Brucine
- BRUCINE
- 357-57-3
- 10,11-Dimethoxystrychnine
- Brucinum
- 2,3-Dimethoxystrychnine
- Create:2005-06-24
- Modify:2025-01-18
- 10,11-dimethoxystrychnine
- brucine
- bruzin
- dimethoxystrychnine
- BRUCINE
- 357-57-3
- 10,11-Dimethoxystrychnine
- Brucinum
- 2,3-Dimethoxystrychnine
- (-)-Brucine
- l-Brucine
- 2,3-Dimethoxystrychnidin-10-one
- Brucine, Anhydrous
- Strychnidin-10-one, 2,3-dimethoxy-
- 10,11-Dimethystrychnine
- Brucina
- Brucin
- 6NG17YCK6H
- 63428-84-2
- Brucine alkaloid
- CHEBI:3193
- DTXSID2024662
- NSC-757797
- 145428-94-0
- Bruzin
- 2,3-Dimethoxy-strychnine
- RCRA waste number P018
- Strychnine, 2,3-dimethoxy-
- DTXCID204662
- Brucin [German]
- Brucina [Italian]
- CAS-357-57-3
- SMR000112281
- C23H26N2O4
- 5892-11-5
- UNII-6NG17YCK6H
- 10,11-dimethoxy strychnine
- CCRIS 4754
- HSDB 307
- anhydrous brucine
- Bisdesmethylbrucin
- UN 1570
- NCGC00094861-01
- EINECS 206-614-7
- UN1570
- BRUCINE [VANDF]
- BRUCINUM [HPUS]
- BRUCINE [HSDB]
- BRUCINE [MI]
- RCRA waste no. P018
- Brucine, anhydrous, 98%
- BRUCINE [NFLIS-DRUG]
- GTPL342
- MLS000515808
- MLS001424166
- SCHEMBL113229
- CHEMBL501756
- MEGxp0_001865
- ACon1_001990
- Brucine [UN1570] [Poison]
- HMS2052O03
- HMS2268L16
- Tox21_111349
- Tox21_302174
- BDBM50401037
- MFCD00005942
- NSC833996
- AKOS015955678
- AKOS024282466
- CCG-101078
- NC00328
- NSC 757797
- NSC-833996
- NCGC00255253-01
- NCGC00263445-02
- NCGC00384497-01
- 1ST23017
- B0670
- B0946
- Polyamide curing agent pound 651 pound(c)
- C09084
- AA-504/21114018
- AE-848/02291057
- Q411022
- SR-01000712407
- Q-100426
- SR-01000712407-5
- BRD-K68077509-001-01-6
- Brucine, European Pharmacopoeia (EP) Reference Standard
- BrucineBrucinum; 2,3-Dimethoxystrychnine; (-)-Brucine
- (1R,11S,18S,20R,21R,22S)-4,5-dimethoxy-12-oxa-8,17-diazaheptacyclo[15.5.2.0^{1,18}.0^{2,7}.0^{8,22}.0^{11,21}.0^{15,20}]tetracosa-2(7),3,5,14-tetraen-9-one
- (4aR,5aS,8aR,13aS,15aS,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one
179.91 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
189.6 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
395.1974 999
396.2005 220
397.2032 29
395.197 999
396.2002 219
397.2029 32
- Brucine; 2,3-dimethoxystrychnine (annotation moved to)
- Strychnidin-10-one, 2,3-dimethoxy-, (brucine) (annotation moved to)
H300+H330 (32.9%): Fatal if swallowed or if inhaled [Danger Acute toxicity, oral; acute toxicity, inhalation]
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
H330 (100%): Fatal if inhaled [Danger Acute toxicity, inhalation]
H412 (100%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P260, P264, P270, P271, P273, P284, P301+P316, P304+P340, P316, P320, P321, P330, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 85 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 2 (100%)
Acute Tox. 2 (100%)
Aquatic Chronic 3 (100%)
Acute Tox. 2 (90.5%)
Acute Tox. 2 (100%)
Aquatic Chronic 3 (100%)
· Highly toxic, may be fatal if inhaled, ingested or absorbed through skin.
· Avoid any skin contact.
· Fire may produce irritating, corrosive and/or toxic gases.
· Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination.
· Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes.
· Containers may explode when heated.
· Runoff may pollute waterways.
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. Strychnine is an exceptionally toxic poison but inducing vomiting may cause a seizure. IMMEDIATELY call a hospital or poison control center and locate activated charcoal, egg whites, or milk in case the medical advisor recommends administering one of them. If advice from a physician is not readily available and the victim is conscious and not convulsing, give the victim a glass of activated charcoal slurry in water or, if this is not available, a glass of milk, or beaten egg whites and IMMEDIATELY transport victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, assure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
General First Aid:
· Call 911 or emergency medical service.
· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.
· Move victim to fresh air if it can be done safely.
· Administer oxygen if breathing is difficult.
· If victim is not breathing:
-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingestedor inhaled the substance.
-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).
-- If no pulse detected or no respiratory medical device available, provide continuouscompressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.
· Remove and isolate contaminated clothing and shoes.
· For minor skin contact, avoid spreading material on unaffected skin.
· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.
· For severe burns, immediate medical attention is required.
· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.
· Keep victim calm and warm.
· Keep victim under observation.
· For further assistance, contact your local Poison Control Center.
· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.
In Canada, an Emergency Response Assistance Plan (ERAP) may be required for this product. Please consult the shipping paper and/or the "ERAP" section.
Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
SMALL FIRE: Dry chemical, CO2 or water spray.
LARGE FIRE: Water spray, fog or regular foam. If it can be done safely, move undamaged containers away from the area around the fire. Dike runoff from fire control for later disposal. Avoid aiming straight or solid streams directly onto the product.
FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Do not get water inside containers. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.
· Keep unauthorized personnel away.
· Stay upwind, uphill and/or upstream.
· Do not touch damaged containers or spilled material unless wearing appropriate protective clothing.
· Stop leak if you can do it without risk.
· Prevent entry into waterways, sewers, basements or confined areas.
· Cover with plastic sheet to prevent spreading.
· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.
· DO NOT GET WATER INSIDE CONTAINERS.
· For solids, prevent dust cloud and avoid inhalation of dust.
Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Immediate precautionary measure
· Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
Spill
· For highlighted materials: see Table 1 - Initial Isolation and Protective Action Distances.
· For non-highlighted materials: increase the immediate precautionary measure distance, in the downwind direction, as necessary.
Fire
· If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions.
Excerpt from ERG Guide 151 [Substances - Toxic (Non-Combustible)]:
Do not touch damaged containers or spilled material unless wearing appropriate protective clothing. Stop leak if you can do it without risk. Prevent entry into waterways, sewers, basements or confined areas. Cover with plastic sheet to prevent spreading. Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers. DO NOT GET WATER INSIDE CONTAINERS. For solids, prevent dust cloud and avoid inhalation of dust. (ERG, 2024)
· Wear positive pressure self-contained breathing apparatus (SCBA).
· Wear chemical protective clothing that is specifically recommended by the manufacturer when there is NO RISK OF FIRE.
· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.
Small Fire
· Dry chemical, CO2 or water spray.
Large Fire
· Water spray, fog or regular foam.
· If it can be done safely, move undamaged containers away from the area around the fire.
· Dike runoff from fire control for later disposal.
· Avoid aiming straight or solid streams directly onto the product.
Fire Involving Tanks, Rail Tank Cars or Highway Tanks
· Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles.
· Do not get water inside containers.
· Cool containers with flooding quantities of water until well after fire is out.
· Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank.
· ALWAYS stay away from tanks in direct contact with flames.
· For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn.
Amides and Imides
Amines, Phosphines, and Pyridines
Ethers
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=RRKTZKIUPZVBMF-IBTVXLQLSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Strychnidin-10-one, 2,3-dimethoxy-https://services.industrialchemicals.gov.au/search-assessments/Strychnidin-10-one, 2,3-dimethoxy-https://services.industrialchemicals.gov.au/search-inventory/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falseCAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Polyamide fibershttps://commonchemistry.cas.org/detail?cas_rn=63428-84-2
- ChemIDplusChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA Chemicals under the TSCAStrychnidin-10-one, 2,3-dimethoxy-https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSToxCompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
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- Hazardous Substances Data Bank (HSDB)
- ILO-WHO International Chemical Safety Cards (ICSCs)BRUCINE, ANHYDROUShttps://www.ilo.org/dyn/icsc/showcard.display?p_version=2&p_card_id=1017
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- NITE-CMCbrucine - FY2006 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/06-imcg-1334e.htmlBrucine - FY2018 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/18-moe-2036e.html
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- SpectraBase2,3-Dimethoxystrychnidin-10-onehttps://spectrabase.com/spectrum/4URmTPfOqzI2,3-Dimethoxystrychnidin-10-onehttps://spectrabase.com/spectrum/8IKRD80wzfj
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