Hydroquinone
- C6H6O2
- C6H4(OH)2
- hydroquinone
- 123-31-9
- Benzene-1,4-diol
- 1,4-benzenediol
- Quinol
- Create:2004-09-16
- Modify:2025-01-18
C6H6O2
C6H4(OH)2
- 1,4-benzenediol
- 1,4-dihydroxybenzene
- Artra
- beta-quinol
- Eldopaque
- Eldoquin
- Esoterica
- Hidroquilaude
- Hidroquin
- Hidroquinona Isdin
- hydroquinone
- hydroquinone, copper (1+) salt
- hydroquinone, lead (2+) salt (2:1)
- hydroquinone, monocopper (2+) salt
- Licostrata
- Lustra
- Melanasa
- Melanex
- Melpaque
- Melquin
- Neostrata HQ
- p-benzenediol
- Phiaquin
- Solaquin
- Ultraquin
- hydroquinone
- 123-31-9
- Benzene-1,4-diol
- 1,4-benzenediol
- Quinol
- 1,4-Dihydroxybenzene
- p-Benzenediol
- p-Hydroquinone
- p-Hydroxyphenol
- 4-Hydroxyphenol
- p-Dihydroxybenzene
- Benzoquinol
- hydroquinol
- Dihydroquinone
- Eldoquin
- p-Dioxybenzene
- Solaquin forte
- Eldopaque
- Hydroquinole
- Idrochinone
- Tecquinol
- Phiaquin
- Benzohydroquinone
- Hidroquinone
- Arctuvin
- Tequinol
- Dihydroxybenzene
- Eldopaque Forte
- Eldoquin Forte
- Derma-Blanch
- Hydrochinon
- Tenox HQ
- Diak 5
- Benzene, p-dihydroxy-
- Hydrochinone
- 1,4-Dihydroxy-benzol
- Artra
- Usaf ek-356
- 1,4-Diidrobenzene
- p-Dioxobenzene
- 1,4-Dihydroxybenzen
- para-Dioxybenzene
- para-Hydroquinone
- NCI-C55834
- Black and White Bleaching Cream
- 1,4-Dihydroxy-benzeen
- para-Dihydroxybenzene
- beta-quinol
- HE 5
- Pyrogentistic acid
- Epiquin
- Melanex
- Sunvanish
- Idrochinone [Italian]
- p-Dihydroquinone
- alpha-hydroquinone
- CHEBI:17594
- NSC 9247
- Hydrochinon [Czech, Polish]
- CCRIS 714
- 1,4-Dihydroxybenzen [Czech]
- 1,4-Diidrobenzene [Italian]
- HSDB 577
- DTXSID7020716
- 1,4-Dihydroxy-benzeen [Dutch]
- 1,4-Dihydroxy-benzol [German]
- AI3-00072
- CHEMBL537
- UNII-XV74C1N1AE
- NSC-9247
- EINECS 204-617-8
- XV74C1N1AE
- MFCD00002339
- UN2662
- Hydroquinone (USP)
- Hydroquinone [USP]
- HQ
- DTXCID70716
- NSC9247
- EC 204-617-8
- Hydroquinone [UN2662] [Poison]
- 1,4-Dihydroxybenzene (ring-d4)
- TRI-LUMA COMPONENT HYDROQUINONE
- NCGC00015523-02
- HYDROQUINONE (IARC)
- HYDROQUINONE [IARC]
- para-Hydroxyphenol
- Quinol; 1,4-Benzenediol; 1,4-Dihydroxybenzene
- HYDROQUINONE (MART.)
- HYDROQUINONE [MART.]
- HYDROQUINONE (USP-RS)
- HYDROQUINONE [USP-RS]
- quinnone
- Eldopacque
- p-Phenylenediol
- p Benzendiol
- HYDROQUINONE (USP MONOGRAPH)
- HYDROQUINONE [USP MONOGRAPH]
- p-Quinol
- 1,4-Benzoquinol
- CAS-123-31-9
- SMR000059154
- 1,4-Hydroxybenzene
- SR-01000075920
- BUTYLHYDROXYANISOLE IMPURITY A (EP IMPURITY)
- BUTYLHYDROXYANISOLE IMPURITY A [EP IMPURITY]
- 4-DIHYDROXYBENZENE
- hydroquinon
- BQ(H)
- Hydroquinoue
- Balancer
- MedisilkeNight
- Supermax
- hydroq uinone
- hydroquinone gr
- MiracleFade
- Reduced quinone
- a-Hydroquinone
- Activator Light
- Corrector Light
- Skin Lightener
- Black & White Bleaching Cream
- Clear Action
- Double White
- Exence White
- Hydroquinone gel
- Idole Carrot
- Movate Carrot
- Movate Lemon
- p-Hydroxybenzene
- Scarlight Md
- b-Quinol
- Caro Light
- Hot Movate
- Idole Black
- 4-Benzenediol
- 4-hydroxyphenoxy
- Hydroquinone 4%
- Hydroquinone cream
- Nova Complex HQ
- Hydroquinone, HQ
- Light The Way
- .beta.-Quinol
- 1,4 benzenediol
- Clarite 4
- Hydro-Q
- Obagi-C
- Seequin 2
- Seequin 4
- Active 4
- Hydroquinone,(S)
- p-dihydroxy benzene
- PLQ
- Artra (Salt/Mix)
- HQLA
- HYDROP
- I-max Lightening 5
- PIONA
- .alpha.-Hydroquinone
- Skin lightening Cream
- African Formula Black
- NeovaComplex HQ Plus
- phenol derivative, 4
- Skin Beautifying Milk
- African Formula Carrot
- Essential Fade Complex
- Clear-N-Smooth PLUS
- 4-hydroxyphenyl alcohol
- NU-DERM BLENDER
- NU-DERM CLEAR
- Skin Lightening Complex
- Spectrum_001757
- SYMBA Skin Lightening
- 4e3h
- Image Md Lightening Rx
- BRIGHTENLIGHTENING
- HYDROQUINONE 6%
- HYDROQUINONE 8%
- SpecPlus_000769
- 1,4-Dihydrobenzoquinone
- Clear-N-Smooth Ultimate
- Clear-N-Smooth SuperMax
- Clear-N-Smooth UltraMax
- ELDOQUIN (TN)
- EB5 Age Spot Treatment
- Gold Cosmetics Adi Clear
- hydroquinone for synthesis
- Hydroquinone Time Release
- Rejuvaderm Medispa Fading
- Spectrum2_001672
- Spectrum3_000656
- Spectrum4_000633
- Spectrum5_001430
- HYDROQUINONE [MI]
- Lopac-H-9003
- HYDROQUINONE 8%.
- WLN: QR DQ
- bmse000293
- Dark Spot Lightening Cream
- Epitope ID:116206
- Sh18
- HYDROQUINONE [HSDB]
- Skin LighteningRodan Fields
- PLUS Skin lightening Cream
- Gold Cosmetics Bleach Cream
- Vividly Brilliant Perfecting
- HYDROQUINONE [VANDF]
- 1,4-Dihydroxybenzene Quinol
- Lopac0_000577
- SCHEMBL15516
- BSPBio_002291
- KBioGR_001246
- KBioSS_002237
- 1,4-Dihydroxybenzene, XIII
- MLS000069815
- MLS001074911
- Pure Valley Miracle Age Spot
- BIDD:ER0340
- DivK1c_006865
- HYDROQUINONE [WHO-DD]
- Hydroquinone, LR, >=99%
- SPECTRUM1504237
- Clear-N-Smooth Super-Ultimate
- Hydrochinon(CZECH, POLISH)
- SPBio_001883
- Precious Beauty Skin Lightening
- Body Fade CremeMaximum Strength
- PLEXADERM Dark Spot Fade Gel
- ULTIMATE Skin lightening Cream
- BDBM26190
- Hydroquinone, puriss., 99.0%
- KBio1_001809
- KBio2_002237
- KBio2_004805
- KBio2_007373
- KBio3_001511
- Benzene-1,4-diol (Hydroquinone)
- Gold Cosmetics Bleach Cream Forte
- HQ Plus Brightening CreamVI Derm
- DTXSID001316808
- HMS1922H15
- HMS2093E08
- HMS3261D16
- HYDROQUINONE [ORANGE BOOK]
- OLIVIA QUIDO BLEMISH ERASER
- Pharmakon1600-01504237
- Ageless Total Skin Bleaching Serum
- DermisaSkin Fade Vitamin C infused
- Gold Cosmetics Bleach Cream Silver
- Divine Derrier Skin Bleaching cream
- Dr. Lightening Ultra-Potent Facial
- HY-B0951
- Obagi-C Rx system C-Therapy Night
- Tox21_110169
- Tox21_202345
- Tox21_300015
- Tox21_500577
- 141010 HYDROQUINONE 4%
- 141011 HYDROQUINONE 6%
- 141030 HYDROQUINONE 8%
- 141055 HYDROQUINONE 6%
- 141067 HYDROQUINONE 8%
- CCG-39082
- MD Acne Medicated Dark Spot Remover
- NSC758707
- Olivia Quido Skincare Blemish Eraser
- s4580
- STK397446
- AKOS000119003
- Obagi C Rx System C Clarifying Serum
- Teatrical Pro-Aclarant Skin Lightening
- Tox21_110169_1
- 1ST2901
- DB09526
- LP00577
- NSC-758707
- RP10102
- SDCCGSBI-0050559.P003
- UN 2662
- Hydroquinone, ReagentPlus(R), >=99%
- Hydroquinone, USP, 99.0-100.5%
- NCGC00015523-01
- NCGC00015523-03
- NCGC00015523-04
- NCGC00015523-05
- NCGC00015523-06
- NCGC00015523-07
- NCGC00015523-08
- NCGC00015523-09
- NCGC00015523-10
- NCGC00015523-11
- NCGC00015523-12
- NCGC00015523-13
- NCGC00015523-19
- NCGC00090880-01
- NCGC00090880-02
- NCGC00090880-03
- NCGC00090880-04
- NCGC00090880-05
- NCGC00254037-01
- NCGC00259894-01
- NCGC00261262-01
- BP-21160
- DA-33570
- Dr. Throwers Skin Lightening Moisturizing
- HYDROQUINONE COMPONENT OF TRI-LUMA
- Hydroquinone, ReagentPlus(R), >=99.5%
- SBI-0050559.P002
- Hydroquinone, SAJ first grade, >=99.0%
- NU-DERM CLEARSkin Bleaching and Corrector
- EU-0100577
- H0186
- Hydroquinone, SAJ special grade, >=99.0%
- MEDITOWELILLUMINATING SKIN BRIGHTENING
- NS00004421
- NU-DERM BLENDERSkin Lightener and Blending
- EN300-18053
- Hydroquinone, meets USP testing specifications
- Advanced Dual Complex FadeMaximum Strength Plus
- C00530
- D00073
- H 9003
- AB00053361_08
- Q419164
- ZO Skin Health Pigment Control Creme Hydroquinone
- J-004910
- J-521469
- SR-01000075920-1
- SR-01000075920-4
- BRD-K11227669-001-07-8
- BRD-K11227669-001-08-6
- Q27102742
- Z57127551
- 094CADDB-59BF-4EDF-B278-59791B203EA2
- F1908-0167
- Hydroquinone, certified reference material, TraceCERT(R)
- OBAGI-C Rx system C-CLARIFYING SERUM NORMAL TO oily
- ZO Skin Health Pigment Control Program Plus Hydroquinone
- CONDITION AND ENHANCE BLENDERSkin Lightener and Blending
- CONDITION AND ENHANCE CLEARSkin Bleaching and Corrector
- ZO Skin Health Pigment Control Plus Blending Creme Hydroquinone
- ELASTIDERM DECOLLETAGE SKIN LIGHTENING COMPLEXChest and Neck
- Hydroquinone, United States Pharmacopeia (USP) Reference Standard
- InChI=1/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8
- Obagi-C Rx system C-Therapy NightSkin Lightening with Vitamins C and E
- Hydroquinone, Pharmaceutical Secondary Standard; Certified Reference Material
- ZO MEDICAL MELAMIN-C Skin Bleaching and Correcting with Vitamin C Hydroquinone
- ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C
- 3225-30-7
- OBAGI-C Rx system C-CLARIFYING SERUM NORMAL TO oilySKIN LIGHTENING SERUM WITH VITAMIN C
128.79 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
119.07 Ų [M-H]- [CCS Type: DT; Method: stepped-field]
118.7 Ų [M-H]-
113.9 Ų [M+H]+
- 13C nuclear magnetic resonance spectrum
- Schoenflies notation
- Angular frequency
- Boiling point
- Chemical bond
- Chemical shift
- Crystal structure
- Density
- Diamagnetic susceptibility
- Electric dipole moment
- External quantum efficiency
- Formula unit
- Formula weight
- Fusion temperature
- Heat of sublimation
- Internuclear distance
- Luminescence
- Luminescence emission linewidth
- Magnetic anisotropy
- Magnetic susceptibility
- Melting temperature
- Molecular structure
- Phase transition
- Point group
- Polarization degree
- Rotational excitation cross section
- Space group
- Spin-spin coupling constant
- Transition enthalpy
- Unit cell
- Unit cell parameter
- Vapor pressure
110.0 99.99
53.0 26.10
39.0 16.90
54.0 12.50
82.0 9.30
110.0 99.99
81.0 48.49
53.0 36.94
55.0 26.51
39.0 18.60
109.02917 100
76.96878 55.90
60.97355 50.60
108.01952 37.40
53.03926 36.70
62.98964 100
43.01692 69.10
78.98438 62.70
82.96115 33.40
41.48511 21.80
111.0451 999
93.0345 65
65.0416 28
83.9988 13
83.0497 9
111.0436 999
65.0418 767
93.0354 462
83.9994 73
83.0499 62
110 999
53 261
39 169
54 125
82 93
- Phenol (has active moiety)
- Quinhydrone (is active moiety of)
- Fluocinolone acetonide; hydroquinone; tretinoin (component of)
- Hydroquinone; Octinoxate (component of)
- Hydroquinone; tretinoin (component of)
- Hydroquinone; padimate O (component of)
- Hydrocortisone; hydroquinone (component of)
- Sodium polydihydroxyphenylene thiosulfonate (monomer of)
- Polydihydroxyphenylene thiosulfonate (monomer of)
- Hydroquinone; octinoxate; oxybenzone (component of)
- Hydroquinone; tretinoin; triamcinolone acetonide (component of)
- Desoximetasone; hydroquinone; tretinoin (component of)
- Avobenzone; Hydroquinone; Octinoxate (component of)
- Hydrocortisone; hydroquinone; tretinoin (component of)
- Hyaluronate sodium; hydroquinone (component of)
- Betamethasone dipropionate; hydroquinone; tretinoin (component of)
- Adenosine triphosphate disodium; anthraquinone; ascorbic acid; aspirin; bilberry; colchicum autumnale bulb; conium maculatum flowering top; galium aparine; goldenseal; histamine dihydrochloride; hydroquinone; lactic acid, L-; magnesium gluconate; manganese phosphate, dibasic; nadide; naphthoquine; niacinamide; norepinephrine bitartrate; pantothenic acid; podophyllum; pyridoxine hydrochloride; riboflavin; salmonella enterica subsp. enterica serovar enteritidis; sodium diethyl oxalacetate; sulfur; thiamine hydrochloride; thioctic acid; ubidecarenone (component of)
- Bone Marrow
- Epidermis
- Fibroblasts
- Kidney
- Liver
Plastic Composites Manufacturing [Category: Industry]
Photographic Processing [Category: Other]
- Antioxidant
- Intermediates
- Not Known or Reasonably Ascertainable
- Intermediate
- Photosensitive chemicals
- Process regulators
- Processing aids, not otherwise listed
- Other (specify)
- Not Known or Reasonably Ascertainable
- Photosensitive chemicals
Information on 49 consumer products that contain Hydroquinone in the following categories is provided:
• Auto Products
• Inside the Home
• Personal Care
2019: 10,000,000 - <50,000,000 lb
2018: 20,000,000 lb - <100,000,000 lb
2017: 10,000,000 - <50,000,000 lb
2016: 50,000,000 - <100,000,000 lb
- Other (requires additional information)
- All Other Basic Organic Chemical Manufacturing
- Photographic Film, Paper, Plate, and Chemical Manufacturing
- Plastics Material and Resin Manufacturing
- Rubber Product Manufacturing
H302+H312 (17.9%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]
H302 (99.7%): Harmful if swallowed [Warning Acute toxicity, oral]
H312 (17.9%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H317 (> 99.9%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H318 (99.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H341 (99.9%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H351 (> 99.9%): Suspected of causing cancer [Warning Carcinogenicity]
H400 (> 99.9%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (20.7%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
P203, P261, P264, P264+P265, P270, P272, P273, P280, P301+P317, P302+P352, P305+P354+P338, P317, P318, P321, P330, P333+P317, P362+P364, P391, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 2464 reports by companies from 36 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 1 of 2464 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 35 notifications provided by 2463 of 2464 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 4 (99.7%)
Acute Tox. 4 (17.9%)
Skin Sens. 1 (> 99.9%)
Eye Dam. 1 (99.9%)
Muta. 2 (99.9%)
Carc. 2 (> 99.9%)
Aquatic Acute 1 (> 99.9%)
Aquatic Chronic 1 (20.7%)
Acute toxicity - category 4
Carcinogenicity - category 2
Germ cell mutagenicity - category 2
Eye damage - category 1
Skin sensitisation - category 1
Hazardous to the aquatic environment (acute) - category 1
Signs and Symptoms of Acute Hydroquinone Exposure: Signs and symptoms of acute exposure to hydroquinone may be severe and include dyspnea (shortness of breath), a sense of suffocation, increased respiratory rate, and respiratory failure. Pallor (paleness of the skin), cyanosis (blue tint to skin and mucous membranes), and cardiovascular collapse may occur. Neurologic effects include headache, tinnitus (ringing in the ears), dizziness, delirium, muscle twitching, tremor, and convulsions. Nausea, vomiting, and the production of green to brown-green urine may also occur. Hydroquinone may be irritating and corrosive to the skin, eyes, and mucous membranes. Jaundice (yellow tint to skin) may be noticed.
Emergency Life-Support Procedures: Acute exposure to hydroquinone may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to hydroquinone.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to hydroquinone.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas twice with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen.
2. IMMEDIATELY give the victims water or milk: children up to 1 year old, 125 mL (4 oz or 1/2 cup); children 1 to 12 years old, 200 mL (6 oz or 3/4 cup); adults, 250 mL (8 oz or 1 cup). Water or milk should be given only if victims are conscious and alert.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of hydroquinone is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
5.Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of hydroquinone may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
5.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
5. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
6. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
7. Transport to a health care facility. (EPA, 1998)
(See general first aid procedures)
Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.
Skin: Water flush - If this chemical contacts the skin, flush the contaminated skin with water. Where there is evidence of skin irritation, get medical attention.
Breathing: Respiratory support
Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately.
Wear self-contained (positive pressure if available) breathing apparatus and full protective clothing.
For small fires use dry chemical, carbon dioxide, water spray or foam. Move container from fire area if you can do so without risk. This compound is a slight fire or explosion hazard. (EPA, 1998)
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Excerpt from ERG Guide 171 [Substances (Low to Moderate Hazard)]:
Do not touch or walk through spilled material. Stop leak if you can do it without risk. Prevent dust cloud. For Asbestos, avoid inhalation of dust. Cover spill with plastic sheet or tarp to minimize spreading. Do not clean up or dispose of, except under supervision of a specialist.
SMALL DRY SPILL: With clean shovel, place material into clean, dry container and cover loosely; move containers from spill area.
SMALL SPILL: Pick up with sand or other non-combustible absorbent material and place into containers for later disposal.
LARGE SPILL: Dike far ahead of liquid spill for later disposal. Cover powder spill with plastic sheet or tarp to minimize spreading. Prevent entry into waterways, sewers, basements or confined areas. (ERG, 2024)
50.0 [mg/m3]
Excerpts from Documentation for IDLHs: Human data: It has been reported that 5 to 12 grams is the lethal oral dose [Zeidman and Deutel 1945]. [Note: An oral dose of 5 to 12 grams is equivalent to a worker being exposed to 3,333 to 8,000 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]
50 mg/m3
See: 123319
Excerpt from NIOSH Pocket Guide for Hydroquinone:
Skin: PREVENT SKIN CONTACT - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: PREVENT EYE CONTACT - Wear appropriate eye protection to prevent eye contact.
Wash skin: WHEN CONTAMINATED - The worker should immediately wash the skin when it becomes contaminated.
Remove: WHEN WET OR CONTAMINATED - Work clothing that becomes wet or significantly contaminated should be removed and replaced.
Change: DAILY - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
Provide: EYEWASH (>7%) - Eyewash fountains should be provided in areas where there is any possibility that workers could be exposed to the substances; this is irrespective of the recommendation involving the wearing of eye protection. (>7%) (NIOSH, 2024)
(See personal protection and sanitation codes)
Skin: Prevent skin contact - Wear appropriate personal protective clothing to prevent skin contact.
Eyes: Prevent eye contact - Wear appropriate eye protection to prevent eye contact.
Wash skin: When contaminated
Remove: When wet or contaminated
Change: Daily - Workers whose clothing may have become contaminated should change into uncontaminated clothing before leaving the work premises.
Provide: Eyewash (>7%)
NIOSH/OSHA
Up to 50 mg/m3 :
(APF = 25) Any powered, air-purifying respirator with a high-efficiency particulate filter./
(APF = 50) Any air-purifying, full-facepiece respirator with an N100, R100, or P100 filter.
Click here for information on selection of N, R, or P filters.
(APF = 50) Any supplied-air respirator that has a tight-fitting facepiece and is operated in a continuous-flow mode
(APF = 50) Any self-contained breathing apparatus with a full facepiece
(APF = 50) Any supplied-air respirator with a full facepiece
Emergency or planned entry into unknown concentrations or IDLH conditions:
(APF = 10,000) Any self-contained breathing apparatus that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode
(APF = 10,000) Any supplied-air respirator that has a full facepiece and is operated in a pressure-demand or other positive-pressure mode in combination with an auxiliary self-contained positive-pressure breathing apparatus
Escape:
(APF = 50) Any air-purifying, full-facepiece respirator with an N100, R100, or P100 filter.
Click here for information on selection of N, R, or P filters.
Any appropriate escape-type, self-contained breathing apparatus
Phenols and Cresols
Acids, Weak
Hazard Traits - Carcinogenicity
Authoritative List - CA TACs
Report - if used as a fragrance or flavor ingredient
Status: Active Update: 05-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/14417
Status: Active Update: 04-08-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/23249
Status: Active Update: 22-05-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/6231
IMAP assessments - 1,4-Benzenediol: Human health tier II assessment
Evaluation - Hydroquinone and p-benzoquinone
Volume 15: (1977) Some Fumigants, the Herbicides 2,4-D and 2,4,5-T, Chlorinated Dibenzodioxins and Miscellaneous Industrial Chemicals
Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)
Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of hydroquinone for male F344/N rats, as shown by marked increases in tubular cell adenomas of the kidney. There was some evidence of carcinogenic activity of hydroquinone for female F344/N rats, as shown by increases in mononuclear cell leukemia. There was no evidence of carcinogenic activity of hydroquinone for male B6C3F1 mice administered 50 or 100 mg/kg in water by gavage. There was some evidence of carcinogenic activity of hydroquinone for female B6C3F1 mice, as shown by increases in hepatocellular neoplasms, mainly adenomas.
Administration of hydroquinone was associated with thyroid follicular cell hyperplasia in both male and female mice and anisokaryosis, multinucleated hepatocytes, and basophilic foci of the liver in male mice.
◉ Summary of Use during Lactation
Topical hydroquinone has not been studied during breastfeeding. Although hydroquinone is not contraindicated during breastfeeding, some experts feel that long-term use of hydroquinone is difficult to justify in a nursing mother. If hydroquinone is used, ensure that the infant's skin does not come into direct contact with the areas of maternal skin that have been treated and the infant does not ingest the product from the mother's skin.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Methemoglobinemia - The presence of increased methemoglobin in the blood; the compound is classified as secondary toxic effect
Skin Sensitizer - An agent that can induce an allergic reaction in the skin.
ACGIH Carcinogen - Confirmed Animal.
Merck Manual of Diagnosis and Therapy.
Geigy Scientific Tables, 8th Rev edition, pp. 165-177. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Geigy Scientific Tables, 8th Rev edition, pp. 80-82. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp., Basel, Switzerland c1981-1992.
Geigy Scientific Tables, 8th Rev edition, pp. 130. Edited by C. Lentner, West Cadwell, N.J.: Medical education Div., Ciba-Geigy Corp. Basel, Switzerland c1981-1992.
David F. Putnam Composition and Concentrative Properties of Human Urine. NASA Contractor Report. July 1971
National Health and Nutrition Examination Survey (NHANES Survey) 2013
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=QIGBRXMKCJKVMJ-UHFFFAOYSA-N
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