Succinylcholine
- succinylcholine
- Suxamethonium
- Succinyldicholine
- Succinocholine
- Succinoylcholine
- Create:2005-03-25
- Modify:2025-01-18
541-19-5 (diiodide)
55-94-7 (dibromide)
71-27-2 (dichloride)
- Anectine
- Bromide, Suxamethonium
- Celocurine
- Dibromide, Succinylcholine
- Dichloride, Succinylcholine
- dicholine succinate
- Diiodide, Succinylcholine
- Diperchlorate, Succinylcholine
- Ditilin
- Listenon
- Lysthenon
- Myorelaxin
- Quelicin
- Succicuran
- Succinate, Dicholine
- Succinylcholine
- Succinylcholine Chloride
- Succinylcholine Dibromide
- Succinylcholine Dichloride
- Succinylcholine Dichloride, Di H2O
- Succinylcholine Dichloride, Di-H2O
- Succinylcholine Diiodide
- Succinylcholine Diperchlorate
- Succinylcholine Iodide
- Succinyldicholine
- Suxamethonium
- Suxamethonium Bromide
- Suxamethonium Chloride
- succinylcholine
- Suxamethonium
- Succinyldicholine
- Succinocholine
- Succinoylcholine
- Dicholine succinate
- Succinylbischoline
- 306-40-1
- Diacetylcholine
- Ditiline
- Quelicin
- Succinyl choline
- Anectine
- Ditilin
- suxamethonium chloride
- Choline, succinyl-
- Choline, succinate (ester)
- Suxamethonium ion
- Succinylcholine ion
- Suxamethonium cation
- Sucostrin
- Succinic acid, diester with choline
- Succinylcholine cation
- Choline, succinate (2:1) (ester)
- CHEBI:45652
- HSDB 3254
- 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM)
- UNII-J2R869A8YF
- Scoline
- BRN 1805311
- J2R869A8YF
- CHEMBL703
- Ethanaminium, 2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,N-trimethyl-
- trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium
- DTXSID7048455
- 4-04-00-01451 (Beilstein Handbook Reference)
- trimethyl[2-({4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl}oxy)ethyl]azanium
- Succinate, Dicholine
- .Succinylcholin
- 2,2'-((1,4-dioxobutane-1,4-diyl)bis(oxy))bis(N,N,N-trimethylethanaminium)
- diester with choline
- SUXEMETHONIUM
- succinylcholine-chloride
- 2ha2
- 2ha6
- Lopac-S-8251
- Epitope ID:116045
- Ethanaminium, 2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,N-trimethyl)-
- Lopac0_001080
- SCHEMBL41537
- MLS001183716
- SUCCINYLCHOLINE [HSDB]
- SUCCINYLCHOLINE [VANDF]
- SUXAMETHONIUM [WHO-DD]
- GTPL4004
- DTXCID3028429
- AXOIZCJOOAYSMI-UHFFFAOYSA-
- HMS2090P14
- BDBM50061568
- STK177290
- AKOS022084126
- CCG-205157
- DB00202
- ETHANAMINIUM,2,2'-[(1,4-DIOXO-1,4-BUTANEDIYL)BIS(OXY)]BIS[N,N,N-TRIMETHYL-
- trimethyl-[2-[4-oxo-4-(2-trimethylazaniumylethoxy)butanoyl]oxyethyl]azanium diio
- NCGC00015971-01
- NCGC00015971-02
- NCGC00015971-03
- NCGC00015971-04
- NCGC00015971-07
- NCGC00162336-01
- SMR000677912
- NS00002317
- C07546
- AB00375912-06
- L000926
- Q424378
- BRD-K45497762-300-01-2
- BRD-K45497762-336-01-6
- BRD-K45497762-336-02-4
- BRD-K45497762-336-03-2
- 2,2''-[(1,4-dioxobutane-1,4-diyl)bis(oxy)]bis(N,N,N-trimethylethanaminium)
- ETHANAMINIUM, 2,2'-((1.4-DIOXO-1,4-BUTANEDIYL)BIS(OXY))BIS(N,N,N-TRIMETHYL-
- InChI=1/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2
145.1 999
113.1 126
115.8 112
81 97
128.1 62
93.5 999
115.8 705
79.8 525
65.5 324
86.2 122
- Succinylcholine Chloride (has salt form)
- Succinylcholine chloride dihydrate (active moiety of)
- Succinylcholine Iodide (is active moiety of)
- Cytoplasm
- Membrane
Use (kg; approx.) in Germany (2009): >100
Consumption (g per capita; approx.) in Germany (2009): 0.00122
Calculated removal (%): 92.1
H301 (93.1%): Toxic if swallowed [Danger Acute toxicity, oral]
H311 (62.1%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H315 (69%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (69%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H332 (62.1%): Harmful if inhaled [Warning Acute toxicity, inhalation]
H335 (65.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P317, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 29 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 3 (93.1%)
Acute Tox. 3 (62.1%)
Skin Irrit. 2 (69%)
Eye Irrit. 2 (69%)
Acute Tox. 4 (62.1%)
STOT SE 3 (65.5%)
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
No information is available on the use of succinylcholine during breastfeeding. Because it is rapidly eliminated and poorly absorbed orally, it is not likely to reach the bloodstream of the infant or cause any adverse effects in breastfed infants. General anesthetic regimens that include succinylcholine for cesarean section caused a delay in the time to the first breastfeeding, but the part that succinylcholine played in this difference in outcome in unknown.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
A randomized, but nonblinded, study in women undergoing cesarean section compared epidural anesthesia with bupivacaine to general anesthesia with intravenous thiopental 4 mg/kg and succinylcholine 1.5 mg/kg for induction followed by nitrous oxide and isoflurane. The time to the first breastfeed was significantly shorter (107 vs 228 minutes) with the epidural anesthesia than with general anesthesia. This difference was probably caused by the anesthesia's effects on the infant, because the Apgar and neurologic and adaptive scores were significantly lower in the general anesthesia group of infants. It is not known what part succinylcholine played in this difference in outcome.
A nonrandomized, nonblinded study in a Serbian hospital of women near term who underwent cesarean section compared general anesthesia (n = 284) to spinal or epidural anesthesia (n = 249). Spinal anesthesia consisted of hyperbaric bupivacaine 12 mg and fentanyl 0.01 mg; epidural anesthesia consisted of isobaric bupivacaine 0.5% (0.5 mg per 10 cm height) and fentanyl 0.05 mg. General anesthesia consisted of propofol 2.3 mg/kg and succinylcholine 1.5 mg/kg for induction and intubation, followed by an anesthetic gas mixture and oxygen. Reportedly, nitric oxide (possibly nitrous oxide) was 50% of the gas before delivery and 67% after delivery. Sevoflurane was also used in some cases. After delivery and cord clamping, mothers received fentanyl 3 mcg/kg and rocuronium 0.5 mg/kg intravenously for placental delivery. After surgery, neuromuscular block reversal was performed with neostigmine and atropine. All patients received 1 mg/kg of diclofenac every 8 h for 24 hours after delivery and 98% of general anesthesia patients also received 100 mg of tramadol and 78.5% received acetaminophen 1 gram. No regional anesthesia patients received tramadol or acetaminophen. Patients receiving one of the regional anesthetic protocols established lactation sooner (56% and 29% after 18 and 24 hours, respectively), while 86% of women receiving general anesthesia did not establish lactation until 36 to 48 hours after surgery. It is not known what part succinylcholine played in this difference in outcome.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=AXOIZCJOOAYSMI-UHFFFAOYSA-N
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=XSDVNBDVYJJUBM-UHFFFAOYSA-N
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/Succinylcholinehttps://commonchemistry.cas.org/detail?cas_rn=306-40-1
- ChemIDplusChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useSuccinylcholinehttps://www.drugbank.ca/drugs/DB00202
- EPA DSSToxSuccinylcholinehttps://comptox.epa.gov/dashboard/DTXSID7048455CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeSuxamethonium chloridehttps://echa.europa.eu/substance-information/-/substanceinfo/100.000.680Suxamethonium chloride (EC: 200-747-4)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/76921
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Hazardous Substances Data Bank (HSDB)SUCCINYLCHOLINEhttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/3254
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citingSuccinylcholinehttp://www.hmdb.ca/metabolites/HMDB0014347
- ChEBISuccinylcholinehttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:45652
- FDA Pharm ClassesLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingFDA Pharmacological Classificationhttps://www.fda.gov/ForIndustry/DataStandards/StructuredProductLabeling/ucm162549.htm
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- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jspSuccinylcholinehttps://ctdbase.org/detail.go?type=chem&acc=D013390
- Drug Gene Interaction database (DGIdb)LICENSEThe data used in DGIdb is all open access and where possible made available as raw data dumps in the downloads section.http://www.dgidb.org/downloadsSUCCINYLCHOLINEhttps://www.dgidb.org/drugs/rxcui:10154
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- Therapeutic Target Database (TTD)Succinylcholinehttps://idrblab.net/ttd/data/drug/details/D0Q7ZQ
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- DailyMed
- Drug Induced Liver Injury Rank (DILIrank) DatasetLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Drugs and Lactation Database (LactMed)Succinylcholinehttps://www.ncbi.nlm.nih.gov/books/n/lactmed/LM706/
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- EU Clinical Trials Register
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- Japan Chemical Substance Dictionary (Nikkaji)
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- MassBank Europe
- MassBank of North America (MoNA)LICENSEThe content of the MoNA database is licensed under CC BY 4.0.https://mona.fiehnlab.ucdavis.edu/documentation/license
- Metabolomics Workbench
- NIPH Clinical Trials Search of Japan
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- NMRShiftDB
- WHO Anatomical Therapeutic Chemical (ATC) ClassificationLICENSEUse of all or parts of the material requires reference to the WHO Collaborating Centre for Drug Statistics Methodology. Copying and distribution for commercial purposes is not allowed. Changing or manipulating the material is not allowed.https://www.whocc.no/copyright_disclaimer/Suxamethoniumhttps://www.whocc.no/atc_ddd_index/?code=M03AB01
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- Protein Data Bank in Europe (PDBe)
- RCSB Protein Data Bank (RCSB PDB)LICENSEData files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.https://www.rcsb.org/pages/policies
- Springer Nature
- Wikidatasuccinylcholinehttps://www.wikidata.org/wiki/Q424378
- WikipediaSuxamethonium chloridehttps://en.wikipedia.org/wiki/Suxamethonium_chloride
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlSuccinylcholinehttps://www.ncbi.nlm.nih.gov/mesh/68013390Neuromuscular Depolarizing Agentshttps://www.ncbi.nlm.nih.gov/mesh/68009467
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 390546127https://pubchem.ncbi.nlm.nih.gov/substance/390546127SID 445957297https://pubchem.ncbi.nlm.nih.gov/substance/445957297
- NCBI