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PAFAH2 - platelet activating factor acetylhydrolase 2 (domestic cattle)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-01-28

1 Names and Identifiers

1.1 Synonyms

  • platelet-activating factor acetylhydrolase 2, cytoplasmic
  • PAF acetylhydrolase II
  • PAF:lysophospholipid transacetylase
  • PAF:sphingosine transacetylase
  • SD-PLA2
  • platelet-activating factor acetylhydrolase 2, 40kDa
  • platelet-activating factor acetyltransferase PAFAH2
  • serine-dependent phospholipase A2

1.1.1 MeSH Entry Terms

  • Lipoprotein-Associated Phospholipase A(2)
  • Lipoprotein-Associated Phospholipase A2
  • Lp-PLA2
  • Lp-PLA(2)
  • PAF 2-Acetylhydrolase
  • PAF Acetylhydrolase
  • PAF 2-Acylhydrolase
  • PAF Acetylhydrolase II
  • Platelet-activating Factor Acetylhydrolase IB
  • Platelet-Activating Factor Hydrolase

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Bgee Gene ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 GlyCosmos Gene

1.2.5 VEuPathDB ID

3 Proteins

3.1 Protein Function

Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PMID: 7673213, PMID: 8955149, PMID: 9405438). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (PMID: 7673213). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity).

3.2 Protein Targets

4 Interactions and Pathways

4.1 Pathways

5 Biochemical Reactions

6 Expression

7 Literature

7.1 NLM Curated PubMed Citations

7.2 Gene-Chemical Co-Occurrences in Literature

7.3 Gene-Gene Co-Occurrences in Literature

7.4 Gene-Disease Co-Occurrences in Literature

8 Patents

8.1 Gene-Chemical Co-Occurrences in Patents

8.2 Gene-Gene Co-Occurrences in Patents

8.3 Gene-Disease Co-Occurrences in Patents

9 Classification

9.1 MeSH Tree

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
    1-Alkyl-2-acetylglycerophosphocholine Esterase
    https://meshb.nlm.nih.gov/record/ui?ui=D043203
  4. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  5. NCBI Gene Expression Omnibus (GEO)
  6. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  7. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  8. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  9. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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