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L-amino acid oxidase (Bothrops pictus)

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-18
Description
Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme (By similarity). This enzyme shows activity on L-Leu (PMID: 29024770). This enzyme inhibits platelet aggregation in human platelet rich plasma induced by ADP (IC(50)=3.2 mg/mL), and shows antibacterial activities on both Gram-positive and Gram-negative bacteria (P.aeruginosa, V.cholerae, S.aureus, E.faecalis and E.coli) (PMID: 29024770). These two effects are due to hydrogen peroxide, since they are inhibited by catalase (PMID: 29024770). It also induces edema in mouse paw pads but does not show hemolytic activity (PMID: 29024770). This protein may also have activities in hemorrhage, and apoptosis (By similarity).

1 Names and Identifiers

1.1 Synonyms

  • L-amino acid oxidase
  • Bpic-LAAO
  • LAO
  • EC 1.4.3.2

1.1.1 MeSH Entry Terms

  • Apoxin I
  • Apoxin-I
  • L-Amino Acid-Oxygen Oxidoreductase (Deaminating)
  • Ophio-Amino-Acid Oxidase

1.2 Other Identifiers

1.2.1 UniProt ID

1.2.2 Enzyme Commission (EC) Number

1.2.3 InterPro Protein

2 Sequence

>sp|X2L4E2|OXLA_BOTPC L-amino acid oxidase (Run BLAST)

SLLFLAAVGSCADDRNPLEECFRETDYEEFLEIAKNGLSTTSNPKRVVIVGAGMSGLSAAYVLANAGHQVTVLEASERAGGRVKTYRNEKEGWYANLGPMRLPEKHRIVREYIKKFDLRLNEFSQENENAWYFLQNIKKRVREVNKDPGVLEYPVKPSEVGKSAGQLYEESLRKAVEELRRTNCSYMLNKYDTYSTKEYLLKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDKLPTSMYQAIQEKVHLNARVIEIQQDVKEVTVTYQTSQKETLSVTADYVIVCTTSRAARRITFEPPLPPKKAHALLSVHYRSGTKIFLTCTKKFWEDDGIHGGKSTTDLPSRFIYYPNHNFPNGVGVIIAYGIGDDANYFQALDFEDCGDIVINDLSLIHQLPKEEIQAICRPSMIQRWSLDNYAMGGITTFTPYHFQHFSEALTAPVDRIYFAGEYTAQAHGWIDSTIKSGLRAATDVNRASENK

3 Domains

3.1 CDD Domains

3.2 InterPro Domains

4 Biochemical Reactions

5 Literature

5.1 Consolidated References

5.2 NLM Curated PubMed Citations

6 Patents

7 Classification

7.1 MeSH Tree

8 Information Sources

  1. NCBI Protein
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  2. PubChem
  3. Medical Subject Headings (MeSH)
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    https://www.nlm.nih.gov/copyright.html
  4. InterPro
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    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  5. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  6. UniProt
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    https://www.uniprot.org/help/license
  7. Rhea - annotated reactions database
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    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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