Citric Acid
- C6H8O7
- CH2COOH-C(OH)COOH-CH2COOH
- citric acid
- 77-92-9
- Citric acid, anhydrous
- 2-hydroxypropane-1,2,3-tricarboxylic acid
- Anhydrous citric acid
- Create:2004-09-16
- Modify:2025-01-18
C6H8O7
CH2COOH-C(OH)COOH-CH2COOH
- Anhydrous Citric Acid
- Citrate
- Citric Acid
- Citric Acid Monohydrate
- Citric Acid, Anhydrous
- Uralyt U
- citric acid
- 77-92-9
- Citric acid, anhydrous
- 2-hydroxypropane-1,2,3-tricarboxylic acid
- Anhydrous citric acid
- Aciletten
- Citro
- Citretten
- Citric acid anhydrous
- Chemfill
- Hydrocerol A
- 1,2,3-Propanetricarboxylic acid, 2-hydroxy-
- Kyselina citronova
- 2-hydroxy-1,2,3-propanetricarboxylic acid
- 2-Hydroxytricarballylic acid
- Caswell No. 221C
- 3-Carboxy-3-hydroxypentane-1,5-dioic acid
- FEMA No. 2306
- 2-Hydroxypropanetricarboxylic acid
- FEMA Number 2306
- beta-Hydroxytricarballylic acid
- Citric acid,anhydrous
- Citricum acidum
- Citric acid monoglyceride
- CCRIS 3292
- HSDB 911
- K-Lyte
- EPA Pesticide Chemical Code 021801
- Kyselina citronova [Czech]
- K-Lyte DS
- AI3-06286
- NSC 30279
- Citronensaeure
- NSC 626579
- Acidum citricum
- Uro-trainer
- BRN 0782061
- UNII-XF417D3PSL
- H3cit
- EINECS 201-069-1
- Suby G
- XF417D3PSL
- NSC-30279
- NSC-626579
- DTXSID3020332
- CHEBI:30769
- Kyselina 2-hydroxy-1,2,3-propantrikarbonova
- MFCD00011669
- NSC-112226
- CHEMBL1261
- Kyselina 2-hydroxy-1,2,3-propantrikarbonova [Czech]
- E330
- DTXCID50332
- 2-hydroxy-1,2,3-propanetricarboxyic acid
- .beta.-Hydroxytricarballylic acid
- EC 201-069-1
- citr
- 4-03-00-01272 (Beilstein Handbook Reference)
- NSC30279
- NSC626579
- 79586-22-4
- Citric acid, 99%
- NCGC00090954-03
- Ubiquitin
- E 330
- CLENPIQ COMPONENT ANHYDROUS CITRIC ACID
- CITRATE ANION
- Acidum citricum monohydrate
- C6H8O7
- Citralite
- ANHYDROUS CITRIC ACID (II)
- ANHYDROUS CITRIC ACID [II]
- ANHYDROUS CITRIC ACID (MART.)
- ANHYDROUS CITRIC ACID [MART.]
- Citric acid [USAN:JAN]
- CAS-77-92-9
- 1,3-Propanetricarboxylic acid, 2-hydroxy-
- ANHYDROUS CITRIC ACID (USP MONOGRAPH)
- ANHYDROUS CITRIC ACID [USP MONOGRAPH]
- CITRIC ACID, ANHYDROUS (EP IMPURITY)
- CITRIC ACID, ANHYDROUS [EP IMPURITY]
- CITRIC ACID, ANHYDROUS (USP IMPURITY)
- CITRIC ACID, ANHYDROUS [USP IMPURITY]
- 2-hydroxy-1,2,3-propane-tricarboxylic acid
- B1650
- Citraclean
- Citronensaure
- acido citrico
- citric-acid
- Citric Acid Anhydrous; 2-Hydroxypropane-1,2,3-tricarboxylic acid
- Anhydrous citrate
- 2fwp
- 4aci
- 4nrm
- Citric acid, anhydrous [USP:JAN]
- Citric Acid,(S)
- Citric acid (8CI)
- K-Lyte (Salt/Mix)
- 1i2s
- 1o4l
- 1rq2
- 1y4a
- 2bo4
- 2c4v
- 2fw6
- 4to8
- Citraclean (Salt/Mix)
- Spectrum3_001850
- WLN: QV1XQVQ1VQ
- beta-Hydroxytricarballylate
- cid_311
- K-Lyte/Cl (Salt/Mix)
- CITRIC ACID [MI]
- K-Lyte DS (Salt/Mix)
- bmse000076
- HOC(CH2COOH)2COOH
- CITRIC ACID [FHFI]
- CITRIC ACID [HSDB]
- NCIStruc1_000057
- NCIStruc2_000099
- NCIOpen2_004062
- NCIOpen2_004502
- Oprea1_502996
- BSPBio_003240
- Citric acid anhydrous (JAN)
- Citric Acid, anhydrous, USP
- MLS001066346
- CITRIC ACID [WHO-DD]
- Citric acid, anhydrous (USP)
- CITRICUM ACIDUM [HPUS]
- Anhydrous citric acid (JP18)
- GTPL2478
- Citric acid, analytical standard
- BDBM14672
- Citric acid, p.a., 99.5%
- KBio3_002740
- Citric Acid, anhydrous, granular
- 4o61
- Citric acid, Electrophoresis Grade
- HMS1787N01
- HMS2268B04
- Pharmakon1600-01300013
- ANHYDROUS CITRIC ACID [JAN]
- HY-N1428
- STR12052
- 1,2,3-Tricarboxy-2-hydroxypropane
- Tox21_113436
- Tox21_202405
- Tox21_300124
- BBL002530
- NSC759606
- s5761
- STK286098
- CITRIC ACID,ANHYDROUS [VANDF]
- AKOS000119911
- BETA-HYDROXY-TRICARBOXYLIC ACID
- Citric Acid, anhydrous, fine granular
- Citric acid, LR, anhydrous, >=99%
- USEPA/OPP Pesticide Code: 21801
- 2-hydroxy-1,2,3-propanetricarboxylate
- ACIDUM CITRICUM [WHO-IP LATIN]
- CS-6965
- DB04272
- 3-Carboxy-3-hydroxypentane-1,5-dioate
- Citric acid, >=99.5%, FCC, FG
- Citric acid, ACS reagent, >=99.5%
- Citric Acid, anhydrous powder, A.C.S.
- 2-Hydroxy-1,3-propanetricarboxylic acid
- CITRIC ACID, ANHYDROUS [WHO-IP]
- NCGC00090954-01
- NCGC00090954-02
- NCGC00090954-04
- NCGC00090954-05
- NCGC00090954-06
- NCGC00254055-01
- NCGC00259954-01
- 134367-01-4
- 2-hydroxypropane-1,2,3-tricarboxylicacid
- BP-31028
- Citric Acid, anhydrous granular, A.C.S.
- DA-72240
- NCI60_022579
- SMR000471840
- SBI-0206765.P001
- Citric acid, SAJ first grade, >=99.5%
- 2-Hydroxy-1,2,3-propane tricarboxylic acid
- C1949
- Citric acid, Vetec(TM) reagent grade, 99%
- NS00007335
- 1,2,3-Propanetricarboxylio acid, 2-hydroxy-
- EN300-16683
- C00158
- D00037
- G91031
- SBI-0206765.0002
- AE-562/40806920
- ANHYDROUS CITRIC ACID COMPONENT OF CLENPIQ
- Citric acid, BioUltra, anhydrous, >=99.5% (T)
- Q159683
- J-520099
- 1,2,3-Propanetricarboxylic acid, 2-hydroxy- (9CI)
- 2-Hydroxy-1,2,3-propanetricarboxylic Acid, Anhydrous
- BRD-K76792669-001-08-1
- Citric acid, certified reference material, TraceCERT(R)
- Citric acid, meets USP testing specifications, anhydrous
- F2191-0222
- 8F5D336A-442D-434A-9FB0-E400FF74E343
- Citrate standard for IC, 1000 mg/L, analytical standard
- 1,2,3-PROPANETRICARBOXYLIC ACID,2-HYDROXY (CITRIC ACID)
- CITRIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION)
- Citric acid, United States Pharmacopeia (USP) Reference Standard
- CITRIC ACID (CONSTITUENT OF CRANBERRY LIQUID PREPARATION) [DSC]
- CITRIC ACID (CONSTITUENT OF GARCINIA CAMBOGIA AND GARCINIA INDICA)
- Citric acid, anhydrous, cell culture tested, plant cell culture tested
- Citric acid, anhydrous, European Pharmacopoeia (EP) Reference Standard
- Citric acid, anhydrous, free-flowing, Redi-Dri(TM), ACS reagent, >=99.5%
- CITRIC ACID (CONSTITUENT OF GARCINIA CAMBOGIA AND GARCINIA INDICA) [DSC]
- Citric acid, Anhydrous, Pharmaceutical Secondary Standard; Certified Reference Material
- 141633-96-7
- Citric acid, meets analytical specification of Ph. Eur., BP, USP, E330, anhydrous, 99.5-100.5% (based on anhydrous substance)
- InChI=1/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12
127.1 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
143.1 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
146.11 Ų [M+Na]+ [CCS Type: DT; Method: stepped-field]
148.9 Ų [M+H]+ [CCS Type: DT; Method: stepped-field]
129.49 Ų [M-H]- [CCS Type: DT; Method: stepped-field]
146.1 Ų [M+Na]+
129 Ų [M-H]-
127.4 Ų [M-H]-
143 Ų [M+Na]+
273.0 1
274.0 0.25
211.0 0.24
347.0 0.23
133.0 0.21
147.0 100
273.0 51.85
133.0 18.12
149.0 18.02
148.0 16.92
110.997 100
190.922 48.34
87.067 26.82
85.086 20.36
128.984 6.83
87.059 100
110.958 51.72
85.078 45.40
67.159 43.10
43.355 41.95
41.0032 999
57.0341 111
191 100
190 10.63
111 6.77
- All Tissues
- Placenta
- Prostate
- Cytoplasm
- Extracellular
- Mitochondria
- 2-ketoglutarate dehydrogenase complex deficiency
- Citric Acid Cycle
- Congenital lactic acidosis
- Fumarase deficiency
- Glutaminolysis and Cancer
- Mitochondrial complex II deficiency
- Pyruvate dehydrogenase deficiency (E2)
- Pyruvate dehydrogenase deficiency (E3)
- The oncogenic action of 2-hydroxyglutarate
- The oncogenic action of D-2-hydroxyglutarate in Hydroxygluaricaciduria
- Total 15 pathways, visit the HMDB page for details
Use (kg; approx.) in Germany (2009): >100000
Consumption (g per capita; approx.) in Germany (2009): 1.22
Calculated removal (%): 92.1
- Other (specify)
- Lubricants and lubricant additives
- Opacifer
- Laboratory chemicals
- Defoamer
- Surface modifier
- Solvents (which become part of product formulation or mixture)
- Oxidizing/reducing agents
- Corrosion inhibitors and anti-scaling agents
- Not Known or Reasonably Ascertainable
- Adhesives and sealant chemicals
- Aerating and deaerating agents
- Process regulators
- Filler
- Processing aids not otherwise specified
- Flocculating agent
- Other
- Surface active agents
- pH regulating agent
- Agricultural chemicals (non-pesticidal)
- Paint additives and coating additives not described by other categories
- Surfactant (surface active agent)
- Plating agents and surface treating agents
- Processing aids, not otherwise listed
- Not Known or Reasonably Ascertainable
- Chelating agent
- Solvents (for cleaning or degreasing)
- Lubricants and lubricant additives
- Pigment
- pH regulating agent
- Cleaning agent
- Processing aids, not otherwise listed
- Softener and conditioner
- Agricultural chemicals (non-pesticidal)
- Surfactant (surface active agent)
- Preservative
- Binder
- Process regulators
- Processing aids not otherwise specified
- Hardener
- Other
Information on 2599 consumer products that contain Citric acid in the following categories is provided:
• Auto Products
• Commercial / Institutional
• Home Maintenance
• Inside the Home
• Landscaping/Yard
• Personal Care
• Pesticides
• Pet Care
2019: 100,000,000 - <250,000,000 lb
2018: 250,000,000 - <500,000,000 lb
2017: 250,000,000 - <500,000,000 lb
2016: 250,000,000 - <500,000,000 lb
- Other (requires additional information)
- Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing
- All Other Basic Inorganic Chemical Manufacturing
- Paint and Coating Manufacturing
- Agriculture, Forestry, Fishing and Hunting
- Textiles, apparel, and leather manufacturing
- Wholesale and Retail Trade
- Food, beverage, and tobacco product manufacturing
- Soap, Cleaning Compound, and Toilet Preparation Manufacturing
- Plastics Material and Resin Manufacturing
- Not Known or Reasonably Ascertainable
- All Other Chemical Product and Preparation Manufacturing
- Oil and Gas Drilling, Extraction, and Support activities
- Primary Metal Manufacturing
- Construction
- Fabricated Metal Product Manufacturing
- Utilities
- Paper Manufacturing
H319 (84.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (21.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264+P265, P271, P280, P304+P340, P305+P351+P338, P319, P337+P317, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 4343 reports by companies from 51 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 359 of 4343 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 50 notifications provided by 3984 of 4343 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Eye Irrit. 2 (84.6%)
STOT SE 3 (21.7%)
Eye irritation - category 2A
Skin irritation - category 2
Specific target organ toxicity (single exposure) - category 3
Chemical: Citric acid, anhydrous
Green circle - The chemical has been verified to be of low concern based on experimental and modeled data.
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this chemical under refrigerated temperatures, and protect it from moisture. (NTP, 1992)
Acids, Carboxylic
Alcohols and Polyols
IMAP assessments - Citric acid: Human health tier II assessment
IMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-: Environment tier I assessment
◉ Summary of Use during Lactation
No data are available on cellulose and citric acid use during breastfeeding. However, the drug is not absorbed from the gastrointestinal tract, so it cannot enter the breastmilk. Cellulose and citric acid is acceptable to use during breastfeeding.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Plants containing citric acid, concentrations reported(1).
Table: Reported Concentrations
Plants containing citric acid, concentrations not reported(1).
Table: Detected, Not Quantified
The Merck Manual, 17th ed. Mark H. Beers, MD, Robert Berkow, MD, eds. Whitehouse Station, NJ: Merck Research Labs, 1999.
PubMed: 1640293, 7075624, 8295396
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
PubMed: 12067838, 22279428, 16452910
Lorena Ivona ŞTEFAN, Alina NICOLESCU, Simona POPA, Maria MOŢA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037
PubMed: 5075233, 19551947, 12408190
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
PubMed: 19809936, 19551947, 2226555, 28853722
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
PubMed: 19551947, 25443793, 12872835, 22455637
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
Physician's Guide to the Laboratory Diagnosis of Metabolic Diseases. 2nd ed. Berlin, Germany, Springer, 2003
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
PubMed: 12101068, 10508118, 10472531, 19551947, 11978597, 10234605, 6422161, 23430924, 18088602
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
Peritoneal dialysis in maple-syrup-urine disease: Studies on branched-chain amino and keto acids. Eur J Pediatr (1980) 134: 57. https://doi.org/10.1007/BF00442404
Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=KRKNYBCHXYNGOX-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)1,2,3-Propanetricarboxylic acid, 2-hydroxy-https://services.industrialchemicals.gov.au/search-assessments/1,2,3-Propanetricarboxylic acid, 2-hydroxy-https://services.industrialchemicals.gov.au/search-inventory/
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- Cosmetic Ingredient Review (CIR)
- EPA Chemical and Products Database (CPDat)EPA CPDat Classificationhttps://www.epa.gov/chemical-research/chemical-and-products-database-cpdat
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- The Cambridge Structural Database
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- IUPAC Digitized pKa Dataset1,2,3-Propanetricarboxylio acid, 2-hydroxy-https://github.com/IUPAC/Dissociation-Constants
- Drugs and Lactation Database (LactMed)Cellulose and Citric Acidhttps://www.ncbi.nlm.nih.gov/books/n/lactmed/LM1477/
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- ECI Group, LCSB, University of Luxembourgcitric acid
- Natural Product Activity and Species Source (NPASS)
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- Flavor and Extract Manufacturers Association (FEMA)
- NMRShiftDB
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- SpectraBase3-CARBOXY-3-HYDROXYPENTANEDIOIC ACIDhttps://spectrabase.com/spectrum/1BishNflhG21,2,3-Propanetricarboxylic acid, 2-hydroxy-https://spectrabase.com/spectrum/7sY9VeRpJJ3CITRIC ACIDhttps://spectrabase.com/spectrum/4UwvzR0JhHBCITRIC ACIDhttps://spectrabase.com/spectrum/CwPhTL0xWi8Citric acidhttps://spectrabase.com/spectrum/FiksohOxcvLCitric acidhttps://spectrabase.com/spectrum/FOgKHA260ApCitric acidhttps://spectrabase.com/spectrum/Jut1hMGN3jrCitric acidhttps://spectrabase.com/spectrum/AFc2KAGf06HCitric acidhttps://spectrabase.com/spectrum/2fYCi7nfg0n1,2,3-Propanetricarboxylic acid, 2-hydroxy-https://spectrabase.com/spectrum/Jy4uytepdkZ
- Japan Chemical Substance Dictionary (Nikkaji)
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- MarkerDBLICENSEThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.https://markerdb.ca/Citric acidhttps://markerdb.ca/chemicals/62
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- Wikidatacitric acidhttps://www.wikidata.org/wiki/Q159683
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- Wiley
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlCitric Acidhttps://www.ncbi.nlm.nih.gov/mesh/68019343Anticoagulantshttps://www.ncbi.nlm.nih.gov/mesh/68000925Calcium Chelating Agentshttps://www.ncbi.nlm.nih.gov/mesh/68065096
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
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- PATENTSCOPE (WIPO)SID 403029880https://pubchem.ncbi.nlm.nih.gov/substance/403029880
- NCBI