Estradiol
- estradiol
- beta-Estradiol
- 17beta-Estradiol
- 50-28-2
- Oestradiol
- Create:2004-09-16
- Modify:2025-01-18
- 17 beta Estradiol
- 17 beta Oestradiol
- 17 beta-Estradiol
- 17 beta-Oestradiol
- Aerodiol
- Delestrogen
- Estrace
- Estraderm TTS
- Estradiol
- Estradiol 17 alpha
- Estradiol 17 beta
- Estradiol 17beta
- Estradiol Anhydrous
- Estradiol Hemihydrate
- Estradiol Hemihydrate, (17 alpha)-Isomer
- Estradiol Monohydrate
- estradiol valerate
- estradiol valeriante
- Estradiol, (+-)-Isomer
- Estradiol, (-)-Isomer
- Estradiol, (16 alpha,17 alpha)-Isomer
- Estradiol, (16 alpha,17 beta)-Isomer
- Estradiol, (17-alpha)-Isomer
- Estradiol, (8 alpha,17 beta)-(+-)-Isomer
- Estradiol, (8 alpha,17 beta)-Isomer
- Estradiol, (9 beta,17 alpha)-Isomer
- Estradiol, (9 beta,17 beta)-Isomer
- Estradiol, Monosodium Salt
- Estradiol, Sodium Salt
- Estradiol-17 alpha
- Estradiol-17 beta
- Estradiol-17beta
- Oestradiol
- Ovocyclin
- Progynon Depot
- Progynon-Depot
- Progynova
- Vivelle
- estradiol
- beta-Estradiol
- 17beta-Estradiol
- 50-28-2
- Oestradiol
- Dihydrofolliculin
- Estrace
- Vivelle
- progynon
- Diogynets
- Ovocyclin
- Aquadiol
- Climara
- Diogyn
- Vagifem
- Dihydrotheelin
- Dihydroxyestrin
- Dimenformon
- Divigel
- Estraderm
- Gynergon
- Gynoestryl
- Oestroglandol
- Aerodiol
- Corpagen
- Estraldine
- Estrogel
- Estrovite
- Femestral
- Follicyclin
- Ginosedol
- Macrodiol
- Oestergon
- Ovahormon
- Ovasterol
- Ovastevol
- Perlatanol
- Primofol
- Profoliol
- Altrad
- Bardiol
- Evorel
- Femogen
- Lamdiol
- Syndiol
- Dihydromenformon
- estradiol-17beta
- cis-Estradiol
- Estraderm TTS
- Estroclim
- Trocosone
- Estring
- Innofem
- Menorest
- Nordicol
- Zumenon
- Alora
- Systen
- 17beta-Oestradiol
- D-Oestradiol
- D-Estradiol
- Progynon DH
- Climaderm
- Compudose
- Dermestril
- Estrasorb
- Fempatch
- Gynodiol
- Ovocycline
- Ovocylin
- Encore
- Esclim
- Menest
- Oesclim
- Dihydroxyoestrin
- SK-Estrogens
- Progynon-DH
- Elestrin
- Gynestrel
- Microdiol
- Oestrogynal
- Ovociclina
- Tradelia
- Estroclim 50
- Evamist
- Macrol
- Zerella
- Oestradiol R
- Estring vaginal ring
- Trial SAT
- Theelin, dihydro-
- Estradot
- Menostar
- Oestrogel
- Compudose 200
- Compudose 365
- 17 beta-Estradiol
- Profoliol B
- VIVELLE-DOT
- Estradiol-17-beta
- Estradiolum
- Estrogen
- Gelestra
- 3,17-Epidihydroxyestratriene
- Zesteem
- Dihydroxyesterin
- cis-Oestradiol
- Estraderm TTS 50
- Estrogens, esterified
- NSC-9895
- 17.beta.-Estradiol
- 17b-Oestradiol
- Epiestriol 50
- 17beta oestradiol
- Estra-1,3,5(10)-triene-3,17beta-diol
- (17beta)-Estra-1,3,5(10)-triene-3,17-diol
- Estradiol Anhydrous
- 17-beta-estradiol
- Estradiol-17 beta
- Amnestrogen
- Elestrim
- Femanest
- Minivelle
- B-Estradiol
- 3,17-Epidihydroxyoestratriene
- Sandrena 1
- 17b-Estradiol
- Estraderm (TN)
- [3H]-estradiol
- 17|A-estradiol
- 17|A-Oestradiol
- Estrogel (TN)
- Climara (TN)
- Divigel (TN)
- Estrace (TN)
- Estring (TN)
- Innofem (TN)
- Vagifem (TN)
- Vivelle (TN)
- (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
- 17.beta.-Oestradiol
- CHEBI:16469
- 3,17.beta.-Estradiol
- .beta.-Estradiol
- .beta.-Oestradiol
- [3H]]estradiol
- NSC-20293
- Estradiol 17-beta
- 17-beta-oestradiol
- IMVEXXY
- (17beta)-estra-1(10),2,4-triene-3,17-diol
- Estradiol (Standard)
- Estradiol, .beta.-
- Estradiol-17.beta.
- Estra-1,3,5(10)-triene-3,17-diol (17beta)-
- Oestradiol-17.beta.
- 17-.beta.-oestradiol
- 4TI98Z838E
- Oestra-1,3,5(10)-triene-3,17beta-diol
- Estrasorb (TN)
- 17.beta.-OH-estradiol
- 17.beta.-OH-oestradiol
- 17beta estradiol (E2)
- Extrasorb
- 17beta-Estra-1,3,5(10)-triene-3,17-diol
- Estreva
- Estrifam
- Femtran
- Ginedisc
- WC3011
- C18H24O2
- CHEMBL135
- GynPolar
- Sandrena Gel
- D-3,17.beta.-Estradiol
- WC-3011
- D-3,17.beta.-Oestradiol
- Sisare Gel
- Estra-1,3,5(10)-triene-3,17-diol, (17beta)-
- Estrofem 2
- MLS000069494
- 3,17b-Dihydroxyestra-1,3,5(10)-triene
- (+)-3,17.beta.-Estradiol
- 141290-02-0
- Oestradiolum
- DTXSID0020573
- Estradiol valerate metabolite e2
- BIJUVA COMPONENT ESTRADIOL
- NSC9895
- ANGELIQ COMPONENT ESTRADIOL
- Climara Forte
- ORIAHNN COMPONENT ESTRADIOL
- PREFEST COMPONENT ESTRADIOL
- Oestradiol Berco
- Estraderm MX
- ACTIVELLA COMPONENT ESTRADIOL
- 1,3,5-Estratriene-3,17beta-diol
- COMBIPATCH COMPONENT ESTRADIOL
- [3H]E2
- CLIMARA PRO COMPONENT ESTRADIOL
- Oestradiol-17beta
- Estrapak 50
- E2
- Estradiolum [INN]
- Estradiolo [DCIT]
- NCGC00091544-04
- Oestradiol-17-beta
- Estrodiolum
- Estradiolo
- Femestrol
- SMR000059126
- Estradiol-3,17beta
- 17-beta-OH-estradiol
- 3,17-beta-Estradiol
- 3,17beta-Dihydroxy-1,3,5(10)-estratriene
- 3,17beta-Dihydroxyestra-1,3,5(10)-triene
- 3,17-beta-Oestradiol
- D-3,17beta-Estradiol
- ESTRADIOL (USP-RS)
- ESTRADIOL [USP-RS]
- 3,17.beta.-Dihydroxyestra-1,3,5(10)-triene
- E(sub 2)
- Methyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate.
- Benzogynestry
- Estropause
- Estasorb
- (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-triene-5,14-diol
- (8R,9S,13S,14S,17S)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
- [2,4,6,7-3H]-E2
- E 2
- DTXCID80573
- ESTRADIOL (USP MONOGRAPH)
- ESTRADIOL [USP MONOGRAPH]
- Destradiol
- ESTRADIOL IMPURITY A (IP)
- ESTRADIOL IMPURITY A [IP]
- Yuvvexy
- Zesteen
- .alpha.-Estradiol
- 17-beta-OH-oestradiol
- D-3,17beta-Oestradiol
- D-3,17-beta-Estradiol
- Estrodiolum [INN-Latin]
- MFCD00003693
- Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-
- D-3,17-beta-Oestradiol
- Activella (Salt/Mix)
- Combipatch (Salt/Mix)
- CCRIS 280
- component of Menrium
- Estradiol-17 alpha
- Climara Pro (Salt/Mix)
- 3,17beta-Estradiol
- 3,17-.beta.-Oestradiol
- Estraderm TTS 100
- HSDB 3589
- 3,3,5(10)-triene
- SR-01000075866
- 17-.BETA.-Estradiol
- EINECS 200-023-8
- 1,3,5-Estratriene-3,17-beta-diol
- oestrodiol
- Estradiol [USP:INN:BAN]
- 3,17beta-Dihydroxyestra-1,3,5-triene
- 3,17beta-Dihydroxyoestra-1,3,5-triene
- Yuvafem
- delta-Estradiol
- dihydro-Theelin
- dl-estradiol
- 3,17-beta-Dihydroxyoestra-1,3,5-triene
- NSC20293
- UNII-4TI98Z838E
- beta -estradiol
- delta-Oestradiol
- Estradiol pellet
- Estradiol,
- TX-004HR
- Vivelle Dot
- Estra-1,3,5(10)-triene-3,17-beta-diol
- Estradiol Vaginal
- Estrogel HBF
- Oestra-1,3,5(10)-triene-3,17-beta-diol
- 1jgl
- 1lhu
- 1qkt
- 1qku
- 3,17-beta-Dihydroxyestra-1,3,5(10)-triene
- [3H]estradiol
- 1,3,5-Estratriene-3,17.beta.-diol
- 3,17-beta-Dihydroxy-1,3,5(10)-oestratriene
- CAS-50-28-2
- 17-beta-Estra-1,3,5(10)-triene-3,17-diol
- 17beta-Oestra-1,3,5(10)-triene-3,17-diol
- .alpha.-Oestradiol
- 17-beta-Oestra-1,3,5(10)-triene-3,17-diol
- Estra-1,3,5(10)-triene-3,17-diol
- Estradiol1557
- Prestwick_207
- 3,17b-Estradiol
- Bio-E-Gel
- Fem7
- [3H]-Estrogen
- 3,17.beta.-Dihydroxyestra-1,3,5-triene
- 3,17.beta.-Dihydroxyoestra-1,3,5-triene
- CMC_11154
- Therapeutic Estradiol
- DOTTI
- LYLLANA
- Estra-25
- Estra-50
- 1,3,5,(10)-Estratrien-3,17.beta.-diol
- SL-1100
- Beta-estradiol (E2)
- Estra-1,3,5(10)-triene-3,17.beta.-diol
- Oestra-1,3,5(10)-triene-3,17.beta.-diol
- Estradiol Gel 0.1%
- Estradiol Vaginal Cream
- 2j7x
- 3,17.beta.-Dihydroxy-1,3,5(10)-estratriene
- 3,17.beta.-Dihydroxy-1,3,5(10)-oestratriene
- 3,3,5-triene
- [3H]17beta-estradiol
- ESTROGEN PHENOLIC
- ESTRADIOL [INN]
- ESTRADIOL [JAN]
- 17.beta.-Estra-1,3,5(10)-triene-3,17-diol
- ESTRADIOL [MI]
- ESTRADIOL [HSDB]
- 17.beta.-Oestra-1,3,5(10)-triene-3,17-diol
- Opera_ID_1688
- Prestwick0_000441
- Prestwick1_000441
- Prestwick2_000441
- Prestwick3_000441
- Spectrum5_002055
- 17beta-estradiol (E2)
- ESTRADIOL [VANDF]
- alpha-estradiol (obsolete)
- beta-Estradiol, >=98%
- bmse000642
- Epitope ID:136018
- (+)-3,17b-Estradiol
- E 8875
- EC 200-023-8
- ESTRADIOL [WHO-DD]
- SCHEMBL8049
- Estradiol Transdermal System
- (+)-3,17beta-Estradiol
- Estradiol (JAN/USP/INN)
- Tritiated estradiol-17-beta
- BIDD:PXR0065
- Lopac0_000503
- S-21400
- BSPBio_000482
- BSPBio_001065
- KBioGR_000405
- KBioGR_002269
- KBioSS_000405
- KBioSS_002270
- MLS000758312
- MLS001076331
- MLS001424022
- BIDD:ER0125
- SPBio_002421
- ESTRADIOL [GREEN BOOK]
- BPBio1_000532
- GTPL1012
- GTPL1013
- ESTRADIOL [ORANGE BOOK]
- ESTRADIOL VAGINAL INSERTS
- NIOSH/KG7030000
- BDBM17292
- HY-B0141R
- KBio2_000405
- KBio2_002269
- KBio2_002973
- KBio2_004837
- KBio2_005541
- KBio2_007405
- KBio3_000769
- KBio3_000770
- KBio3_002749
- 1a52
- 1g50
- 2d06
- cMAP_000005
- Bio1_000403
- Bio1_000892
- Bio1_001381
- Bio2_000363
- Bio2_000843
- HMS1362E07
- HMS1569I04
- HMS1792E07
- HMS1990E07
- HMS2051C17
- HMS2090E18
- HMS2096I04
- HMS2236H04
- HMS3261F07
- HMS3403E07
- HMS3713I04
- HMS3884A08
- beta-Estradiol, analytical standard
- (8S,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
- 17916-67-5
- BCP08579
- ESTRADIOL 17-BETA [VANDF]
- HY-B0141
- ESTRADIOL COMPONENT OF BIJUVA
- Tox21_111148
- Tox21_202057
- Tox21_300288
- Tox21_500503
- 1,5-Estratriene-3,17.beta.-diol
- HB2494
- LMST02010001
- s1709
- ESTRADIOL COMPONENT OF ANGELIQ
- ESTRADIOL COMPONENT OF ORIAHNN
- ESTRADIOL COMPONENT OF PREFEST
- Estradiol-17-beta-6,7-(sup 3)H
- [2,4,6,7-3H]-17beta-estradiol
- AKOS015896570
- CCG-100808
- CS-1938
- DB00783
- ESTRADIOL COMPONENT OF ACTIVELLA
- LP00503
- NC00058
- SDCCGSBI-0050487.P002
- ESTRADIOL COMPONENT OF COMBIPATCH
- IDI1_002118
- SMP1_000121
- NCGC00091544-00
- NCGC00091544-01
- NCGC00091544-02
- NCGC00091544-05
- NCGC00091544-06
- NCGC00091544-07
- NCGC00091544-09
- NCGC00091544-10
- NCGC00091544-11
- NCGC00091544-12
- NCGC00091544-13
- NCGC00091544-14
- NCGC00091544-15
- NCGC00091544-16
- NCGC00091544-18
- NCGC00091544-27
- NCGC00179321-01
- NCGC00179321-02
- NCGC00254177-01
- NCGC00259606-01
- NCGC00261188-01
- 17-E
- AC-22346
- AS-13729
- CPD000059126
- ESTRADIOL COMPONENT OF CLIMARA PRO
- Estra-1,3,5(10)-triene-3,17b-diol
- Oestra-1,3,5(10)-triene-3,17b-diol
- WLN: L E5 B666TTT&J E1 FQ OQ
- 17 beta-Estradiol, 1mg/ml in Acetonitrile
- DB-246618
- Estra-1,5(10)-triene-3,17.beta.-diol
- Estradiol, meets USP testing specifications
- 3,17beta-dihydroxyestra-1,3,5(10)-trien
- CS-0694760
- Estra-1,3,5(10)-triene-3,17beta-diol-
- EU-0100503
- KG70300000
- NS00008517
- NS00115904
- Oestra-1,5(10)-triene-3,17.beta.-diol
- C00951
- D00105
- EN300-119518
- (17b)-Estra-1,3,5(10)-triene-3,17-diol
- 13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol
- 17.beta.-Estra-1,5(10)-triene-3,17-diol
- 17.beta.-Oestra-1,5(10)-triene-3,17-diol
- ETHINYLESTRADIOL IMPURITY D [EP IMPURITY]
- 17-beta-Estradiol 100 microg/mL in Acetonitrile
- Q422416
- SR-01000721892
- 13beta-Methyl-1,3,5(10)-gonatriene-3,17beta-ol
- Estra-1,5(10)-triene-3,17-diol (17.beta.)-
- ESTRADIOL BENZOATE IMPURITY A [EP IMPURITY]
- ESTRADIOL VALERATE IMPURITY A [EP IMPURITY]
- Q-201503
- SR-01000075866-1
- SR-01000075866-4
- SR-01000721892-3
- BRD-K18910433-001-04-4
- BRD-K18910433-001-36-6
- BRD-K18910433-001-43-2
- estra-1(10),2,4-triene-3,17-diol, (17beta)-
- Estra-1,5(10)-triene-3,17-diol, (17.beta.)-
- Z1521553843
- B8B5AEF5-4957-49EB-A14F-444A8212C482
- beta-Estradiol, BioReagent, powder, suitable for cell culture
- Estradiol, United States Pharmacopeia (USP) Reference Standard
- 13.BETA.-METHYL-1,3,5(10)-GONATRIENE-3,17.BETA.-OL
- beta-Estradiol, powder, gamma-irradiated, suitable for cell culture
- Estra-1,3,5(10)-triene-3,17-diol, (6,7-(sup 3)H,17-beta)-
- (9beta,13alpha,14beta,17alpha)-estra-1,3,5(10)-triene-3,17-diol
- Estradiol, Pharmaceutical Secondary Standard; Certified Reference Material
- (13S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-beta-diol
- (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0;{2,7}.0;{11,15}]heptadeca-2,4,6-triene-5,14-diol
- (1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
173.34 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
159.7 Ų [M+H-H2O]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
156.66 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
162.82 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
161.04 Ų [M+Na]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
158.2 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
272.0 99.99
213.0 29.20
146.0 23.30
172.0 22.70
273.0 20.70
272.0 99.99
160.0 39.80
18.0 33
172.0 30.70
133.0 24.80
109.0645 100
83.049 29.02
100.0756 8.28
145.1014 8.19
107.0852 7.21
271.1689 999
123.0821 53
183.08 44
142.0394 40
239.1401 17
272 999
213 292
146 233
172 227
273 207
- Estradiol Valerate (active moiety of)
- Estradiol Benzoate (active moiety of)
- Estradiol Cypionate (active moiety of)
- Estradiol Acetate (active moiety of)
- Estradiol dipropionate (is active moiety of)
- Estradiol Enanthate (is active moiety of)
- 17beta-Estradiol hemisuccinate (is active moiety of)
- Estradiol Hemihydrate (active moiety of)
- Estradiol undecylate (is active moiety of)
- Estradiol-17-phenylpropionate (is active moiety of)
- Estradiol dienanthate (is active moiety of)
- Polyestradiol Phosphate (monomer of)
- Estradiol hexahydrobenzoate (is active moiety of)
- Estradiol; Norethindrone Acetate (component of)
- Estradiol furoate (is active moiety of)
- Estradiol; progesterone (component of)
- Estradiol 3-pivalate (is active moiety of)
- Drospirenone; estradiol (component of)
- Estradiol 17-p-propoxyphenyl propionate (is active moiety of)
- Estradiol/norgestimate (component of)
- Estradiol; levonorgestrel (component of)
- Estradiol; Trenbolone Acetate (component of)
- Polyestradiol (monomer of)
- Estradiol; Oxytetracycline (component of)
- Estradiol; estriol (component of)
- Estradiol; Trenbolone Acetate; Tylosin Tartrate (component of)
- Estradiol; norethindrone acetate; relugolix (component of)
- Estradiol; estrone; sus scrofa ovary (component of)
- Estradiol; Testosterone; Tylosin (component of)
- Estradiol; prasterone; pregnenolone; progesterone; testosterone (component of)
- Bos taurus spleen; estradiol; prasterone; pregnenolone; progesterone; sus scrofa pituitary gland; sus scrofa thymus; testosterone; thyroid, porcine (component of)
- Arsenic trioxide; asterias rubens; calcium fluoride; conium maculatum flowering top; elymus repens root; estradiol; euphorbia resinifera resin; phytolacca americana root; progesterone; saw palmetto; taraxacum officinale; thuja occidentalis leafy twig (component of)
- Angelica sinensis root; apis mellifera; arnica montana; asian ginseng; black cohosh; chaste tree; estradiol; estriol; estrone; galium aparine; glycyrrhiza glabra; progesterone; sepia officinalis juice; sus scrofa ovary; thuja occidentalis leafy twig; viscum album fruiting top (component of)
- Adenosine triphosphate disodium; alpha lipoic acid; ambergris; barium carbonate; chaste tree fruit; conium maculatum flowering top; estradiol; estrone; lactic acid, L-; levodopa; melatonin; nadide; pantothenic acid; petroselinum crispum whole; pork liver; proteus morganii; selenium; somatropin; sus scrofa adrenal gland; sus scrofa bone marrow; sus scrofa hypothalamus; sus scrofa lymph; sus scrofa ovary; sus scrofa pancreas; sus scrofa spleen; sus scrofa testicle; sus scrofa umbilical cord; testosterone; ubidecarenone (component of)
- gamma-AMINOBUTYRIC ACID; ACETALDEHYDE; ACETYLCHOLINE CHLORIDE; ASCORBIC ACID; ASPARTAME; BUTYLATED HYDROXYTOLUENE; CAFFEIC ACID; CANDIDA ALBICANS; CHLOROGENIC ACID; CINNAMIC ACID; CONIFERYL ALCOHOL; COUMARIN; DOPAMINE HYDROCHLORIDE; ESTRADIOL; GALLIC ACID MONOHYDRATE; HISTAMINE DIHYDROCHLORIDE; HYDROCORTISONE; INDOLE; LEVODOPA; MALVIN; MANNOSE, D-; MELATONIN; MENADIONE; NOREPINEPHRINE BITARTRATE; OXITRIPTAN; PETROSELINUM CRISPUM; PHENYL ISOTHIOCYANATE; PHENYLALANINE; PHLORIZIN; PIPERINE; PROGESTERONE; PYRROLE; QUERCETIN; RUTIN; SEROTONIN HYDROCHLORIDE; TAURINE; TYRAMINE (component of)
- gamma-AMINOBUTYRIC ACID; ADENOSINE TRIPHOSPHATE DISODIUM; ALPHA LIPOIC ACID; AMBERGRIS; APIOLE (PARSLEY); BARIUM CARBONATE; CHASTE TREE FRUIT; CONIUM MACULATUM FLOWERING TOP; ESTRADIOL; ESTRONE; LACTIC ACID, L-; LEVODOPA; MELATONIN; NADIDE; PANTOTHENIC ACID; PETROSELINUM CRISPUM WHOLE; PORK LIVER; PROTEUS MORGANII; SELENIUM; SUS SCROFA ADRENAL GLAND; SUS SCROFA BONE MARROW; SUS SCROFA HYPOTHALAMUS; SUS SCROFA LYMPH; SUS SCROFA OVARY; SUS SCROFA PANCREAS; SUS SCROFA PITUITARY GLAND; SUS SCROFA SPLEEN; SUS SCROFA TESTICLE; SUS SCROFA UMBILICAL CORD; TESTOSTERONE; UBIDECARENONE (component of)
- Aconitic acid, (Z)-; alcaligenes faecalis; apis mellifera venom; aquilegia vulgaris; cypripedium parviflorum var. pubescens root; escherichia coli; estradiol; estrone; goldenseal; lachesis muta venom; lilium lancifolium whole flowering; lycoperdon utriforme fruiting body; magnesium phosphate, dibasic trihydrate; mercurius solubilis; petroselinum crispum; pork heart; progesterone; sepia officinalis juice; sus scrofa adrenal gland; sus scrofa ovary; sus scrofa pineal gland; sus scrofa pituitary gland; sus scrofa placenta; sus scrofa umbilical cord; sus scrofa uterus; testosterone; wood creosote (component of)
- Aconitic acid, (Z)-; alcaligenes faecalis; apiole (parsley); apis mellifera venom; aquilegia vulgaris; cypripedium parviflorum var. pubescens root; escherichia coli; estradiol; estrone; goldenseal; lachesis muta venom; lilium lancifolium whole flowering; lycoperdon utriforme fruiting body; magnesium phosphate, dibasic trihydrate; mercurius solubilis; pork heart; progesterone; sepia officinalis juice; sus scrofa adrenal gland; sus scrofa ovary; sus scrofa pineal gland; sus scrofa pituitary gland; sus scrofa placenta; sus scrofa umbilical cord; sus scrofa uterus; testosterone; wood creosote (component of)
- Acetic acid; anhydrous trisodium citrate; arsenic trioxide; aspartame; benzalkonium chloride; benzoic acid; benzyl alcohol; boric acid; chlorine; cholesterol; corticotropin; cortisone acetate; estradiol; estrone; eugenol; formaldehyde solution; isopropyl palmitate; lactic acid, DL-; lead; lycopodium clavatum spore; methylene chloride; methylparaben; petrolatum; phenylbutazone; phosphoric acid; phosphorus; potassium sorbate; progesterone; propylparaben; resorcinol; salicylic acid; sodium benzoate; sorbitol; squalene; stearyl alcohol; strychnos nux-vomica seed; titanium dioxide; xylitol; zinc oxide (component of)
- gamma-AMINOBUTYRIC ACID; ACETALDEHYDE; ACETYLCHOLINE CHLORIDE; APIOLE (PARSLEY); ASCORBIC ACID; ASPARTAME; BUTYLATED HYDROXYTOLUENE; CAFFEIC ACID; CANDIDA ALBICANS; CHLOROGENIC ACID; CINNAMIC ACID; CONIFERYL ALCOHOL; COUMARIN; DOPAMINE HYDROCHLORIDE; ESTRADIOL; GALLIC ACID MONOHYDRATE; HISTAMINE DIHYDROCHLORIDE; HYDROCORTISONE; INDOLE; LEVODOPA; MALVIN; MELATONIN; MENADIONE; NOREPINEPHRINE BITARTRATE; OCTOPAMINE HYDROCHLORIDE; OXITRIPTAN; PHENYL ISOTHIOCYANATE; PHENYLALANINE; PHLORIZIN; PIPERINE; PROGESTERONE; PYRROLE; QUERCETIN; RUTIN; SALSOLINOL HYDROCHLORIDE; SEROTONIN HYDROCHLORIDE; TAURINE; YEAST MANNAN (component of)
- Estrogens, Esterified (annotation moved to)
In a Phase I study of 14 postmenopausal women, the insertion of ESTRING (estradiol vaginal ring) rapidly increased serum estradiol (E2) levels. The time to attain peak serum estradiol levels (Tmax) was 0.5 to 1 hour. Peak serum estradiol concentrations post-initial burst declined rapidly over the next 24 hours and were virtually indistinguishable from the baseline mean (range: 5 to 22 pg/mL). Serum levels of estradiol and estrone (E1) over the following 12 weeks during which the ring was maintained in the vaginal vault remained relatively unchanged
Table: PHARMACOKINETIC MEAN ESTIMATES FOLLOWING SINGLE ESTRING APPLICATION
- Adipose Tissue
- Adrenal Cortex
- Adrenal Gland
- Brain
- Epidermis
- Fibroblasts
- Kidney
- Liver
- Neuron
- Ovary
- Placenta
- Platelet
- Prostate
- Skeletal Muscle
- Spleen
- Testis
- Cytoplasm
- Endoplasmic reticulum
- Extracellular
- Membrane
Use (kg; approx.) in Germany (2009): >250
Use (kg) in USA (2002): 515
Consumption (g per capita; approx.) in Germany (2009): 0.00305
Consumption (g per capita) in the USA (2002): 0.00183
Calculated removal (%): 67
Cosmetics product ingredient: Estradiol 17beta (Estradiol)
Also known as: estradiol; oestradiol; E2; estrace
Source: Estradiol is a form of estrogen, a steroid hormone that is critical to the function of the reproductive system. Estradiol in cosmetics often comes from placental extract. Estradiol may also be isolated from urine of pregnant horses or synthesized from a plant-based compound. Placental extracts containing estradiol are added to some skin and hair treatments, including shampoos.
Potential health impacts: The major routes of exposure to estradiol in cosmetics are by absorption through the skin or by ingestion, depending on the specific product. Exposure to certain estrogens during fetal development is known to cause abnormalities of the urinary system or genital organs in both females and males. The U.S. Food and Drug Administration (U.S. FDA) categorizes estradiol as Pregnancy Category X, meaning that there is a risk to human fetuses from exposure to it. Studies of women exposed to estradiol have found an increase in risk of endometrial cancer. Use of estrogens after menopause is associated with an increased risk of breast cancer, as well as stroke, blood clots, and heart attacks. The National Toxicology Program (NTP) classifies estradiol and other steroidal estrogens as known human carcinogens.
Product count: 2
H350 (39.6%): May cause cancer [Danger Carcinogenicity]
H351 (57.9%): Suspected of causing cancer [Warning Carcinogenicity]
H360 (82.4%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H360FD (11.3%): May damage fertility; May damage the unborn child [Danger Reproductive toxicity]
H362 (32.1%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
H372 (34.6%): Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
H400 (30.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (35.8%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
P203, P260, P263, P264, P270, P273, P280, P318, P319, P391, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 159 reports by companies from 19 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Carc. 1A (39.6%)
Carc. 2 (57.9%)
Repr. 1A (82.4%)
Repr. 1A (11.3%)
Lact. (32.1%)
STOT RE 1 (34.6%)
Aquatic Acute 1 (30.2%)
Aquatic Chronic 1 (35.8%)
Hazard Traits - Carcinogenicity
Authoritative List - Prop 65
Report - regardless of intended function of ingredient in the product
IMAP assessments - Estra-1,3,5(10)-triene-3,17-diol, (17.beta.)-: Environment tier I assessment
IMAP assessments - Estra-1,3,5(10)-triene-3,17-diol, (17.beta.)-: Human health tier I assessment
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
Limited information on the use of estradiol during breastfeeding indicates that the route of administration and dosage form have influences on the amount transferred into breastmilk. Vaginal administration results in measurable amounts in milk, but transdermal patches do not. Maternal doses of up to 200 mcg daily transdermally do not increase estradiol or estriol in breastfed infants or cause any adverse effects in breastfed infants. Vaginal administration results in unpredictable peak times for estradiol in breastmilk, so timing of the dose with respect to breastfeeding is probably not useful. Milk estradiol levels have not been studied after use of the estradiol gel, but maternal blood levels only increase slightly in a dose-dependent manner.
Estrogens can decrease the milk supply, especially if started before the milk supply is well established at about 6 weeks postpartum. The decrease can happen over the first few days of estrogen exposure. A case report of inadequate milk production and inadequate infant weight gain was possibly caused by transdermal estradiol initiated on the first day postpartum, but 2 small studies found no such effect when the drug was initiated after lactation was well established.
◉ Effects in Breastfed Infants
A mother who had severe postpartum depression with 2 previous infants was prescribed a transdermal estradiol patch that released 50 mcg daily beginning on day 1 postpartum to prevent recurrence of depression. At 11 days of age, the infant was jaundiced and had gained only 60 grams since birth. With more frequent nursing, weight gain improved, but remained inadequate until day 28 when the estradiol was discontinued. The infant then experienced above average weight gain through day 66 postpartum. The delayed and reduced weight gain was possibly caused by estradiol.
Six nursing mothers received transdermal estradiol as part of a study comparing estradiol to sertraline and placebo for postpartum depression. The mothers received estradiol dosages between 50 and 200 mcg daily (mean 133 mcg daily) at the time of serum level analysis at 4 and 8 weeks of therapy. Four of the 6 infants were exclusively breastfed and the other two were more than 50% breastfed. There was no difference in infant length, weight, and head circumference nor in the average daily gains in any of these parameters between treatments.
◉ Effects on Lactation and Breastmilk
Thirteen women who were 12 weeks postpartum and fully breastfeeding their infants were given a transdermal patch that released 100 mcg of estradiol daily. The average number of breast feeds per day did not change significantly during 3 days of patch application.
Nineteen women who were 6 weeks postpartum, using a barrier contraceptive method and breastfeeding their infants were randomized to transdermal patches that released estradiol 50 mcg daily or placebo patches for 12 weeks. An additional control group received no patches. The number of breast feeds per day decreased in all groups over the course of the study, but there were no important differences among the groups.
A retrospective cohort study compared 371 women who received high-dose estrogen (either 3 mg of diethylstilbestrol or 150 mcg of ethinyl estradiol daily) during adolescence for adult height reduction to 409 women who did not receive estrogen. No difference in breastfeeding duration was found between the two groups, indicating that high-dose estrogen during adolescence has no effect on later breastfeeding.
A transgender woman took and spironolactone 50 mg twice daily to suppress testosterone, domperidone 10 mg three times daily, increasing to 20 mg four times daily, oral micronized progesterone 200 mg daily and oral estradiol to 8 mg daily and pumped her breasts 6 times daily to induce lactation. After 3 months of treatment, estradiol regimen was changed to a 0.025 mg daily patch and the progesterone dose was lowered to 100 mg daily. Two weeks later, she began exclusively breastfeeding the newborn of her partner. Breastfeeding was exclusive for 6 weeks, during which the infant's growth, development and bowel habits were normal. The patient continued to partially breastfeed the infant for at least 6 months.
A transgender woman was taking sublingual estradiol 4 mg twice daily, spironolactone 100 mg twice daily and progesterone 200 mg at bedtime for gender-affirming therapy. In order to prepare for the birth of the infant being carried by her partner, sublingual estradiol was increased to 6 mg twice daily and progesterone was increased to 400 mg at bedtime. Domperidone 10 mg twice daily was also started to increase serum prolactin levels and later increased to 20 mg 4 times daily. Before the delivery date, progesterone was stopped, spironolactone was decreased to 100 mg daily and estradiol was changed to 25 mcg per day transdermally. At day 59 postpartum, estradiol was changed to 2 mg per day sublingually and spironolactone was increased to 100 mg twice daily. The patient was able to produce up to 240 mL of milk daily. The patient was able to produce up to 240 mL of milk daily containing typical macronutrient and oligosaccharide levels.
A transgender woman who wished to breastfeed was given estradiol transdermal patch 150 mcg daily and progesterone 100 mg daily by mouth. Later estradiol spray 100 mcg and domperidone 10 mg 4 times daily were added. Domperidone dosage was then doubled to 20 mg 4 times daily and progesterone was doubled to 100 mg twice daily. After further adjustment of estradiol and progesterone dosages, 7 mL of milk was produced with pumping, but 2 weeks after the infant’s birth, lactation induction was discontinued at the patient’s request.
A 50-year-old transgender woman wished to breastfeed her grandchild was taking baseline treatment with estradiol 0.3 mg transdermal patch every 72 hours and micronized progesterone 200 mg oral once daily. To initiate lactation, her estradiol dose was increased to a 0.4 mg transdermal patch every 72 hours and nipple stimulation was initiated. Later the patient’s progesterone was increased to 300 mg daily and metoclopramide oral 10 mg three times daily was initiated. She lactated for a total of two weeks and nursed the four-month-old infant on multiple occasions. Her peak milk production was 30 mL from her larger right breast, and 8 mL from her smaller left breast.
A 50-year-old transgender woman wished to breastfeed the expected infant of her partner. She was given estradiol in dosages increasing from 6 to 8 mg (6 mg oral and 2 mg gel) daily along with progesterone and domperidone to stimulate lactation. Progesterone was discontinued after 123 days of treatment. The patient was able to produce small quantities of milk and was able to directly breastfeed the infant.
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Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=VOXZDWNPVJITMN-ZBRFXRBCSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Estra-1,3,5(10)-triene-3,17-diol, (17.beta.)-https://services.industrialchemicals.gov.au/search-assessments/
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- California Safe Cosmetics Program (CSCP) Product DatabaseEstradiol 17beta (Estradiol)https://cscpsearch.cdph.ca.gov/search/detailresult/292
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- SpectraBase17β-Estradiolhttps://spectrabase.com/spectrum/1htkRYmS12P3,17.BETA.-DIHYDROXY-ESTRA-1,3,5(10)-TRIENEhttps://spectrabase.com/spectrum/9DvjVwsjdO417β-Estradiolhttps://spectrabase.com/spectrum/LIFuHexNtmHbeta-Estradiolhttps://spectrabase.com/spectrum/Cp90A5xTXnv17β-Estradiolhttps://spectrabase.com/spectrum/C4Kxubn2LL617β-Estradiolhttps://spectrabase.com/spectrum/GZLTgloqSzyESTRA-1,3,5(10)-TRIEN-3,17-BETA-DIOLhttps://spectrabase.com/spectrum/BsM9LYB6srv17β-Estradiolhttps://spectrabase.com/spectrum/BwrAplWb7yMbeta-Estradiolhttps://spectrabase.com/spectrum/836i426lpmx17β-Estradiolhttps://spectrabase.com/spectrum/IqzGQDkyMsU17β-Estradiolhttps://spectrabase.com/spectrum/6c7ECeQaFTx
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.htmlCompounds with biological roleshttp://www.genome.jp/kegg-bin/get_htext?br08001.kegTherapeutic category of drugs in Japanhttp://www.genome.jp/kegg-bin/get_htext?br08301.kegUSP drug classificationhttp://www.genome.jp/kegg-bin/get_htext?br08302.kegAnatomical Therapeutic Chemical (ATC) classificationhttp://www.genome.jp/kegg-bin/get_htext?br08303.kegTarget-based classification of drugshttp://www.genome.jp/kegg-bin/get_htext?br08310.kegRisk category of Japanese OTC drugshttp://www.genome.jp/kegg-bin/get_htext?br08312.kegClassification of Japanese OTC drugshttp://www.genome.jp/kegg-bin/get_htext?br08313.keg
- LIPID MAPSLipid Classificationhttps://www.lipidmaps.org/
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- Metabolomics Workbench
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- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
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