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Method of producing antibacterial agents and bioconverting microorganism therefor

Patent
US-4522919-A
Inventor

SHREVE BARBARA B (US)

TURNER JAN R (US)

Assignee
LILLY CO ELI (US)
Country
United States
Dates
  • Priority:
    1983/03/03
  • Grant:
    1985/06/11
Description
This web page summarizes information in PubChem about patent US-4522919-A. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed, please visit the PubChem patents help page.

1 Abstract

Improved bioconverting strain of Streptomyces thermotolerans useful in preparing tylosin esters and new antibacterial macrocin or lactenocin ester derivatives of the formula: <IMAGE> wherein R is formyl or hydroxymethyl; R1 is hydrogen, acetyl or propionyl; R2 is hydrogen or <IMAGE> and R3 is hydrogen, acetyl, propionyl, n-butyryl or isovaleryl; provided that one of R1 or R3 must be other than hydrogen.

2 Full Text

3 Important Dates

3.1 Priority Date

1983/03/03

3.2 Filing Date

1983/03/03

3.3 Publication Date

1985/06/11

3.4 Grant Date

1985/06/11

4 Inventor

SHREVE BARBARA B (US)

TURNER JAN R (US)

5 Assignee

LILLY CO ELI (US)

6 Country

United States

7 Linked Chemicals

7.1 PubChem Compounds

7.2 PubChem Substances

8 Patent Family

9 Classification

9.1 IPC

C12P19/62 (inventive)

C07H17/08 (inventive)

9.2 CPC

C12R2001/465

C12P19/62 (inventive)

Y10S435/886

C07H17/08 (inventive, first)

C12N1/205 (inventive)

10 Citations

  • US-3326759-A (SEA)
  • US-4092473-A (SEA)
  • US-4205163-A (SEA)
  • US-4385116-A (SEA)
  • Derwent Abstract Nos. 66634C/38, 27592A/15 of Japanese Unexamined Patent Nos. J5 5043 013, J5 3021 182, 3 26 80, 2 27 78 (Sanraku Ocean). (SEA)
  • Derwent Abstract Nos. 66634C/38, 27592A/15 of Japanese Unexamined Patent Nos. J5 5043-013, J5 3021-182, 3-26-80, 2-27-78 (Sanraku Ocean). (UNKNOWN)
  • M. Tsuchiya et al., "Studies of Tylosin Derivatives Effective Against Macrolide-Resistant Strains: Synthesis and Structure-Activity Relationships", J. Antibiotics 35(6), 661-671 (1982). (UNKNOWN)
  • M. Tsuchiya et al., "Studies on the Effects of 3-Acetyl-4"-Isovaleryltylosin Against Multiple-Drug Resistant Strains of Staphylococcus Aureus", J. Antibiotics 34(3), 305-306 (1981). (UNKNOWN)
  • M. Tsuchiya et al., Studies of Tylosin Derivatives Effective Against Macrolide Resistant Strains: Synthesis and Structure Activity Relationships , J. Antibiotics 35(6), 661 671 (1982). (SEA)
  • M. Tsuchiya et al., Studies on the Effects of 3 Acetyl 4 Isovaleryltylosin Against Multiple Drug Resistant Strains of Staphylococcus Aureus , J. Antibiotics 34(3), 305 306 (1981). (SEA)
  • Okamoto et al., "Biological Properties of New Acyl Derivatives of Tylosin", J. Antibiotics 33, 1309-1315 (1980). (UNKNOWN)
  • Okamoto et al., "The Activity of 4"-Acylated Tylosin Derivatives Against Macrolide-Resistant Gram-Positive Bacteria: J. Antibiotics 32, 542-544 (1979). (UNKNOWN)
  • Okamoto et al., Biological Properties of New Acyl Derivatives of Tylosin , J. Antibiotics 33, 1309 1315 (1980). (SEA)
  • Okamoto et al., The Activity of 4 Acylated Tylosin Derivatives Against Macrolide Resistant Gram Positive Bacteria: J. Antibiotics 32, 542 544 (1979). (SEA)
  • Sebek et al., Genetics of Industrial Microorganisms, Pub. by American Society for Microbiology, pp. 117 122 (1979). (SEA)
  • Sebek et al., Genetics of Industrial Microorganisms, Pub. by American Society for Microbiology, pp. 117-122 (1979). (UNKNOWN)

11 Cited By

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13 Information Sources

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