Ochratoxin A
- OCHRATOXIN A
- 303-47-9
- Phenylalanine - ochratoxin A
- Antibiotic 9663
- 3R14S-Ochratoxin A
- Create:2005-06-24
- Modify:2025-01-18
- OCHRATOXIN A
- 303-47-9
- Phenylalanine - ochratoxin A
- Antibiotic 9663
- 3R14S-Ochratoxin A
- CHEBI:7719
- (-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenylalanine
- OTA
- MFCD00078079
- Ochratoxin A-BSA conjugate from Aspergillus ochraceus
- N-(((3R)-5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl-L-alanine
- L-Phenylalanine, N-((5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)-, (R)-
- NCI-C56586
- NSC 201422
- Alanine, N-((5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl)-3-phenyl-, (-)-
- N-[(3R)-(5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-L-phenylalanine
- (2S)-2-[[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydroisochromene-7-carbonyl]amino]-3-phenylpropanoic acid
- N-{[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromen-7-yl]carbonyl}-L-phenylalanine
- Ochratoxin A(OTA)
- (2~{S})-2-[[(3~{R})-5-chloranyl-3-methyl-8-oxidanyl-1-oxidanylidene-3,4-dihydroisochromen-7-yl]carbonylamino]-3-phenyl-propanoic acid
- (2S)-2-{[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-yl]formamido}-3-phenylpropanoic acid
- Ochratoxin A (10?g/mL in Acetonitrile)
- Ochratoxin A 2 microg/mL in Acetonitrile
- Ochratoxin A 10 microg/mL in Acetonitrile
- Phenylalanine-ochratoxin A
- (R)-N-((5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-benzo(c)pyran-7-yl)carbonyl)-3-phenylalanine
- 1779SX6LUY
- NSC-201422
- Alanine, N-[(5-chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl]-3-phenyl-, (-)-
- Ochratoxin A, aspergillus ochraceus
- 97U
- L-Phenylalanine, N-[(5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-, (R)-
- 03 - Mycotoxin
- N-{[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-yl]carbonyl}-L-phenylalanine
- OCHRATOXIN A [MI]
- OCHRATOXIN A [HSDB]
- OCHRATOXIN A [IARC]
- CBiol_002012
- SCHEMBL15105
- CHEMBL589366
- GTPL4672
- MEGxm0_000357
- DTXSID7021073
- ACon0_000200
- ACon1_001268
- Bio1_000298
- Bio1_000787
- Bio1_001276
- GLXC-10695
- L-Phenylalanine, N-(((3R)-5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)-
- BDBM50485598
- AKOS024456512
- Ochratoxin A 2 microg/mL in Methanol
- 1ST7211
- 1ST7211-10A
- Ochratoxin A 10 microg/mL in Methanol
- SMP2_000132
- NCGC00162403-01
- NCGC00162403-02
- NCGC00162403-03
- NCGC00162403-04
- NCGC00162403-05
- Ochratoxin A 100 microg/mL in Methanol
- 1ST7211-100M
- NS00003381
- Ochratoxin A solution in Methanol, 100ug/mL
- C09955
- G91050
- Ochratoxin A solution in Acetonitrile, 10ug/mL
- J-017922
- Ochratoxin A 10 microg/mL in Acetonitrile:Methanol
- Q1885038
- BRD-K39944607-001-01-4
- Ochratoxin A, from Petromyces albertensis, >=98% (HPLC)
- Ochratoxin A, reference material, from Aspergillus ochraceus
- Ochratoxin A, purum, >=98.0% (TLC), from Aspergillus ochraceus
- (-)-N-((5-Chloro-8-hydroxy-3-methyl-1-oxo-7-isochromanyl)carbonyl-3-phenylalanine
- (2S)-2-{[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carbonyl]amino}-3-phenylpropanoic acid
- (R)-N-((5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)-carbonyl)-L-phenylalanine
- (R)-N-((5-CHLORO-3,4-DIHYDRO-8-HYDROXY-3-METHYL-1-OXO-1H-2-BENZOPYRAN-7-YL)CARBONYL)-L-PHENYLALANINE
- (R)-N-((5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)phenylalanine
- (S)-2-((R)-5-chloro-8-hydroxy-3-methyl-1-oxoisochroman-7-carboxamido)-3-phenylpropanoic acid
- InChI=1/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26
- N-[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carbonyl]-L-phenylalanine
- N-[(5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]phenylalanine, 9CI
193.27 Ų [M-H]-
188.74 Ų [M+H]+
358.0841 999
404.0895 898
239.0106 192
257.0211 180
386.079 146
358.0841 999
257.0211 773
239.0106 735
341.0575 325
120.0808 155
H300 (90.9%): Fatal if swallowed [Danger Acute toxicity, oral]
H319 (36.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H330 (27.3%): Fatal if inhaled [Danger Acute toxicity, inhalation]
H351 (100%): Suspected of causing cancer [Warning Carcinogenicity]
H361 (36.4%): Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]
H413 (54.5%): May cause long lasting harmful effects to aquatic life [Hazardous to the aquatic environment, long-term hazard]
P203, P260, P264, P264+P265, P270, P271, P273, P280, P284, P301+P316, P304+P340, P305+P351+P338, P316, P318, P320, P321, P330, P337+P317, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 11 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 2 (90.9%)
Eye Irrit. 2 (36.4%)
Acute Tox. 2 (27.3%)
Carc. 2 (100%)
Repr. 2 (36.4%)
Aquatic Chronic 4 (54.5%)
SYMPTOMS: Symptoms of exposure to this compound may include irritation. It can also interfere with the carbohydrate metabolism of eye lenses.
ACUTE/CHRONIC HAZARDS: This compound is highly toxic orally. It may be fatal by ingestion or inhalation. When heated to decomposition it emits very toxic fumes of chlorine and nitrogen oxides. (NTP, 1992)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
OTHER: Since this chemical is a known or suspected carcinogen you should contact a physician for advice regarding the possible long term health effects and potential recommendation for medical monitoring. Recommendations from the physician will depend upon the specific compound, its chemical, physical and toxicity properties, the exposure level, length of exposure, and the route of exposure. (NTP, 1992)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
SMALL SPILLS AND LEAKAGE: Should a spill occur while you are handling this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then you should dampen the solid spill material with 60-70% ethanol and transfer the dampened material to a suitable container. Use absorbent paper dampened with 60-70% ethanol to pick up any remaining material. Seal the absorbent paper, and any of your clothes, which may be contaminated, in a vapor-tight plastic bag for eventual disposal. Solvent wash all contaminated surfaces with 60-70% ethanol followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this material under freezer conditions. (NTP, 1992)
Acids, Carboxylic
Amides and Imides
Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
Phenols and Cresols
Hazard Traits - Carcinogenicity
Authoritative List - IARC Carcinogens - 2B; NTP RoC - reasonable; Prop 65
Report - regardless of intended function of ingredient in the product
Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Volume 56: (1993) Some Naturally Occurring Substances: Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins
Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity of ochratoxin A for male F344/N rats as shown by substantially increased incidences of uncommon tubular cell adenomas and of tubular cell carcinomas of the kidney. There was clear evidence of carcinogenic activity for female F344/N rats shown by increased incidences of uncommon tubular cell adenomas and of tubular cell carcinomas of the kidney and by increased incidences and multiplicity of fibroadenomas of the mammary gland.
Ochratoxin A administration also caused nonneoplastic renal changes including tubular cell hyperplasia, tubular cell proliferation, cytoplasmic alteration, karyomegaly, and degeneration of the renal tubular epithelium.
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Nephrotoxin - The chemical is potentially toxic to the kidneys in the occupational setting.
IARC Carcinogen - Class 3: Chemicals are not classifiable by the International Agency for Research on Cancer.
NTP Carcinogen - Reasonably anticipated to be a human carcinogen.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=RWQKHEORZBHNRI-BMIGLBTASA-N
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- ChEBI
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