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PF 477736

PubChem SID
252157928
Structure
PF 477736_small.png
Source
Tocris Bioscience
External ID
4277
Source Category

Chemical Vendors

Legacy Depositors

Version
Status
Live
Related Compounds
PubChem CID
CID 135565545 (PF-477736)
Dates
  • Deposit:
    2015-08-06
  • Modify:
    2020-04-15
  • Available:
    2015-08-06
Description

NOTE: LEGACY RECORD. This record is no longer maintained in PubChem by the data contributor; therefore, it may contain outdated information. Read More...

Please note that the substance record is presented as provided to PubChem by the source (depositor). For standardized chemical structure and/or annotation information, please visit the summary page for CID 135565545.

1 2D Structure

Chemical Structure Depiction
PF 477736.png

2 Identity

2.1 Source

Tocris Bioscience

2.2 External ID

4277

2.3 Source Category

Chemical Vendors

Legacy Depositors

2.4 Depositor-Supplied Synonyms

2.5 Deposit Date

2015-08-06

2.6 Modify Date

Version 1
Version 2
Version 3
Version 4
2020-04-15 (currently shown)

2.7 Available Date

2015-08-06

2.8 Status

Live

3 Depositor Comments

Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Enhances docetaxel (Cat. No. 4056) efficacy in tumor cells and xenografts.

5 Information Sources

CONTENTS