Pentostatin
- pentostatin
- Deoxycoformycin
- Nipent
- 53910-25-1
- 2'-Deoxycoformycin
- Create:2005-06-24
- Modify:2025-01-18
- 2' Deoxycoformycin
- 2'-Deoxycoformycin
- CI 825
- CI-825
- CI825
- Co-vidarabine
- Deoxycoformycin
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
- Nipent
- NSC 218321
- NSC-218321
- NSC218321
- Pentostatin
- pentostatin
- Deoxycoformycin
- Nipent
- 53910-25-1
- 2'-Deoxycoformycin
- Pentostatina
- Pentostatine
- PD-ADI
- Pentostatinum
- 2'-DCF
- CO-Vidarabine
- CI-825
- YK-176
- Vidarbine
- (R)-2'-Deoxycoformycin
- NSC-218321
- (R)-Deoxycoformycin
- PD 81565
- PD-81565
- Covidarabine
- 8R-2'-Deoxycoformycin
- Co-V
- Vira A deaminase inhibitor
- DTXSID2023436
- UNII-395575MZO7
- HSDB 6547
- 2'-Dexoycoformycin
- 395575MZO7
- Pentostatine [INN-French]
- Pentostatinum [INN-Latin]
- Pentostatina [INN-Spanish]
- BRN 1223097
- DTXCID403436
- Deaminase inhibitor (PD)
- Deaminase, inhibitor for adenosine arabinoside
- (8R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
- (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol
- dCF
- NCGC00182045-01
- NSC 218321
- Pentostatine (INN-French)
- Pentostatinum (INN-Latin)
- Pentostatina (INN-Spanish)
- PENTOSTATIN (MART.)
- PENTOSTATIN [MART.]
- (R)-3-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
- (R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo(4,5-d)(1,3)diazepin-8-ol
- (R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo(4,5-d)(1,3)diazepin-8-ol
- CL 67310465
- 2' Deoxycoformycin
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydro-, (R)-
- CI-825;Deoxycoformycin
- (8R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
- Pentostatn
- Pentostatin (JAN/USAN/INN)
- (R)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
- Pentostatin [USAN:INN:BAN:JAN]
- Pentostatin (PTN)
- CI 825
- MFCD00078802
- Pentostatin (Standard)
- PENTOSTATIN [MI]
- 2'dCF
- PENTOSTATIN [INN]
- PENTOSTATIN [JAN]
- CL-67310465
- PENTOSTATIN [HSDB]
- PENTOSTATIN [USAN]
- PENTOSTATIN [VANDF]
- SCHEMBL2817
- CHEMBL1580
- PENTOSTATIN [WHO-DD]
- (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
- BIDD:GT0136
- GTPL4805
- BDBM22925
- CHEBI:27834
- HY-A0006R
- Pentostatin, >=95% (HPLC)
- L01XX08
- PENTOSTATIN [ORANGE BOOK]
- BDBM223291
- HY-A0006
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydro-, (R)-
- Tox21_113417
- s9521
- AKOS024456918
- AKOS032949742
- CS-0374
- DB00552
- NCGC00388420-02
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
- Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-
- Imidazo[4,5-d][1,3]diazepin-8-ol, 3-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (8R)-
- CAS-53910-25-1
- NS00005086
- C02267
- D00155
- EN300-222177
- Q425470
- SR-01000883935
- J-523899
- SR-01000883935-1
- BRD-K91543828-001-02-0
- Adenosine Deaminase Inhibitor, DCF - CAS 53910-25-1
- Z2204459563
- (R)-3-(2-Deoxy-beta-D-erythro-pento-furanosyl)-3,6,7,8-tetrahydroimidazo
- (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,4H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol
- (8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-8-ol
- (R)-3-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
- (R,Z)-3-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
135.066498 100
136.050461 27.53
108.055649 22.26
81.044930 12.49
118.039948 9.30
P264, P270, P301+P316, P321, P330, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Hazard Traits - Developmental Toxicity
Authoritative List - Prop 65
Report - regardless of intended function of ingredient in the product
In clinical trials, serum enzymes elevations occurred in up to 25% of patients receiving pentostatin, but the abnormalities were generally mild and transient and rarely required dose modification. Clinically apparent liver injury from pentostatin is rare, but striking instances of severe liver injury leading rapidly to multiorgan failure and death have been described both in adults and children. The time to onset varied from a few days to six months. The possible role of shock, ischemia, opportunistic infections and sepsis in these cases has not always been well defined. Both hepatocellular and cholestatic patterns of enzyme elevations have been described. Immunoallergic features and autoantibodies were not typical.
Likelihood score: D (possible rare cause of clinically apparent liver disease).
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=FPVKHBSQESCIEP-JQCXWYLXSA-N
- BindingDBLICENSEAll data curated by BindingDB staff are provided under the Creative Commons Attribution 3.0 License (https://creativecommons.org/licenses/by/3.0/us/).https://www.bindingdb.org/rwd/bind/info.jspPentostatin (PTN)https://www.bindingdb.org/rwd/bind/chemsearch/marvin/MolStructure.jsp?monomerid=223291(8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-olhttps://www.bindingdb.org/rwd/bind/chemsearch/marvin/MolStructure.jsp?monomerid=22925
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- LiverTox
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