Polynucleotide synthesis procedure
Patent
EP-0067597-A1
Inventor
BENDER ROBERT (CA)
OGILVIE KEVIN K (CA)
Assignee
ENS BIO LOGICALS INC (CA)
Country
European Patent Office
Dates
- Priority:1981/05/29
Description
This web page summarizes information in PubChem about patent EP-0067597-A1. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes. To read more about how this page was constructed, please visit the PubChem patents help page.
There is provided a process of preparing oligodeoxyribonucleotides which comprises incorporating ribonucleotide units at specific locations in deoxyribonucleotide chains, to provide predetermined cleavage sites which allow ease of chain cleavage. In one embodiment, a ribo unit is used as the a-unit to couple directly to a polymer support in synthesis, to increase the polymer-nucleoside initial loading. In another embodiment ribo units are used near the m-end of the chain, followed by a small terminal nucleotide sequence which can be used to separate the product from unwanted products by means of an affinity column. The polynucleotide chain can be treated with base or RNAse, to remove the ribo units therefrom after synthesis and purification.
1981/05/29
1982/05/28
1982/12/22
BENDER ROBERT (CA)
OGILVIE KEVIN K (CA)
ENS BIO LOGICALS INC (CA)
European Patent Office
C07H21/00 (inventive)
C07H21/00 (inventive, first)
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- Google PatentsLICENSE"Google Patents Research Data" by Google, based on data provided by IFI CLAIMS Patent Services and OntoChem, is licensed under a Creative Commons Attribution 4.0 International License.https://creativecommons.org/licenses/by/4.0/legalcode
- PubChem
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