Foscarnet
- foscarnet
- Phosphonoformic acid
- Phosphonoformate
- Carboxyphosphonic acid
- 4428-95-9
- Create:2005-03-25
- Modify:2025-01-18
Foscarnet sodium is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of cytomegalovirus (CMV) retinitis in individuals with AIDS. Foscarnet sodium is also FDA-approved for the treatment of a certain type of herpes simplex virus (HSV)infection, called acyclovir-resistant mucocutaneous HSV infection, in people with weakened immune systems.
CMV diseases—such as those affecting the eye (retinitis)—and HSV diseases can be opportunistic infections (OIs) of HIV.
- Foscarnet
- Foscarnet Barium (2:3) Salt
- Foscarnet Calcium (2:3) Salt
- Foscarnet Disodium Salt
- Foscarnet Magnesium (2:3) Salt
- Foscarnet Manganese (2+) (2:3) Salt
- Foscarnet Sodium
- Foscarnet Sodium Hexahydrate
- Foscarnet Trilithium Salt
- Foscarnet Tripotassium Salt
- Foscarnet Trisodium Salt
- Foscavir
- Phosphonoformate
- Phosphonoformic Acid
- Trisodium Phosphonoformate
- foscarnet
- Phosphonoformic acid
- Phosphonoformate
- Carboxyphosphonic acid
- 4428-95-9
- Foscarmet
- Foscavir
- phosphonocarboxylic acid
- phosphonomethanoic acid
- Dihydroxyphosphinecarboxylic acid oxide
- Formic acid, phosphono-
- UNII-364P9RVW4X
- 364P9RVW4X
- HSDB 8122
- CHEBI:127780
- Phosphinecarboxylic acid, dihydroxy-, oxide
- dihydroxyphosphanecarboxylic acid oxide
- CHEMBL666
- DTXSID0048478
- J05AD01
- Phgosphonocarboxylic acid
- NSC313410
- Forscarnet
- 1nki
- Foscarnet (PFA)
- Spectrum_001359
- PFA & rIFN.alpha.A
- Spectrum2_000668
- Spectrum3_001484
- Spectrum4_000840
- Spectrum5_000932
- FOSCARNET [VANDF]
- phosphonoformic acid(PFA)
- MSL & PFA
- FOSCARNET [WHO-DD]
- Phosphono-formic acid(PFA)
- hydroxycarbonylphosphonic acid
- SCHEMBL23633
- BSPBio_003067
- Foscarnet & IFN-.ALPHA.
- KBioGR_001419
- KBioSS_001839
- DivK1c_000915
- SPBio_000735
- GTPL5497
- DTXCID0028452
- KBio1_000915
- KBio2_001839
- KBio2_004407
- KBio2_006975
- KBio3_002567
- NINDS_000915
- ZJAOAACCNHFJAH-UHFFFAOYSA-N
- BDBM50011181
- Phosphonoformic acid & IFN-.ALPHA.
- AKOS006281397
- DB00529
- IDI1_000915
- (PFA)dihydroxyphosphinecarboxylic acid oxide
- dihydroxyphosphinecarboxylic acid oxide(PFA)
- NS00005428
- C06456
- EN300-708767
- Q420387
- BRD-K85146014-314-05-4
- BRD-K85146014-314-06-2
- BRD-K85146014-314-07-0
- Phosphonoformate(trisodium) & Recombinant Alpha-A Interferon
- Dihydroxyphosphinecarboxylic acid oxide and MSL, neutralizing monoclonal antibody
Foscarnet sodium is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of cytomegalovirus (CMV) retinitis in individuals with AIDS. Foscarnet sodium is also FDA-approved for the treatment of a certain type of herpes simplex virus (HSV)infection, called acyclovir-resistant mucocutaneous HSV infection, in people with weakened immune systems.
CMV diseases—such as those affecting the eye (retinitis)—and HSV diseases can be opportunistic infections (OIs) of HIV.
2.13 +/- 0.71 mL/min/kg [patients had normal renal function (CrCl > 80 mL/min]
68 +/- 8 mL/min/kg [CrCl was 50-80 mL/min]
34 +/- 9 mL/min/kg [CrCl was 25-49 mL/min]
20 +/- 4 mL/min/kg [CrCl was 10 - 24 mL/min]
- Cytoplasm
- Membrane
H341 (100%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
P203, P260, P280, P318, P319, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Muta. 2 (100%)
STOT RE 2 (100%)
Intravenous foscarnet therapy is associated with mild-to-moderate serum ALT elevations in a proportion of patients, but the drug is usually given to patients with multiorgan disease and conditions that may be associated with some degree of hepatic injury. The ALT elevations are usually asymptomatic and resolve even with continuation of foscarnet. Single case reports of clinically apparent liver injury that were possibly attributable to foscarnet have been reported. The pattern of injury was cholestatic arising within weeks of starting foscarnet but the clinical features of the liver injury have not been described in any detail.
Likelihood score: D (possible cause of clinically apparent liver injjry).
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=ZJAOAACCNHFJAH-UHFFFAOYSA-N
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