Hydroxyproline
- L-Hydroxyproline
- 51-35-4
- trans-4-Hydroxy-L-proline
- hydroxyproline
- (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
- Create:2004-09-16
- Modify:2025-01-04
- N-methyl-trans-4-hydroxy-L-proline
- NMH-Pro
- trans-4-hydroxy-L-proline
- L-Hydroxyproline
- 51-35-4
- trans-4-Hydroxy-L-proline
- hydroxyproline
- (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
- L-4-hydroxyproline
- trans-4-Hydroxyproline
- Hypro
- H-Hyp-OH
- hydroxy-L-proline
- 4-Hydroxy-L-proline
- 4-hydroxyproline
- trans-L-Hydroxyproline
- L-Proline, 4-hydroxy-, (4R)-
- (4R)-4-hydroxy-L-proline
- trans-Hydroxyproline
- 4-Hydroxy-2-pyrrolidinecarboxylic acid
- delta-Hydroxyproline
- L-Proline, 4-hydroxy-, trans-
- Proline, 4-hydroxy-, L-
- Hydroxyproline (VAN)
- L-Proline, 4-hydroxy-
- Ls-Hydroxyproline
- UNII-RMB44WO89X
- RMB44WO89X
- (2S,4R)-4-hydroxyproline
- 4-L-Hydroxyproline
- Proline, 4-hydroxy- (VAN)
- LUMISTOR
- CHEBI:18095
- (2S,4R)-trans-4-hydroxyproline
- L-threo-4-hydroxyproline
- EINECS 200-091-9
- NSC 46704
- NSC-46704
- Proline, 4-hydroxy-
- CHEMBL352418
- 618-28-0
- Hyp
- trans-L-4-hydroxyproline
- DTXSID10883225
- (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid
- NSC46704
- trans-oxyproline
- MFCD00064320
- trans-hydroxy-L-proline
- (2S,4R)-rel-4-Hydroxypyrrolidine-2-carboxylic acid
- trans-L-4-hydroxy-proline
- L-Proline, 4-hydroxy-, trans- (9CI)
- 4 HYDROXYPROLINE
- SMR000857104
- trans-4-hydroxy-proline
- 147028-80-6
- 6912-67-0
- CHEBI:18240
- hydroxiproline
- oxyproline
- hydroxy-proline
- H-trans-Hyp-OH
- Hydroxyproline,(l)
- L-Proline, trans-
- NMH-Pro
- (4r)-hydroxyproline
- 4(R)-hydroxyproline
- (2S,4R)-(-)-4-Hydroxy-2-Pyrrolidinecarboxylic Acid
- .delta.-Hydroxyproline
- L-Hydroxyproline,(S)
- L-4-transhydroxyproline
- trans-4-hydroxyL-proline
- Trans4-hydroxy-L-proline
- trans 4-hydroxy-l-proline
- bmse000123
- bmse000966
- L-trans-4-hydroxy-proline
- trans-4-hydroxy(L)proline
- HYDROXYPROLINE [MI]
- trans-4-hydroxyl-l-proline
- L-Hydroxyproline (Standard)
- SCHEMBL21185
- MLS001332463
- MLS001332464
- trans-4-hydroxy-(L)-proline
- (2S, 4R)-4-hydroxyproline
- GTPL4704
- (2s,4r)-4-hydroxy-l-proline
- HYDROXYPROLINE [WHO-DD]
- (2S, 4R)-4-hydroxy-proline
- CHEBI:24741
- DTXCID001022774
- BDBM50357233
- HY-40135R
- s5820
- O Hui Wrinkle Science Wrinkle Repair
- trans-4-Hydroxy-L-proline, >=99%
- AKOS007930607
- AC-2249
- CS-W008928
- DB08847
- PS-5807
- Ohui Wrinkle Science Wrinkle Repair Eye
- (2S,4R)-2-carboxy-4-hydroxypyrrolidine
- BP-10638
- HY-40135
- NCI60_004102
- DB-179157
- DB-265199
- DB-266976
- NS00078838
- EN300-53732
- C01157
- H-7290
- M03214
- P16433
- trans-4-Hydroxy-L-proline, analytical standard
- (2S, 4R)-4-hydroxy-2-pyrrolidinecarboxylic acid
- (2S,4R)-4-hydroxy-pyrrolidine-2-carboxylic acid
- 4-(R)-hydroxy-pyrrolidine-2-(S)-carboxylic acid
- (2S, 4R)-4-hydroxy-2-pyrrolidine-carboxylic acid
- J-525022
- Q27089020
- trans-4-Hydroxy-L-proline, BioXtra, >=99.0% (NT)
- F8889-8652
- Z802856442
- F05487BD-FA1D-4C80-83AD-3A91E2078031
- trans-4-Hydroxy-L-proline, microbial, cell culture tested
- trans-4-Hydroxy-L-proline, Vetec(TM) reagent grade, 99%
- trans-4-Hydroxy-L-proline, BioReagent, suitable for cell culture, >=98.5%
- Hydroxyproline, Pharmaceutical Secondary Standard; Certified Reference Material
126.3 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
126.2 Ų [M-H]- [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
139.3 Ų [M+Na]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
127.9 Ų [M+H]+ [CCS Type: DT; Method: single field calibrated with ESI Low Concentration Tuning Mix (Agilent)]
127.9 Ų [M+H]+
126.7 Ų [M-H]-
139.4 Ų [M+Na]+
158.0 1
159.0 0.19
103.0 0.16
142.0 0.13
116.0 0.12
230.1 100
140.1 41.74
231.1 19.56
232.1 8.52
147.1 7.99
86.049 100
131.917 99.51
68.114 17.65
68.114 100
86.026 65.77
41.323 27.08
58.179 18.68
131.839 4.15
86.0606 999
68.0505 612
132.0654 434
41.0395 111
114.054 18
68.0504 999
86.0606 656
58.0663 192
132.0672 31
67.0389 2
230.1 999
140.1 417
231.1 195
232.1 85
147.1 80
130 100
129 13.57
- Hydroxyproline; octinoxate (component of)
- Hydroxyproline; niacinamide (component of)
- Atractylodes japonica root oil; hydroxyproline; octinoxate; titanium dioxide; zinc oxide (component of)
- Epidermis
- Fibroblasts
- Kidney
- Liver
- Pancreas
- Placenta
- Platelet
- Prostate
- Skeletal Muscle
- Spleen
- Endoplasmic reticulum
- Mitochondria
- Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency)
- Creatine deficiency, guanidinoacetate methyltransferase deficiency
- Guanidinoacetate Methyltransferase Deficiency (GAMT Deficiency)
- Hyperornithinemia with gyrate atrophy (HOGA)
- Hyperornithinemia-hyperammonemia-homocitrullinuria [HHH-syndrome]
- Hyperprolinemia Type I
- Hyperprolinemia Type II
- L-arginine:glycine amidinotransferase deficiency
- Ornithine Aminotransferase Deficiency (OAT Deficiency)
- Prolidase Deficiency (PD)
- Total 13 pathways, visit the HMDB page for details
H315 (11.1%): Causes skin irritation [Warning Skin corrosion/irritation]
H319 (11.1%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (11.1%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 27 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Reported as not meeting GHS hazard criteria per 24 of 27 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 3 notifications provided by 3 of 27 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Skin Irrit. 2 (11.1%)
Eye Irrit. 2A (11.1%)
STOT SE 3 (11.1%)
Status: Active Update: 27-04-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21207
Status: Active Update: 03-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/25734
IMAP assessments - L-Proline, 4-hydroxy-, trans-: Environment tier I assessment
Evaluation - Chemicals that are unlikely to require further regulation to manage risks to human health
Silke Matysik, Caroline Ivanne Le Roy, Gerhard Liebisch, Sandrine Paule Claus. Metabolomics of fecal samples: A practical consideration. Trends in Food Science & Technology. Vol. 57, Part B, Nov. 2016, p.244-255: http://www.sciencedirect.com/science/article/pii/S0924224416301984
PubMed: 432003, 19033659
MetaGene: Metabolic & Genetic Information Center (MIC: http://www.metagene.de)
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=PMMYEEVYMWASQN-DMTCNVIQSA-N
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=SOGTUKFCMNGXDV-UHFFFAOYSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)L-Proline, 4-hydroxy-, (4R)-https://services.industrialchemicals.gov.au/search-assessments/L-Proline, 4-hydroxy-, (4R)-https://services.industrialchemicals.gov.au/search-inventory/
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/DL-Hydroxyprolinehttps://commonchemistry.cas.org/detail?cas_rn=618-28-0L-Hydroxyprolinehttps://commonchemistry.cas.org/detail?cas_rn=51-35-4L-Proline, 4-hydroxy-, (4R)-, homopolymerhttps://commonchemistry.cas.org/detail?cas_rn=25249-07-4
- ChemIDplusChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useHydroxyprolinehttps://www.drugbank.ca/drugs/DB08847
- DTP/NCILICENSEUnless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.https://www.cancer.gov/policies/copyright-reuse
- EPA Chemicals under the TSCAL-Proline, 4-hydroxy-, (4R)-https://www.epa.gov/chemicals-under-tscaEPA TSCA Classificationhttps://www.epa.gov/tsca-inventory
- EPA DSSToxHydroxyprolinehttps://comptox.epa.gov/dashboard/DTXSID10883225CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticeL-4-hydroxyprolinehttps://chem.echa.europa.eu/100.000.084L-4-hydroxyproline (EC: 200-091-9)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/10182
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- CCSbaseCCSbase Classificationhttps://ccsbase.net/
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/4-hydroxyprolineNORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- ChEBITrans-4-hydroxy-L-prolinehttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18095
- E. coli Metabolome Database (ECMDB)
- LOTUS - the natural products occurrence databaseLICENSEThe code for LOTUS is released under the GNU General Public License v3.0.https://lotus.nprod.net/Hydroxyprolinehttps://www.wikidata.org/wiki/Q12460151LOTUS Treehttps://lotus.naturalproducts.net/
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- DailyMed
- ECI Group, LCSB, University of Luxembourgtrans-4-hydroxy-L-proline
- Natural Product Activity and Species Source (NPASS)(2S,4R)-4-Hydroxypyrrolidine-2-Carboxylic Acidhttps://bidd.group/NPASS/compound.php?compoundID=NPC196359
- EPA Chemical and Products Database (CPDat)EPA CPDat Classificationhttps://www.epa.gov/chemical-research/chemical-and-products-database-cpdat
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutHydroxyprolinehttps://haz-map.com/Agents/14832
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- MassBank Europetrans-4-Hydroxy-L-prolinehttps://massbank.eu/MassBank/Result.jsp?inchikey=PMMYEEVYMWASQN-DMTCNVIQSA-N
- MassBank of North America (MoNA)LICENSEThe content of the MoNA database is licensed under CC BY 4.0.https://mona.fiehnlab.ucdavis.edu/documentation/license
- SpectraBasetrans-4-HYDROXY-L-PROLINEhttps://spectrabase.com/spectrum/7eZ5hirKSM4trans-4-Hydroxy-L-prolinehttps://spectrabase.com/spectrum/DytlIUN9xX3trans-4-hydroxy-L-prolinehttps://spectrabase.com/spectrum/ygEW3z9LPttrans-4-Hydroxy-L-prolinehttps://spectrabase.com/spectrum/3yb6qctqqkUtrans-4-HYDROXY-L-PROLINEhttps://spectrabase.com/spectrum/GY6M7UpKKWLtrans-4-Hydroxy-L-prolinehttps://spectrabase.com/spectrum/5z2MFzZsJQyL-4-Hydroxyprolinehttps://spectrabase.com/spectrum/GJSfy73rwwKL-4-Hydroxyprolinehttps://spectrabase.com/spectrum/A4E4ATh5fDQ
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.htmlCompounds with biological roleshttp://www.genome.jp/kegg-bin/get_htext?br08001.keg
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- Metabolomics Workbench4-Hydroxy-L-prolinehttps://www.metabolomicsworkbench.org/data/StructureData.php?RegNo=38814Trans-4-hydroxyprolinehttps://www.metabolomicsworkbench.org/data/StructureData.php?RegNo=73611
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- Protein Data Bank in Europe (PDBe)
- RCSB Protein Data Bank (RCSB PDB)LICENSEData files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.https://www.rcsb.org/pages/policies
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- Wikidatatrans-4-hydroxy-L-proline zwitterionhttps://www.wikidata.org/wiki/Q106345465
- WikipediaHydroxyprolinehttps://en.wikipedia.org/wiki/Hydroxyproline
- Wiley
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmltrans-4-hydroxy-L-prolinehttps://www.ncbi.nlm.nih.gov/mesh/2099859
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403432228https://pubchem.ncbi.nlm.nih.gov/substance/403432228SID 440343633https://pubchem.ncbi.nlm.nih.gov/substance/440343633