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Flap endonuclease 1 (Aspergillus terreus NIH2624)

Protein
Encoding Gene
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-21
Description
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

1 Names and Identifiers

1.1 Synonyms

  • Flap endonuclease 1
  • FEN-1
  • EC 3.1.-.-
  • Flap structure-specific endonuclease 1

1.1.1 MeSH Entry Terms

  • FEN-1
  • Fen1 Protein
  • Flap Endonuclease-1
  • Flap Endonuclease
  • RAD2 Homolog-1 Nuclease
  • RTH-1 Nuclease

1.2 Other Identifiers

1.2.1 RefSeq Accession

1.2.2 UniProt ID

1.2.3 Enzyme Commission (EC) Number

1.2.4 InterPro Protein

2 Sequence

>sp|Q0CBS0|FEN1_ASPTN Flap endonuclease 1 (Run BLAST)

MGIKQLYQVISENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSDTGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKTEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLSRALEGLDMDRAKFIDLCILLGCDYLEPIPKVGPNTALKLIRDHGSLEKVVEYIQNDPKKKYVIPEDWPYQDARELFLHPDVRDANDPECDFKWEAPDIEGLVEFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVARSDEEKATLKRKHDEKLQEQKKRKKEEAKAKKEAKARPRGAG

3 Domains

3.1 CDD Domains

3.2 InterPro Domains

4 Literature

4.1 NLM Curated PubMed Citations

5 Patents

6 Classification

6.1 MeSH Tree

7 Information Sources

  1. NCBI Protein
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
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    https://www.nlm.nih.gov/copyright.html
  4. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  5. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  6. UniProt
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    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
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