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Methionine aminopeptidase (Staphylococcus aureus subsp. aureus MRSA252)

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-18
Description
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.

1 Names and Identifiers

1.1 Synonyms

  • Methionine aminopeptidase
  • MAP
  • MetAP
  • EC 3.4.11.18
  • Peptidase M

1.1.1 MeSH Entry Terms

  • Methionyl Aminopeptidase
  • N-Terminal Methionine-Specific Peptidase
  • Peptidase M

1.2 Other Identifiers

1.2.1 RefSeq Accession

1.2.2 UniProt ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 InterPro Protein

2 Sequence

>sp|Q6GFG9|MAP1_STAAR Methionine aminopeptidase (Run BLAST)

MIVKTEEELQALKEIGYICAKVRNTMQAATKPGITTKELDNIAKELFEEYGAISAPIHDENFPGQTCISVNEEVAHGIPSKRVIREGDLVNIDVSALKNGYYADTGISFVVGESDDPMKQKVCDVATMAFENAIAKVKPGTKLSNIGKAVHNTARQNDLKVIKNLTGHGVGLSLHEAPAHVLNYFDPKDKTLLTEGMVLAIEPFISSNASFVTEGKNEWAFETSDKSFVAQIEHTVIVTKDGPILTTKIEEE

3 3D Structures

3.1 PDB Structures

4 Domains

4.1 CDD Domains

4.2 InterPro Domains

5 Literature

5.1 Consolidated References

5.2 NLM Curated PubMed Citations

6 Patents

7 Classification

7.1 MeSH Tree

8 Information Sources

  1. NCBI Protein
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  2. PubChem
  3. Medical Subject Headings (MeSH)
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    https://www.nlm.nih.gov/copyright.html
  4. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  5. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  6. RCSB Protein Data Bank (RCSB PDB)
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    Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.
    https://www.rcsb.org/pages/policies
  7. UniProt
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    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
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