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3-isopropylmalate dehydrogenase (Sordaria macrospora)

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-18
Description
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.

1 Names and Identifiers

1.1 Synonyms

  • 3-isopropylmalate dehydrogenase
  • 3-IPM-DH
  • IMDH
  • EC 1.1.1.85
  • Beta-IPM dehydrogenase

1.1.1 MeSH Entry Terms

  • beta-IPM Dehydrogenase
  • beta-Isopropylmalate Dehydrogenase

1.2 Other Identifiers

1.2.1 UniProt ID

1.2.2 Enzyme Commission (EC) Number

1.2.3 InterPro Protein

2 Sequence

>sp|Q6TWC4|LEU3_SORMA 3-isopropylmalate dehydrogenase (Run BLAST)

MATHNIVVFGGDHCGPEVVVEAIKVLKSIETNSPSAGKFNLQNHLLGGASIDKHHDPLTDEALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDSSPLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGSGYACDTEPYSRAEIERIARLAGFLALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNPRALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDISGKGIVNPVGTILSVAMMLRYSLNLPKEADAVEAAVKAAIDNGTKTKDLGGSATTSDMGNAVVAELEKILKA

3 Domains

3.1 CDD Domains

3.2 InterPro Domains

4 Biochemical Reactions

5 Literature

5.1 Consolidated References

5.2 NLM Curated PubMed Citations

6 Patents

7 Classification

7.1 MeSH Tree

8 Information Sources

  1. NCBI Protein
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
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    https://www.nlm.nih.gov/copyright.html
    3-Isopropylmalate Dehydrogenase
    https://meshb.nlm.nih.gov/record/ui?ui=D050539
  4. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  5. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  6. UniProt
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    https://www.uniprot.org/help/license
  7. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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