and limited reproduction notices.https://www.ema.europa.eu/en/about-us/legal-noticeMethoxyflurane (P/0525/2021)https://www.ema.europa.eu/en/medicines/human/paediatric-investigation-plans/emea-000334-pip01-08-m10
- Drugs@FDALICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingMETHOXYFLURANEhttps://www.accessdata.fda.gov/scripts/cder/daf/
- EU Clinical Trials Register
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.htmlAnatomical Therapeutic Chemical (ATC) classificationhttp://www.genome.jp/kegg-bin/get_htext?br08303.keg
- Metabolomics Workbench
- NCI Thesaurus (NCIt)LICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuseNCI Thesaurushttps://ncit.nci.nih.gov
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-lawMethoxyfluranehttp://www.nist.gov/srd/nist1a.cfm
- SpectraBaseEthane, 2,2-dichloro-1,1-difluoro-1-methoxy-https://spectrabase.com/spectrum/BHtlBWigvxYEthane, 2,2-dichloro-1,1-difluoro-1-methoxy-https://spectrabase.com/spectrum/EASQp701KgJMethoxyfluranehttps://spectrabase.com/spectrum/A3DDwZ0XonJ1-METHOXY-3,3-DICHLORO-2,2-DIFLUOROETHANEhttps://spectrabase.com/spectrum/7jvcF05Xg4d1,1-DIFLUORO-2,2-DICHLOROETHYL METHYL ETHERhttps://spectrabase.com/spectrum/I5hwhPhEEbA1-METHOXY-3,3-DICHLORO-2,2-DIFLUOROETHANEhttps://spectrabase.com/spectrum/CvnmQ8zg9DB
- NLM RxNorm TerminologyLICENSEThe RxNorm Terminology is created by the National Library of Medicine (NLM) and is in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from NLM. Credit to the U.S. National Library of Medicine as the source is appreciated but not required. The full RxNorm dataset requires a free license.https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.htmlmethoxyfluranehttps://rxnav.nlm.nih.gov/id/rxnorm/6857
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/MethoxyfluoraneNORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- PharmGKBLICENSEPharmGKB data are subject to the Creative Commons Attribution-ShareALike 4.0 license (https://creativecommons.org/licenses/by-sa/4.0/).https://www.pharmgkb.org/page/policiesmethoxyfluranehttps://www.pharmgkb.org/chemical/PA450434
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/aboutmethoxyfluranehttps://pharos.nih.gov/ligands/JPY3G79FHGWZ
- Springer Nature
- SpringerMaterials2,2-dichloro-1,1-difluoro-1-methoxyethanehttps://materials.springer.com/substanceprofile/docs/smsid_amzdadwwisrwemjw
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- WHO Anatomical Therapeutic Chemical (ATC) ClassificationLICENSEUse of all or parts of the material requires reference to the WHO Collaborating Centre for Drug Statistics Methodology. Copying and distribution for commercial purposes is not allowed. Changing or manipulating the material is not allowed.https://www.whocc.no/copyright_disclaimer/Methoxyfluranehttps://www.whocc.no/atc_ddd_index/?code=N02BG09
- Wikidatamethoxyfluranehttps://www.wikidata.org/wiki/Q411594
- WikipediaAtracurium besilatehttps://en.wikipedia.org/wiki/Atracurium_besilateMethoxyfluranehttps://en.wikipedia.org/wiki/Methoxyflurane
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlMethoxyfluranehttps://www.ncbi.nlm.nih.gov/mesh/68008733Anesthetics, Inhalationhttps://www.ncbi.nlm.nih.gov/mesh/68018685
- PubChemPFAS and Fluorinated Compounds in PubChemhttps://gitlab.com/uniluxembourg/lcsb/eci/pubchem-docs/-/raw/main/pfas-tree/PFAS_Tree.pdf?inline=false
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403427141https://pubchem.ncbi.nlm.nih.gov/substance/403427141
- NCBI