Hydrocortisone
- hydrocortisone
- Cortisol
- 50-23-7
- Acticort
- Cetacort
- Create:2004-09-16
- Modify:2025-01-18
- 11 Epicortisol
- 11-Epicortisol
- Cortef
- Cortifair
- Cortisol
- Cortril
- Epicortisol
- Hydrocortisone
- Hydrocortisone, (11 alpha)-Isomer
- Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer
- Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
- hydrocortisone
- Cortisol
- 50-23-7
- Acticort
- Cetacort
- Cortef
- Hydrasson
- Hydrocortisyl
- Hydrocortone
- Cobadex
- Hytone
- Cortenema
- Cortril
- Dermacort
- Proctocort
- Hycort
- Signef
- 17-Hydroxycorticosterone
- Optef
- Kendall's compound F
- Cort-Dome
- Cortanal
- Corticreme
- Cortifan
- Cortiment
- Cortispray
- Cortonema
- Dermolate
- Efcorbin
- Efcortelan
- Eldecort
- Ficortril
- Genacort
- Hycortol
- Hycortole
- Penecort
- Permicort
- Tarcortin
- Traumaide
- Alacort
- Cleiton
- Epicort
- Dihydrocostisone
- Hytone lotion
- Hidro-Colisona
- Hydro-Adreson
- Scheroson F
- Incortin-H
- Reichstein's substance M
- Ala-Scalp
- Domolene-HC
- Epiderm H
- Esiderm H
- Otosone-F
- Polcort H
- Aeroseb-HC
- Cortolotion
- Cortoxide
- Cremesone
- Eldercort
- Heb-Cort
- Maintasone
- Nutracort
- Delacort
- Dioderm
- Mildison
- Rectoid
- Synacort
- Anflam
- Hydrocorticosterone
- Hydroxycortisone
- H-Cort
- Hydro-Colisona
- Cortisol alcohol
- Incortin-hydrogen
- Ala-Cort
- Barseb HC
- Dermocortal
- Flexicort
- Texacort
- Timocort
- Evacort
- Komed HC
- Hydrocortisone base
- Lacticare-HC
- Texacort lotion 25
- Hydrocortisone alcohol
- Hidrocortisona
- Algicirtis
- Aquacort
- Colocort
- Cortesal
- Cortisolonum
- Hidalone
- Hytisone
- Kyypakkaus
- Lactisona
- Lubricort
- Meusicort
- Milliderm
- Sanatison
- Schericur
- Sigmacort
- Stiefcorcil
- Amberin
- Cutisol
- Dermil
- Glycort
- Uniderm
- Foille Insetti
- Gyno-Cortisone
- Balneol-hc
- Transderma H
- Basan-Corti
- Clear aid
- Cremicort-H
- Dome-cort
- Stie-cort
- Beta-hc
- Neosporin-H Ear
- Remederm HC
- Aquanil HC
- Cortisporin Otico
- Derm-Aid
- Heb Cort
- Nogenic HC
- Scalpicin Capilar
- Systral Hydrocort
- Prevex HC
- Cortisporin
- Efcortelin
- Fiocortril
- Hydrocortisone free alcohol
- Hydrocortisonum
- Proctofoam
- Hydracort
- Medicort
- Otocort
- Zenoxone
- Drotic
- Vytone
- 11beta-Hydroxycortisone
- Nystaform-HC
- Aeroseb HC
- CaldeCORT Spray
- Anusol HC
- Pediotic Suspension
- Idrocortisone
- 17alpha-Hydroxycorticosterone
- Alphaderm
- Hydrocortal
- Hydroskin
- Otalgine
- Otobiotic
- Plenadren
- Protocort
- Hysone
- Hydrocortisone (Cortisol)
- Ef corlin
- 11beta-Hydrocortisone
- Compound F
- Lacticare HC
- Compound F (kendall)
- 11-beta-Hydrocortisone
- 11-beta-Hydroxycortisone
- VoSol HC
- Chronocort
- Preparation H Hydrocortisone Cream
- Neo-Cort-Dome
- 11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione
- 11beta,17alpha,21-Trihydroxypregn-4-ene-3,20-dione
- Otic-Neo-Cort-Dome
- 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione
- NSC 10483
- HC
- [3H]cortisol
- NSC-10483
- Prestwick_265
- 4-Pregnene-11beta,17alpha,21-triol-3,20-dione
- CHEBI:17650
- (11beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione
- NSC10483
- 11.beta.-Hydrocortisone
- Dermaspray
- Hydrocortisone (Standard)
- MFCD00011654
- WI4X0X7BPJ
- (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
- 11beta,17,21-Trihydroxyprogesterone
- 11.beta.-Hydroxycortisone
- Ophthocort
- Terra-cortril
- MLS000069609
- 17.alpha.-Hydroxycorticosterone
- DTXSID7020714
- Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-
- Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)-
- 4-Pregnen-11beta,17alpha,21-triol-3,20-dione
- Idrocortisone [DCIT]
- Genacort (lotion)
- Anucort
- hydrocortisone(cortisol)
- Prepcort
- SMR000059022
- Hydrocortisonum [INN-Latin]
- Proctozone HC
- Scalp-Cort
- Hidrocortisona [INN-Spanish]
- Rectasol-HC
- Hydro-RX
- (8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one
- DTXCID10714
- HC (HYDROCORTISONE)
- 11.beta.,17,21-Trihydroxypregn-4-ene-3,20-dione
- Corhydron
- (11alpha,14beta)-11,17,21-Trihydroxypregn-4-Ene-3,20-Dione
- DuoCort
- HYDROCORTISONE IN ABSORBASE
- Proctosol-HC
- HC #1
- HC #4
- Acticort (TN)
- Colocort (TN)
- SMR000653523
- Cortef (TN)
- Hytone (TN)
- CCRIS 5854
- component of Otalgine
- Anusol HC (TN)
- component of Lubricort
- COR-OTICIN
- HSDB 3339
- EINECS 200-020-1
- UNII-WI4X0X7BPJ
- component of Neo-Cort-Dome
- Cortizol
- Efmody
- AI3-25006
- 3h-cortisol
- 11beta-cortisol
- CAS-50-23-7
- 11-Hydrocortisone
- Plenadren (TN)
- NCGC00022848-06
- 11b-Hydrocortisone
- Kendalls compound F
- Hydrocortisone [USP:INN:BAN:JAN]
- Drotic (Salt/Mix)
- 11b-Hydroxycortisone
- Otocort (Salt/Mix)
- Pregn-4-ene-3,20-dione, 11beta,17,21-trihydroxy-
- Otalgine (Salt/Mix)
- Hydrocortisone, 98%
- 11,17,21-Trihydroxypregn-4-ene-3,20-dione
- ALKINDI SPRINKLE
- Alphaderm (Salt/Mix)
- Hydrocortisone, topical
- Otobiotic (Salt/Mix)
- Reichsteins substance M
- 4p6x
- Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11b)-
- Cort-Quin (Salt/Mix)
- Cortisporin (Salt/Mix)
- VoSol HC (Salt/Mix)
- 11a-Hydroxycorticosterone
- 17a-Hydroxycorticosterone
- Opera_ID_1292
- Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11-beta)-
- Prestwick0_000447
- Prestwick1_000447
- Prestwick2_000447
- Prestwick3_000447
- Epitope ID:174851
- UPCMLD-DP133
- EC 200-020-1
- H 4001
- HYDROCORTISONE [II]
- HYDROCORTISONE [MI]
- SCHEMBL4148
- Neo-Cort-Dome (Salt/Mix)
- HYDROCORTISONE [INN]
- HYDROCORTISONE [JAN]
- Lopac0_000594
- 11alpha-Hydroxycorticosterone
- BSPBio_000494
- HYDROCORTISONE [HSDB]
- MLS001148103
- MLS002207135
- MLS002222189
- MLS002548868
- HYDROCORTISONE [VANDF]
- Cortisol, 1mg/ml in Methanol
- SPBio_002433
- HYDROCORTISONE [MART.]
- BPBio1_000544
- CHEMBL389621
- GTPL2868
- HYDROCORTISONE [USP-RS]
- HYDROCORTISONE [WHO-DD]
- HYDROCORTISONE [WHO-IP]
- Pediotic Suspension (Salt/Mix)
- UPCMLD-DP133:001
- BDBM13775
- HY-N0583R
- Otic-Neo-Cort-Dome (Salt/Mix)
- 2v95
- Hydrocortisone (JP17/USP/INN)
- HMS1569I16
- HMS2090M04
- HMS2096I16
- HMS2230B18
- HMS2235F17
- HMS3259C05
- HMS3261H10
- HMS3713I16
- Hydrocortisone, >=98% (HPLC)
- Vioform-Hydrocortisone (Salt/Mix)
- 11b,17,21-Trihydroxyprogesterone
- HYDROCORTISONE [GREEN BOOK]
- BCP09054
- HY-N0583
- HYDROCORTISONE [ORANGE BOOK]
- Tox21_110883
- Tox21_200815
- Tox21_500594
- HYDROCORTISONE [EP MONOGRAPH]
- LMST02030001
- s1696
- HYDROCORTISONE [USP MONOGRAPH]
- AKOS001582651
- HYDROCORTISONUM [WHO-IP LATIN]
- OTICAIR COMPONENT HYDROCORTISONE
- OTOCORT COMPONENT HYDROCORTISONE
- Tox21_110883_1
- 1ST2226
- CCG-204683
- DB00741
- LP00594
- NC00456
- SDCCGSBI-0050576.P003
- 11.beta.,17,21-trihydroxyprogesterone
- CIPRO HC COMPONENT HYDROCORTISONE
- ORLEX HC COMPONENT HYDROCORTISONE
- OTOBIONE COMPONENT HYDROCORTISONE
- PEDIOTIC COMPONENT HYDROCORTISONE
- PYOCIDIN COMPONENT HYDROCORTISONE
- SMP1_000156
- VOSOL HC COMPONENT HYDROCORTISONE
- ALPHADERM COMPONENT HYDROCORTISONE
- NCGC00022848-07
- NCGC00022848-09
- NCGC00022848-10
- NCGC00022848-11
- NCGC00022848-12
- NCGC00022848-13
- NCGC00022848-14
- NCGC00022848-15
- NCGC00022848-17
- NCGC00022848-26
- NCGC00258369-01
- NCGC00261279-01
- OTOBIOTIC COMPONENT HYDROCORTISONE
- (1S,10S,11S,15S,17S,2R,14R)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyl tetracyclo[8.7.0.0<2,7>.0<11,15>]heptadec-6-en-5-one
- AC-12902
- AS-11651
- BP-20390
- NCI60_000118
- ACETASOL HC COMPONENT HYDROCORTISONE
- CALMURID HC COMPONENT HYDROCORTISONE
- 4-Pregnene-11alpha,21-triol 3,20-dione
- CS-0694892
- EU-0100594
- NS00000570
- PREDNISOLONE IMPURITY A [EP IMPURITY]
- 4-Pregnene-11b,17a,21-triol-3,20-dione
- C00735
- D00088
- EN300-120630
- U 1851
- Hydrocortisone, meets USP testing specifications
- Pregn-4-ene-3, 11.beta.,17,21-trihydroxy-
- A929789
- Hydrocortisone, VETRANAL(TM), analytical standard
- Q190875
- SR-01000000139
- Q-201211
- SR-01000000139-3
- BRD-K93568044-001-03-1
- BRD-K93568044-001-11-4
- BRD-K93568044-001-32-0
- HYDROCORTISONE ACETATE IMPURITY A [EP IMPURITY]
- Hydrocortisone, BioReagent, suitable for cell culture
- 4-Pregnen-11.beta.,17.alpha.,21-triol-3,20-dione
- 4-Pregnene-11.beta.,17.alpha.,21-triol-3,20-dione
- Pregn-4-ene-3,20-dione, 11.beta.,17,21-trihydroxy-
- Z1530425064
- (11beta)-11,17,21-Trihydroxy-pregn-4-ene-3,20-dione
- 11.beta.,17.alpha.,21-Trihydroxy-4-pregnene-3,20-dione
- 11.beta.,17.alpha.,21-Trihydroxypregn-4-ene-3,20-dione
- B48448A1-24BA-47CA-8D9E-43E5BC949386
- Hydrocortisone, British Pharmacopoeia (BP) Assay Standard
- Pregn-4-ene-3, 11,17,21-trihydroxy-, (11.beta.)-
- 11,17,21-Trihydroxypregn-4-ene-3,20-dione, (11.beta.)-
- HYDROCORTISONE SODIUM SUCCINATE IMPURITY A [EP IMPURITY]
- Hydrocortisone, European Pharmacopoeia (EP) Reference Standard
- HYDROCORTISONE HYDROGEN SUCCINATE IMPURITY A [EP IMPURITY]
- Hydrocortisone, United States Pharmacopeia (USP) Reference Standard
- Hydrocortisone-Water Soluble, BioReagent, suitable for cell culture
- Hydrocortisone, gamma-irradiated, powder, BioXtra, suitable for cell culture
- Hydrocortisone for peak identification, European Pharmacopoeia (EP) Reference Standard
- Hydrocortisone, Pharmaceutical Secondary Standard; Certified Reference Material
- (10R,13S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one
- (1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-1-(2-hydroxyacetyl)-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-one
- (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
212.9 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
210.7 Ų [M+K]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
191.9 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
188.6 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
189.27 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
213.72 Ų [M+Na]+ [CCS Type: DT; Method: stepped-field]
184.11 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
180.18 Ų [M+H-H2O]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
182.99 Ų [M-H2O-H]- [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
189.1 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with Agilent tune mix (Agilent)]
213.91 Ų [M+Na]+ [CCS Type: DT; Method: stepped-field]
188.88 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
192.1 Ų [M-H]-
188.9 Ų [M+H]+
213.2 Ų [M+K]+
211.6 Ų [M+Na]+
188.95 Ų [M+Cl]-
191.54 Ų [M+HCOO]-
187.79 Ų [M+H]+
191.98 Ų [M-H]-
Adrenal hormones and synthetic substitutes
Anti-inflammatory medicines
Antiallergics and medicines used in anaphylaxis
Dermatological medicines > Anti-inflammatory and antipruritic medicines
Hormones and antihormones
Ophthalmological preparations > Anti-inflammatory agents
103.0 1
91.0 0.64
84.0 0.63
89.0 0.61
105.0 0.47
91.0 100
105.0 47.65
93.0 41.34
152.0 34.23
117.0 28.43
363.2158 100
327.1947 33.42
364.2197 25.12
309.184 20.66
121.0639 18.26
121.064 100
259.1689 57.16
145.1 46.95
131.0842 43.84
143.0841 39.24
121.065 999
97.0646 333
363.2144 292
267.1743 262
309.1838 260
363.2167 999
121.0646 312
309.185 164
327.1937 137
345.2049 128
332 999
362 677
302 632
163 608
344 571
- Acetic acid, glacial; hydrocortisone (annotation moved to)
- Hydrocortisone Acetate (annotation moved to)
- Hydrocortisone; polymyxin B sulfate (annotation moved to)
- Hydrocortisone; neomycin sulfate; polymyxin B sulfate (annotation moved to)
- Chloramphenicol; hydrocortisone acetate; polymyxin B sulfate (annotation moved to)
- Hydrocortisone Acetate; Neomycin Sulfate (annotation moved to)
D - Dermatologicals
D07 - Corticosteroids, dermatological preparations
D07X - Corticosteroids, other combinations
D07XA - Corticosteroids, weak, other combinations
D07XA01 - Hydrocortisone
S - Sensory organs
S01 - Ophthalmologicals
S01B - Antiinflammatory agents
S01BA - Corticosteroids, plain
S01BA02 - Hydrocortisone
S - Sensory organs
S02 - Otologicals
S02B - Corticosteroids
S02BA - Corticosteroids
S02BA01 - Hydrocortisone
S - Sensory organs
S01 - Ophthalmologicals
S01C - Antiinflammatory agents and antiinfectives in combination
S01CB - Corticosteroids/antiinfectives/mydriatics in combination
S01CB03 - Hydrocortisone
A - Alimentary tract and metabolism
A01 - Stomatological preparations
A01A - Stomatological preparations
A01AC - Corticosteroids for local oral treatment
A01AC03 - Hydrocortisone
C - Cardiovascular system
C05 - Vasoprotectives
C05A - Agents for treatment of hemorrhoids and anal fissures for topical use
C05AA - Corticosteroids
C05AA01 - Hydrocortisone
D - Dermatologicals
D07 - Corticosteroids, dermatological preparations
D07A - Corticosteroids, plain
D07AA - Corticosteroids, weak (group i)
D07AA02 - Hydrocortisone
H - Systemic hormonal preparations, excl. sex hormones and insulins
H02 - Corticosteroids for systemic use
H02A - Corticosteroids for systemic use, plain
H02AB - Glucocorticoids
H02AB09 - Hydrocortisone
A - Alimentary tract and metabolism
A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents
A07E - Intestinal antiinflammatory agents
A07EA - Corticosteroids acting locally
A07EA02 - Hydrocortisone
- Adipose Tissue
- Adrenal Cortex
- Adrenal Gland
- Adrenal Medulla
- Bladder
- Brain
- Epidermis
- Fibroblasts
- Intestine
- Kidney
- Leukocyte
- Liver
- Neuron
- Ovary
- Pancreas
- Placenta
- Platelet
- Prostate
- Skeletal Muscle
- Spleen
- Testis
- Cytoplasm
- Endoplasmic reticulum
- Extracellular
- Membrane
- Mitochondria
- 11-beta-hydroxylase deficiency (CYP11B1)
- 17-alpha-hydroxylase deficiency (CYP17)
- 21-hydroxylase deficiency (CYP21)
- 3-Beta-Hydroxysteroid Dehydrogenase Deficiency
- Adrenal Hyperplasia Type 3 or Congenital Adrenal Hyperplasia due to 21-hydroxylase Deficiency
- Adrenal Hyperplasia Type 5 or Congenital Adrenal Hyperplasia due to 17 Alpha-hydroxylase Deficiency
- Apparent mineralocorticoid excess syndrome
- Congenital Lipoid Adrenal Hyperplasia (CLAH) or Lipoid CAH
- Corticosterone methyl oxidase I deficiency (CMO I)
- Corticosterone methyl oxidase II deficiency - CMO II
- Total 12 pathways, visit the HMDB page for details
Use (kg; approx.) in Germany (2009): >1000
Use (kg) in USA (2002): 21000
Use (kg) in France (2004): 453
Consumption (g per capita; approx.) in Germany (2009): 0.0122
Consumption (g per capita) in the USA (2002): 0.0744
Consumption (g per capita) in France (2004): 0.0075
Excretion rate: 0.06
Calculated removal (%): 45.9
Information on 6 consumer products that contain Hydrocortisone in the following categories is provided:
• Personal Care
• Pet Care
H361 (86.8%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H373 (31.5%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
P203, P260, P280, P318, P319, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 273 reports by companies from 33 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 3 of 273 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 32 notifications provided by 270 of 273 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Repr. 2 (86.8%)
STOT RE 2 (31.5%)
IMAP assessments - Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-: Human health tier I assessment
IMAP assessments - Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11.beta.)-: Environment tier I assessment
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
Hydrocortisone (cortisol) is a normal component of breastmilk, but it has not been studied in milk after exogenous administration in pharmacologic amounts. Although it is unlikely that dangerous amounts of hydrocortisone would reach the infant, a better studied corticosteroid might be preferred. Maternal use of hydrocortisone as an enema would not be expected to cause any adverse effects in breastfed infants. Local maternal injections, such as for tendinitis, would not be expected to cause any adverse effects in breastfed infants. Medium to large doses of corticosteroids given systemically or injected into joints or the breast have been reported to cause temporary reduction of lactation. See also Hydrocortisone, Topical.
Cortisol in breastmilk might have a role in intestinal maturation, the intestinal microbiome, growth, body composition or neurodevelopment, but adequate studies are lacking. Concentrations follow a diurnal rhythm, with the highest concentrations in the morning at about 7:00 am and the lowest concentrations in the late afternoon and evening. Cortisol concentration in milk also increase with infant age and decrease with complementary feeding and infant illness. Cortisol in milk may protect against later infant obesity, especially in girls; however, in another study, milk glucocorticoid levels were positively associated with percent fat mass, adiposity and head circumference at 1 year of age. Maternal stress can increase breastmilk cortisol levels, especially with preterm births. Some information indicates that maternal adverse childhood experiences may decrease cortisol concentration in their breastmilk.
◉ Effects in Breastfed Infants
None reported with any systemic corticosteroid.
◉ Effects on Lactation and Breastmilk
Published information on the effects of hydrocortisone on serum prolactin or on lactation in nursing mothers was not found as of the revision date. Medium to large doses of corticosteroids given systemically or injected into joints or the breast have been reported to cause temporary reduction of lactation.
A study of 46 women who delivered an infant before 34 weeks of gestation found that a course of another corticosteroid (betamethasone, 2 intramuscular injections of 11.4 mg of betamethasone 24 hours apart) given between 3 and 9 days before delivery resulted in delayed lactogenesis II and lower average milk volumes during the 10 days after delivery. Milk volume was not affected if the infant was delivered less than 3 days or more than 10 days after the mother received the corticosteroid. An equivalent dosage regimen of hydrocortisone might have the same effect.
A study of 87 pregnant women found that betamethasone given as above during pregnancy caused a premature stimulation of lactose secretion during pregnancy. Although the increase was statistically significant, the clinical importance appears to be minimal. An equivalent dosage regimen of hydrocortisone might have the same effect.
◉ Summary of Use during Lactation
Topical hydrocortisone has not been studied during breastfeeding. Since only extensive application of the most potent corticosteroids may cause systemic effects in the mother, it is unlikely that short-term application of topical hydrocortisone would pose a risk to the breastfed infant by passage into breastmilk. However, it would be prudent to use the least potent drug on the smallest area of skin possible. It is important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Current guidelines allow topical corticosteroids to be applied to the nipples just after nursing for eczema, with the nipples cleaned gently before nursing. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking. Maternal use rectally with a cream or by suppository poses little to no risk to the breastfed infant.
◉ Effects in Breastfed Infants
Topical application of a corticosteroid with relatively high mineralocorticoid activity (isofluprednone acetate) to the mother's nipples resulted in prolonged QT interval, cushingoid appearance, severe hypertension, decreased growth and electrolyte abnormalities in her 2-month-old breastfed infant. The mother had used the cream since birth for painful nipples.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
PubMed: 25870516, 210721
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
PubMed: 6157502, 11129331, 28583327, 15505778, 25557019, 23705938, 1886403, 12072887, 19893767
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
PubMed: 6589104, 16277678, 15338487, 10361015, 15249323
Tie-juan ShaoZhi-xing HeZhi-jun XieHai-chang LiMei-jiao WangCheng-ping Wen. Characterization of ankylosing spondylitis and rheumatoid arthritis using 1H NMR-based metabolomics of human fecal extracts. Metabolomics. April 2016, 12:70: https://link.springer.com/article/10.1007/s11306-016-1000-2
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