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Optoelectronic sensor

Patent
US-6087114-A
Inventor
RIDER TODD H (US)
Assignee
MASSACHUSETTS INST TECHNOLOGY (US)
Country
United States
Dates
  • Priority:
    1997/12/09
  • Grant:
    2000/07/11
Description
This web page summarizes information in PubChem about patent US-6087114-A. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed, please visit the PubChem patents help page.

1 Abstract

A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the cytosol of the cell, the cell further having a emitter molecule which, in response to the increased calcium concentration in the cytosol, emits a photon; (2) a liquid medium for receiving the antigen and in which the cell is immersed; and (3) an optical detector arranged for receiving the photon emitted from the cell.

2 Full Text

3 Important Dates

3.1 Priority Date

1997/12/09

3.2 Filing Date

1997/12/09

3.3 Publication Date

2000/07/11

3.4 Grant Date

2000/07/11

4 Inventor

RIDER TODD H (US)

5 Assignee

MASSACHUSETTS INST TECHNOLOGY (US)

6 Country

United States

7 Linked Chemicals

7.1 PubChem Compounds

7.2 PubChem Substances

8 Classification

8.1 IPC

G01N21/76 (inventive)

G01N33/58 (inventive)

G01N33/569 (inventive)

8.2 CPC

G01N33/56972 (inventive, first)

G01N21/76 (inventive)

G01N33/582 (inventive)

Y10S435/808

Y10S436/805

9 Citations

  • US-5126276-A (SEA)
  • US-5139937-A (SEA)
  • US-5360728-A (SEA)
  • US-5541309-A (SEA)
  • US-5714666-A (SEA)
  • US-5798441-A (SEA)
  • Button et al., "Aequorin-expressing Mammalian Cell Lines Used to Report Ca2+ Mobilization", Cell Calcium 14:663-671, 1993. (UNKNOWN)
  • Button et al., Aequorin expressing Mammalian Cell Lines Used to Report Ca 2 Mobilization , Cell Calcium 14:663 671, 1993. (SEA)
  • Chalfie, "Green Fluorescent Protein", Photochemistry and Photobiology 62:651-656, 1995. (UNKNOWN)
  • Chalfie, Green Fluorescent Protein , Photochemistry and Photobiology 62:651 656, 1995. (SEA)
  • Mosier, "Primary In Vitro Antibody Responses by Purified Murine B Lymphocytes in Serum-Free Defined Medium", The Journal of Immunology 127:1490-1493, 1981. (UNKNOWN)
  • Mosier, Primary In Vitro Antibody Responses by Purified Murine B Lymphocytes in Serum Free Defined Medium , The Journal of Immunology 127:1490 1493, 1981. (SEA)
  • Paddle, "Biosensors for Chemical and Biological Agents of Defence Interest", Biosensors & Bioelectronics 11:1079-1113, 1996. (UNKNOWN)
  • Paddle, Biosensors for Chemical and Biological Agents of Defence Interest , Biosensors & Bioelectronics 11:1079 1113, 1996. (SEA)
  • Page et al., "A Cell-based Immunobiosensor with Engineered Molecular Recognition--Part II: Enzyme Amplification Systems", Biosensors & Bioelectronics 12:457-466, 1997. (UNKNOWN)
  • Page et al., A Cell based Immunobiosensor with Engineered Molecular Recognition Part II: Enzyme Amplification Systems , Biosensors & Bioelectronics 12:457 466, 1997. (SEA)
  • Pizziconi et al., "A Cell-based Immunobiosensor with Engineered Molecular Recognition--Part I: Design Feasibility", Biosensors & Bioelectronics 12:287-299, 1997. (UNKNOWN)
  • Pizziconi et al., A Cell based Immunobiosensor with Engineered Molecular Recognition Part I: Design Feasibility , Biosensors & Bioelectronics 12:287 299, 1997. (SEA)
  • Shimomura et al., "Calcium Binding, Quantum Yield, and Emitting Molecule in Aequorin Bioluminescence", Nature 227:1356-1357, 1970. (UNKNOWN)
  • Shimomura et al., "Light-emitting Properties of Recombinant Semi-Synthetic Aequorins and Recombinant Fluorescein-conjugated Aequorin for Measuring Cellular Calcium", Cell Calcium 14:373-378, 1993. (UNKNOWN)
  • Shimomura et al., Calcium Binding, Quantum Yield, and Emitting Molecule in Aequorin Bioluminescence , Nature 227:1356 1357, 1970. (SEA)
  • Shimomura et al., Light emitting Properties of Recombinant Semi Synthetic Aequorins and Recombinant Fluorescein conjugated Aequorin for Measuring Cellular Calcium , Cell Calcium 14:373 378, 1993. (SEA)
  • Wilson et al., "Crosslinkage of B Lymphocyte Surface Immunoglobulin by Anti Ig or Antigen Induces Prolonged Oscillation of Intracellular Ionized Calcium", Journal of Experimental Medicine 166:601-606, 1987. (UNKNOWN)
  • Wilson et al., "The B Lymphocyte Calcium Response to Anti-Ig Is Dimished by Membrane Immunoglobulin Cross-Linkage . . . ", The Journal of Immunology 138:1712-1718, 1987. (UNKNOWN)
  • Wilson et al., Crosslinkage of B Lymphocyte Surface Immunoglobulin by Anti Ig or Antigen Induces Prolonged Oscillation of Intracellular Ionized Calcium , Journal of Experimental Medicine 166:601 606, 1987. (SEA)
  • Wilson et al., The B Lymphocyte Calcium Response to Anti Ig Is Dimished by Membrane Immunoglobulin Cross Linkage . . . , The Journal of Immunology 138:1712 1718, 1987. (SEA)

10 Cited By

11 Similar Patents

12 Information Sources

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