Toxaphene
- toxaphene
- 8001-35-2
- 1,4,5,6,7,7-hexachloro-2,2-bis(chloromethyl)-3-methylidenebicyclo[2.2.1]heptane
- NCGC00091881-01
- TOXAPHENE (IARC)
- Create:2005-11-20
- Modify:2025-01-11
- Polychlorocamphene
- Toxaphene
- toxaphene
- 8001-35-2
- 1,4,5,6,7,7-hexachloro-2,2-bis(chloromethyl)-3-methylidenebicyclo[2.2.1]heptane
- NCGC00091881-01
- TOXAPHENE (IARC)
- TOXAPHENE [IARC]
- DSSTox_CID_1368
- Camphechlore (ISO-French)
- Camphechlore [ISO-French]
- DSSTox_RID_76114
- TOXAPHENE, (LIQUID)
- TOXAPHENE, [LIQUID]
- DSSTox_GSID_21368
- 1,2,3,4,7,7-hexachloro-6,6-bis(chloromethyl)-5-methylidenebicyclo[2.2.1]heptane
- CAS-8001-35-2
- Camphoclor
- Chlorcamphene
- Agricide
- Coopertox
- Cristoxo
- Toxaphen
- Toxaphene fume
- Hercules toxaphene
- Polychlorochamphene
- 1,2,3,4,7,7-hexachloro-6,6-bis(chloromethyl)-5-methylidenebicyclo(2.2.1)heptane
- Cristoxo-90
- Toxaphene (OSHA)
- CANFECLOR
- TOXYPEN
- Toxaphene (technical)
- Caswell No. 861
- STROBANE T
- Polychlorinated camphenes
- TOXAPHENE [MI]
- Camphechlor [BSI:ISO]
- TOXAPHENE [HSDB]
- CAMPHECHLOR [ISO]
- CAMPHOPHENE HUILEUX
- Chlorinated camphene 60%
- CHLOR CHEM T-590
- Chlorinated camphene (OSHA)
- Chlorinated camphene (60%)
- CCRIS 600
- UNII-9924JQ4D5J
- Chlorinated camphene, technical
- Clor Chem T-590 Insecticide
- GTPL2830
- SCHEMBL5933656
- POLYCHLORCAMPHENE (USSR)
- CHEMBL1566504
- DTXSID7021368
- CHEBI:77850
- HSDB 1616
- DTXSID70858934
- DTXSID90858936
- NSC8932
- OEJNXTAZZBRGDN-UHFFFAOYSA-N
- ENT 9735
- NSC 8932
- Chlorinated camphene 60% (ACGIH)
- EINECS 232-283-3
- Tox21_111173
- Tox21_200912
- NSC406917
- EPA Pesticide Chemical Code 080501
- NSC 406917
- CHLORINATED CAMPHENE (TOXAPHENE)
- NCGC00091881-02
- NCGC00091881-03
- NCGC00258466-01
- 1ST20034
- NS00021362
- Q63381159
- 1852481-29-8
H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]
H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]
H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
P203, P261, P264, P270, P271, P273, P280, P301+P316, P302+P352, P304+P340, P317, P318, P319, P321, P330, P332+P317, P362+P364, P391, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 41 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 3 (100%)
Acute Tox. 4 (100%)
Skin Irrit. 2 (100%)
STOT SE 3 (100%)
Carc. 2 (100%)
Aquatic Acute 1 (100%)
Aquatic Chronic 1 (100%)
Carcinogenicity - category 2
Specific target organ toxicity (single exposure) - category 3
Hazardous to the aquatic environment (acute) - category 1
Hazardous to the aquatic environment (chronic) - category 1
Skin irritation - category 2
Acute toxicity (ingestion) - category 3
Acute toxicity (dermal) - category 4
Signs and Symptoms of Camphechlor Exposure: Signs and symptoms of acute exposure to camphechlor may be severe and include headache, dizziness, agitation, nervousness, tremor, seizures, and coma. Convulsive episodes may alternate with periods of severe central nervous system depression. Hypersalivation, nausea, vomiting, and diarrhea are common. Hypertension (high blood pressure), tachycardia (rapid heart rate), and cardiac arrhythmias (abnormal heart beating) and sudden exertional dyspnea (labored breathing) may be noted. Respiratory depression may lead to respiratory arrest. Contact with the skin, eyes, and mucous membranes may result in redness and irritation. Victims often have an elevated temperature.
Emergency Life-Support Procedures: Acute exposure to camphechlor exposure may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to camphechlor.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self-exposure to camphechlor.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas three times. Wash initially with soap and water, follow with an alcohol wash, then again with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of camphechlor is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4. Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of camphechlor may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3- 1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)
(See general first aid procedures)
Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
Skin: Soap wash promptly - If this chemical contacts the skin, promptly wash the contaminated skin with soap and water. If this chemical penetrates the clothing, promptly remove the clothing and wash the skin with soap and water. Get medical attention promptly.
Breathing: Respiratory support
Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
Move container from fire area if this can be done without risk. Fight fire from a maximum distance. Dike fire control water for later disposal; do not scatter the material. Wear positive pressure breathing apparatus and special protective clothing.
Small fires: dry chemical, carbon dioxide, water spray, or foam. Large fires: water spray, fog, or foam. Water may be ineffective on fire. (EPA, 1998)
Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Ca [200 mg/m3]
See: 8001352
Excerpt from NIOSH Pocket Guide for Chlorinated camphene:
Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.
Wash skin:
• WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
• DAILY - The worker should wash daily at the end of each work shift, and prior to eating, drinking, smoking, etc.
Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
Provide:
• EYEWASH - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection.
• QUICK DRENCH - Facilities for quickly drenching the body should be provided within the immediate work area for emergency use where there is a possibility of exposure. [Note: It is intended that these facilities provide a sufficient quantity or flow of water to quickly remove the substance from any body areas likely to be exposed. The actual determination of what constitutes an adequate quick drench facility depends on the specific circumstances. In certain instances, a deluge shower should be readily available, whereas in others, the availability of water from a sink or hose could be considered adequate.] (NIOSH, 2024)
(See personal protection and sanitation codes)
Skin: Prevent skin contact - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: Prevent eye contact - Wear appropriate eye protection to prevent eye contact.
Wash skin: When contaminated/Daily
Remove: When wet or contaminated
Change: Daily - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
Provide: Eyewash, Quick drench
NIOSH
At concentrations above the NIOSH REL, or where there is no REL, at any detectable concentration:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator (gas mask) with a chin-style, front- or back-mounted organic vapor canister having an N100, R100, or P100 filter.
Click here for information on selection of N, R, or P filters.
Any appropriate escape-type, self-contained breathing apparatus
Halogenated Organic Compounds
Hydrocarbons, Aliphatic Unsaturated
Hazard Traits - Bioaccumulation; Carcinogenicity; Environmental Persistence; Neurotoxicity; Respiratory Toxicity
Authoritative List - ATSDR Neurotoxicants; CA MCLs; CA TACs; CWA 303(c); CWA 303(d); IARC Carcinogens - 2B; IRIS Carcinogens - B2; NTP RoC - reasonable; Prop 65; US EPA TRI PBTs; WA PBTs
Report - regardless of intended function of ingredient in the product
Substance: Toxaphene
EC: 232-283-3
Date of inclusion in the POPs Regulation: 29-Apr-2004
POPs Regulation Annex: Annex I, part A; Annex IV
IMAP assessments - Toxaphene: Human health tier I assessment
IMAP assessments - Toxaphene: Environment tier I assessment
Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Volume 79: (2001) Some Thyrotropic Agents
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Other Poison - Organochlorine
IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.
NTP Carcinogen - Reasonably anticipated to be a human carcinogen.
ACGIH Carcinogen - Confirmed Animal.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=OEJNXTAZZBRGDN-UHFFFAOYSA-N
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