Pergolide
- pergolide
- 66104-22-1
- Permax
- Pergolida
- Pergolidum
- Create:2005-03-26
- Modify:2025-02-01
- Celance
- LY-127,809
- LY-127809
- LY127,809
- LY127809
- Mesylate, Pergolide
- Parkotil
- Pergolide
- Pergolide Mesylate
- Permax
- Pharken
- pergolide
- 66104-22-1
- Permax
- Pergolida
- Pergolidum
- Pergolidum [INN-Latin]
- Pergolida [INN-Spanish]
- Pergolide (INN)
- UNII-24MJ822NZ9
- CHEBI:63617
- 24MJ822NZ9
- Permax (TN)
- CHEMBL531
- (6aR,9R,10aR)-9-(methylsulfanylmethyl)-7-propyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline
- 8beta-[(Methylthio)methyl]-6-propylergoline
- DTXSID2023438
- (8beta)-8-[(methylsulfanyl)methyl]-6-propylergoline
- Ergoline, 8-((methylthio)methyl)-6-propyl-, (8beta)-
- LY 141B
- PERGOLIDE [INN]
- Pergolidum (INN-Latin)
- Pergolida (INN-Spanish)
- Pergolide [INN:BAN]
- D-8beta-((Methylthio)methyl)-6-propylergoline
- CHEMBL1275
- (2R,4R,7R)-4-[(methylsulfanyl)methyl]-6-propyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraene
- NCGC00017366-04
- (8beta)-8-((methylsulfanyl)methyl)-6-propylergoline
- TNP00315
- SR-01000721840
- Spectrum_001647
- PERGOLIDE [MI]
- Prestwick0_000295
- Prestwick1_000295
- Prestwick2_000295
- Prestwick3_000295
- Spectrum2_001970
- Spectrum3_001588
- Spectrum4_000835
- Spectrum5_001649
- PERGOLIDE [VANDF]
- Biomol-NT_000025
- GTPL48
- PERGOLIDE [WHO-DD]
- (8beta)-8-[(methylthio)methyl]-6-propylergoline
- Lopac0_000984
- SCHEMBL26921
- BSPBio_000230
- BSPBio_003156
- KBioGR_001409
- KBioSS_002127
- cid_47811
- BIDD:GT0177
- DivK1c_000442
- SPBio_002099
- SPBio_002449
- BPBio1_000254
- BPBio1_001211
- DTXCID203438
- KBio1_000442
- KBio2_002127
- KBio2_004695
- KBio2_007263
- KBio3_002656
- N04BC02
- NINDS_000442
- YEHCICAEULNIGD-MZMPZRCHSA-N
- HMS2089C18
- BCP18331
- BDBM50017543
- BDBM50028421
- AKOS040744817
- CCG-205064
- DB01186
- SDCCGSBI-0050957.P004
- IDI1_000442
- NCGC00017366-02
- NCGC00017366-03
- NCGC00017366-05
- NCGC00017366-06
- NCGC00017366-10
- NCGC00017366-13
- NCGC00142538-01
- NCGC00142538-02
- NCGC00142538-03
- (6aR,9R,10aR)-9-(Methylthiomethyl)-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline
- HY-13720
- SBI-0050957.P003
- [2-(1H-Indol-4-yl)-ethyl]-methyl-amine
- CS-0007749
- NS00098765
- P2200
- C07425
- D08339
- D92194
- AB00053740-13
- AB00053740_14
- AB00053740_15
- EN300-6482031
- Q415752
- SR-01000721840-8
- BRD-K60770992-001-01-8
- BRD-K60770992-066-05-2
- BRD-K60770992-066-15-1
- BRD-K60770992-066-25-0
- 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline
- (2R,4R,7R)-4-[(methylsulfanyl)methyl]-6-propyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(15),9,12(16),13-tetraene
- (6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-7-ium
- (6aR,9R,10aR)-9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline
- 5-Bromo-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid (10b-hydroxy-5-isobutyl-2-isopropyl-3,6-dioxo-octahydro-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl)-amide
- 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinolin-7-ium(Pergolide)
- 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline(pergolide)
- 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline, mesylate (Pergolide)
- 9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10a-octahydro-indolo[4,3-fg]quinoline; compound with methanesulfonic acid
- InChI=1/C19H26N2S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3/t13-,16-,18-/m1/s
315.1869 100
208.1108 3.87
267.1818 0.77
193.087 0.76
154.0645 0.75
315.1871 100
208.1107 56.42
167.0706 8.95
154.0644 8.31
196.1108 7.60
315.1869 999
208.1108 39
267.1818 8
193.087 8
154.0645 8
315.1871 999
208.1107 564
167.0706 89
154.0644 83
196.1108 76
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]
H361 (100%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
P203, P264, P270, P280, P301+P316, P318, P321, P330, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Acute Tox. 2 (100%)
Carc. 2 (100%)
Repr. 2 (100%)
Pergolide has been reported to cause serum aminotransferase elevations in a small proportion of patients, but these abnormalities are usually mild, asymptomatic and self-limiting even without dose adjustment. In addition, pergolide has been implicated in a small number of cases of clinically apparent, acute liver injury, but the frequency, severity, clinical characteristics and typical pattern of enzyme elevations have not been characterized. Thus, pergolide is may be a rare cause of clinically apparent liver injury.
Likelihood score: E* (unproven but suspected cause of clinically apparent liver injury).
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=YEHCICAEULNIGD-MZMPZRCHSA-N
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