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Cd93 - CD93 antigen (house mouse)

Gene
Symbol
Dates
  • Create:
    2016-09-14
  • Modify:
    2025-02-02
Description
Predicted to enable complement component C1q complex binding activity. Predicted to be involved in cell-cell adhesion. Located in cell surface; cytoplasmic vesicle; and plasma membrane. Is expressed in blood vessel and early conceptus. Orthologous to human CD93 (CD93 molecule).

1 Names and Identifiers

1.1 Synonyms

  • 6030404G09Rik
  • AA4.1
  • C1qr1
  • C1qrp
  • Ly68
  • complement component C1q receptor
  • C1q/MBL/SPA receptor
  • C1qR(p)
  • cell surface antigen AA4
  • complement component 1, q subcomponent, receptor 1
  • ly-68
  • lymphocyte antigen 68

1.2 Other Identifiers

1.2.1 Ensembl ID

1.2.2 Alliance Gene ID

1.2.3 Bgee Gene ID

1.2.4 MGI ID

1.2.5 VEuPathDB ID

1.2.6 Wikidata

3 Proteins

3.1 Protein Function

Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion (PMID: 15004139, PMID: 20439917, PMID: 38441970). Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PMID: 15004139). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function (By similarity). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (PMID: 38441970).

3.2 Protein 3D Structures

3.2.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

3.3 Protein Targets

4 BioAssays

4.1 RNAi BioAssays

5 Interactions and Pathways

5.1 Interactions

6 Expression

7 Literature

7.1 Gene-Chemical Co-Occurrences in Literature

7.2 Gene-Gene Co-Occurrences in Literature

7.3 Gene-Disease Co-Occurrences in Literature

8 Patents

8.1 Gene-Chemical Co-Occurrences in Patents

8.2 Gene-Gene Co-Occurrences in Patents

8.3 Gene-Disease Co-Occurrences in Patents

9 Classification

9.1 Gene Ontology: Biological Process

9.2 Gene Ontology: Cellular Component

9.3 Gene Ontology: Molecular Function

10 Information Sources

  1. NCBI Gene
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Alliance of Genome Resources
    LICENSE
    All annotations and data produced by Alliance members that are accessible from alliancegenome.org are distributed under a CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
    https://www.alliancegenome.org/privacy-warranty-licensing
  4. Mouse Genome Informatics (MGI)
    LICENSE
    MGI data and annotations are licensed under a Creative Commons Attribution 4.0 International License (CC-BY).
    https://www.informatics.jax.org/mgihome/other/copyright.shtml
  5. NCBI Gene Expression Omnibus (GEO)
  6. STRING: functional protein association networks
  7. Swiss Institute of Bioinformatics Bgee
    LICENSE
    Creative Commons Zero license (CC0)
    https://www.bgee.org/about/
  8. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  9. VEuPathDB: The Eukaryotic Pathogen, Vector and Host Informatics Resource
    LICENSE
    All data on VEuPathDB websites are provided freely for public use.
    https://veupathdb.org/veupathdb/app/static-content/about.html
  10. Wikidata
  11. Gene Ontology (GO)
    LICENSE
    Gene Ontology Consortium data and data products are licensed under the Creative Commons Attribution 4.0 Unported License (https://creativecommons.org/licenses/by/4.0/legalcode)
    http://geneontology.org/docs/go-citation-policy/
  12. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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