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Ras GTPase-activating protein-binding protein 1 (human)

Protein
Encoding Gene
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-27
Description
A Ras GTPase-activating protein-binding protein 1 that is encoded in the genome of human.
Protein involved in various processes, such as stress granule formation and innate immunity (PMID: 12642610, PMID: 20180778, PMID: 23279204, PMID: 30510222, PMID: 30804210). Plays an essential role in stress granule formation (PMID: 12642610, PMID: 20180778, PMID: 23279204, PMID: 32302570, PMID: 32302571, PMID: 32302572, PMID: 34739333, PMID: 35977029, PMID: 36183834, PMID: 36279435, PMID: 36692217, PMID: 37379838). Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress (PMID: 12642610, PMID: 20180778, PMID: 23279204, PMID: 27022092, PMID: 32302570, PMID: 32302571, PMID: 32302572, PMID: 36279435, PMID: 37379838). Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations (PMID: 32302570, PMID: 32302571, PMID: 32302572, PMID: 34739333, PMID: 36279435, PMID: 36692217). Also acts as an ATP- and magnesium-dependent helicase: unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency (PMID: 9889278). Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA (PMID: 9889278). Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends (PMID: 9889278). Plays an essential role in innate immunity by promoting CGAS and RIGI activity (PMID: 30510222, PMID: 30804210). Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS (PMID: 30510222). Triggers the condensation of cGAS, a process probably linked to the formation of membrane-less organelles (PMID: 34779554). Enhances also RIGI-induced type I interferon production probably by helping RIGI at sensing pathogenic RNA (PMID: 30804210). May also act as a phosphorylation-dependent sequence-specific endoribonuclease in vitro: Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR (PMID: 11604510).

1 Names and Identifiers

1.1 Synonyms

  • Ras GTPase-activating protein-binding protein 1
  • G3BP-1
  • EC 3.6.4.12
  • EC 3.6.4.13
  • ATP-dependent DNA helicase VIII
  • hDH VIII
  • GAP SH3 domain-binding protein 1

1.2 Other Identifiers

1.2.1 RefSeq Accession

1.2.2 UniProt ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 PRO ID

1.2.5 GlyCosmos Protein

1.2.6 GlyGen Protein

1.2.7 Pharos Target

1.2.8 Open Targets ID

1.2.9 STRING Protein ID

1.2.10 Wikidata

1.2.11 neXtProt Accession

1.2.12 HPA ID

1.2.13 IntAct Protein

1.2.14 InterPro Protein

3 Sequence

>sp|Q13283|G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (Run BLAST)

MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSVANKFYVHNDIFRYQDEVFGGFVTEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQAVVSNDMEEHLEEPVAEPEPDPEPEPEQEPVSEIQEEKPEPVLEETAPEDAQKSSSPAPADIAQTVQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPPQRPQRDQRVREQRINIPPQRGPRPIREAGEQGDIEPRRMVRHPDSHQLFIGNLPHEVDKSELKDFFQSYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREGDRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRGLAPRQ

4 3D Structures

4.1 PDB Structures

4.2 NCBI Protein Structures

4.3 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

5 Domains

5.1 CDD Domains

5.2 InterPro Domains

6 Interactions and Pathways

6.1 Interactions

7 Biochemical Reactions

8 Glycobiology

8.1 Glycosylation

6 sites, 1 O-linked glycan (6 sites)

9 Target Development Level

10 Literature

10.1 Consolidated References

11 Patents

12 Information Sources

  1. NCBI Protein
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  4. STRING: functional protein association networks
  5. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  6. GlyGen
  7. Human Protein Atlas (HPA)
    LICENSE
    The Human Protein Atlas is licensed under the Creative Commons Attribution-ShareAlike 3.0 International License for all copyrightable parts of our database.
    https://www.proteinatlas.org/about/licence
  8. IntAct Molecular Interaction Database
    LICENSE
    Creative Commons Attribution 4.0 International (CC BY 4.0) License
    https://www.ebi.ac.uk/intact/about#license_privacy
  9. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  10. NCBI Conserved Domains (CDD)
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  11. NCBI Structure
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  12. Open Targets
    LICENSE
    Datasets generated by the Open Targets Platform are freely available for download.
    https://platform-docs.opentargets.org/licence
    G3BP stress granule assembly factor 1
    https://platform.opentargets.org/target/ENSG00000145907
  13. Pharos
    LICENSE
    Data accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.
    https://pharos.nih.gov/about
    Ras GTPase-activating protein-binding protein 1
    https://pharos.nih.gov/targets/Q13283
  14. Protein Ontology
    LICENSE
    PRO is distributed under the Creative Commons CC-BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
  15. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  16. RCSB Protein Data Bank (RCSB PDB)
    LICENSE
    Data files contained in the PDB archive (ftp://ftp.wwpdb.org) are free of all copyright restrictions and made fully and freely available for both non-commercial and commercial use. Users of the data should attribute the original authors of that structural data.
    https://www.rcsb.org/pages/policies
  17. Swiss Institute of Bioinformatics neXtProt
    LICENSE
    Creative Commons Attribution 4.0 International (CC BY 4.0)
    https://www.nextprot.org/help/faq
  18. Wikidata
    G3BP stress granule assembly factor 1
    https://www.wikidata.org/wiki/Q21112719
  19. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  20. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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