Beta-Carotene
- beta-carotene
- 7235-40-7
- beta Carotene
- beta,beta-Carotene
- Solatene
- Create:2004-09-16
- Modify:2025-01-18
- BellaCarotin
- beta Carotene
- beta-Carotene
- Betacarotene
- Carotaben
- Carotene, beta
- Max Caro
- Max-Caro
- MaxCaro
- Provatene
- Solatene
- Vetoron
- beta-carotene
- 7235-40-7
- beta Carotene
- beta,beta-Carotene
- Solatene
- Betacarotene
- Provatene
- Carotaben
- Provitamin A
- Serlabo
- all-trans-beta-Carotene
- Food orange 5
- Lucaratin
- BetaVit
- KPMK
- b,b-Carotene
- Betacaroteno
- Provatenol
- Karotin
- Natural Yellow 26
- beta-Karotin
- Solatene (caps)
- C.I. Food Orange 5
- Zlut prirodni 26
- Betacarotenum
- CI Food Orange 5
- Carotene,beta
- .beta.-Carotene
- Lucarotin 30sun
- .beta.,.beta.-Carotene
- trans-beta-Carotene
- beta-Carotene, all-trans-
- Beta, beta-carotene
- CI 40800
- CI 75130
- Betacarotenum [Latin]
- NSC 62794
- C.I. 75130
- CCRIS 3245
- Ins-160a(iii)
- Ins no.160a(iii)
- Caroten base 35468
- beta-Carotin
- HSDB 3264
- beta;-Carotene
- Diet,beta-carotene supplementation
- E-160a(iii)
- E160A
- .beta. Carotene
- all-trans-.beta.-Carotene
- (all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene)
- EINECS 230-636-6
- UNII-01YAE03M7J
- Betacarotene [INN]
- 01YAE03M7J
- 1,3,3-trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohexen-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]cyclohexene
- 116-32-5
- DTXSID3020253
- CHEBI:17579
- Rovimix .beta.-carotene
- NSC62794
- NSC-62794
- DTXCID10253
- b-Carotene
- MLS001066383
- 1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene), (all E)-
- 2,2'-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(1,3,3-trimethylcyclohex-1-ene)
- C.I.-40800
- EC 230-636-6
- Betacarotene (INN)
- MFCD00001556
- Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis(2,6,6-trimethyl-, (all-E)-
- Betacarotenum (Latin)
- CAROTENE, BETA
- NCGC00096081-01
- SMR000112037
- Karotin [Czech]
- BETACAROTENE (MART.)
- BETACAROTENE [MART.]
- .beta.-Carotene, all-trans-
- beta carotene [USAN]
- Betacaroteno [Spanish]
- BETACAROTENE (EP IMPURITY)
- BETACAROTENE [EP IMPURITY]
- BETACAROTENE (EP MONOGRAPH)
- BETACAROTENE [EP MONOGRAPH]
- beta -carotene
- BETA CAROTENE (USP MONOGRAPH)
- BETA CAROTENE [USP MONOGRAPH]
- Betacarotenum [INN-Latin]
- Betacaroteno [INN-Spanish]
- Zlut prirodni 26 [Czech]
- 1,1'-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl]bis(2,6,6-trimethylcyclohexene)
- SR-01000763803
- Beta carotene [USAN:USP]
- Lucarotin
- Lumitene
- Lurotin
- 9-cis--Carotene
- all-E-b-Carotene
- Rovimix b-carotene
- Carotene, .beta.
- Solatene (TN)
- 1,1'-((1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyloctadeca-1,3,5,7,9,11,13,15,17-nonaene-1,18-diyl)bis(2,6,6-trimethylcyclohexene)
- Cyclohexene, 1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethyl-, (all-E)-
- I(2)-Carotene
- Carotene Base 80S
- all-trans-b-Carotene
- beta Carotene (USP)
- trans-.beta.-Carotene
- all trans beta-Carotene
- b-Carotene - 30%
- all-E-.beta.-Carotene
- all-epsilon-beta-Carotene
- Spectrum5_000505
- ROVIMIX beta-CAROTENE
- .beta., .beta.-Carotene
- bmse000832
- C40H56 (beta-carotene)
- BETA CAROTENE [DSC]
- BETA-CAROTENE [FCC]
- CHEMBL1293
- BIDD:PXR0110
- BETA CAROTENE [HSDB]
- BSPBio_003404
- BETA CAROTENE [VANDF]
- BETACAROTENE [WHO-DD]
- CAROTENE,BETA [VANDF]
- .BETA.-CAROTENE [MI]
- BETA CAROTENE [USP-RS]
- BDBM54988
- cid_5280489
- HMS501A12
- HY-N0411R
- .beta.,.beta.-Carotene, neo B
- A11CA02
- D02BB01
- HMS2091M17
- Pharmakon1600-01500143
- BETA CAROTENE [ORANGE BOOK]
- HY-N0411
- beta-Carotene, >=97.0% (UV)
- Tox21_111557
- CCG-36062
- LMPR01070001
- NSC755910
- s1767
- AKOS015896682
- 1ST1569
- AC-1869
- DB06755
- NSC-755910
- SDCCGMLS-0066579.P001
- IDI1_000330
- NCGC00096081-02
- |A
- AS-13354
- XC175229
- CAS-7235-40-7
- SBI-0051295.P003
- NS00002019
- SW220035-1
- C02094
- D03101
- AB00051925_06
- AB00051925_07
- BETA-CAROTENE (CONSTITUENT OF SPIRULINA)
- beta-Carotene, Vetec(TM) reagent grade, >=93%
- EN300-21680271
- Q306135
- Q-200706
- SR-01000763803-2
- SR-01000763803-3
- SR-01000763803-4
- BETA-CAROTENE (CONSTITUENT OF SPIRULINA) [DSC]
- BRD-K74225533-001-08-8
- BRD-K74225533-001-09-6
- BRD-K74225533-001-10-4
- beta-Carotene, Type I, synthetic, >=93% (UV), powder
- 89648336-F9B2-44A0-9BF8-62E73369CB9B
- Beta Carotene, United States Pharmacopeia (USP) Reference Standard
- beta-Carotene, Type II, synthetic, >=95% (HPLC), crystalline
- BETA-CAROTENE (CONSTITUENT OF LYCOPENE AND TOMATO EXTRACT CONTAINING LYCOPENE)
- beta-Carotene, Pharmaceutical Secondary Standard; Certified Reference Material
- (all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5, 7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6, 6-trimethylcyclohexene]
- (all-E)-1,1'-(3,7,12,16-Tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis
- (all-E)-1,1'-(3,7,12,16-tetramethyl-1,3,5,7,9,11,13,15,17-octadecanonaene-1,18-diyl)bis[2,6,6-trimethyl-Cyclohexene
- 1,3,3-trimethyl-2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethylcyclohex-1-en-1-yl)octadeca-1,3,5,7,9,11,13,15,17-nonaen-1-yl]cyclohex-1-ene
- 3,7,12,16-tetramethyl-1,18-bis(2,6,6-trimethyl-1-cyclohexenyl)-octadeca-1,3,5,7,9,11,13,15,17-nonaene
536.5316 1
105.0893 1
119.0738 0.90
91.068 0.81
69.0671 0.69
444.388519 100
445.342072 30.19
281.320251 6
399.321381 5.60
255.197662 5.06
444.3765 999
105.0709 624
171.1159 550
107.0871 541
237.1633 519
536.4366 999
444.3743 836
161.1307 199
119.0857 194
445.3763 144
536.5316 999
105.0893 999
119.0738 901
91.068 805
69.0671 689
- Lycopene (part of)
- Broccoli (part of)
- Lycium barbarum fruit (part of)
- Adipose Tissue
- Adrenal Gland
- Epidermis
- Erythrocyte
- Fibroblasts
- Intestine
- Liver
- Placenta
- Platelet
- Prostate
- Spleen
- Cytoplasm
- Extracellular
- Membrane
Use (kg; approx.) in Germany (2009): >50
Consumption (g per capita; approx.) in Germany (2009): 0.000611
Calculated removal (%): 94
Information on 35 consumer products that contain beta-Carotene in the following categories is provided:
• Personal Care
Not Classified
Reported as not meeting GHS hazard criteria by 294 of 350 companies
Aggregated GHS information provided per 350 reports by companies from 7 notifications to the ECHA C&L Inventory.
Reported as not meeting GHS hazard criteria per 294 of 350 reports by companies. For more detailed information, please visit ECHA C&L website.
There are 6 notifications provided by 56 of 350 reports by companies with hazard statement code(s).
Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.
◉ Summary of Use during Lactation
Beta-carotene is a plant pigment that is converted into vitamin A in the body. Maternal vitamin A requirements are increased during lactation, but there are no specific guidelines for increased beta-carotene intake or indications for high-dose supplementation in nursing mothers. Typical beta-carotene intake in a Western diet is 6 to 8 mg daily. Beta-carotene is a normal component of human colostrum and mature milk, where it contributes to antioxidant defenses in the neonate. A systematic review found that in infants younger than 6 months, those fed primarily human milk have greater blood carotenoid concentrations than those fed formula. Some evidence suggests that there is a correlation between beta-carotene and infant motor development in exclusively breastfed infants, but not in overall psychomotor performance. Beta-carotene supplementation during pregnancy and for 6 months postpartum in nursing mothers with poor diets in a resource-poor setting reduced the number of days of illness in the mothers, but does not reduce infant morbidity or mortality according to another study. The bioavailability of beta-carotene is dependent on the fat content of the meal and the form in which it is administered, with synthetic pharmaceutical forms having the best bioavailability. High-dose beta-carotene supplements lead to a slow increase in breastmilk beta-carotene concentrations, with an accumulation half-life of about 9 days. Levels drop towards baseline slowly over several weeks after discontinuation. In general, beta-carotene is well tolerated, although excessive maternal intake of beta-carotene can lead to a harmless, reversible discoloration of the breastfed infant's skin. In HIV-infected women, high-dose beta-carotene plus vitamin A supplementation increases the rate of HIV viral shedding into breastmilk and increases HIV infection in breastfed infants, although the mortality rate over the first 2 years of life is not increased. The viral shedding may be a result of an increase in subclinical mastitis caused by beta-carotene. Beta-carotene concentration in breastmilk is not affected by refrigeration, freezing, or low-temperature microwaving. The concentration does decrease when milk passes through a tube feeding system, regardless of light exposure.
Dietary supplements do not require extensive pre-marketing approval from the U.S. Food and Drug Administration. Manufacturers are responsible to ensure the safety, but do not need to prove the safety and effectiveness of dietary supplements before they are marketed. Dietary supplements may contain multiple ingredients, and differences are often found between labeled and actual ingredients or their amounts. A manufacturer may contract with an independent organization to verify the quality of a product or its ingredients, but that does not certify the safety or effectiveness of a product. Because of the above issues, clinical testing results on one product may not be applicable to other products. More detailed information about dietary supplements is available elsewhere on the LactMed Web site.
◉ Effects in Breastfed Infants
A nursing mother was eating 2 to 3 pounds of carrots a week as raw and cooked carrots. The mother's skin was yellow in color, but her sclera were clear. At 2 months of age, her breastfed infant was diagnosed as having jaundice because of a yellow coloration of the skin. Breastfeeding was discontinued and the infant's skin returned to a normal color. The mother continued her diet and examination of the maternal serum found elevated levels of beta-carotene which was probably the cause of her infant's skin discoloration.
HIV-infected women in Tanzania received 1 of 4 supplements during pregnancy and lactation in a series of studies. Groups received either multivitamins (thiamine, riboflavin, vitamin B6, niacin, vitamin B12, vitamin C, vitamin E, and folic acid), multivitamins plus vitamin A and beta-carotene, vitamin A and beta-carotene alone, or placebo daily. The beta-carotene dose was 30 mg. At 24 months of age, the multivitamin-supplemented group's infants had significantly better growth parameters than the other groups. One study found that the infants of mothers supplemented with vitamin A and beta-carotene had a higher rate of HIV transmission than those supplemented with multivitamins alone or placebo. After 6 months postpartum, women who received vitamin A plus beta-carotene had greater shedding of the HIV virus into breastmilk than women who had not; multivitamins without vitamin A and beta-carotene did not increase viral shedding. Beta-carotene appeared to have a shedding effect that was independent of vitamin A. One possible explanation comes from another similar study in which those who received vitamin A plus beta-carotene alone had a 45% increased risk of severe subclinical mastitis and those who received multivitamins plus vitamin A and beta-carotene had a 29% increased risk of severe subclinical mastitis.
Breastmilk samples were collected at the first, third and sixth months postpartum from 39 mother-infant pairs of exclusively breastfed infants. Psychomotor testing found a correlation between beta-carotene intake in breastmilk during the first 3 months of life and infant motor development, but not overall psychomotor development, at 6 months of life. Some long-chain polyunsaturated fatty acids, DHA, alpha-linolenic acid and total n-3 PUFAs, also correlated with motor development.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
PubMed: 12067838, 22279428, 16452910
Lorena Ivona ŞTEFAN, Alina NICOLESCU, Simona POPA, Maria MOŢA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037
Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children
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- Australian Industrial Chemicals Introduction Scheme (AICIS).beta.,.beta.-Carotenehttps://services.industrialchemicals.gov.au/search-inventory/
- EU Food Improvement AgentsBETA-CAROTENEhttp://data.europa.eu/eli/reg/2012/231/2024-04-23
- CAS Common ChemistryLICENSEThe data from CAS Common Chemistry is provided under a CC-BY-NC 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc/4.0/
- ChemIDplusBeta carotene [USAN:USP]https://pubchem.ncbi.nlm.nih.gov/substance/?source=chemidplus&sourceid=0007235407ChemIDplus Chemical Information Classificationhttps://pubchem.ncbi.nlm.nih.gov/source/ChemIDplus
- DrugBankLICENSECreative Common's Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/legalcode)https://www.drugbank.ca/legal/terms_of_useBeta carotenehttps://www.drugbank.ca/drugs/DB06755
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- EPA DSSToxbeta-Carotenehttps://comptox.epa.gov/dashboard/DTXSID3020253CompTox Chemicals Dashboard Chemical Listshttps://comptox.epa.gov/dashboard/chemical-lists/
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- ChEBI
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- DailyMed
- Drugs and Lactation Database (LactMed)Beta-Carotenehttps://www.ncbi.nlm.nih.gov/books/n/lactmed/LM985/
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- ECI Group, LCSB, University of Luxembourgbeta-carotene
- KNApSAcK Species-Metabolite Database
- Natural Product Activity and Species Source (NPASS)
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- KEGGLICENSEAcademic users may freely use the KEGG website. Non-academic use of KEGG generally requires a commercial licensehttps://www.kegg.jp/kegg/legal.htmlPhytochemical compoundshttp://www.genome.jp/kegg-bin/get_htext?br08003.kegAnatomical Therapeutic Chemical (ATC) classificationhttp://www.genome.jp/kegg-bin/get_htext?br08303.keg
- LIPID MAPSBeta-carotenehttps://lipidmaps.org/databases/lmsd/LMPR01070001Lipid Classificationhttps://www.lipidmaps.org/
- MarkerDBLICENSEThis work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.https://markerdb.ca/B-Carotenehttps://markerdb.ca/chemicals/294
- Metabolomics Workbench
- National Drug Code (NDC) DirectoryLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
- Nature Chemical Biology
- NIST Mass Spectrometry Data CenterLICENSEData covered by the Standard Reference Data Act of 1968 as amended.https://www.nist.gov/srd/public-law.beta. Carotenehttp://www.nist.gov/srd/nist1a.cfm
- SpectraBase.beta.,.beta.-Carotenehttps://spectrabase.com/spectrum/58h2OvtEgxn.beta.,.beta.-Carotenehttps://spectrabase.com/spectrum/36hDwcd11wbbeta-CAROTENEhttps://spectrabase.com/spectrum/7xrKAb82ocIbeta,beta-Carotenehttps://spectrabase.com/spectrum/4wt7HRno7Vvbeta-Carotenehttps://spectrabase.com/spectrum/CKq837LVa0Cbeta-Carotenehttps://spectrabase.com/spectrum/G3qiBvH2Ddfbeta-carotenehttps://spectrabase.com/spectrum/1OgxapO6lh7beta-Carotenehttps://spectrabase.com/spectrum/H57sgjvlPQf.BETA.,.BETA.-CAROTENEhttps://spectrabase.com/spectrum/7drtEgQ7X23.beta.-Carotenehttps://spectrabase.com/spectrum/K5LOh54gD3Q
- NLM RxNorm TerminologyLICENSEThe RxNorm Terminology is created by the National Library of Medicine (NLM) and is in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from NLM. Credit to the U.S. National Library of Medicine as the source is appreciated but not required. The full RxNorm dataset requires a free license.https://www.nlm.nih.gov/research/umls/rxnorm/docs/termsofservice.htmlbeta carotenehttps://rxnav.nlm.nih.gov/id/rxnorm/19143
- WHO Anatomical Therapeutic Chemical (ATC) ClassificationLICENSEUse of all or parts of the material requires reference to the WHO Collaborating Centre for Drug Statistics Methodology. Copying and distribution for commercial purposes is not allowed. Changing or manipulating the material is not allowed.https://www.whocc.no/copyright_disclaimer/Betacarotenehttps://www.whocc.no/atc_ddd_index/?code=A11CA02Betacarotenehttps://www.whocc.no/atc_ddd_index/?code=D02BB01
- PharosLICENSEData accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.https://pharos.nih.gov/aboutbeta-CAROTENEhttps://pharos.nih.gov/ligands/27VJF3VGNDZTBeta-carotenehttps://pharos.nih.gov/ligands/377Q585USY9W
- Protein Data Bank in Europe (PDBe)
- RCSB Protein Data Bank (RCSB PDB)LICENSEData files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.https://www.rcsb.org/pages/policies
- Rhea - Annotated Reactions DatabaseLICENSERhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.https://www.rhea-db.org/help/license-disclaimer
- Springer Nature
- SpringerMaterialsC40H56 (beta-carotene)https://materials.springer.com/substanceprofile/docs/smsid_oyaacijsdozntwqu
- The Cambridge Structural Database
- Thieme ChemistryLICENSEThe Thieme Chemistry contribution within PubChem is provided under a CC-BY-NC-ND 4.0 license, unless otherwise stated.https://creativecommons.org/licenses/by-nc-nd/4.0/
- Wikidataβ-carotenehttps://www.wikidata.org/wiki/Q306135
- Wiley
- Medical Subject Headings (MeSH)LICENSEWorks produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.https://www.nlm.nih.gov/copyright.htmlbeta Carotenehttps://www.ncbi.nlm.nih.gov/mesh/68019207Provitaminshttps://www.ncbi.nlm.nih.gov/mesh/2016761
- PubChem
- GHS Classification (UNECE)GHS Classification Treehttp://www.unece.org/trans/danger/publi/ghs/ghs_welcome_e.html
- EPA Substance Registry ServicesEPA SRS List Classificationhttps://sor.epa.gov/sor_internet/registry/substreg/LandingPage.do
- MolGenieMolGenie Organic Chemistry Ontologyhttps://github.com/MolGenie/ontology/
- PATENTSCOPE (WIPO)SID 390304493https://pubchem.ncbi.nlm.nih.gov/substance/390304493SID 392465630https://pubchem.ncbi.nlm.nih.gov/substance/392465630SID 403433368https://pubchem.ncbi.nlm.nih.gov/substance/403433368SID 403879257https://pubchem.ncbi.nlm.nih.gov/substance/403879257