Oseltamivir
- oseltamivir
- 196618-13-0
- Tamvir
- (-)-oseltamivir
- Tamiflu-Free
- Create:2005-06-24
- Modify:2025-01-18
- GS 4071
- GS 4104
- GS-4071
- GS-4104
- GS4071
- GS4104
- Oseltamivir
- Tamiflu
- oseltamivir
- 196618-13-0
- Tamvir
- (-)-oseltamivir
- Tamiflu-Free
- GS-4104
- GS 4104
- oseltamivirum
- (3R,4R,5S)-Ethyl 4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate
- GS4104
- HSDB 7433
- Agucort
- Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
- Ro-640796
- Ro-64-0796
- ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxycyclohexene-1-carboxylate
- Oseltamivir (INN)
- Ro 640796
- UNII-20O93L6F9H
- CHEBI:7798
- GS-4071 ETHYL ESTER
- 20O93L6F9H
- RO64-0796
- 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R-(3alpha,4beta,5alpha))-
- DTXSID9044291
- ebilfumin
- RO640796
- Oseltamivir 100 microg/mL in Acetonitrile
- OSELTAMIVIR [INN]
- Oseltamivir [INN:BAN]
- ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
- ethyl (3R,4R,5S)-4-acetamido-5-amino-3-pentan-3-yloxy-cyclohexene-1-carboxylate
- ethyl (3R,4R,5S)-5-amino-4-acetamido-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
- Agucort (TN)
- Tamiflu (*Phosphate salt 1:1*)
- SR-05000001499
- 1-Cyclohexene-1-carboxylic acid, 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-, ethyl ester, (3R,4R,5S)-
- oseltamivir-phosphate
- GOP-A-Flu
- Oseltamivir (Standard)
- OSELTAMIVIR [MI]
- GS 4104;GOP-A-Flu;GS-4104;Tamiflu-Free;Tamvir
- OSELTAMIVIR [HSDB]
- OSELTAMIVIR [VANDF]
- CHEMBL1229
- SCHEMBL32035
- OSELTAMIVIR [WHO-DD]
- BIDD:GT0426
- OSELTAMIVIR [EMA EPAR]
- BDBM5025
- DTXCID7024291
- GTPL11427
- J05AH02
- VSZGPKBBMSAYNT-RRFJBIMHSA-N
- HMS2090C11
- EX-A3415
- HY-13317R
- MFCD00953939
- AKOS015843442
- AKOS015960501
- CS-0552
- DB00198
- DT-0013
- ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)cyclohexene-1-carboxylate
- Ethyl (5S,3R,4R)-4-(acetylamino)-5-amino-3-(ethylpropoxy)cyclohex-1-enecarboxylate
- NCGC00095191-06
- NCGC00095191-12
- NCGC00095191-14
- NCGC00095191-16
- NCGC00178698-01
- NCGC00178698-02
- NCGC00178698-04
- HY-13317
- NS00000301
- O0591
- C08092
- D08306
- E84533
- AB00173476-02
- AB00173476_04
- AR-270/43507961
- Q211509
- SR-05000001499-1
- BRD-K76011241-001-01-8
- BRD-K76011241-001-02-6
- BRD-K76011241-011-02-5
- BRD-K76011241-045-01-5
- Ethyl (3R, 4R, 5S)-4-acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
- ethyl (3r,4r,5s)-4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
- ethyl 4-(acetylamino)-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate
- rel-Ethyl (3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate
- (3r,4r,5s)-4-acetylamino-5-amino-3(1-ethylpropoxy) -1-cyclohexene-1-carboxylic acid ethyl ester
- (3R,4R,5S)-4-acetylamino-5-amino-3-(1-ethyl-propoxy)-cyclohex-1-enecarboxylic acid ethyl ester
- (3R,4R,5S)-4-acetylamino-5-amino-3-(1-ethyl-propoxy)cyclohex-1-enecarboxylic acid ethyl ester
- 182367-47-1
58.0299 100
41.99845 2.60
164.07169 2.30
99.05684 1.10
58.03002 100
240.1115 1.80
164.07169 1.70
41.99852 1.10
225.1234 999
313.2125 678
208.0967 465
166.0856 253
243.1338 159
166.0854 999
208.0961 365
225.1231 131
120.0437 114
167.0885 89
- Oseltamivir Acid (has active moiety)
- Oseltamivir Phosphate (has salt form)
- Cytoplasm
- Extracellular
- Membrane
Use (kg) in Switzerland (2009): >100
Use (kg; approx.) in Germany (2009): >1000
Consumption (g per capita) in Switzerland (2009): 0.013
Consumption (g per capita; approx.) in Germany (2009): 0.012
Excretion rate: 0.1
Calculated removal (%): 22.1
In clinical trials of oseltamivir, serum aminotransferase elevations occurred in 2% of treated subjects, but were asymptomatic and transient in all and there were no reports of clinically apparent liver injury with jaundice. The rates of ALT elevations with oseltamivir were generally similar to those treated with placebo or with a comparative agents. Since its approval in 1999, oseltamivir has been widely used during influenza seasonal outbreaks. There have been a few, isolated reports of mild liver injury in patients receiving oseltamivir, but the relationship of the injury with oseltamivir has not always been very convincingly shown. There have been no reports of acute liver failure or chronic liver disease attributed to oseltamivir use. Furthermore, a proportion of patients with influenza have serum enzyme elevations and even mild jaundice during the acute illness, independent of any therapy.
Likelihood score: D (possible rare cause of clinically apparent liver injury).
M Chen, V Vijay, Q Shi, Z Liu, H Fang, W Tong. FDA-Approved Drug Labeling for the Study of Drug-Induced Liver Injury, Drug Discovery Today, 16(15-16):697-703, 2011. PMID:21624500 DOI:10.1016/j.drudis.2011.05.007
M Chen, A Suzuki, S Thakkar, K Yu, C Hu, W Tong. DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug Discov Today 2016, 21(4): 648-653. PMID:26948801 DOI:10.1016/j.drudis.2016.02.015
◉ Summary of Use during Lactation
Limited data indicate that oseltamivir and its active metabolite are poorly excreted into breastmilk. Maternal dosages of 150 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants. Infants over 2 weeks of age can receive oseltamivir directly in doses much larger than those in breastmilk.
◉ Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
◉ Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Patents are available for this chemical structure:
https://patentscope.wipo.int/search/en/result.jsf?inchikey=VSZGPKBBMSAYNT-RRFJBIMHSA-N
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- Therapeutic Target Database (TTD)
- DailyMed
- Drug Induced Liver Injury Rank (DILIrank) DatasetLICENSEUnless otherwise noted, the contents of the FDA website (www.fda.gov), both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Credit to the U.S. Food and Drug Administration as the source is appreciated but not required.https://www.fda.gov/about-fda/about-website/website-policies#linking
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- Drugs and Lactation Database (LactMed)
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- EU Clinical Trials Register
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