Pafah2 - platelet-activating factor acetylhydrolase 2 (Norway rat)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-01-17
Description
Enables 1-alkyl-2-acetylglycerophosphocholine esterase activity and platelet-activating factor acetyltransferase activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm. Orthologous to human PAFAH2 (platelet activating factor acetylhydrolase 2).
- platelet-activating factor acetylhydrolase 2, cytoplasmic
- PAF:lysophospholipid transacetylase
- PAF:sphingosine transacetylase
- SD-PLA2
- platelet-activating factor acetylhydrolase 2, 40kDa
- platelet-activating factor acetyltransferase PAFAH2
- serine-dependent phospholipase A2
- PAFAH2 (human)
- PAFAH2 (black-footed ferret)
- PAFAH2 (European mink)
- PAFAH2 (Ahaetulla prasina)
- PAFAH2 (red-backed fairy wren)
- PAFAH2 (Oenanthe melanoleuca)
- PAFAH2 (Chinese forest musk deer)
- PAFAH2 (raccoon dog)
- PAFAH2 (Leopard gecko)
- PAFAH2 (Pteronotus mesoamericanus)
- PAFAH2 (black-legged kittiwake)
- PAFAH2 (Aeolian wall lizard)
- PAFAH2 (graceful crag lizard)
- PAFAH2 (lesser prairie-chicken)
- PAFAH2 (takin)
- PAFAH2 (yellow-footed antechinus)
- PAFAH2 (California condor)
- PAFAH2 (Macaca thibetana thibetana)
- PAFAH2 (Northern goshawk)
- PAFAH2 (snow leopard)
- PAFAH2 (rock ptarmigan)
- PAFAH2 (Loggerhead turtle)
- PAFAH2 (Sphaerodactylus townsendi)
- PAFAH2 (Eurasian river otter)
- PAFAH2 (bobcat)
- PAFAH2 (greater spear-nosed bat)
- PAFAH2 (American black bear)
- PAFAH2 (Ring-tailed lemur)
- PAFAH2 (Agile Gracile Mouse Opossum)
- PAFAH2 (Komodo dragon)
- PAFAH2 (American mink)
- PAFAH2 (leopard cat)
- PAFAH2 (wapiti)
- PAFAH2 (fence lizard)
- PAFAH2 (Arctic fox)
- PAFAH2 (rufous-necked snowfinch)
- PAFAH2 (white-rumped snowfinch)
- PAFAH2 (jaguarundi)
- PAFAH2 (common toad)
- PAFAH2 (scimitar-horned oryx)
- PAFAH2 (Barn swallow)
- PAFAH2 (Eurasian tree sparrow)
- PAFAH2 (Reeves's turtle)
- PAFAH2 (Tiger rattlesnake)
- PAFAH2 (striped hyena)
- PAFAH2 (leatherback sea turtle)
- PAFAH2 (mallard)
- PAFAH2 (Iberian mole)
- PAFAH2 (Jamaican fruit-eating bat)
- PAFAH2 (Sturnira hondurensis)
- PAFAH2 (Kuhl's pipistrelle)
- PAFAH2 (Myotis myotis)
- PAFAH2 (Pallas's mastiff bat)
- PAFAH2 (black swan)
- PAFAH2 (common lizard)
- PAFAH2 (Southern elephant seal)
- PAFAH2 (Trachemys scripta elegans)
- PAFAH2 (Pantherophis guttatus)
- PAFAH2 (Gaboon caecilian)
- PAFAH2 (Francois's langur)
- PAFAH2 (greater horseshoe bat)
- PAFAH2 (sea lamprey)
- PAFAH2 (Abingdon island giant tortoise)
- PAFAH2 (silvery gibbon)
- PAFAH2 (vaquita)
- PAFAH2 (tufted duck)
- PAFAH2 (ring-necked pheasant)
- PAFAH2 (Microcaecilia unicolor)
- PAFAH2 (Aquila chrysaetos chrysaetos)
- PAFAH2 (Common wall lizard)
- PAFAH2 (pale spear-nosed bat)
- PAFAH2 (Steller sea lion)
- PAFAH2 (willow flycatcher)
- PAFAH2 (California sea lion)
- PAFAH2 (burrowing owl)
- PAFAH2 (eastern brown snake)
- PAFAH2 (mainland tiger snake)
- PAFAH2 (brown bear)
- PAFAH2 (emu)
- PAFAH2 (Okarito brown kiwi)
- PAFAH2 (Nothoprocta perdicaria)
- PAFAH2 (red fox)
- PAFAH2 (puma)
- PAFAH2 (dingo)
- PAFAH2 (gelada)
- PAFAH2 (Yangtze finless porpoise)
- PAFAH2 (common vampire bat)
- PAFAH2 (blue tit)
- PAFAH2 (Ugandan red Colobus)
- PAFAH2 (beluga whale)
- PAFAH2 (Hawaiian monk seal)
- PAFAH2 (helmeted guineafowl)
- PAFAH2 (koala)
- PAFAH2 (central bearded dragon)
- PAFAH2 (zebu cattle)
- PAFAH2 (great roundleaf bat)
- PAFAH2 (Australian saltwater crocodile)
- PAFAH2 (Gharial)
- PAFAH2 (leopard)
- PAFAH2 (black snub-nosed monkey)
- PAFAH2 (Malayan pangolin)
- PAFAH2 (Panamanian white-faced capuchin)
- PAFAH2 (Miniopterus natalensis)
- PAFAH2 (Egyptian rousette)
- PAFAH2 (Japanese quail)
- PAFAH2 (Taiwan habu)
- PAFAH2 (Great Tit)
- PAFAH2 (Gekko japonicus)
- PAFAH2 (cheetah)
- PAFAH2 (Common starling)
- PAFAH2 (ass)
- PAFAH2 (Thamnophis sirtalis)
- PAFAH2 (North Island brown kiwi)
- PAFAH2 (Swan goose)
- PAFAH2 (gray mouse lemur)
- PAFAH2 (Coquerel's sifaka)
- PAFAH2 (sooty mangabey)
- PAFAH2 (drill)
- PAFAH2 (Colobus angolensis palliatus)
- PAFAH2 (pig-tailed macaque)
- PAFAH2 (large flying fox)
- PAFAH2 (Arabian camel)
- PAFAH2 (Bactrian camel)
- PAFAH2 (Bison bison bison)
- PAFAH2 (bald eagle)
- PAFAH2 (golden snub-nosed monkey)
- PAFAH2 (East African grey crowned-crane)
- PAFAH2 (White-tailed tropicbird)
- PAFAH2 (white-throated tinamou)
- PAFAH2 (chuck-will's-widow)
- PAFAH2 (sunbittern)
- PAFAH2 (Buceros rhinoceros silvestris)
- PAFAH2 (yellow-throated sandgrouse)
- PAFAH2 (chimney swift)
- PAFAH2 (red-crested turaco)
- PAFAH2 (common barn owl)
- PAFAH2 (cuckoo roller)
- PAFAH2 (hoatzin)
- PAFAH2 (Downy woodpecker)
- PAFAH2 (bar-tailed trogon)
- PAFAH2 (red-throated loon)
- PAFAH2 (African ostrich)
- PAFAH2 (little egret)
- PAFAH2 (Northern fulmar)
- PAFAH2 (common cuckoo)
- PAFAH2 (Dalmatian pelican)
- PAFAH2 (crested ibis)
- PAFAH2 (Adelie penguin)
- PAFAH2 (emperor penguin)
- PAFAH2 (Common canary)
- PAFAH2 (rifleman)
- PAFAH2 (carmine bee-eater)
- PAFAH2 (polar bear)
- PAFAH2 (American crow)
- PAFAH2 (Sunda flying lemur)
- PAFAH2 (Przewalski's horse)
- PAFAH2 (big brown bat)
- PAFAH2 (Philippine tarsier)
- PAFAH2 (green monkey)
- PAFAH2 (Yangtze River dolphin)
- PAFAH2 (Burmese python)
- PAFAH2 (minke whale)
- PAFAH2 (sperm whale)
- PAFAH2 (tiger)
- PAFAH2 (Green sea turtle)
- PAFAH2 (black flying fox)
- PAFAH2 (Myotis davidii)
- PAFAH2 (Weddell seal)
- PAFAH2 (American alligator)
- PAFAH2 (alpaca)
- PAFAH2 (Wild Bactrian camel)
- PAFAH2 (Chinese tree shrew)
- PAFAH2 (Chinese soft-shelled turtle)
- PAFAH2 (little brown bat)
- PAFAH2 (water buffalo)
- PAFAH2 (Chinese alligator)
- PAFAH2 (wild yak)
- PAFAH2 (Brandt's bat)
- PAFAH2 (goat)
- PAFAH2 (crab-eating macaque)
- PAFAH2 (Tibetan ground-tit)
- PAFAH2 (Saker falcon)
- PAFAH2 (medium ground-finch)
- Pafah2 (long-tailed chinchilla)
- PAFAH2 (western painted turtle)
- PAFAH2 (peregrine falcon)
- PAFAH2 (Collared flycatcher)
- PAFAH2 (domestic ferret)
- PAFAH2 (small Madagascar hedgehog)
- PAFAH2 (European shrew)
- PAFAH2 (American pika)
- PAFAH2 (nine-banded armadillo)
- PAFAH2 (Pacific walrus)
- PAFAH2 (western lowland gorilla)
- PAFAH2 (sheep)
- PAFAH2 (domestic cat)
- PAFAH2 (Bolivian squirrel monkey)
- PAFAH2 (olive baboon)
- PAFAH2 (pygmy chimpanzee)
- PAFAH2 (small-eared galago)
- PAFAH2 (Tasmanian devil)
- PAFAH2 (African savanna elephant)
- PAFAH2 (pig)
- PAFAH2 (northern white-cheeked gibbon)
- PAFAH2 (turkey)
- PAFAH2 (giant panda)
- PAFAH2 (Sumatran orangutan)
- PAFAH2 (white-tufted-ear marmoset)
- pafah2 (tropical clawed frog)
- PAFAH2 (rabbit)
- PAFAH2 (platypus)
- PAFAH2 (horse)
- PAFAH2 (gray short-tailed opossum)
- PAFAH2 (chicken)
- PAFAH2 (Rhesus monkey)
- PAFAH2 (dog)
- PAFAH2 (chimpanzee)
- PAFAH2 (domestic cattle)
- Pafah2 (house mouse)
Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PMID: 10085103). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively (PMID: 10085103). Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (PMID: 10085103).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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