2,3,4,7,8-Pentachlorodibenzofuran
- 2,3,4,7,8-PENTACHLORODIBENZOFURAN
- 57117-31-4
- Dibenzofuran, 2,3,4,7,8-pentachloro-
- 4-PeCDF
- HSDB 7178
- Create:2005-08-08
- Modify:2025-01-18
- 2,3,4,7,8-PENTACHLORODIBENZOFURAN
- 57117-31-4
- Dibenzofuran, 2,3,4,7,8-pentachloro-
- 4-PeCDF
- HSDB 7178
- 2,3,4,7,8-PeCDF
- CCRIS 3492
- UNII-U4C2RV3124
- PCDF 114
- U4C2RV3124
- Pentachlorodibenzofuran, 2,3,4,7,8-
- CHEMBL335558
- DTXSID7030066
- CHEBI:81508
- PeCDF
- 2,3,4,7,8-pentachlorodibenzo[b,d]furan
- 2,3,4,7,8-PENTACHLORODIBENZOFURAN [MI]
- 2,3,4,7,8-PENTACHLORODIBENZOFURAN [HSDB]
- 2,3,4,7,8-PENTACHLORODIBENZOFURAN [IARC]
- 2,3,4,7,8-pentachlorodibenzo(b,d)furan
- 2,3,4,7,8-Pentachlorodibenzofuran (~90%)
- 2,3,4,7,8-PENTACHLORODIBENZOFURAN (IARC)
- 4,5,6,11,12-pentachloro-8-oxatricyclo(7.4.0.02,7)trideca-1(13),2,4,6,9,11-hexaene
- 4,5,6,11,12-pentachloro-8-oxatricyclo[7.4.0.02,7]trideca-1(13),2,4,6,9,11-hexaene
- 4PeCDF
- SCHEMBL2281485
- DTXCID5010066
- BDBM50408369
- 2,3,4,7,8-penta-chlorodibenzofuran
- 2,3,4,7,8-Pentachloro-dibenzofuran
- Dibenzofuran, 2,3,4,7,8pentachloro
- 2,3,4,7,8Pentapolychlorinated dibenzofuran
- NS00098497
- 2,3,4,7,8-pentachlorodibenzofuran (PeCDF)
- C18106
- Q26841329
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
H350 (100%): May cause cancer [Danger Carcinogenicity]
H373 (100%): May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]
H400 (100%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (100%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
P203, P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P316, P304+P340, P305+P351+P338, P318, P319, P321, P330, P337+P317, P391, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 39 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 1 (100%)
Eye Irrit. 2 (100%)
STOT SE 3 (100%)
Carc. 1A (100%)
STOT RE 2 (100%)
Aquatic Acute 1 (100%)
Aquatic Chronic 1 (100%)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
TOXIC and/or CORROSIVE; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause environmental contamination. (ERG, 2024)
EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Generally, the induction of vomiting is NOT recommended outside of a physician's care due to the risk of aspirating the chemical into the victim's lungs. However, if the victim is conscious and not convulsing and if medical help is not readily available, consider the risk of inducing vomiting because of the high toxicity of the chemical ingested. Ipecac syrup or salt water may be used in such an emergency. IMMEDIATELY transport the victim to a hospital. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)
Excerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
SMALL SPILLS AND LEAKAGE: If you spill this chemical, FIRST REMOVE ALL SOURCES OF IGNITION, then dampen the solid spill material with toluene, then transfer the dampened material to a suitable container. Use absorbent paper dampened with toluene to pick up any remaining material. Your contaminated clothing and absorbent paper should be sealed in a vapor-tight plastic bag for eventual disposal. Solvent-wash all contaminated surfaces with toluene followed by washing with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.
STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)
Ethers
Aryl Halides
Hazard Traits - Bioaccumulation; Carcinogenicity; Dermatotoxicity; Developmental Toxicity; Endocrine Toxicity; Environmental Persistence; Environmental tox; Hematotoxicity; Hepatotoxicity and Digestive System Toxicity; Reproductive Toxicity
Authoritative List - CA TACs; CWA 303(d); IARC Carcinogens - 1; OEHHA RELs; WA PBTs
Report - regardless of intended function of ingredient in the product
Under the conditions of this 2-year gavage study, there was some evidence of carcinogenic activity of PeCDF in female Harlan Sprague-Dawley rats, based on increased incidences of hepatocellular adenoma and cholangiocarcinoma of the liver and gingival squamous cell carcinoma of the oral mucosa. Occurrences of cystic keratinizing epithelioma of the lung, neoplasms of the pancreatic acinus, and carcinoma of the uterus may have been related to administration of PeCDF.
PeCDF administration caused increased incidences of nonneoplastic lesions of the liver, oral mucosa, uterus, lung, pancreas, thyroid gland, thymus, adrenal cortex, kidney, heart, and forestomach in female rats.
Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
Reproductive Toxin - A chemical that is toxic to the reproductive system, including defects in the progeny and injury to male or female reproductive function. Reproductive toxicity includes developmental effects. See Guidelines for Reproductive Toxicity Risk Assessment.
Dermatotoxin - Chloracne.
IARC Carcinogen - Class 1: International Agency for Research on Cancer classifies chemicals as established human carcinogens.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=OGBQILNBLMPPDP-UHFFFAOYSA-N
- California Safe Cosmetics Program (CSCP) Product Database2,3,4,7,8-Pentachlorodibenzofuranhttps://www.cdph.ca.gov/Programs/CCDPHP/DEODC/OHB/CSCP/Pages/About-CSCP.aspx
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=false2,3,4,7,8-PENTACHLORODIBENZOFURANhttps://cameochemicals.noaa.gov/chemical/20851CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/2,3,4,7,8-Pentachlorodibenzofuranhttps://commonchemistry.cas.org/detail?cas_rn=57117-31-4
- ChemIDplus2,3,4,7,8-Pentachlorodibenzofuranhttps://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0057117314ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA DSSTox2,3,4,7,8-Pentachlorodibenzofuranhttps://comptox.epa.gov/dashboard/DTXSID7030066CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-notice2,3,4,7,8-Pentachlorodibenzofuranhttps://echa.europa.eu/substance-information/-/substanceinfo/100.222.9832,3,4,7,8-Pentachlorodibenzofuran (EC: 694-761-1)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/228837
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking2,3,4,7,8-PENTACHLORODIBENZOFURANhttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/U4C2RV3124
- Hazardous Substances Data Bank (HSDB)2,3,4,7,8-PENTACHLORODIBENZOFURANhttps://pubchem.ncbi.nlm.nih.gov/source/hsdb/7178
- Risk Assessment Information System (RAIS)LICENSEThis work has been sponsored by the U.S. Department of Energy (DOE), Office of Environmental Management, Oak Ridge Operations (ORO) Office through a joint collaboration between United Cleanup Oak Ridge LLC (UCOR), Oak Ridge National Laboratory (ORNL), and The University of Tennessee, Ecology and Evolutionary Biology, The Institute for Environmental Modeling (TIEM). All rights reserved.https://rais.ornl.gov/PeCDF, 2,3,4,7,8-https://rais.ornl.gov/cgi-bin/tools/TOX_search
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/About2,3,4,7,8-Pentachlorodibenzofuranhttps://haz-map.com/Agents/2948
- ChEBI2,3,4,7,8-Pentachlorodibenzofuranhttps://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:81508
- Toxin and Toxin Target Database (T3DB)LICENSET3DB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (T3DB) and the original publication.http://www.t3db.ca/downloads2,3,4,7,8-Pentachlorodibenzofuranhttp://www.t3db.ca/toxins/T3D0168
- ChEMBLLICENSEAccess to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).http://www.ebi.ac.uk/Information/termsofuse.htmlChEMBL Protein Target Treehttps://www.ebi.ac.uk/chembl/g/#browse/targets
- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jsp2,3,4,7,8-pentachlorodibenzofuranhttps://ctdbase.org/detail.go?type=chem&acc=C038890
- Human Metabolome Database (HMDB)LICENSEHMDB is offered to the public as a freely available resource. Use and re-distribution of the data, in whole or in part, for commercial purposes requires explicit permission of the authors and explicit acknowledgment of the source material (HMDB) and the original publication (see the HMDB citing page). We ask that users who download significant portions of the database cite the HMDB paper in any resulting publications.http://www.hmdb.ca/citing2,3,4,7,8-Pentachlorodibenzofuranhttp://www.hmdb.ca/metabolites/HMDB0245434
- International Agency for Research on Cancer (IARC)LICENSEMaterials made available by IARC/WHO enjoy copyright protection under the Berne Convention for the Protection of Literature and Artistic Works, under other international conventions, and under national laws on copyright and neighbouring rights. IARC exercises copyright over its Materials to make sure that they are used in accordance with the Agency's principles. All rights are reserved.https://publications.iarc.fr/Terms-Of-Use2,3,4,7,8-Pentachlorodibenzofuranhttps://monographs.iarc.who.int/list-of-classificationsIARC Classificationhttps://www.iarc.fr/
- NTP Technical ReportsToxic Equivalency Factor Evaluation of 2,3,4,7,8- Pentachlorodibenzofuran (PeCDF)https://ntp.niehs.nih.gov/data/tr
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.htmlEndocrine disrupting compoundshttp://www.genome.jp/kegg-bin/get_htext?br08006.keg
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-lawDibenzofuran, 2,3,4,7,8-pentachloro-http://www.nist.gov/srd/nist1a.cfm
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/NORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/about2,3,4,7,8-Pentachloro-dibenzofuranhttps://pharos.nih.gov/ligands/48K8NJAT6NL2
- SpectraBaseDibenzofuran, 2,3,4,7,8-pentachloro-https://spectrabase.com/spectrum/3O71hJOTvT6
- Springer Nature
- SpringerMaterials2,3,4,7,8-Penta-chlorodibenzofuranhttps://materials.springer.com/substanceprofile/docs/smsid_dxjkksaaxupnpkkk
- Wikidata2,3,4,7,8-pentachlorodibenzofuranhttps://www.wikidata.org/wiki/Q26841329
- Wiley
- PubChem
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.html2,3,4,7,8-pentachlorodibenzofuranhttps://www.ncbi.nlm.nih.gov/mesh/67038890
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403768580https://pubchem.ncbi.nlm.nih.gov/substance/403768580
- NCBI