Eng - endoglin (house mouse)
Gene
Symbol
Taxonomy
Dates
- Create:2016-09-14
- Modify:2025-02-02
Description
Enables protein homodimerization activity and transforming growth factor beta binding activity. Involved in several processes, including circulatory system development; positive regulation of cell differentiation; and regulation of gene expression. Acts upstream of or within angiogenesis; cell migration involved in endocardial cushion formation; and positive regulation of angiogenesis. Located in endothelial microparticle. Is expressed in several structures, including aorta-gonad-mesonephros; brain; cardiovascular system; extraembryonic component; and liver. Used to study arteriovenous malformations of the brain and hereditary hemorrhagic telangiectasia. Human ortholog(s) of this gene implicated in artery disease (multiple); breast cancer; hemangioma (multiple); and hereditary hemorrhagic telangiectasia. Orthologous to human ENG (endoglin).
- CD105
- Endo
- S-endoglin
- cell surface MJ7/18 antigen
- transmembrane glycoprotein
- CD105 Antigen
- Endoglin Protein
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis (PMID: 10625534). Required for normal structure and integrity of adult vasculature (By similarity). Regulates the migration of vascular endothelial cells (PMID: 17540773). Required for normal extraembryonic angiogenesis and for embryonic heart development (PMID: 10625534). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (PMID: 28530658). May play a role in the binding of endothelial cells to integrins. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors (PMID: 23300529). Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3 (By similarity).
Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605
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