Canagliflozin
- Canagliflozin
- 842133-18-0
- Invokana
- Canagliflozin anhydrous
- TA-7284
- Create:2008-06-23
- Modify:2025-01-18
- 1-(Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene - T777973
- canagliflozin
- Canagliflozin Hemihydrate
- Canagliflozin, Anhydrous
- Invokana
- Canagliflozin
- 842133-18-0
- Invokana
- Canagliflozin anhydrous
- TA-7284
- JNJ-28431754
- Canagliflozin [INN]
- (2S,3R,4R,5S,6R)-2-(3-((5-(4-FLUOROPHENYL)THIOPHEN-2-YL)METHYL)-4-METHYLPHENYL)-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-3,4,5-TRIOL
- Canagliflozin hydrate
- 1-(Glucopyranosyl)-4-methyl-3-(5-(4-fluorophenyl)-2-thienylmethyl)benzene
- D-Glucitol,1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-, (1S)-
- CHEBI:73274
- 6S49DGR869
- (2S,3R,4R,5S,6R)-2-[3-[[5-(4-fluorophenyl)thiophen-2-yl]methyl]-4-methylphenyl]-6-(hydroxymethyl)oxane-3,4,5-triol
- TA 7284
- (1S)-1,5-Anhydro-1-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-D-glucitol
- (1S)-1,5-anhydro-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methylphenyl)-D-glucitol
- (1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol
- JNJ 28431754
- MFCD18251436
- (1s)-1,5-anhydro-1-c-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-d-glucitol
- (2S,3R,4R,5S,6R)-2-(3-{[5-(4-fluorophenyl)thiophen-2-yl]methyl}-4-methylphenyl)-6-(hydroxymethyl)oxane-3,4,5-triol
- JNJ 24831754ZAE
- UNII-6S49DGR869
- JNJ 24831754AAA
- JNJ 24831754
- Canagliflozin (Standard)
- CANAGLIFLOZIN [MI]
- MLS006011126
- SCHEMBL157162
- CANAGLIFLOZIN [WHO-DD]
- GTPL4582
- CHEMBL2048484
- HSDB 8284
- BCPP000303
- DTXSID601004469
- BDBM50386885
- HY-10451R
- s2760
- AKOS025401827
- BCP9000477
- CCG-229581
- CS-0522
- DB08907
- KS-1443
- NCGC00346691-02
- (1S)-1,5-Anhydro-1-c-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-D-glucitol
- AC-26303
- HY-10451
- SMR004702906
- NS00099376
- SW219119-1
- EN300-6733492
- J-500391
- Q5030940
- BRD-K90868879-001-02-0
- BRD-K90868879-001-03-8
- Z2235801995
- (1S)-1,5-anhydro-1-(3-{[5-(4-fluorophenyl)-2-thienyl]methyl}-4-methyl-phenyl)-D-glucitol
- (1S)-1,5-ANHYDRO-1-C-(3-((5-(4-FLUOROPHENYL)THIOPHEN-2-YL)METHYL)-4-METHYLPHENYL)-D- GLUCITOL
- D-Glucitol, 1,5-anhydro-1-C-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4- methylphenyl)-, (1S)-
- D-glucitol, 1,5-anhydro-1-c-(3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4- methylphenyl)-, (1s)-
- D-GLUCITOL, 1,5-ANHYDRO-1-C-(3-((5-(4-FLUOROPHENYL)-2-THIENYL)METHYL)-4-METHYLPHENYL)-
- JNJ 24831754ZAE , JNJ 28431754AAA , TA 7284 , JNJ 28431754
H302 (60%): Harmful if swallowed [Warning Acute toxicity, oral]
H318 (20%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
H319 (60%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H361 (80%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H362 (20%): May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
H411 (80%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]
P203, P260, P263, P264, P264+P265, P270, P273, P280, P301+P317, P305+P351+P338, P305+P354+P338, P317, P318, P330, P337+P317, P391, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 5 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 4 (60%)
Eye Dam. 1 (20%)
Eye Irrit. 2 (60%)
Repr. 2 (80%)
Lact. (20%)
Aquatic Chronic 2 (80%)
◉ Summary of Use during Lactation
No information is available on the clinical use of canagliflozin during breastfeeding. Canagliflozin is 99% protein bound in plasma, so it is unlikely to pass into breastmilk in clinically important amounts. The manufacturer does not recommend canagliflozin during breastfeeding because of a theoretical risk to the infant's developing kidney. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=XTNGUQKDFGDXSJ-ZXGKGEBGSA-N
- Avoid alcohol. Excess alcohol intake may promote ketoacidosis.
- Drink plenty of fluids.
- Take before a meal. It is recommended to take this drug before the first meal of the day.
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