Phosphamidon
- PHOSPHAMIDON
- Dimecron
- 13171-21-6
- (Z)-Phosphamidon
- Fosfamidone
- Create:2005-03-27
- Modify:2025-01-11
- Dimecron
- Phosphamidon
- PHOSPHAMIDON
- Dimecron
- 13171-21-6
- (Z)-Phosphamidon
- Fosfamidone
- Phosphamidone
- Apamidon
- Fosfamidon
- Famfos
- Merkon
- Dixon
- Dimecron 100
- 23783-98-4
- Sundaram 1975
- Ciba 570
- Phosphoric acid, 2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl ester
- NCI-C00588
- OMS 1325
- ENT 25515
- O,O-Dimethyl O-(2-chloro-2-(N,N-diethylcarbamoyl)-1-methylvinyl) phosphate
- 2-Chloro-3-dimethoxyphosphinoyloxy-N,N-diethylbut-2-enamide
- C 570
- 2-Chloro-2-dimethylcarbamoyl-1-methylvinyl dimethyl phosphate
- HQ7958Q90Z
- Dimethyl diethylamido-1-chlorocrotonyl (2) phosphate
- Phosphoric acid, dimethyl ester, ester with 2-chloro-N,N-diethyl-3-hydroxycrotonamide
- NCGC00166317-01
- 2-Chloro-2-diethylcarbamoyl-1-methylvinyl dimethylphosphate
- Dimethyl 2-chloro-2-diethylcarbamoyl-1-methylvinyl phosphate
- Dimethyl phosphate of 2-chloro-N,N-diethyl-3-hydroxycrotonamide
- Crotonamide, 2-chloro-N,N-diethyl-3-hydroxy-, dimethyl phosphate
- cis-Phosphamidon
- (2-Chloor-3-diethylamino-1-methyl-3-oxo-prop-1-en-yl)-dimethyl-fosfaat
- (2-Cloro-3-dietilamino-1-metil-3-oxo-prop-1-en-il)-dimetil-fosfato
- [(Z)-3-chloro-4-(diethylamino)-4-oxobut-2-en-2-yl] dimethyl phosphate
- (2-Chlor-3-diaethylamino-1-methyl-3-oxo-prop-1-en-yl)-dimethyl-phosphat
- (O,O-Dimethyl-O-(1-methyl-2-chloro-2-diethylcarbamoyl-vinyl) phosphate)
- O,O-Dimethyl-O-(1-methyl-2-chlor-2-N,N-diaethyl-carbamoyl)-vinyl-phosphat
- DTXCID201156
- Z-Phosphamidon
- 2-chloro-3-(diethylamino)-1-methyl-3-oxoprop-1-en-1-yl dimethyl phosphate
- Fosfamidon [Dutch]
- CAS-13171-21-6
- Caswell No. 661
- Fosfamidone [Italian]
- Phosphamidon 85 WSC
- Foszfamidon (Hungarian)
- DTXSID7021156
- CHEBI:38832
- Foszfamidon
- CCRIS 516
- UNII-7H857A6N6H
- UNII-HQ7958Q90Z
- Phosphamidon [ANSI:BSI:ISO]
- HSDB 1754
- Dimecron 50
- Dimecron-20
- EINECS 236-116-5
- EPA Pesticide Chemical Code 018201
- Phosphamidon, (Z)-
- Phosphamidon peak # 2
- AI3-25515
- (Z)-2-Chloro-N,N-diethyl-3-hydroxycrotonamide dimethyl phosphorate
- PHOSPHAMIDON, CIS-
- Phosphoric acid, (1Z)-2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl-, dimethyl ester
- Phosphoric acid, dimethyl ester, ester with 2-chloro-N,N-diethyl-3-hydroxycrotanamide, (Z)-
- SCHEMBL27697
- PHOSPHAMIDON, Z ISOMER
- N,N-Diethyl 2-chloro-3-dimethylphosphate crotonamide
- CHEMBL1892391
- 2-Chloro-2-diethylcarbamyl-1-methylvinyl-dimethyl phosphate
- 2-Chloro-N,N-diethyl-3-(dimethylphosphono)crotonic amide
- RGCLLPNLLBQHPF-UHFFFAOYSA-N
- 2-Chloro-N,N-diethyl-3-hydroxycrotonamide dimethyl phosphate
- 7H857A6N6H
- DTXSID601030915
- Tox21_112409
- Tox21_202100
- Tox21_302848
- 2-Chloro-N,N-diethyl-3-hydroxycrotonamide ester with dimethyl phosphate
- Phosphate de dimethyle et de (2-chloro-2-diethylcarbamoyl-1-methyl-vinyle)
- (2-Chloor-3-diethylamino-1-methyl-3-oxo-prop-1-en-yl)-dimethyl-fosfaat [Dutch]
- (2-Chlor-3-diaethylamino-1-methyl-3-oxo-prop-1-en-yl)-dimethyl-phosphat [German]
- (2-Cloro-3-dietilamino-1-metil-3-oxo-prop-1-en-il)-dimetil-fosfato [Italian]
- O,O-Dimethyl-O-(1-methyl-2-chlor-2-N,N-diaethyl-carbamoyl)-vinyl-phosphat [German]
- Phosphate de dimethyle et de (2-chloro-2-diethylcarbamoyl-1-methyl-vinyle) [French]
- NCGC00166317-02
- NCGC00256550-01
- NCGC00259649-01
- 1ST20107
- 1ST20655
- NS00001323
- C18689
- Q424889
- J-006041
- Q27280053
- dimethyl[2-chloro-1-m-2-(N,N-dimethylcarbamoyl)vinyl]phosphate
- (Z)-2-CHLORO-2-DIETHYLCARBAMOYL-1-METHYLVINYL DIMETHYL PHOSPHATE
- Dimethyl phosphate ester with 2-chloro-N,N-diethyl-3-hydroxycrotonamide
- PHOSPHORIC ACID, (1Z)-2-CHLORO-3-(DIETHYLAMINO)-1-METHYL-3-OXO-1-PROPEN-1-YL DIMETHYL ESTER
162.25 Ų [M+Na]+
155.99 Ų [M+H]+
H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]
H311 (87.2%): Toxic in contact with skin [Danger Acute toxicity, dermal]
H330 (12.8%): Fatal if inhaled [Danger Acute toxicity, inhalation]
H341 (87.2%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
H400 (87.2%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
H410 (87.2%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]
P203, P260, P262, P264, P270, P271, P273, P280, P284, P301+P316, P302+P352, P304+P340, P316, P318, P320, P321, P330, P361+P364, P391, P403+P233, P405, and P501
(The corresponding statement to each P-code can be found at the GHS Classification page.)
Aggregated GHS information provided per 47 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
Acute Tox. 2 (100%)
Acute Tox. 3 (87.2%)
Acute Tox. 1 (12.8%)
Muta. 2 (87.2%)
Aquatic Acute 1 (87.2%)
Aquatic Chronic 1 (87.2%)
Germ cell mutagenicity - category 2
Hazardous to the aquatic environment (acute) - category 1
Hazardous to the aquatic environment (chronic) - category 1
Acute toxicity (dermal) - category 3
Acute toxicity (ingestion) - category 2
NR=Not recommended due to insufficient data
AEGLs Status: Proposed
Note: Phosphamidon is a cholinesterase inhibitor.
Signs and Symptoms of Acute Phosphamidon Exposure: Acute exposure to phosphamidon may produce pinpoint pupils, blurred vision, headache, dizziness, muscle spasms, and profound weakness. Vomiting, diarrhea, abdominal pain, seizures, and coma may also occur. The heart rate may decrease following oral exposure or increase following dermal exposure. Hypotension (low blood pressure) may occur, although hypertension (high blood pressure) is not uncommon. Chest pain may be noted. Respiratory effects include dyspnea (shortness of breath), respiratory depression, and respiratory paralysis. Psychosis may occur.
Emergency Life-Support Procedures: Acute exposure to phosphamidon may require decontamination and life support for the victims. Emergency personnel should wear protective clothing appropriate to the type and degree of contamination. Air-purifying or supplied-air respiratory equipment should also be worn, as necessary. Rescue vehicles should carry supplies such as plastic sheeting and disposable plastic bags to assist in preventing spread of contamination.
Inhalation Exposure:
1. Move victims to fresh air. Emergency personnel should avoid self-exposure to phosphamidon.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
4. Transport to a health care facility.
Dermal/Eye Exposure:
1. Remove victims from exposure. Emergency personnel should avoid self- exposure to phosphamidon.
2. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
3. Remove contaminated clothing as soon as possible.
4. If eye exposure has occurred, eyes must be flushed with lukewarm water for at least 15 minutes.
5. Wash exposed skin areas three times with soap and water.
6. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
7. Transport to a health care facility.
Ingestion Exposure:
1. Evaluate vital signs including pulse and respiratory rate, and note any trauma. If no pulse is detected, provide CPR. If not breathing, provide artificial respiration. If breathing is labored, administer oxygen or other respiratory support.
2. Obtain authorization and/or further instructions from the local hospital for administration of an antidote or performance of other invasive procedures.
3. Vomiting may be induced with syrup of Ipecac. If elapsed time since ingestion of phosphamidon is unknown or suspected to be greater than 30 minutes, do not induce vomiting and proceed to Step
4.Ipecac should not be administered to children under 6 months of age.Warning: Ingestion of phosphamidon may result in sudden onset of seizures or loss of consciousness. Syrup of Ipecac should be administered only if victims are alert, have an active gag-reflex, and show no signs of impending seizure or coma. If ANY uncertainty exists, proceed to Step
4.The following dosages of Ipecac are recommended: children up to 1 year old, 10 mL (1/3 oz); children 1 to 12 years old, 15 mL (1/2 oz); adults, 30 mL (1 oz). Ambulate (walk) the victims and give large quantities of water. If vomiting has not occurred after 15 minutes, Ipecac may be readministered. Continue to ambulate and give water to the victims. If vomiting has not occurred within 15 minutes after second administration of Ipecac, administer activated charcoal.
4. Activated charcoal may be administered if victims are conscious and alert. Use 15 to 30 g (1/2 to 1 oz) for children, 50 to 100 g (1-3/4 to 3-1/2 oz) for adults, with 125 to 250 mL (1/2 to 1 cup) of water.
5. Promote excretion by administering a saline cathartic or sorbitol to conscious and alert victims. Children require 15 to 30 g (1/2 to 1 oz) of cathartic; 50 to 100 g (1-3/4 to 3-1/2 oz) is recommended for adults.
6. Transport to a health care facility. (EPA, 1998)
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Stay upwind; keep out of low areas. Move containers from fire area if you can do it without risk. Fight fire from maximum distance. Dike fire control water for later disposal; do not scatter the material.
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) This material may burn, but does not ignite readily. For small fires, use dry chemical, carbon dioxide, water spray, or foam. For large fires, use water spray, fog, or foam. (EPA, 1998)
Excerpt from ERG Guide 152 [Substances - Toxic (Combustible)]:
IMMEDIATE PRECAUTIONARY MEASURE: Isolate spill or leak area in all directions for at least 50 meters (150 feet) for liquids and at least 25 meters (75 feet) for solids.
SPILL: Increase the immediate precautionary measure distance, in the downwind direction, as necessary.
FIRE: If tank, rail tank car or highway tank is involved in a fire, ISOLATE for 800 meters (1/2 mile) in all directions; also, consider initial evacuation for 800 meters (1/2 mile) in all directions. (ERG, 2024)
Caution : Explosion potential is high. Containers may explode in heat of fire. Highly toxic phosphorus oxides and chlorides may be emitted when phosphamidon is heated to decomposition. Avoid sources of extreme heat.
(Non-Specific -- Organophosphorus Pesticide, Liquid, n.o.s.) Stay upwind; keep out of low areas. Ventilate closed spaces before entering them. Do not touch spilled material; stop leak if you can do so without risk. Use water spray to reduce vapors.
Small spills: absorb with sand or other noncombustible absorbent material and place into containers for later disposal.
Large spills: dike far ahead of spill for later disposal. (EPA, 1998)
Amides and Imides
Esters, Sulfate Esters, Phosphate Esters, Thiophosphate Esters, and Borate Esters
Halogenated Organic Compounds
Hydrocarbons, Aliphatic Unsaturated
IMAP assessments - Phosphoric acid, 2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl ester: Human health tier I assessment
IMAP assessments - Phosphoric acid, 2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl ester: Environment tier I assessment
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=RGCLLPNLLBQHPF-HJWRWDBZSA-N
- Australian Industrial Chemicals Introduction Scheme (AICIS)Phosphoric acid, 2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl esterhttps://services.industrialchemicals.gov.au/search-assessments/
- CAMEO ChemicalsLICENSECAMEO Chemicals and all other CAMEO products are available at no charge to those organizations and individuals (recipients) responsible for the safe handling of chemicals. However, some of the chemical data itself is subject to the copyright restrictions of the companies or organizations that provided the data.https://cameochemicals.noaa.gov/help/reference/terms_and_conditions.htm?d_f=falsePHOSPHAMIDONhttps://cameochemicals.noaa.gov/chemical/5129CAMEO Chemical Reactivity Classificationhttps://cameochemicals.noaa.gov/browse/react
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/cis-Phosphamidonhttps://commonchemistry.cas.org/detail?cas_rn=23783-98-4
- ChemIDplusPhosphamidon [ANSI:BSI:ISO]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0013171216ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- EPA Acute Exposure Guideline Levels (AEGLs)
- EPA DSSTox(E)-Phosphamidonhttps://comptox.epa.gov/dashboard/DTXSID601030915CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
- European Chemicals Agency (ECHA)LICENSEUse of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.https://echa.europa.eu/web/guest/legal-noticePhosphamidon (EC: 236-116-5)https://echa.europa.eu/information-on-chemicals/cl-inventory-database/-/discli/details/55635
- FDA Global Substance Registration System (GSRS)LICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linkingPHOSPHAMIDON, (Z)-https://gsrs.ncats.nih.gov/ginas/app/beta/substances/HQ7958Q90Z
- Hazardous Substances Data Bank (HSDB)
- ILO-WHO International Chemical Safety Cards (ICSCs)
- NJDOH RTK Hazardous Substance List
- Risk Assessment Information System (RAIS)LICENSEThis work has been sponsored by the U.S. Department of Energy (DOE), Office of Environmental Management, Oak Ridge Operations (ORO) Office through a joint collaboration between United Cleanup Oak Ridge LLC (UCOR), Oak Ridge National Laboratory (ORNL), and The University of Tennessee, Ecology and Evolutionary Biology, The Institute for Environmental Modeling (TIEM). All rights reserved.https://rais.ornl.gov/Phosphamidonhttps://rais.ornl.gov/cgi-bin/tools/TOX_search
- Haz-Map, Information on Hazardous Chemicals and Occupational DiseasesLICENSECopyright (c) 2022 Haz-Map(R). All rights reserved. Unless otherwise indicated, all materials from Haz-Map are copyrighted by Haz-Map(R). No part of these materials, either text or image may be used for any purpose other than for personal use. Therefore, reproduction, modification, storage in a retrieval system or retransmission, in any form or by any means, electronic, mechanical or otherwise, for reasons other than personal use, is strictly prohibited without prior written permission.https://haz-map.com/AboutPhosphamidonhttps://haz-map.com/Agents/6675
- ChEBI
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- Comparative Toxicogenomics Database (CTD)LICENSEIt is to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of NC State University.http://ctdbase.org/about/legal.jsp
- EPA Pesticide Ecotoxicity Database
- EU Pesticides Database
- USDA Pesticide Data ProgramPhosphamidonhttps://www.ams.usda.gov/datasets/pdp
- Hazardous Chemical Information System (HCIS), Safe Work Australia
- NITE-CMCphosphamidon - FY2006 (New/original classication)https://www.chem-info.nite.go.jp/chem/english/ghs/06-imcg-1009e.html
- Regulation (EC) No 1272/2008 of the European Parliament and of the CouncilLICENSEThe copyright for the editorial content of this source, the summaries of EU legislation and the consolidated texts, which is owned by the EU, is licensed under the Creative Commons Attribution 4.0 International licence.https://eur-lex.europa.eu/content/legal-notice/legal-notice.htmlphosphamidon (ISO); 2-chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphatehttps://eur-lex.europa.eu/eli/reg/2008/1272/oj
- Japan Chemical Substance Dictionary (Nikkaji)
- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.html
- Metabolomics Workbench
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-lawPhosphamidonhttp://www.nist.gov/srd/nist1a.cfm
- SpectraBasePhosphamidonhttps://spectrabase.com/spectrum/GV8xhjrxikKPhosphamidon Ihttps://spectrabase.com/spectrum/DmfR88m2uuW
- USGS Columbia Environmental Research CenterLICENSEhttps://www.usgs.gov/foia
- NORMAN Suspect List ExchangeLICENSEData: CC-BY 4.0; Code (hosted by ECI, LCSB): Artistic-2.0https://creativecommons.org/licenses/by/4.0/PhosphamidonNORMAN Suspect List Exchange Classificationhttps://www.norman-network.com/nds/SLE/
- NTP Technical ReportsPhosphamidonhttps://ntp.niehs.nih.gov/data/tr
- Springer Nature
- SpringerMaterialsdimethyl[2-chloro-1-m-2-(N,N-dimethylcarbamoyl)vinyl]phosphatehttps://materials.springer.com/substanceprofile/docs/smsid_xnpsbmtmflgtgsgj
- Wikidata(Z)-phosphamidonhttps://www.wikidata.org/wiki/Q27280053
- WikipediaPhosphamidonhttps://en.wikipedia.org/wiki/Phosphamidon
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlPhosphamidonhttps://www.ncbi.nlm.nih.gov/mesh/68010707Cholinesterase Inhibitorshttps://www.ncbi.nlm.nih.gov/mesh/68002800Insecticideshttps://www.ncbi.nlm.nih.gov/mesh/68007306
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 403408826https://pubchem.ncbi.nlm.nih.gov/substance/403408826
- NCBI