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Ammonium Laureth Sulfate

PubChem CID
61913
Structure
Ammonium Laureth Sulfate_small.png
Ammonium Laureth Sulfate_3D_Structure.png
Molecular Formula
Synonyms
  • Ammonium lauryl ether sulfate
  • 32612-48-9
  • Ammonium laureth sulfate
  • azane;2-dodecoxyethyl hydrogen sulfate
  • DTXSID00873913
Molecular Weight
327.48 g/mol
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Dates
  • Create:
    2005-08-08
  • Modify:
    2025-01-25
Description
Ammonium laureth sulfate is a surfactant often found in shampoos. It can be mildly irritating. (L1888)
L1888: Dead Sea Cosmetics (2009). Ingredient FAQs. http://www.deadsea-cosmetics.com/ingrediantsnew.htm

1 Structures

1.1 2D Structure

Chemical Structure Depiction
Ammonium Laureth Sulfate.png

1.2 3D Conformer

3D Conformer of Parent

2 Names and Identifiers

2.1 Computed Descriptors

2.1.1 IUPAC Name

azane;2-dodecoxyethyl hydrogen sulfate
Computed by Lexichem TK 2.7.0 (PubChem release 2021.10.14)

2.1.2 InChI

InChI=1S/C14H30O5S.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-18-13-14-19-20(15,16)17;/h2-14H2,1H3,(H,15,16,17);1H3
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.3 InChIKey

OPVLOHUACNWTQT-UHFFFAOYSA-N
Computed by InChI 1.0.6 (PubChem release 2021.10.14)

2.1.4 SMILES

CCCCCCCCCCCCOCCOS(=O)(=O)O.N
Computed by OEChem 2.3.0 (PubChem release 2024.12.12)

2.2 Molecular Formula

C14H33NO5S
Computed by PubChem 2.2 (PubChem release 2021.10.14)

2.3 Other Identifiers

2.3.1 CAS

32612-48-9

2.3.2 Deprecated CAS

119764-44-2, 1307690-40-9, 2095676-35-8, 2135780-84-4, 71892-96-1, 86298-01-3, 871810-22-9

2.3.3 European Community (EC) Number

2.3.4 Wikidata

2.4 Synonyms

2.4.1 Depositor-Supplied Synonyms

3 Chemical and Physical Properties

3.1 Computed Properties

Property Name
Molecular Weight
Property Value
327.48 g/mol
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Donor Count
Property Value
2
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Hydrogen Bond Acceptor Count
Property Value
6
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Rotatable Bond Count
Property Value
15
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Exact Mass
Property Value
327.20794433 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Monoisotopic Mass
Property Value
327.20794433 Da
Reference
Computed by PubChem 2.2 (PubChem release 2021.10.14)
Property Name
Topological Polar Surface Area
Property Value
82.2 Ų
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Heavy Atom Count
Property Value
21
Reference
Computed by PubChem
Property Name
Formal Charge
Property Value
0
Reference
Computed by PubChem
Property Name
Complexity
Property Value
284
Reference
Computed by Cactvs 3.4.8.18 (PubChem release 2021.10.14)
Property Name
Isotope Atom Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Atom Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Defined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Undefined Bond Stereocenter Count
Property Value
0
Reference
Computed by PubChem
Property Name
Covalently-Bonded Unit Count
Property Value
2
Reference
Computed by PubChem
Property Name
Compound Is Canonicalized
Property Value
Yes
Reference
Computed by PubChem (release 2021.10.14)

3.2 Experimental Properties

3.2.1 Physical Description

Light yellow viscous liquid; [MSDSonline]

3.3 Chemical Classes

3.3.1 Cosmetics

Cosmetic ingredients (Ammonium Laureth Sulfate) -> CIR (Cosmetic Ingredient Review)
Foaming; Surfactant; Cleansing
S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118

3.3.2 Polymers

Other Classes -> Polyoxyethylenes

5 Chemical Vendors

6 Pharmacology and Biochemistry

6.1 Metabolism / Metabolites

Nitrosamines can enter the body via ingestion, inhalation, or dermal contact. Once in the body, nitrosamines are metabolized by cytochrome P-450 enzymes, which essentially activates them into carcinogens. (A2878, A2879)
A2878: Oyama T, Sugio K, Uramoto H, Iwata T, Onitsuka T, Isse T, Nozoe T, Kagawa N, Yasumoto K, Kawamoto T: Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis. Front Biosci. 2007 May 1;12:4497-503. PMID:17485391
A2879: Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R: Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1. Am J Epidemiol. 2008 Mar 15;167(6):719-26. doi: 10.1093/aje/kwm360. Epub 2008 Jan 23. PMID:18218609

7 Use and Manufacturing

7.1 Uses

Cosmetic Ingredient Review Link
CIR ingredient: Ammonium Laureth Sulfate
Sources/Uses
Used as a foaming and cleansing agent in shampoos and cleaners; [MSDSonline]
Ammonium laureth sulfate is a surfactant often found in shampoos. (L1888)
L1888: Dead Sea Cosmetics (2009). Ingredient FAQs. http://www.deadsea-cosmetics.com/ingrediantsnew.htm

7.1.1 Use Classification

Cosmetics -> Foaming; Surfactant; Cleansing
S13 | EUCOSMETICS | Combined Inventory of Ingredients Employed in Cosmetic Products (2000) and Revised Inventory (2006) | DOI:10.5281/zenodo.2624118

7.1.2 Household Products

Household & Commercial/Institutional Products

Information on 205 consumer products that contain Ammonium laureth sulfate in the following categories is provided:

• Auto Products

• Commercial / Institutional

• Inside the Home

• Personal Care

• Pet Care

7.2 General Manufacturing Information

EPA TSCA Commercial Activity Status
Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1): ACTIVE
EPA TSCA Regulatory Flag
XU - indicates a substance exempt from reporting under the Chemical Data Reporting Rule, (40 CFR 711).

8 Safety and Hazards

8.1 Hazards Identification

8.1.1 GHS Classification

1 of 3
View All
Note
Pictograms displayed are for 88.2% (441 of 500) of reports that indicate hazard statements. This chemical does not meet GHS hazard criteria for 11.8% (59 of 500) of reports.
Pictogram(s)
Corrosive
Irritant
Signal
Danger
GHS Hazard Statements

H315 (88.2%): Causes skin irritation [Warning Skin corrosion/irritation]

H318 (17.8%): Causes serious eye damage [Danger Serious eye damage/eye irritation]

H319 (70.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Precautionary Statement Codes

P264, P264+P265, P280, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P332+P317, P337+P317, and P362+P364

(The corresponding statement to each P-code can be found at the GHS Classification page.)

ECHA C&L Notifications Summary

Aggregated GHS information provided per 500 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Reported as not meeting GHS hazard criteria per 59 of 500 reports by companies. For more detailed information, please visit ECHA C&L website.

There are 5 notifications provided by 441 of 500 reports by companies with hazard statement code(s).

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

8.1.2 Hazard Classes and Categories

Skin Irrit. 2 (88.2%)

Eye Dam. 1 (17.8%)

Eye Irrit. 2 (70.4%)

Not Classified

8.1.3 Hazards Summary

An eye irritant; [MSDSonline]

8.2 Regulatory Information

The Australian Inventory of Industrial Chemicals
Chemical: Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt
New Zealand EPA Inventory of Chemical Status
Poly(oxyethylene) lauryl ether ammonium sulfate: Does not have an individual approval but may be used under an appropriate group standard

8.3 Other Safety Information

Chemical Assessment
IMAP assessments - Sodium and ammonium laureth sulfate: Human health tier II assessment

9 Toxicity

9.1 Toxicological Information

9.1.1 Toxicity Summary

While ammonium laureth sulfate itself is not toxic, it is a nitrosating agent. Nitrosating agents may decompose and/or react to cause nitrosamine contamination. Nitrosamines are produced from secondary amines and amides in the presence of nitrite ions and are believed to be carcinogenic. Once in the body, nitrosamines are activated by cytochrome P-450 enzymes. They are then believed to induce their carcinogenic effects by forming DNA adducts at the N- and O-atoms. (L1889, L1890, A2878, A2879, A2880)
A2878: Oyama T, Sugio K, Uramoto H, Iwata T, Onitsuka T, Isse T, Nozoe T, Kagawa N, Yasumoto K, Kawamoto T: Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis. Front Biosci. 2007 May 1;12:4497-503. PMID:17485391
A2879: Sasaki S, Sata F, Katoh S, Saijo Y, Nakajima S, Washino N, Konishi K, Ban S, Ishizuka M, Kishi R: Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1. Am J Epidemiol. 2008 Mar 15;167(6):719-26. doi: 10.1093/aje/kwm360. Epub 2008 Jan 23. PMID:18218609
A2880: Drablos F, Feyzi E, Aas PA, Vaagbo CB, Kavli B, Bratlie MS, Pena-Diaz J, Otterlei M, Slupphaug G, Krokan HE: Alkylation damage in DNA and RNA--repair mechanisms and medical significance. DNA Repair (Amst). 2004 Nov 2;3(11):1389-407. PMID:15380096
L1889: Wikipedia. Nitrosamine. Last Updated 16 November 2009. http://en.wikipedia.org/wiki/Nitrosamine
L1890: Organic Natural Health (1998). Cancer Causing Toxic Chemical Ingredients in Cosmetic and Skin Care Products. http://www.health-report.co.uk/ingredients-directory.htm

9.1.2 Carcinogen Classification

Carcinogen Classification
Not listed by IARC. Certain nitrosamines are classified by IARC as either probably or possibly carcinogenic to humans (Groups 2A and 2B, respectively). (L135)

9.1.3 Health Effects

Ammonium laureth sulfate itself only causes mild irritation. However, it may react to produce nitrosamines, which are believed to be carcinogenic. (L1888, L1890)
L1888: Dead Sea Cosmetics (2009). Ingredient FAQs. http://www.deadsea-cosmetics.com/ingrediantsnew.htm
L1890: Organic Natural Health (1998). Cancer Causing Toxic Chemical Ingredients in Cosmetic and Skin Care Products. http://www.health-report.co.uk/ingredients-directory.htm

9.1.4 Exposure Routes

Oral (A2880) ; inhalation (A2880) ; dermal (L1889)
A2880: Drablos F, Feyzi E, Aas PA, Vaagbo CB, Kavli B, Bratlie MS, Pena-Diaz J, Otterlei M, Slupphaug G, Krokan HE: Alkylation damage in DNA and RNA--repair mechanisms and medical significance. DNA Repair (Amst). 2004 Nov 2;3(11):1389-407. PMID:15380096
L1889: Wikipedia. Nitrosamine. Last Updated 16 November 2009. http://en.wikipedia.org/wiki/Nitrosamine

9.1.5 Symptoms

Ammonium laureth sulfate can cause mild irritation. (L1888)
L1888: Dead Sea Cosmetics (2009). Ingredient FAQs. http://www.deadsea-cosmetics.com/ingrediantsnew.htm

10 Literature

10.1 Consolidated References

10.2 Chemical Co-Occurrences in Literature

10.3 Chemical-Gene Co-Occurrences in Literature

10.4 Chemical-Disease Co-Occurrences in Literature

11 Patents

11.1 Depositor-Supplied Patent Identifiers

11.2 Chemical Co-Occurrences in Patents

11.3 Chemical-Disease Co-Occurrences in Patents

11.4 Chemical-Gene Co-Occurrences in Patents

12 Classification

12.1 UN GHS Classification

12.2 NORMAN Suspect List Exchange Classification

12.3 Consumer Product Information Database Classification

12.4 EPA TSCA and CDR Classification

12.5 EPA Substance Registry Services Tree

12.6 MolGenie Organic Chemistry Ontology

13 Information Sources

  1. Australian Industrial Chemicals Introduction Scheme (AICIS)
    Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt
    https://services.industrialchemicals.gov.au/search-assessments/
    Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt
    https://services.industrialchemicals.gov.au/search-inventory/
  2. CAS Common Chemistry
    LICENSE
    The data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.
    https://creativecommons.org/licenses/by-nc/4.0/
  3. EPA Chemicals under the TSCA
    Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-(dodecyloxy)-, ammonium salt (1:1)
    https://www.epa.gov/chemicals-under-tsca
    EPA TSCA Classification
    https://www.epa.gov/tsca-inventory
  4. European Chemicals Agency (ECHA)
    LICENSE
    Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.
    https://echa.europa.eu/web/guest/legal-notice
    Poly(oxy-1,2-ethanediyl), .alpha.-sulpho-.omega.-(dodecyloxy)-, ammonium salt (3 EO)
    https://echa.europa.eu/substance-information/-/substanceinfo/100.125.985
    Poly(oxy-1,2-ethanediyl), .alpha.-sulpho-.omega.-(dodecyloxy)-, ammonium salt (3 EO) (EC: 608-760-0)
    https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/98338
  5. New Zealand Environmental Protection Authority (EPA)
    LICENSE
    This work is licensed under the Creative Commons Attribution-ShareAlike 4.0 International licence.
    https://www.epa.govt.nz/about-this-site/general-copyright-statement/
  6. Consumer Product Information Database (CPID)
    LICENSE
    Copyright (c) 2024 DeLima Associates. All rights reserved. Unless otherwise indicated, all materials from CPID are copyrighted by DeLima Associates. No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.
    https://www.whatsinproducts.com/contents/view/1/6
    Consumer Products Category Classification
    https://www.whatsinproducts.com/
  7. Cosmetic Ingredient Review (CIR)
  8. Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
    LICENSE
    Copyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.
    https://haz-map.com/About
    Ammonium laureth sulfate
    https://haz-map.com/Agents/7955
  9. Toxin and Toxin Target Database (T3DB)
    LICENSE
    T3DB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (T3DB) and the original publication.
    http://www.t3db.ca/downloads
    Ammonium laureth sulfate
    http://www.t3db.ca/toxins/T3D3619
  10. NORMAN Suspect List Exchange
    LICENSE
    Data: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0
    https://creativecommons.org/licenses/by/4.0/
    NORMAN Suspect List Exchange Classification
    https://www.norman-network.com/nds/SLE/
  11. Hazardous Chemical Information System (HCIS), Safe Work Australia
  12. Wikidata
    Ammonium lauryl ether sulfate
    https://www.wikidata.org/wiki/Q81981338
  13. PubChem
  14. GHS Classification (UNECE)
  15. EPA Substance Registry Services
  16. MolGenie
    MolGenie Organic Chemistry Ontology
    https://github.com/MolGenie/ontology/
CONTENTS