Oxyquinoline
- 8-HYDROXYQUINOLINE
- quinolin-8-ol
- 148-24-3
- 8-quinolinol
- Oxyquinoline
- Create:2005-03-25
- Modify:2025-01-18
- 8 Hydroxyquinoline
- 8 Hydroxyquinoline Sulfate
- 8 Oxyquinoline
- 8 Quinolinol
- 8-Hydroxyquinoline
- 8-Hydroxyquinoline Sulfate
- 8-Oxyquinoline
- 8-Quinolinol
- Bioquin
- Chinosol
- Khinozol
- Leioderm
- Oxine
- Oxyquinol
- Oxyquinoline
- Oxyquinoline Potassium Sulfate (2:1)
- Oxyquinoline Sulfate
- Quinosol
- Sulfate, 8-Hydroxyquinoline
- Sulfate, Oxyquinoline
- Superol
- 8-HYDROXYQUINOLINE
- quinolin-8-ol
- 148-24-3
- 8-quinolinol
- Oxyquinoline
- Oxine
- Quinophenol
- Oxychinolin
- 8-Quinol
- 8-Oxyquinoline
- Phenopyridine
- Oxin
- Oxybenzopyridine
- Hydroxybenzopyridine
- 1-Azanaphthalene-8-ol
- 8-Hydroxychinolin
- Bioquin
- Tumex
- 8-Chinolinol
- 8-Hydroxy-chinolin
- Fennosan H 30
- 8-OQ
- Fennosan
- Oxyquinol
- o-Oxychinolin
- Usaf ek-794
- 8-Oxychinolin
- Quinoline, 8-hydroxy-
- 8 Hydroxyquinoline
- Fennosan HF-15
- Oxyquinoline [USAN]
- Caswell No. 719
- NCI-C55298
- NSC 2039
- MFCD00006807
- 8-hydroxy-quinoline
- CCRIS 340
- Oxoquinoline
- Albisal
- NSC 615011
- HSDB 4073
- NSC-2039
- EINECS 205-711-1
- UNII-5UTX5635HP
- 8-hydroxy quinoline
- EPA Pesticide Chemical Code 059803
- NSC-285166
- NSC-402623
- NSC-615011
- BRN 0114512
- 5UTX5635HP
- DTXSID5020730
- CHEBI:48981
- AI3-00483
- NSC-48037
- NSC-54230
- NSC-82404
- NSC-82405
- NSC-82409
- NSC-82410
- NSC-82412
- NSC285166
- J2.960B
- DTXCID30730
- MLS002702126
- CHEMBL310555
- quinoline-8-ol
- EC 205-711-1
- Oxyquinoline (8-Hydroxyquinoline)
- 5-21-03-00252 (Beilstein Handbook Reference)
- NSC 82404
- NSC615011
- Oxyquinoline (USAN)
- NCGC00090708-03
- NCGC00090708-05
- OXYQUINOLINE (II)
- OXYQUINOLINE [II]
- WLN: T66 BNJ JQ
- Oxine;8-Hydroxyquinoline;Quinophenol;8-Quinolinone
- 8-HYDROXYQUINOLINE (IARC)
- 8-HYDROXYQUINOLINE [IARC]
- 8-Chinolinol [Czech]
- o-Oxychinolin [German]
- 8 Oxyquinoline
- 8 Quinolinol
- CAS-148-24-3
- Manganese, bis(8-quinolinolato)-
- SMR000112313
- 8-Hydroxy-chinolin [German]
- Oxychinoline
- 8-Oxyquinolin
- 8-Quinolinone
- 8-Quinolol
- 8-hydroxiquinoline
- 8-hydroxychinoline
- 8-hydroxylquinoline
- HQY
- UDDER BALM
- 8-Quinolinol, p.a.
- Spectrum_001053
- 3vh9
- 8-Hydroxyquinoline Oxine
- Spectrum2_000697
- Spectrum3_000534
- Spectrum4_000465
- Spectrum5_001280
- 8-Hydroxyquinoline, 99%
- NCIMech_000694
- OXYQUINOLINE [HSDB]
- cid_1923
- NCIStruc1_000152
- NCIStruc2_000240
- Oxyquinol Reference Spectrum
- NCIOpen2_000962
- NCIOpen2_001020
- NCIOpen2_001220
- NCIOpen2_004264
- OXYQUINOLINE [VANDF]
- Pesticide Code: 059803
- SCHEMBL37189
- BSPBio_002147
- KBioGR_000910
- KBioSS_001533
- MLS001055492
- BIDD:ER0371
- DivK1c_000757
- 8-Hydroxyquinoline (Standard)
- SPBio_000853
- 8-Hydroxyquinoline, crystalline
- HYDROXYQUINOLINE [VANDF]
- 8-HYDROXYQUINOLINE [MI]
- BDBM32203
- HMS502F19
- HY-B1005R
- KBio1_000757
- KBio2_001533
- KBio2_004101
- KBio2_006669
- KBio3_001647
- HYDROXYQUINOLINE [WHO-DD]
- NSC2039
- NINDS_000757
- 8-Quinolinol (7CI,8CI,9CI)
- HY-B1005
- STR00721
- Tox21_113083
- Tox21_202986
- Tox21_400006
- 8-Oxychinolin, 8-Quinolinol, Oxine
- CCG-35870
- NSC 48037
- NSC 54230
- NSC 82405
- NSC 82409
- NSC 82410
- NSC 82412
- NSC402623
- s4547
- STK943764
- 8-Hydroxyquinoline ACS Reagent Grade
- AKOS001061311
- AC-5109
- CS-4502
- DB11145
- NSC 285166
- NSC 402623
- PS-4553
- SB40773
- 8-Hydroxyquinoline, ACS reagent, 99%
- IDI1_000757
- NCGC00090708-01
- NCGC00090708-02
- NCGC00090708-04
- NCGC00090708-06
- NCGC00090708-07
- NCGC00090708-08
- NCGC00090708-11
- NCGC00260531-01
- NCI60_001712
- NCI60_002335
- SBI-0051472.P003
- DB-012222
- H0305
- NS00010316
- 8-Quinolinol, JIS special grade, >=99.0%
- 8-Quinolinol, Vetec(TM) reagent grade, 99%
- EN300-17403
- C19434
- D05321
- P17615
- US9394254, 6
- 8-Quinolinol, PESTANAL(R), analytical standard
- AB00052065_08
- 8-Quinolinol, >=99% (perchloric acid titration)
- AP-065/40180076
- Q270162
- CU-01000012874-2
- W-108106
- BRD-K66808046-065-01-1
- BRD-K66808046-065-03-7
- Z56926518
- F0001-0526
- InChI=1/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11
- 8-Quinolinol, puriss. p.a., ACS reagent, for the detection and determination of Al, Mg and others, >=99.0% (NT)
- 8-Quinolinol, puriss. p.a., ACS reagent, reag. Ph. Eur., >=99% (perchloric acid titration)
122.76 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
150 Ų [M+K]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
124.77 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
- 15N nuclear magnetic resonance spectrum
- Angular frequency
- Boiling point
- Chemical shift
- Crystal structure
- Density
- Diamagnetic susceptibility
- External quantum efficiency
- Formula unit
- Fusion temperature
- Heat of sublimation
- Luminescence
- Luminescence emission linewidth
- Magnetic susceptibility
- Melting temperature
- Phase transition
- Polarization degree
- Space group
- Spin-spin coupling constant
- Surface tension
- Transition enthalpy
- Unit cell
- Unit cell parameter
- Vapor pressure
- Viscosity
145 99.99
117 56.13
90 15.66
89 15.18
146 10.97
145 99.99
117 69.41
89 22.97
90 21.53
63 20.33
146.0601 999
118.065 15
146.0601 999
118.0652 150
128.0496 43
86.0035 24
91.0542 16
145 999
117 561
90 157
89 152
146 110
- Benzoxiquine (is active moiety of)
- Acetic acid; oxyquinoline (component of)
G - Genito urinary system and sex hormones
G01 - Gynecological antiinfectives and antiseptics
G01A - Antiinfectives and antiseptics, excl. combinations with corticosteroids
G01AC30 - Oxyquinoline
A - Alimentary tract and metabolism
A01 - Stomatological preparations
A01A - Stomatological preparations
A01AB - Antiinfectives and antiseptics for local oral treatment
A01AB07 - Oxyquinoline
Steel Producing [Category: Industry]
Electroplating [Category: Plate]
Using Disinfectants or Biocides [Category: Clean]
Use (kg; approx.) in Germany (2009): >750
Consumption (g per capita; approx.) in Germany (2009): 0.00916
Excretion rate: 1
Calculated removal (%): 75.6
Cosmetics product ingredient: quinolin-8-ol (8-hydroxyquinoline; Oxyquinoline)
Reason for Listing: Classified by the European Union as a reproductive toxicant Category 1B in Annex VI to Regulation (EC) 1272/2008
Potential Health Impacts: Reproductive Toxicity
Product count: 5
H301 (46.2%): Toxic if swallowed [Danger Acute toxicity, oral]
H302 (53.2%): Harmful if swallowed [Warning Acute toxicity, oral]
H317 (46.5%): May cause an allergic skin reaction [Warning Sensitization, Skin]
H318 (46.5%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H360 (37.2%): May damage fertility or the unborn child [Danger Reproductive toxicity]
H400 (46.5%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (46.5%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
P203, P261, P264, P264+P265, P270, P272, P273, P280, P301+P316, P301+P317, P302+P352, P305+P354+P338, P317, P318, P321, P330, P333+P317, P362+P364, P391, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 325 reports by companies from 20 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 2 of 325 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 19 notifications provided by 323 of 325 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 3 (46.2%)
Acute Tox. 4 (53.2%)
Skin Sens. 1 (46.5%)
Eye Dam. 1 (46.5%)
Repr. 1B (37.2%)
Aquatic Acute 1 (46.5%)
Aquatic Chronic 1 (46.5%)
Acute toxicity (ingestion) - category 4
Eye damage - category 1
Reproductive toxicity - category 2
Skin sensitisation - category 1
Hazardous to the aquatic environment (acute) - category 1
SYMPTOMS: Symptoms of exposure to this compound may include irritation of the skin, eyes, mucous membranes and respiratory tract. It also causes irritation of the gastrointestinal tract.
ACUTE/CHRONIC HAZARDS: This compound is toxic by ingestion. It may be harmful by inhalation or skin absorption. It is an irritant of the skin, eyes, IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should protect this material from exposure to light, and store it in a refrigerator. (NTP, 1992)
Amines, Phosphines, and Pyridines
Phenols and Cresols
Hazard Traits - Reproductive Toxicity
Authoritative List - EC Annex VI CMRs - Cat. 1B
Report - if used as a fragrance or flavor ingredient
Status: Active Update: 13-03-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/19356
Status: Active Update: 15-07-2013 https://echa.europa.eu/registration-dossier/-/registered-dossier/8172
Volume 13: (1977) Some Miscellaneous Pharmaceutical Substances
Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=MCJGNVYPOGVAJF-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=false8-HYDROXYQUINOLINEhttps://cameochemicals.noaa.gov/chemical/20511CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/8-Hydroxyquinolinehttps://commonchemistry.cas.org/detail?cas_rn=148-24-38-Quinolinol, homopolymerhttps://commonchemistry.cas.org/detail?cas_rn=84063-18-3
- ChemIDplusOxyquinoline [USAN]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0000148243ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useOxyquinolinehttps://www.drugbank.ca/drugs/DB11145
- DTP/NCILICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuse8-HYDROXYQUINOLINEhttps://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=6150118-HYDROXYQUINOLINEhttps://dtp.cancer.gov/dtpstandard/servlet/dwindex?searchtype=NSC&outputformat=html&searchlist=402623
- EPA Chemicals under the TSCA8-Quinolinolhttps://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSTox8-Hydroxyquinolinehttps://comptox.epa.gov/dashboard/DTXSID5020730CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
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- California Safe Cosmetics Program (CSCP) Product Databasequinolin-8-ol (8-hydroxyquinoline; Oxyquinoline)https://cscpsearch.cdph.ca.gov/search/detailresult/3040
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- ChEBI
- LOTUS - the natural products occurrence databaseLICENSEThe code for LOTUS is released under the GNU General Public License v3.0.https://lotus.nprod.net/8-Hydroxyquinolinehttps://www.wikidata.org/wiki/Q270162LOTUS Treehttps://lotus.naturalproducts.net/
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- Drug Gene Interaction database (DGIdb)LICENSEThe data used in DGIdb is all open access and where possible made available as raw data dumps in the downloads section.http://www.dgidb.org/downloadsOXYQUINOLINEhttps://www.dgidb.org/drugs/rxcui:110
- Therapeutic Target Database (TTD)OXYQUINOLINEhttps://idrblab.net/ttd/data/drug/details/D0FO2B
- Cosmetic Ingredient Review (CIR)
- EPA Chemical and Products Database (CPDat)8-Hydroxyquinolinehttps://comptox.epa.gov/dashboard/DTXSID5020730#exposureEPA CPDat Classificationhttps://www.epa.gov/chemical-research/chemical-and-products-database-cpdat
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- The Cambridge Structural Database
- DailyMed
- IUPAC Digitized pKa Dataset8-Quinolinolhttps://github.com/IUPAC/Dissociation-Constants
- Hazardous Chemical Information System (HCIS), Safe Work Australia
- NITE-CMC8-Quinolinol - FY2009 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/09-mhlw-0031e.html8-Quinolinol - FY2021 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/21-mhlw-2080e.html8-Quinolinol - FY2018 (Revised classification)https://www.chem-info.nite.go.jp/chem/english/ghs/18-mhlw-2062e.html
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- NMRShiftDB
- MassBank Europe
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- Japan Chemical Substance Dictionary (Nikkaji)
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- SpectraBaseQUINOLIN-8-OLhttps://spectrabase.com/spectrum/AQh1TAb4htq8-Hydroxyquinoline @https://spectrabase.com/spectrum/FfZIcVQkzrY8-HYDROXYQUINOLINEhttps://spectrabase.com/spectrum/E6qbRbVsGI68-Hydroxyquinolinehttps://spectrabase.com/spectrum/IexF4H6VIVk8-Hydroxyquinolinehttps://spectrabase.com/spectrum/5UzfARWZ5008-Quinolinolhttps://spectrabase.com/spectrum/BW9Xyt7LYaL8-QUINOLINOLhttps://spectrabase.com/spectrum/Dgyqbl3eLK08-quinolinolhttps://spectrabase.com/spectrum/6qrp1dyZc0U8-QUINOLINOLhttps://spectrabase.com/spectrum/HQK57kkJHBY8-Hydroxyquinolinehttps://spectrabase.com/spectrum/5dF4V62Hx3X8-QUINOLINOLhttps://spectrabase.com/spectrum/3ODZ5Ht16qV8-Quinolinolhttps://spectrabase.com/spectrum/FiUxyEXG7sC8-Hydroxyquinolinehttps://spectrabase.com/spectrum/HjWspBGhfbM
- Metabolomics Workbench
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- NLM RxNorm TerminologyLICENSEThe RxNorm Terminology is created by the National Library of Medicine (NLM) and is in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from NLM. Credit to the U.S. National Library of Medicine as the source is appreciated but not required. The full RxNorm dataset requires a free license.https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.htmloxyquinolinehttps://rxnav.nlm.nih.gov/id/rxnorm/110
- Protein Data Bank in Europe (PDBe)
- RCSB Protein Data Bank (RCSB PDB)LICENSEData files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.https://www.rcsb.org/pages/policies
- Rhea - Annotated Reactions DatabaseLICENSERhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.https://www.rhea-db.org/help/license-disclaimer
- Springer Nature
- SpringerMaterials8-hydroxy-quinolinehttps://materials.springer.com/substanceprofile/docs/smsid_wrlljzjoibpipeuy
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- WHO Anatomical Therapeutic Chemical (ATC) ClassificationLICENSEUse of all or parts of the material requires reference to the WHO Collaborating Centre for Drug Statistics Methodology. Copying and distribution for commercial purposes is not allowed. Changing or manipulating the material is not allowed.https://www.whocc.no/copyright_disclaimer/Oxyquinolinehttps://www.whocc.no/atc_ddd_index/?code=G01AC30Oxyquinolinehttps://www.whocc.no/atc_ddd_index/?code=A01AB07Oxyquinolinehttps://www.whocc.no/atc_ddd_index/?code=D08AH03Oxyquinolinehttps://www.whocc.no/atc_ddd_index/?code=R02AA14
- Wikidataoxyquinolinehttps://www.wikidata.org/wiki/Q270162
- Wikipedia8-hydroxyquinolinehttps://en.wikipedia.org/wiki/8-hydroxyquinoline
- Wiley
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlOxyquinolinehttps://www.ncbi.nlm.nih.gov/mesh/68015125
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403378781https://pubchem.ncbi.nlm.nih.gov/substance/403378781