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Interleukin-18 receptor 1 (human)

Protein
Encoding Gene
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-02-01
Description
An interleukin-18 receptor 1 that is encoded in the genome of human.
Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PMID: 14528293, PMID: 25261253, PMID: 25500532, PMID: 37993714, PMID: 8626725). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PMID: 10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).

1 Names and Identifiers

1.1 Synonyms

  • Interleukin-18 receptor 1
  • IL-18R-1
  • IL-18R1
  • EC 3.2.2.6
  • CD218 antigen-like family member A
  • CDw218a
  • IL1 receptor-related protein
  • IL-1Rrp
  • IL1R-rp
  • Interleukin-18 receptor alpha
  • IL-18R-alpha
  • IL-18Ralpha

1.1.1 MeSH Entry Terms

  • Antigens, CDw218a
  • CDw218a Antigens
  • CDw218a Antigen
  • IL1 Receptor-Related Protein
  • Interleukin 18 Receptor 1
  • Interleukin-18 Receptor alpha Chain

1.2 Other Identifiers

1.2.1 RefSeq Accession

1.2.2 UniProt ID

1.2.3 NCI Thesaurus Code

1.2.4 Enzyme Commission (EC) Number

1.2.5 PRO ID

1.2.6 GlyCosmos Protein

1.2.7 GlyGen Protein

1.2.8 Pharos Target

1.2.9 Open Targets ID

1.2.10 STRING Protein ID

1.2.11 Wikidata

1.2.12 neXtProt Accession

1.2.13 HPA ID

1.2.14 IntAct Protein

1.2.15 InterPro Protein

3 Sequence

>sp|Q13478|IL18R_HUMAN Interleukin-18 receptor 1 (Run BLAST)

MNCRELPLTLWVLISVSTAESCTSRPHITVVEGEPFYLKHCSCSLAHEIETTTKSWYKSSGSQEHVELNPRSSSRIALHDCVLEFWPVELNDTGSYFFQMKNYTQKWKLNVIRRNKHSCFTERQVTSKIVEVKKFFQITCENSYYQTLVNSTSLYKNCKKLLLENNKNPTIKKNAEFEDQGYYSCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVELGKNVRLNCSALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHASKVLRIENIGESNLNVLYNCTVASTGGTDTKSFILVRKADMADIPGHVFTRGMIIAVLILVAVVCLVTVCVIYRVDLVLFYRHLTRRDETLTDGKTYDAFVSYLKECRPENGEEHTFAVEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIVLSKSYMSNEVRYELESGLHEALVERKIKIILIEFTPVTDFTFLPQSLKLLKSHRVLKWKADKSLSYNSRFWKNLLYLMPAKTVKPGRDEPEVLPVLSES

4 3D Structures

4.1 PDB Structures

4.2 NCBI Protein Structures

4.3 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

5 Domains

5.1 CDD Domains

5.2 InterPro Domains

6 Interactions and Pathways

6.1 Interactions

6.2 Pathways

7 Biochemical Reactions

8 Glycobiology

8.1 Glycosylation

9 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)

9 Target Development Level

10 Literature

10.1 Consolidated References

10.2 NLM Curated PubMed Citations

11 Classification

11.1 MeSH Tree

11.2 NCI Thesaurus Tree

12 Information Sources

  1. NCBI Protein
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
    Interleukin-18 Receptor alpha Subunit
    https://meshb.nlm.nih.gov/record/ui?ui=D053727
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. STRING: functional protein association networks
  6. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  7. GlyGen
  8. Human Protein Atlas (HPA)
    LICENSE
    The Human Protein Atlas is licensed under the Creative Commons Attribution-ShareAlike 3.0 International License for all copyrightable parts of our database.
    https://www.proteinatlas.org/about/licence
  9. IntAct Molecular Interaction Database
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    Creative Commons Attribution 4.0 International (CC BY 4.0) License
    https://www.ebi.ac.uk/intact/about#license_privacy
  10. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  11. NCBI Conserved Domains (CDD)
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  12. NCBI Structure
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  13. NCI Thesaurus (NCIt)
    LICENSE
    Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.
    https://www.cancer.gov/policies/copyright-reuse
  14. Open Targets
    LICENSE
    Datasets generated by the Open Targets Platform are freely available for download.
    https://platform-docs.opentargets.org/licence
  15. Pharos
    LICENSE
    Data accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.
    https://pharos.nih.gov/about
    Interleukin-18 receptor 1
    https://pharos.nih.gov/targets/Q13478
  16. Protein Ontology
    LICENSE
    PRO is distributed under the Creative Commons CC-BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
  17. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  18. RCSB Protein Data Bank (RCSB PDB)
    LICENSE
    Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.
    https://www.rcsb.org/pages/policies
  19. Swiss Institute of Bioinformatics neXtProt
    LICENSE
    Creative Commons Attribution 4.0 International (CC BY 4.0)
    https://www.nextprot.org/help/faq
  20. Wikidata
  21. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  22. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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