Testosterone
- testosterone
- 58-22-0
- Testosteron
- Androderm
- Testim
- Create:2004-09-16
- Modify:2025-01-18
- 17 beta Hydroxy 4 Androsten 3 one
- 17 beta Hydroxy 8 alpha 4 Androsten 3 one
- 17-beta-Hydroxy-4-Androsten-3-one
- 17-beta-Hydroxy-8 alpha-4-Androsten-3-one
- 8 Isotestosterone
- 8-Isotestosterone
- Androderm
- AndroGel
- Andropatch
- Androtop
- Histerone
- Sterotate
- Sustanon
- Testim
- Testoderm
- Testolin
- Testopel
- Testosterone
- Testosterone Sulfate
- testosterone
- 58-22-0
- Testosteron
- Androderm
- Testim
- Homosterone
- Virosterone
- Testiculosterone
- Androlin
- Mertestate
- Sustanon
- Testoderm
- AndroGel
- Synandrol F
- Testosteroid
- Andronaq
- Andrusol
- Homosteron
- Orquisteron
- Primotest
- Primoteston
- Sustanone
- Testandrone
- Testobase
- Testogel
- Testopropon
- Testrone
- Oreton
- Relibra
- Teslen
- Testryl
- Cristerona T
- Testoviron T
- Andropatch
- Neotestis
- Perandren
- Malerone
- Cristerone T
- Testoviron Schering
- Geno-cristaux gremy
- Testosterona
- Testostosterone
- Testoviron
- trans-Testosterone
- LibiGel
- 17beta-Hydroxyandrost-4-en-3-one
- Sustason 250
- Percutacrine androgenique
- Neo-Hombreol F
- Oreton-F
- Testosteronum
- Testolin
- Striant
- Testoject-50
- Testoderm Tts
- Testosterone hydrate
- Neo-testis
- Malestrone (amps)
- Intrinsa
- Andro 100
- Virormone
- beta testosterone
- Malogen, aquaspension injection
- Testro AQ
- Livensa
- Vogelxo
- Testosteronum [INN-Latin]
- Testosterona [INN-Spanish]
- Androst-4-en-17beta-ol-3-one
- CDB 111C
- Nasobol
- Natesto
- Axiron
- Tefina
- CompleoTRT
- 17beta-Hydroxy-4-androsten-3-one
- 7-beta-Hydroxyandrost-4-en-3-one
- COL 1621
- Testosterone ciii
- 17beta-Hydroxyandrost-4-ene-3-one
- 17-beta-Hydroxyandrost-4-en-3-one
- 4-Androsten-17beta-ol-3-one
- Androgel 1%
- Bio-T-Gel
- CP 601B
- ANDROLAN
- delta4-Androsten-17beta-ol-3-one
- CCRIS 574
- 17-Hydroxy-(17beta)-androst-4-en-3-one
- Androgel 1.62%
- ANDROID-T
- 17beta-Hydroxy-delta(sup4)-androsten-3-one
- delta(sup 4)-Androsten-17(beta)-ol-3-one
- 17-Hydroxy-(17-beta)-androst-4-en-3-one
- 17-beta-Hydroxy-delta(sup 4)-androsten-3-one
- AA 2500
- Androst-4-en-3-one, 17beta-hydroxy-
- HSDB 3398
- Androst-4-en-3-one, 17-beta-hydroxy-
- NSC 9700
- EINECS 200-370-5
- (+)-testosterone
- UNII-3XMK78S47O
- Androst-4-en-3-one, 17-hydroxy-, (17beta)-
- DTXSID8022371
- CHEBI:17347
- LPCN 1021
- NSC-9700
- (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
- Androst-4-en-3-one, 17-hydroxy-, (17-beta)-
- (17beta)-17-Hydroxyandrost-4-en-3-one
- Testosterone [USP:INN:BAN]
- 3XMK78S47O
- DTXCID302371
- EC 200-370-5
- Testopel Pellets
- Testosteronum (INN-Latin)
- Testosterona (INN-Spanish)
- TESTOSTERONE (MART.)
- TESTOSTERONE [MART.]
- Testosterone (USP:INN:BAN)
- Halotensin
- Fortesta
- TESTOSTERONE (EP IMPURITY)
- TESTOSTERONE [EP IMPURITY]
- TESTOSTERONE (EP MONOGRAPH)
- TESTOSTERONE [EP MONOGRAPH]
- Androst-4-en-3-one, 17-hydroxy-, (17.beta.)-
- TESTOSTERONE (USP MONOGRAPH)
- TESTOSTERONE [USP MONOGRAPH]
- 17 beta Hydroxy 4 Androsten 3 one
- (8alpha,10alpha,13alpha,14beta,17alpha)-17-hydroxyandrost-4-en-3-one
- Androderm (TN)
- 17.beta.-Testosterone
- Androgel (TN)
- SMR000058344
- Testosterone (1.0mg/mL in Acetonitrile)
- Striant (TN)
- Testim (TN)
- Testosterone (JAN/USP)
- Androst-4-en-3-on-17B-ol
- CHEMBL386630
- component of Duogen (Salt/Mix)
- component of Tostrex (Salt/Mix)
- component of Di-Met (Salt/Mix)
- component of Intrinsa (Salt/Mix)
- Epitestosteron
- Lumitestosteron
- 4-Androsten-17.beta.-ol-3-one
- 4-Androsten-3-one-17.beta.-ol
- Tostrelle
- Tostrex
- Viatrel
- testosterone,
- component of Di-Genik (Salt/Mix)
- 4-Androsten-3-one, 17b-hydroxy-
- 9b-testosterone
- component of Mal-O-Fem (Salt/Mix)
- Natestonasal gel
- 4-androstene-17beta-ol-3-one
- 17b-hydroxy-4-androsten-3-one
- delta4-androsten-17b-ol-3-one
- Testosterone, 1
- 3kdm
- Androst-4-en-3-one, 17-hydroxy-, (17b)-
- 17b-Testosterone
- 17-.beta.-Hydroxyandrost-4-en-3-one
- NCGC00091018-01
- 8-iso-testosterone
- 17-beta-Hydroxy-4-Androsten-3-one
- (+-)-testosterone
- Axiron (TN)
- CMC_13449
- 13-iso-testosterone
- mpp10
- TESTSTERONE
- 9b,10a-testosterone
- 17.beta.-Hydroxy-.DELTA.4-androsten-3-one
- 17-Hydroxyandrost-4-en-3-one, (17.beta.)-
- Testo-100
- Testosterone Gel, 1%
- (+-)-retrotestosterone
- Testosterone, >=98%
- TESTOSTERONE [MI]
- TESTOSTERONE [INN]
- TESTOSTERONE [JAN]
- Epitope ID:135865
- TESTOSTERONE [HSDB]
- (+-)-8-iso-testosterone
- SCHEMBL8452
- TESTOSTERONE [VANDF]
- 4-Androsten-3-one-17b-ol
- MLS000563091
- MLS001032098
- MLS001306401
- MLS001424262
- MLS002174283
- BIDD:ER0555
- TESTOSTERONE [WHO-DD]
- D4-Androsten-17b-ol-3-one
- Androst-4-en-17b-ol-3-one
- BDBM8885
- GTPL2858
- Androst-4-ene-17b-ol-3-one
- TESTOSTERONE [EMA EPAR]
- 17-hydroxy-D4-androsten-3-one
- 17-hydroxy-androst-4-en-3-one
- 17beta-hydroxy-4-androsten-3one
- TESTOSTERONE [GREEN BOOK]
- Testosterone, cell culture tested
- 17b-Hydroxy-androst-4-en-3-on
- 17b-Hydroxy-D4-androsten-3-one
- 17b-Hydroxyandrost-4-ene-3-one
- 1i37
- Testosterone, 1mg/ml in Methanol
- 17a-hydroxy-androst-4-en-3-one
- 17b-hydroxy-androst-4-en-3-one
- HMS2052N11
- HMS2272B03
- HMS2272P03
- TESTOSTERONE [ORANGE BOOK]
- (8R,9S,10R,13S,14S,17S)-17-Hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
- 17-Hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one
- Tox21_200689
- HY-15554A
- LMST02020002
- RB3046
- 17b-hydroxy-8a-androst-4-en-3-one
- rac-17b-hydroxy-androst-4-en-3-one
- AKOS015894897
- 17a-hydroxy-13a-androst-4-en-3-one
- 17a-hydroxy-14b-androst-4-en-3-one
- 17b-hydroxy-13a-androst-4-en-3-one
- 1ST2220
- CCG-101189
- CS-1415
- DB00624
- Human Serum - Testosterone, low level
- NC00439
- CAS-58-22-0
- Human Serum - Testosterone, high level
- Testosterone 1.0 mg/ml in Acetonitrile
- 17b-hydroxy-(8a)-androst-4-en-3-one
- 17b-hydroxy-(9b)-androst-4-en-3-one
- NCGC00258243-01
- (17b)-17-hydroxy-androst-4-en-3-one
- 17a-hydroxy-(13a)-androst-4-en-3-one
- 17b-hydroxy-(10a)-androst-4-en-3-one
- 17b-hydroxy-(13a)-androst-4-en-3-one
- AC-14899
- CPD000058344
- SMR001261453
- Testosterone, purum, >=99.0% (HPLC)
- Testosterone 100 microg/mL in Acetonitrile
- NS00067928
- rac-17b-hydroxy-(13a)androst-4-en-3-one
- rac-17b-hydroxy-(8a)-androst-4-en-3-one
- T0027
- 17b-hydroxy-(8a,10a)-androst-4-en-3-one
- 17b-hydroxy-(9b,10a)-androst-4-en-3-one
- BIM-0061761.0001
- C00535
- D00075
- rac-17b-hydroxy-(9b,10a)androst-4-en-3-one
- S00309
- AB00973630-03
- Testosterone, VETRANAL(TM), analytical standard
- Androst-4-en-3-one, 17-hydroxy, (17.beta.)-
- Q-101251
- Q1318776
- B5DEE83F-632B-48A1-A0ED-A51E7F13DF2E
- TESTOSTERONE ENANTATE IMPURITY D [EP IMPURITY]
- TESTOSTERONE PROPIONATE IMPURITY C [EP IMPURITY]
- Testosterone, European Pharmacopoeia (EP) Reference Standard
- Testosterone; 4-Androsten-17?-ol-3-one; 17?-Hydroxy-4-androsten-3-one
- Testosterone for impurity D identification, European Pharmacopoeia (EP) Reference Standard
- Testosterone for system suitability, European Pharmacopoeia (EP) Reference Standard
- (1S,2R,10R,11S,14S,15S)-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadec-6-en-5-one
- 1050678-68-6
169.4 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
167.69 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
169.13 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
194.07 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
172.7 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
175.64 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
206.07 Ų [M+Na]+ [CCS Type: DT; Method: stepped-field]
183.82 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
129.0 1
91.0 0.22
105.0 0.16
79.0 0.16
130.0 0.14
432.0 1
91.0 0.57
209.0 0.51
433.0 0.41
105.0 0.39
289.2159 100
123.0796 89.29
253.1944 78.88
147.1157 56.76
159.1155 56.26
123.0796 100
145.1004 64.46
131.0845 63.46
129.0684 51.75
133.1001 50.25
97.0653 999
109.0652 708
289.2164 87
81.0704 68
123.0804 55
289.2162 999
97.0646 916
109.0643 680
271.2063 128
253.1943 85
124 999
41 414
246 368
91 361
79 350
- Testosterone Propionate (is active moiety of)
- Testosterone Enanthate (active moiety of)
- Testosterone Cypionate (active moiety of)
- Testosterone Undecanoate (active moiety of)
- Testosterone phenylpropionate (is active moiety of)
- Testosterone Isocaproate (is active moiety of)
- Testosterone decanoate (is active moiety of)
- Testosterone benzoate (is active moiety of)
- Testosterone Caproate (is active moiety of)
- Benzotest (is active moiety of)
- Testosterone enantate benzilic acid hydrazone (is active moiety of)
- Testosterone Phenylacetate (is active moiety of)
- Testosterone palmitate (is active moiety of)
- Testosterone dodecanoate (is active moiety of)
- Somatropin; testosterone (component of)
- Anastrozole; testosterone (component of)
- Estradiol; Testosterone; Tylosin (component of)
- Prasterone; pregnenolone; progesterone; testosterone (component of)
- Estradiol; prasterone; pregnenolone; progesterone; testosterone (component of)
- Adenosine triphosphate; black currant; camphor (natural); silver; testosterone (component of)
- Bos taurus spleen; estradiol; prasterone; pregnenolone; progesterone; sus scrofa pituitary gland; sus scrofa thymus; testosterone; thyroid, porcine (component of)
- Adenosine triphosphate; baptisia tinctoria root; ceanothus americanus leaf; fucus vesiculosus; podophyllum resin; sepia officinalis juice; testosterone (component of)
- Adenosine triphosphate; ammonium chloride; chicory root; kerosene; lycopodium clavatum spore; oyster shell calcium carbonate, crude; phosphorus; spongia officinalis skeleton, roasted; testosterone (component of)
- 7-Oxodehydroepiandrosterone 3-acetate; acetaldehyde; aldosterone; androsterone; cholesterol; cortisone acetate; dopamine hydrochloride; estrone; follitropin; progesterone; sus scrofa ovary; testosterone (component of)
- Asian ginseng; bos taurus testicle; gallium; nuphar lutea leaf; phosphoric acid; populus tremula flowering top; pork liver; sus scrofa adrenal gland; sus scrofa pituitary gland; testosterone; turnera diffusa leafy twig (component of)
- Asian ginseng; galium aparine; nuphar lutea root; phosphoric acid; populus tremuloides whole; pork liver; sus scrofa adrenal gland; sus scrofa pituitary gland; sus scrofa testicle; testosterone; turnera diffusa leafy twig (component of)
- Adenosine triphosphate; ammonium chloride; apis mellifera; baptisia tinctoria root; calcium fluoride; camphor (natural); citrullus colocynthis fruit pulp; sequoia sempervirens bark; spongia officinalis skeleton, roasted; testosterone (component of)
- Avena sativa flowering top; chaste tree; epimedium grandiflorum top; ginkgo; lycopodium clavatum spore; pork liver; serotonin hydrochloride; somatropin; spermidine; spermine; sus scrofa hypothalamus; sus scrofa testicle; testosterone; turnera diffusa leafy twig (component of)
- Adenosine triphosphate disodium; calcium sulfide; chimaphila umbellata; conium maculatum flowering top; equol, (+/-)-; nadide; petroselinum crispum; populus tremuloides bark; populus tremuloides leaf; proteus mirabilis; proteus vulgaris; saw palmetto; succinic acid; sus scrofa prostate; testosterone; wood creosote (component of)
- Asian ginseng; avena sativa flowering top; barium carbonate; epimedium grandiflorum top; eurycoma longifolia whole; fenugreek seed; hamamelis virginiana root bark/stem bark; nuphar lutea root; phosphoric acid; populus tremuloides whole; pork liver; saw palmetto; selenium; sus scrofa testicle; testosterone; tribulus terrestris whole; turnera diffusa leafy twig (component of)
- Aldosterone; alloxan; arsenic trioxide; berberis vulgaris root bark; corticorelin; corticotropin; cortisone acetate; epinephrine; iodine; melatonin; phosphorus; potassium carbonate; prasterone; proteus vulgaris; sepia officinalis juice; silicon dioxide; silver nitrate; sodium chloride; sus scrofa adrenal gland; sus scrofa hypothalamus; sus scrofa pituitary gland; testosterone (component of)
- Arnica montana; asian ginseng; avena sativa flowering top; dieffenbachia seguine; galium aparine; lycopodium clavatum spore; milk thistle; nuphar luteum root; phosphoric acid; populus tremuloides bark; populus tremuloides leaf; pork liver; sus scrofa adrenal gland; sus scrofa pituitary gland; sus scrofa testicle; sus scrofa thymus; testosterone; thuja occidentalis leafy twig; thyroid, porcine; turnera diffusa leafy twig (component of)
- Benzoic acid; bryonia alba root; bufo bufo cutaneous gland; chaste tree; chimaphila umbellata; clematis recta flowering top; conium maculatum flowering top; cortisone acetate; dieffenbachia seguine; gold; lycopodium clavatum spore; potassium arsenite anhydrous; rhododendron aureum leaf; saw palmetto; selenium; sepia officinalis juice; sodium chloride; sus scrofa hypothalamus; sus scrofa prostate; testosterone; thuja occidentalis leafy twig (component of)
- Adenosine triphosphate disodium; alpha lipoic acid; ambergris; barium carbonate; chaste tree fruit; conium maculatum flowering top; estradiol; estrone; lactic acid, L-; levodopa; melatonin; nadide; pantothenic acid; petroselinum crispum whole; pork liver; proteus morganii; selenium; somatropin; sus scrofa adrenal gland; sus scrofa bone marrow; sus scrofa hypothalamus; sus scrofa lymph; sus scrofa ovary; sus scrofa pancreas; sus scrofa spleen; sus scrofa testicle; sus scrofa umbilical cord; testosterone; ubidecarenone (component of)
- gamma-AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE DISODIUM; ALPHA LIPOIC ACID; AMBERGRIS; APIOLE (PARSLEY); BARIUM CARBONATE; CHASTE TREE FRUIT; CONIUM MACULATUM FLOWERING TOP; ESTRADIOL; ESTRONE; LACTIC ACID, L-; LEVODOPA; MELATONIN; NADIDE; PANTOTHENIC ACID; PETROSELINUM CRISPUM WHOLE; PORK LIVER; PROTEUS MORGANII; SELENIUM; SUS SCROFA ADRENAL GLAND; SUS SCROFA BONE MARROW; SUS SCROFA HYPOTHALAMUS; SUS SCROFA LYMPH; SUS SCROFA OVARY; SUS SCROFA PANCREAS; SUS SCROFA PITUITARY GLAND; SUS SCROFA SPLEEN; SUS SCROFA TESTICLE; SUS SCROFA UMBILICAL CORD; TESTOSTERONE; UBIDECARENONE (component of)
- Aconitic acid, (Z)-; alcaligenes faecalis; apis mellifera venom; aquilegia vulgaris; cypripedium parviflorum var. pubescens root; escherichia coli; estradiol; estrone; goldenseal; lachesis muta venom; lilium lancifolium whole flowering; lycoperdon utriforme fruiting body; magnesium phosphate, dibasic trihydrate; mercurius solubilis; petroselinum crispum; pork heart; progesterone; sepia officinalis juice; sus scrofa adrenal gland; sus scrofa ovary; sus scrofa pineal gland; sus scrofa pituitary gland; sus scrofa placenta; sus scrofa umbilical cord; sus scrofa uterus; testosterone; wood creosote (component of)
- Aconitic acid, (Z)-; alcaligenes faecalis; apiole (parsley); apis mellifera venom; aquilegia vulgaris; cypripedium parviflorum var. pubescens root; escherichia coli; estradiol; estrone; goldenseal; lachesis muta venom; lilium lancifolium whole flowering; lycoperdon utriforme fruiting body; magnesium phosphate, dibasic trihydrate; mercurius solubilis; pork heart; progesterone; sepia officinalis juice; sus scrofa adrenal gland; sus scrofa ovary; sus scrofa pineal gland; sus scrofa pituitary gland; sus scrofa placenta; sus scrofa umbilical cord; sus scrofa uterus; testosterone; wood creosote (component of)
- American ginseng; ascorbic acid; chaste tree; conium maculatum flowering top; cortisone acetate; dieffenbachia seguine; ferrosoferric phosphate; lycopodium clavatum spore; lytta vesicatoria; magnesium phosphate, dibasic trihydrate; manganese phosphate, dibasic; pork heart; potassium bromide; salmonella enterica subsp. enterica serovar enteritidis; selenium; strychnine phosphate dihydrate; sus scrofa adrenal gland; sus scrofa diencephalon; sus scrofa pineal gland; sus scrofa pituitary gland; sus scrofa prostate; sus scrofa testicle; sus scrofa umbilical cord; testosterone; turnera diffusa leafy twig; zinc (component of)
- Brain
- Ovary
- Semen
- Skeletal Muscle
- Testis
- Cytoplasm
- Endoplasmic reticulum
- Extracellular
- Membrane
Use (kg) in Switzerland (2009): >50
Use (kg; approx.) in Germany (2009): >500
Use (kg) in USA (2002): 1020
Consumption (g per capita) in Switzerland (2009): 0.0064
Consumption (g per capita; approx.) in Germany (2009): 0.0061
Consumption (g per capita) in the USA (2002): 0.0036
Excretion rate: 0.1
Calculated removal (%): 37.8
H302 (63.5%): Harmful if swallowed [Warning Acute toxicity, oral]
H350 (35.6%): May cause cancer [Danger Carcinogenicity]
H351 (64.9%): Suspected of causing cancer [Warning Carcinogenicity]
H360 (79.7%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H361 (19.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H362 (29.3%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
H372 (16.2%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
H400 (63.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (15.8%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
P203, P260, P263, P264, P270, P273, P280, P301+P317, P318, P319, P330, P391, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 222 reports by companies from 16 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 4 (63.5%)
Carc. 1B (35.6%)
Carc. 2 (64.9%)
Repr. 1A (79.7%)
Repr. 2 (19.8%)
Lact. (29.3%)
STOT RE 1 (16.2%)
Aquatic Acute 1 (63.5%)
Aquatic Chronic 1 (15.8%)
Hazard Traits - Carcinogenicity
Authoritative List - Prop 65
Report - regardless of intended function of ingredient in the product
Status: Active Update: 22-11-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/25237
Status: Active Update: 12-04-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/1915
IMAP assessments - Androst-4-en-3-one, 17-hydroxy-, (17.beta.)-: Human health tier I assessment
IMAP assessments - Androst-4-en-3-one, 17-hydroxy-, (17.beta.)-: Environment tier I assessment
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
Limited data indicate that a low-dose (100 mg) subcutaneous testosterone pellet given to a nursing mother appears not to increase milk testosterone levels markedly. Subcutaneous testosterone cypionate does increase milk testosterone levels. However, testosterone has low oral bioavailability because of extensive first-pass metabolism, so it appears to not increase serum testosterone levels in breastfed infants. Breastfed infants appear not to be adversely affected by maternal or transgender paternal testosterone therapy. High doses of testosterone can suppress lactation.
◉ Effects in Breastfed Infants
After implantation of a 100 mg pellet of testosterone subcutaneously in a postpartum mother, her infant (age not stated) was breastfed (extent not stated). No adverse effects were noted in the infant over a 5-month period.
A transgender male began receiving subcutaneous testosterone cypionate 50 mg weekly 13.75 months after giving birth. The dose was increased to 80 mg weekly after 1 month. His male infant was partially “chestfed” (extent not stated) until the infant self-weaned at 137 days after initiation of testosterone (18 months of age). During this time, no adverse events or signs of virilization were noted by the infant’s pediatrician. The infant grew and developed normally.
◉ Effects on Lactation and Breastmilk
Supraphysiologic serum levels of testosterone, either from a tumor or from exogenously administered testosterone, reduces milk production in postpartum women. Testosterone alone reduces serum prolactin; however, when given in combination with estrogen and progestin, serum prolactin levels are not markedly reduced. Testosterone was previously used therapeutically to suppress lactation, usually in combination with an estrogen.
PubMed: 16551734, 25850025, 10857554, 11038205, 11826238, 26336836
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
PubMed: 10468933
http://en.wikipedia.org/wiki/Testosterone: http://en.wikipedia.org/wiki/Testosterone
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- US8784878
- US8807861
- US8435944
- US8993520
- US8877230
- US8784882
- US8574622
- US8784869
- US8338395
- US7718640
- US9295675
- US8785426
- US9622340
- US9662340
- US11090312
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=MUMGGOZAMZWBJJ-DYKIIFRCSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Androst-4-en-3-one, 17-hydroxy-, (17.beta.)-https://services.industrialchemicals.gov.au/search-assessments/
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- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useTestosteronehttps://www.drugbank.ca/drugs/DB00624
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- EPA DSSToxTestosteronehttps://comptox.epa.gov/dashboard/DTXSID8022371CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
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- SpectraBaseTestosteronehttps://spectrabase.com/spectrum/IW9AvfyvNDU17-BETA-HYDROXY-ANDROST-4-EN-3-ONE,(TESTOSTERON)https://spectrabase.com/spectrum/Fmq3LHfzp04Testosteronehttps://spectrabase.com/spectrum/4YgveOGs556Testosteronehttps://spectrabase.com/spectrum/UZrWaJW9gmTestosteronehttps://spectrabase.com/spectrum/DkSLSnrePXkTestosteronehttps://spectrabase.com/spectrum/GUY9JRA0KHITestosteronehttps://spectrabase.com/spectrum/G9ZpjFkbmqbTestosteronehttps://spectrabase.com/spectrum/LfkLEnGHPZnTestosteronehttps://spectrabase.com/spectrum/6mqt4Jl1jg9Testosteronehttps://spectrabase.com/spectrum/8GXYVBwXf6l
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