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Galactoside alpha-(1,2)-fucosyltransferase 2 (human)

Protein
Encoding Gene
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-17
Description
A galactoside alpha-(1,2)-fucosyltransferase 2 that is encoded in the genome of human.
Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PMID: 12692541, PMID: 7876235, PMID: 8018146). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (By similarity). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PMID: 21625510, PMID: 22068912, PMID: 24733310). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PMID: 7876235).

1 Names and Identifiers

1.1 Synonyms

  • Galactoside alpha-(1,2)-fucosyltransferase 2
  • Alpha(1,2)FT 2
  • Fucosyltransferase 2
  • GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
  • SE2
  • Secretor blood group alpha-2-fucosyltransferase
  • Secretor factor
  • Se
  • Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
  • 2.4.1.69
  • Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
  • 2.4.1.344

1.1.1 MeSH Entry Terms

  • Alpha-2-L-fucosyltransferase
  • Alpha-2-fucosyltransferase
  • Blood Group H Fucosyltransferase
  • Blood Group H alpha-2-fucosyltransferase
  • Fucosyltransferase 1
  • Fucosyltransferase 2
  • GDP-L-fucose-beta-D-galactosyl alpha-2-L-fucosyltransferase
  • GDP-L-fucose-galactoside-2'-fucosyltransferase
  • GDPFG-2-fucosyltransferase
  • GDP-L-fucose-beta-D-galactoside 2-alpha-L-fucosyltransferase
  • GDP-L-fucose-lactose fucosyltransferase
  • Galactoside 2-alpha-L-fucosyltransferase 1
  • Gal alpha1-2 fucosyltransferase
  • Galactoside 2-alpha-L-fucosyltransferase 2
  • Galactoside 2-fucosyltransferase
  • Guanosine Diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase
  • Secretor Blood Group alpha-2-fucosyltransferase
  • beta-galactoside alpha-1,2-fucosyltransferase
  • beta-galactoside alpha1,2-fucosyltransferase

1.2 Other Identifiers

1.2.1 RefSeq Accession

1.2.2 UniProt ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 PRO ID

1.2.5 ChEMBL Target ID

1.2.6 NCBI Proteins

1.2.7 GlyCosmos Protein

1.2.8 Pharos Target

1.2.9 Open Targets ID

1.2.10 STRING Protein ID

1.2.11 Wikidata

1.2.12 neXtProt Accession

1.2.13 HPA ID

1.2.14 BRENDA EC Number

1.2.15 IntAct Protein

1.2.16 InterPro Protein

3 Chemicals and Bioactivities

3.1 Tested Compounds

4 BioAssays

5 Sequence

>sp|Q10981|FUT2_HUMAN Galactoside alpha-(1,2)-fucosyltransferase 2 (Run BLAST)

MLVVQMPFSFPMAHFILFVFTVSTIFHVQQRLAKIQAMWELPVQIPVLASTSKALGPSQLRGMWTINAIGRLGNQMGEYATLYALAKMNGRPAFIPAQMHSTLAPIFRITLPVLHSATASRIPWQNYHLNDWMEEEYRHIPGEYVRFTGYPCSWTFYHHLRQEILQEFTLHDHVREEAQKFLRGLQVNGSRPGTFVGVHVRRGDYVHVMPKVWKGVVADRRYLQQALDWFRARYSSLIFVVTSNGMAWCRENIDTSHGDVVFAGDGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLTGGDTIYLANYTLPDSPFLKIFKPEAAFLPEWTGIAADLSPLLKH

6 3D Structures

6.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

7 Domains

7.1 CDD Domains

7.2 InterPro Domains

8 Interactions and Pathways

8.1 Interactions

8.2 Pathways

9 Biochemical Reactions

10 Target Development Level

11 Literature

11.1 Consolidated References

11.2 NLM Curated PubMed Citations

12 Classification

12.1 MeSH Tree

12.2 ChEMBL Target Tree

12.3 Enzyme Classification

13 Information Sources

  1. NCBI Protein
    LICENSE
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
    LICENSE
    Works produced by the U.S. government are not subject to copyright protection in the United States. Any such works found on National Library of Medicine (NLM) Web sites may be freely used or reproduced without permission in the U.S.
    https://www.nlm.nih.gov/copyright.html
    Galactoside 2-alpha-L-fucosyltransferase
    https://meshb.nlm.nih.gov/record/ui?ui=D000097631
  4. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  5. STRING: functional protein association networks
  6. BRENDA: Enzyme Functional Data
    LICENSE
    The usage of the BRENDA data is licensed under Creative Commons Attribution License CC BY 4.0.
    https://www.brenda-enzymes.org/license.php
  7. ChEMBL
    LICENSE
    Access to the web interface of ChEMBL is made under the EBI's Terms of Use (http://www.ebi.ac.uk/Information/termsofuse.html). The ChEMBL data is made available on a Creative Commons Attribution-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-sa/3.0/).
    http://www.ebi.ac.uk/Information/termsofuse.html
  8. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  9. Human Protein Atlas (HPA)
    LICENSE
    The Human Protein Atlas is licensed under the Creative Commons Attribution-ShareAlike 3.0 International License for all copyrightable parts of our database.
    https://www.proteinatlas.org/about/licence
  10. IntAct Molecular Interaction Database
    LICENSE
    Creative Commons Attribution 4.0 International (CC BY 4.0) License
    https://www.ebi.ac.uk/intact/about#license_privacy
  11. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  12. NCBI Conserved Domains (CDD)
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  13. Open Targets
    LICENSE
    Datasets generated by the Open Targets Platform are freely available for download.
    https://platform-docs.opentargets.org/licence
  14. Pharos
    LICENSE
    Data accessed from Pharos and TCRD is publicly available from the primary sources listed above. Please respect their individual licenses regarding proper use and redistribution.
    https://pharos.nih.gov/about
    Galactoside 2-alpha-L-fucosyltransferase 2
    https://pharos.nih.gov/targets/Q10981
  15. Protein Ontology
    LICENSE
    PRO is distributed under the Creative Commons CC-BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
  16. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  17. Swiss Institute of Bioinformatics neXtProt
    LICENSE
    Creative Commons Attribution 4.0 International (CC BY 4.0)
    https://www.nextprot.org/help/faq
  18. Wikidata
  19. Swiss Institute of Bioinformatics ENZYME
    LICENSE
    Copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/).
    https://enzyme.expasy.org/enzyme.get
    Enzyme Classification
    https://enzyme.expasy.org/
  20. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
  21. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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