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Capreomycin Sulfate

PubChem Reference Collection SID
PubChem CID
Not available and might not be a discrete structure.
Synonyms
  • Capreomycin Sulfate
  • 1405-37-4
  • Capastat sulfate
  • 215-776-8
  • 9H8D3J7V21
Description
Capreomycin Sulfate is a calcium salt form of capreomycin, a cyclic polypeptide isolated from Streptomyces capreolus with antitubercular activity. Capreomycin acts by blocking bacterial ribosomal translocation.
See also: Capreomycin (has active moiety).

1 Synonyms

  • Capreomycin Sulfate
  • 1405-37-4
  • Capastat sulfate
  • 215-776-8
  • 9H8D3J7V21
  • Ogostal
  • CAPREOMYCIN SULFATE (MART.)
  • CAPREOMYCIN SULFATE (USP IMPURITY)
  • CAPREOMYCIN SULFATE (USP MONOGRAPH)
  • CAPREOMYCIN SULPHATE
  • CAPREOMYCIN, SULFATE (1:2) (SALT)
  • CHEBI:3372
  • NSC-755904
  • SULFURIC ACID, COMPD. WITH CAPREOMYCIN (2:1)

2 Names and Identifiers

2.1 Other Identifiers

2.1.1 CAS

1405-37-4
1405-36-3

2.1.2 Deprecated CAS

1405-36-3

2.1.3 European Community (EC) Number

2.1.4 NSC Number

2.1.5 UNII

2.1.6 DSSTox Substance ID

2.1.7 NCI Thesaurus Code

3 Spectral Information

3.1 Mass Spectrometry

3.1.1 LC-MS

1 of 3
View All
MS Category
Experimental
MS Type
LC-MS
MS Level
MS2
Precursor Type
[M+NH4]+
Precursor m/z
768.3529052734375
Instrument
Thermo Q Exactive HF
Instrument Type
ESI-QFT
Ionization Mode
positive
Collision Energy
65HCD
Top 5 Peaks

98.071316 100

70.065179 19

127.097798 13.09

198.098521 8.73

69.044806 6.66

Thumbnail
Thumbnail
2 of 3
View All
MS Category
Experimental
MS Type
LC-MS
MS Level
MS2
Precursor Type
[M+NH4]+
Precursor m/z
768.3529052734375
Instrument
Thermo Q Exactive HF
Instrument Type
ESI-QFT
Ionization Mode
positive
Collision Energy
45HCD
Top 5 Peaks

98.071267 100

507.205477 32.93

198.098380 32.65

265.104288 32.34

239.124958 20.63

Thumbnail
Thumbnail

5 Drug and Medication Information

5.1 FDA Approved Drugs

5.2 FDA Orange Book

6 Use and Manufacturing

6.1 Uses

6.1.1 Use Classification

Human Drugs -> FDA Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book) -> Active Ingredients

7 Safety and Hazards

7.1 Hazards Identification

7.1.1 GHS Classification

Pictogram(s)
Irritant
Health Hazard
Signal
Danger
GHS Hazard Statements

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]

H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]

H360 (100%): May damage fertility or the unborn child [Danger Reproductive toxicity]

Precautionary Statement Codes

P203, P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P318, P321, P330, P362+P364, P405, and P501

(The corresponding statement to each P-code can be found at the GHS Classification page.)

ECHA C&L Notifications Summary

Aggregated GHS information provided per 40 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

7.1.2 Hazard Classes and Categories

Acute Tox. 4 (100%)

Acute Tox. 4 (100%)

Acute Tox. 4 (100%)

Repr. 1B (100%)

7.2 Other Safety Information

Chemical Assessment

IMAP assessments - Capreomycin, sulfate (salt): Human health tier I assessment

IMAP assessments - Capreomycin, sulfate (salt): Environment tier I assessment

8 Toxicity

8.1 Toxicological Information

8.1.1 Acute Effects

9 Literature

9.1 Springer Nature References

10 Information Sources

  1. PubChem
  2. Australian Industrial Chemicals Introduction Scheme (AICIS)
  3. CAS Common Chemistry
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    https://creativecommons.org/licenses/by-nc/4.0/
  4. ChemIDplus
  5. DTP/NCI
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    https://www.cancer.gov/policies/copyright-reuse
  6. EPA DSSTox
    3,6-Diamino-N-{[15-amino-3,6,9,12,16-pentahydroxy-8-({[hydroxy(imino)methyl]amino}methylidene)-11-(2-imino-1,3-diazinan-4-yl)-2-methyl-1,4,7,10,13-pentaazacyclohexadeca-3,6,9,12,16-pentaen-5-yl]methyl}hexanimidic acid
    https://comptox.epa.gov/dashboard/DTXSID90930862
  7. European Chemicals Agency (ECHA)
    LICENSE
    Use of the information, documents and data from the ECHA website is subject to the terms and conditions of this Legal Notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the ECHA website may be reproduced, distributed and/or used, totally or in part, for non-commercial purposes provided that ECHA is acknowledged as the source: "Source: European Chemicals Agency, http://echa.europa.eu/". Such acknowledgement must be included in each copy of the material. ECHA permits and encourages organisations and individuals to create links to the ECHA website under the following cumulative conditions: Links can only be made to webpages that provide a link to the Legal Notice page.
    https://echa.europa.eu/web/guest/legal-notice
  8. FDA Global Substance Registration System (GSRS)
    LICENSE
    Unless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.
    https://www.fda.gov/about-fda/about-website/website-policies#linking
  9. Drugs@FDA
    LICENSE
    Unless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.
    https://www.fda.gov/about-fda/about-website/website-policies#linking
  10. FDA Orange Book
    LICENSE
    Unless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.
    https://www.fda.gov/about-fda/about-website/website-policies#linking
  11. MassBank of North America (MoNA)
    LICENSE
    The content of the MoNA database is licensed under CC BY 4.0.
    https://mona.fiehnlab.ucdavis.edu/documentation/license
  12. NCI Thesaurus (NCIt)
    LICENSE
    Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.
    https://www.cancer.gov/policies/copyright-reuse
  13. Springer Nature
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