N-Methylformamide
- N-METHYLFORMAMIDE
- 123-39-7
- Methylformamide
- Formamide, N-methyl-
- Monomethylformamide
- Create:2005-03-26
- Modify:2025-01-25
- methylformamide
- monomethylformamide
- N-methylformamide
- NSC 3051
- N-METHYLFORMAMIDE
- 123-39-7
- Methylformamide
- Formamide, N-methyl-
- Monomethylformamide
- N-Formylmethylamine
- n-methyl-Formamide
- NSC 3051
- N-Monomethylformamide
- EK 7011
- HCONHCH3
- X 188
- Formamide, methyl-
- methylimidoformic acid
- NMF
- N-Methyl-formimidic acid
- (E)-methylimidoformic acid
- (Z)-methylimidoformic acid
- CHEBI:7438
- XPE4G7Y986
- NSC3051
- N-METHYL-FORMIC ACID-AMIDE
- NSC-3051
- N-Methylformamide, 99%
- methanimidic acid, methyl-
- N-Methyl formamide
- Formic acid amide, N-methyl-
- HSDB 100
- EINECS 204-624-6
- BRN 1098352
- UNII-XPE4G7Y986
- AI3-26076
- n-methylcarboxamide
- N-methylmethanamide
- Methylformamide; Monomethylformamide; N-Methylformimidic Acid; N-Monomethylformamide; NSC 3051
- MFCD00003280
- methyl-Methanimidic acid
- n-methyl Formic acid amide
- WLN: VHM1
- EC 204-624-6
- CHEMBL9240
- Formamide, N-methyl- ( )
- 4-04-00-00170 (Beilstein Handbook Reference)
- N-METHYLFORMAMIDE [MI]
- DTXSID0025608
- N-METHYLFORMAMIDE [HSDB]
- BBL027430
- STL146549
- AKOS000118787
- SB85388
- NCI60_002574
- DB-046834
- F0059
- NS00006200
- EN300-19419
- A805066
- Q138742
- J-004934
- BRD-K33445938-001-01-8
- F0001-0365
- Z104473766
30.0 99.99
28.0 85.67
59.0 80.69
29.0 36.48
15.0 13.69
30 99.99
28 85.67
59 80.69
29 36.48
15 13.69
30 999
28 857
59 807
29 365
15 137
H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
H319 (61.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H360 (93.7%): May damage fertility or the unborn child [Danger Reproductive toxicity]
P203, P264+P265, P280, P302+P352, P305+P351+P338, P317, P318, P321, P337+P317, P362+P364, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 221 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 4 (100%)
Eye Irrit. 2 (61.1%)
Repr. 1B (93.7%)
Reproductive toxicity - category 1B
Acute toxicity - category 4
SYMPTOMS: Symptoms of exposure to this compound include irritation of the mucous membranes and upper respiratory tract. Other symptoms include liver damage, eye irritation with discomfort, tearing or blurring of vision, skin irritation with discomfort or rash, abnormalities of liver function with jaundice, temporary nervous system depression with anesthetic effects such as dizziness, headache, confusion, incoordination and loss of consciousness.
ACUTE/CHRONIC HAZARDS: This compound may be absorbed through the skin and cause skin irritation. It may also irritate the eyes, mucous membranes and upper respiratory tract. When heated to decomposition it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you should spill this chemical, use absorbent paper to pick up all liquid spill material. Seal the absorbent paper, as well as any of your clothing which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Wash any surfaces you may have contaminated with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this material under ambient temperatures and keep away from oxidizers. (NTP, 1992)
Hazard Traits - Reproductive Toxicity
Authoritative List - EC Annex VI CMRs - Cat. 1B
Report - if used as a fragrance or flavor ingredient
Status: Active Update: 24-02-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/12311
Status: Active Update: 11-11-2014 https://echa.europa.eu/registration-dossier/-/registered-dossier/7551
Status: Active Update: 29-10-2012 https://echa.europa.eu/registration-dossier/-/registered-dossier/6092
Neurotoxin - Acute solvent syndrome
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=ATHHXGZTWNVVOU-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Formamide, N-methyl-https://services.industrialchemicals.gov.au/search-assessments/Formamide, N-methyl-https://services.industrialchemicals.gov.au/search-inventory/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falseN-METHYLFORMAMIDEhttps://cameochemicals.noaa.gov/chemical/20654CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/N-Methylformamidehttps://commonchemistry.cas.org/detail?cas_rn=123-39-7
- ChemIDplusChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
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- EPA Chemicals under the TSCAFormamide, N-methyl-https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSToxN-Methylformamidehttps://comptox.epa.gov/dashboard/DTXSID0025608CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeN-methylformamidehttps://chem.echa.europa.eu/100.004.205N-methylformamide (EC: 204-624-6)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/6031
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingN-METHYLFORMAMIDEhttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/XPE4G7Y986
- Hazardous Substances Data Bank (HSDB)N-METHYLFORMAMIDEhttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/100
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citingN-Methylformamidehttp://www.hmdb.ca/metabolites/HMDB0001122HMDB0001122_cms_28265https://hmdb.ca/metabolites/HMDB0001122#spectra
- ILO-WHO International Chemical Safety Cards (ICSCs)
- New Zealand Environmental Protection Authority (EPA)LICENSEThis work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence.https://www.epa.govt.nz/about-this-site/general-copyright-statement/
- California Safe Cosmetics Program (CSCP) Product Database
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutN-Methylformamidehttps://haz-map.com/Agents/6251
- ChEBIN-methylformamidehttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:7438
- LOTUS - the natural products occurrence databaseLICENSEThe code for LOTUS is released under the GNU General Public License v3.0.https://lotus.nprod.net/N-Methylformamidehttps://www.wikidata.org/wiki/Q138742LOTUS Treehttps://lotus.naturalproducts.net/
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- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jspmethylformamidehttps://ctdbase.org/detail.go?type=chem&acc=C002950
- Drug Gene Interaction database (DGIdb)LICENSEThe data used in DGIdb is all open access and where possible made available as raw data dumps in the downloads section.http://www.dgidb.org/downloadsN-METHYLFORMAMIDEhttps://www.dgidb.org/drugs/ncit:C1163
- Crystallography Open Database (COD)LICENSEAll data in the COD and the database itself are dedicated to the public domain and licensed under the CC0 License. Users of the data should acknowledge the original authors of the structural data.https://creativecommons.org/publicdomain/zero/1.0/
- Hazardous Chemical Information System (HCIS), Safe Work Australia
- NITE-CMCN-methylformamide - FY2018 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/18-mhlw-2014e.htmlN-methylformamide - FY2007 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/07-meti-0018e.html
- Regulation (EC) No 1272/2008 of the European Parliament and of the CouncilLICENSEThe copyright for the editorial content of this source, the summaries of EU legislation and the consolidated texts, which is owned by the EU, is licensed under the Creative Commons Attribution 4.0 International licence.https://eur-lex.europa.eu/content/legal-notice/legal-notice.htmlN-methylformamidehttps://eur-lex.europa.eu/eli/reg/2008/1272/oj
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- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/n-methylformamideNORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- NMRShiftDB
- MassBank Europe
- MassBank of North America (MoNA)LICENSEThe content of the MoNA database is licensed under CC BY 4.0.https://mona.fiehnlab.ucdavis.edu/documentation/license
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-lawFormamide, N-methyl-http://www.nist.gov/srd/nist1a.cfm
- SpectraBasen-Methylformamidehttps://spectrabase.com/spectrum/BM11Ut2uF0AMethylformamidehttps://spectrabase.com/spectrum/JJJdBywTUCeN-methylformamidehttps://spectrabase.com/spectrum/CI8Fh472JEpN-Methylformamidehttps://spectrabase.com/spectrum/KyXq5dlQwdES-TRANS-N-METHYLFORMAMIDEhttps://spectrabase.com/spectrum/8hI2MPdbj7AS-CIS-N-METHYLFORMAMIDEhttps://spectrabase.com/spectrum/8dxmDng79h2N-METHYLFORAMIDEhttps://spectrabase.com/spectrum/5uyicKmnzJIN-METHYL-FORMAMIDEhttps://spectrabase.com/spectrum/LxIHG9mR568FORMAMIDE, N-METHYL-,https://spectrabase.com/spectrum/7ddyBoYaFAGFormamide, N-methyl-https://spectrabase.com/spectrum/Ott5wkSHA6Formamide, N-methyl-https://spectrabase.com/spectrum/KhOvzkyhZW4n-Methylformamidehttps://spectrabase.com/spectrum/GQGTRADhg9qFormamide, N-methyl-https://spectrabase.com/spectrum/DTM5CS8QwC7Formamide, N-methyl-https://spectrabase.com/spectrum/CjoKrjELzpPFORMAMIDE, N-METHYL-https://spectrabase.com/spectrum/3CR5s6ycBQsFORMAMIDE, N-METHYL-, TRANS-https://spectrabase.com/spectrum/3J5eKq3iUykN-Methylformamidehttps://spectrabase.com/spectrum/7hgbzxnIWLg
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.html
- Natural Product Activity and Species Source (NPASS)N-Methylformamidehttps://bidd.group/NPASS/compound.php?compoundID=NPC8249
- Metabolomics Workbench
- Nature Chemistry
- Springer Nature
- The Cambridge Structural Database
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- WikidataN-methylformamidehttps://www.wikidata.org/wiki/Q138742
- WikipediaN-Methylformamidehttps://en.wikipedia.org/wiki/N-Methylformamide
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlmethylformamidehttps://www.ncbi.nlm.nih.gov/mesh/67002950Antineoplastic Agentshttps://www.ncbi.nlm.nih.gov/mesh/68000970Radiation-Sensitizing Agentshttps://www.ncbi.nlm.nih.gov/mesh/68011838
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403031668https://pubchem.ncbi.nlm.nih.gov/substance/403031668
- NCBI