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tRNA sulfurtransferase (Shewanella sp. MR-7)

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-20
Description
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.

1 Names and Identifiers

1.1 Synonyms

  • tRNA sulfurtransferase
  • EC 2.8.1.4
  • Sulfur carrier protein ThiS sulfurtransferase
  • Thiamine biosynthesis protein ThiI
  • tRNA 4-thiouridine synthase

1.2 Other Identifiers

1.2.1 UniProt ID

1.2.2 Enzyme Commission (EC) Number

1.2.3 InterPro Protein

2 Sequence

>sp|Q0HSX1|THII_SHESR tRNA sulfurtransferase (Run BLAST)

MKFIVKLYPEIMMKSKPVRMRFTKMLETNIRNVLKKVDEDAKVQRQWDRIWVKVPNDKPELAQAFGERLACIPGIAHVVQVDEYSFTSVDDIYQQVLPVYRDQIAGKTFCVRVKRTGSHDFNSIEVERYVGGGLNQFTDAVGVRLKNPEVTVNLEIEGDKLYMVTKRIEGLGGFPMATQEDVLSLISGGFDSGVSSYQFIKKGARTHYCFFNLGGAQHEIGVKQVAYHLWKTYGESHKVKFVSVPFEPVVAEILEKIDNGQMGVVLKRMMMRTAARIAERMGIQAIVTGESLGQVSSQTLTNLNVIDRCTDMLILRPLIAMDKQDIINECRRIGTEDFAKSMPEYCGVISQKPTVKAVLAKVEAEETKFSEDLIDRIVEQAVAIDIREIAEQMNTRITETETVVAIDTNEVVIDIRAPEEEENKPLEIEGVEIKRIPFFKLATQFADLDKQKTYLLYCERGVMSKLQALYLIEQGYHNVKVYRP

3 Domains

3.1 CDD Domains

3.2 InterPro Domains

4 Biochemical Reactions

5 Literature

5.1 Consolidated References

6 Patents

7 Information Sources

  1. NCBI Protein
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  4. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  5. UniProt
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    https://www.uniprot.org/help/license
  6. Rhea - annotated reactions database
    LICENSE
    Rhea has chosen to apply the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). This means that you are free to copy, distribute, display and make commercial use of the database in all legislations, provided you credit (cite) Rhea.
    https://www.rhea-db.org/help/license-disclaimer
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