Dabigatran Etexilate
- Dabigatran etexilate
- 211915-06-9
- Prazaxa
- Pradax
- BIBR 1048
- Create:2019-01-15
- Modify:2025-01-25
- BIBR 1048
- dabigatran
- dabigatran etexilate
- dabigatran etexilate mesylate
- Etexilate Mesylate, Dabigatran
- Etexilate, Dabigatran
- Mesylate, Dabigatran Etexilate
- N-((2-(((4-(aminoiminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-beta-alanine
- Pradaxa
- Dabigatran etexilate
- 211915-06-9
- Prazaxa
- Pradax
- BIBR 1048
- BIBR 1048 BS RS1
- DTXSID4057681
- 2E18WX195X
- UNII-2E18WX195X
- 1610666-09-5
- DTXCID5031470
- PRADAXA (DABIGATRAN ETEXILATE)
- EC 606-722-8
- Ethyl 3-(((2-(((4-((((hexyloxy)carbonyl)amino)iminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)(pyridin-2-yl)amino)propanoate
- Ethyl 3-[[2-[[4-(N-hexoxycarbonylcarbamimidoyl)anilino]methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoate
- Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbamoyl)-1-methyl-1H-benzo[d]imidazol-2-yl)methyl)amino)benzylidene)hydrazinecarboxylate
- DABIGATRAN ETEXILATE (MART.)
- DABIGATRAN ETEXILATE [MART.]
- 1019206-66-6
- beta-Alanin,N-((2-(((4-((((hexyloxy)carbonyl)amino)iminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-ethylester
- ethyl 3-(1-{2-[({4-[amino({[(hexyloxy)carbonyl]imino})methyl]phenyl}amino)methyl]-1-methyl-1H-1,3-benzodiazol-5-yl}-N-(pyridin-2-yl)formamido)propanoate
- dabigatran-etexilate
- ETHYL 3-(((2-(((4-(((HEXYLOXY)CARBONYL)CARBAMIMIDOYL)PHENYL)AMINO)METHYL)-1-METHYL-1H-BENZIMIDAZOL-5-YL)CARBONYL)(PYRIDIN-2-YL)AMINO)PROPANOATE
- Ethyl 3-{[(2-{[(4-{[(hexyloxy)carbonyl]carbamimidoyl}phenyl)amino]methyl}-1-methyl-1H-benzimidazol-5-yl)carbonyl](pyridin-2-yl)amino}propanoate
- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-ss-Alanine Ethyl Ester; BIBR 1048; Prazaxa
- Etexilate, Dabigatran
- Dabigatran hydrochloride
- Dabigatran etexilate [INN]
- BIBR1048
- GTPL6379
- DABIGATRAN ETEXILATE [MI]
- GLXC-10464
- HMS3744O05
- DABIGATRAN ETEXILATE [USAN]
- BIBR-1048 (Dabigatran etexilate)
- DABIGATRAN ETEXILATE [VANDF]
- Tox21_113924
- DABIGATRAN ETEXILATE [WHO-DD]
- AKOS015951090
- Dabigatran etexilate [USAN:INN:BAN]
- CCG-270280
- CS-0530
- DB06695
- SB19225
- NCGC00262929-01
- NCGC00262929-10
- AC-22314
- BD164344
- HY-10274
- DB-066446
- CAS-211915-06-9
- D5904
- NS00007001
- EN300-1708005
- Z2235811583
- .BETA.-ALANINE, N-((2-(((4-((((HEXYLOXY)CARBONYL)AMINO)IMINOMETHYL)PHENYL)AMINO)METHYL)-1-METHYL-1H-BENZIMIDAZOL-5-YL)CARBONYL)-N-2-PYRIDINYL-, ETHYL ESTER
- beta-Alanine, N-((2-(((4-((((hexyloxy)carbonyl)amino)iminomethyl)phenyl)amino)methyl)-1-methyl-1H-benzimidazol-5-yl)carbonyl)-N-2-pyridinyl-, ethyl ester
- ethyl (Z)-3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate
- Ethyl 3-[[[4-[[[(hexyloxyl)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl](pyridin-2-yl)amino] propanoate (INN)
- ETHYL 3-{1-[2-({[4-({[(HEXYLOXY)CARBONYL]AMINO}METHANIMIDOYL)PHENYL]AMINO}METHYL)-1-METHYL-1,3-BENZODIAZOL-5-YL]-N-(PYRIDIN-2-YL)FORMAMIDO}PROPANOATE
- Ethyl 3-{1-[2-({[4-({[(hexyloxy)carbonyl]amino}methanimidoyl)phenyl]amino}methyl)-1-methyl-1H-1,3-benzodiazol-5-yl]-N-(pyridin-2-yl)formamido}propanoate
628.324646 21288
289.10733 20280
273.158752 9212
629.326416 7688
290.110931 5768
289.108154 100
195.112625 73.81
217.612762 73
145.057159 67.42
434.219177 48.17
289.108154 100
195.112625 73.81
217.612762 73
145.057159 67.42
434.219177 48.17
628.324646 100
289.107330 95.26
273.158752 43.27
629.326416 36.11
290.110931 27.10
- Dabigatran (has active moiety)
- Dabigatran Etexilate Mesylate (has salt form)
- Extracellular
- Membrane
Use (kg; approx.) in Germany (2009): >50
Consumption (g per capita; approx.) in Germany (2009): 0.000611
Calculated removal (%): 95.4
H315 (14.3%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (14.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (14.3%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 7 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 6 of 7 reports by companies. For more detailed information, please visit ECHA C&L website.
There is 1 notification provided by 1 of 7 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Skin Irrit. 2 (14.3%)
Eye Irrit. 2A (14.3%)
STOT SE 3 (14.3%)
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=KSGXQBZTULBEEQ-UHFFFAOYSA-N
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
- Avoid St. John's Wort. This herb induces PGP which may reduce the serum levels of dabigatran.
- Take with a full glass of water.
- Take with or without food.
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Dabigatran etexilatehttps://commonchemistry.cas.org/detail?cas_rn=211915-06-9
- ChemIDplusDabigatran etexilate [USAN:INN:BAN]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0211915069ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useDabigatran etexilatehttps://www.drugbank.ca/drugs/DB06695
- EPA DSSToxDabigatran etexilatehttps://comptox.epa.gov/dashboard/DTXSID4057681CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeß-Alanin,N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-ethylesterhttps://chem.echa.europa.eu/100.126.485ß-Alanin,N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-ethylester (EC: 606-722-8)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/100550
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingDABIGATRAN ETEXILATEhttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/2E18WX195X
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citingDabigatran etexilatehttp://www.hmdb.ca/metabolites/HMDB0015641HMDB0015641_msms_374317https://hmdb.ca/metabolites/HMDB0015641#spectra
- ClinicalTrials.govLICENSEThe ClinicalTrials.gov data carry an international copyright outside the United States and its Territories or Possessions. Some ClinicalTrials.gov data may be subject to the copyright of third parties; you should consult these entities for any additional terms of use.https://clinicaltrials.gov/ct2/about-site/terms-conditions#Use
- Crystallography Open Database (COD)LICENSEAll data in the COD and the database itself are dedicated to the public domain and licensed under the CC0 License. Users of the data should acknowledge the original authors of the structural data.https://creativecommons.org/publicdomain/zero/1.0/
- DailyMed
- EU Clinical Trials Register
- MassBank of North America (MoNA)LICENSEThe content of the MoNA database is licensed under CC BY 4.0.https://mona.fiehnlab.ucdavis.edu/documentation/license
- Metabolomics WorkbenchDabigatran etexilatehttps://www.metabolomicsworkbench.org/data/StructureData.php?RegNo=43676
- National Drug Code (NDC) DirectoryLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- NCI Thesaurus (NCIt)LICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuseNCI Thesaurushttps://ncit.nci.nih.gov
- NIPH Clinical Trials Search of Japan
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/DABIGATRAN ETEXILATENORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- WHO Anatomical Therapeutic Chemical (ATC) ClassificationLICENSEUse of all or parts of the material requires reference to the WHO Collaborating Centre for Drug Statistics Methodology. Copying and distribution for commercial purposes is not allowed. Changing or manipulating the material is not allowed.https://www.whocc.no/copyright_disclaimer/Dabigatran etexilatehttps://www.whocc.no/atc_ddd_index/?code=B01AE07
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/aboutdabigatran etexilatehttps://pharos.nih.gov/ligands/FLAWC2XFBW7X
- Therapeutic Target Database (TTD)Dabigatran etexilatehttps://idrblab.net/ttd/data/drug/details/D0KI5R
- Wikidatadabigatran etexilatehttps://www.wikidata.org/wiki/Q20078502
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlAntithrombinshttps://www.ncbi.nlm.nih.gov/mesh/68000991
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- PATENTSCOPE (WIPO)SID 389317980https://pubchem.ncbi.nlm.nih.gov/substance/389317980