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Differentiation of stem cells into thyroid tissue

Patent
US-10449221-B2
Inventor

Kotton Darrell (US)

SERRA MARIA (IT)

HOLLENBERG ANTHONY N (US)

KURMANN ANITA A (US)

Assignee

UNIV BOSTON (US)

BETH ISRAEL DEACONESS MEDICAL CT INC (US)

Country
United States
Dates
  • Priority:
    2015/07/29
  • Grant:
    2019/10/22
Description
This web page summarizes information in PubChem about patent US-10449221-B2. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed, please visit the PubChem patents help page.

1 Abstract

Embodiments herein relate in vitro methods of stem cell differentiation into thyroid hormone producing cells and tissues, and methods of use of these cells.

2 Full Text

3 Important Dates

3.1 Priority Date

2015/07/29

3.2 Filing Date

2016/07/29

3.3 Publication Date

2019/10/22

3.4 Grant Date

2019/10/22

4 Inventor

Kotton Darrell (US)

SERRA MARIA (IT)

HOLLENBERG ANTHONY N (US)

KURMANN ANITA A (US)

5 Assignee

UNIV BOSTON (US)

BETH ISRAEL DEACONESS MEDICAL CT INC (US)

6 Country

United States

7 Linked Chemicals

7.1 PubChem Compounds

7.2 PubChem Substances

8 Patent Family

9 Classification

9.1 IPC

A61K38/22 (inventive)

A61K38/24 (inventive)

A61K35/55 (inventive, first)

C12N5/071 (inventive)

9.2 CPC

A61K35/55 (inventive, first)

A61K38/22 (inventive)

C12N2500/30

C12N2501/11

C12N2501/155

C12N2501/117

C12N2513/00

C12N2501/375

C12N2501/415

C12N2500/42

A61K38/24 (inventive)

C12N2501/115

C12N2533/90

C12N5/0617 (inventive)

10 Citations

  • US-2014329318-A1 (APP)
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  • Arufe et al., "Directed Differentiation of Mouse Embryonic Stem Cells into Thyroid Follicular Cells", Endocrinology 147(6):3007-3015 (2006). (APP)
  • Arufe et al., Differentiation of Murine Embryonic Stem Cells to Thyrocytes Requires Insulin and Insulin-Like Growth Factor-1 Biochem. Biophys. Res. Commun. 381(2):264-70 (2009). (APP,APP)
  • Bilodeau et al., "Identification of a Proximal Progenitor Population from Murine Fetal Lungs with Clonogenic and Multilineage Differentiation Potential", Stem Cell Reports 3:634-649 (2014). (APP)
  • Cheng et al., "Self-Renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells", Cell Stem Cell 10:371-384 (2012). (APP)
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  • Goss et al., "Wnt2/2b and β-Catenin Signaling Are Necessary and Sufficient to Specify Lung Progenitors in the Foregut", Dev. Cell 17:290-298 (2009). (APP)
  • Gotoh et al., "Generation of Alveolar Epithelial Spheroids via Isolated Progenitor Cells from Human Pluripotent Stem Cells", Stem Cells Reports 3:394-403 (2014). (APP)
  • Hilfer et al., "Follicle formation in the embryonic chick thryroid", Zeitschrift für Zellforschung and Mikroskopische Anatomie, 92(2):256-69 (1968). (APP)
  • Ishii et al., "Region-Specific Expression of Chicken Sox2 in the Developing Gut and Lung Epithelium: Regulation by Epithelial-Mesenchymal Interactions", Dev. Dyn. 213:464-475 (1998). (APP)
  • Jiang et al., "Differentiation of E14 Mouse Embryonic Stem Cells into Thyrocytes In Vitro", Thyroid, 20(1):77-84 (2010). (APP)
  • Krude et al., "Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency", J. Clin. Invest. 109(4):475-480 (2002). (APP)
  • Kurmann et al., "Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells", Cell Stem Cell 17:1-16 (2015). (APP)
  • Lancaster et al., "Organogenesis in a dish: Modeling development and disease using organoid technologies" Science, 345(6194):1247125 (2014). (APP)
  • Lau et al., "Stem Cells and Regenerative Medicine in Lung Biology and Diseases", Mol. Ther. 20(6):1116-1130 (2012). (APP)
  • Lin et al., "Committing Embryonic Stem Cells to Differentiate into Thyrocyte-Like Cells in Vitro", Endocrinology 144 (6):2644-2649 (2003). (APP)
  • Longmire et al., "Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells", Cell Stem Cell 10(4):398-411 (2012). (APP)
  • Ma et al., "Thyrotropin-Independent Induction of Thyroid Endoderm from Embryonic Stem Cells by Activin A", Endocrinology 150(4):1970-1975 (2009). (APP)
  • Mallette et al., "Growth in culture of trypsin dissociated thyroid cells from adult rats", Exp Cell Res, 41(3):642-51 (1966). (APP)
  • Martin et al., "Preservation of functioning human thyroid organoids in the scid mouse: 1. System characterization" J Clin Endocrinol Metab, 77(2):305-10 (1993). (APP)
  • McCracken et al., "Modeling human development and disease in pluripotent stem cell-derived gastric organoids", Nature 516(7531:400-404 (2014). (APP)
  • Mou et al. "Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs", Cell Stem Cell 10:385-397 (2012). (APP)
  • Murry et al., "Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development", 132:661-680 (2008). (APP)
  • Pagliuca et al., "Generation of Functional Human Pancreatic β Cells In Vitro", Cell 159:428-439 (2014). (APP)
  • Postiglione et al., "Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland", PNAS 99(24):15462-15467 (2002). (APP)
  • Sewell et al., "Generation of thyroid follicular cells from pluripotent stem cells: potential for regenerative medicine", Front. Endocrinol. 5(96):1-6 (2014). (APP)
  • Zuckier et al., "Kinetics of Perrhenate Uptake and Comparative Biodistribution of Perrhenate, Pertechnetate, and Iodide by Nal Symporter-Expressing Tissues In Vivo" J. Nucl. Med. 45(3):500-507 (2004). (APP)

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