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Nuclear export protein (Influenza A virus (STRAIN A/PINTAIL/ALBERTA/358/79))

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-18
Description
An influenzavirus nuclear export protein that is encoded in the genome of the H3N6 strain A/Pintail/Alberta/358/1979.
Mediates the nuclear export of encapsidated genomic RNAs (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs complexes and the nuclear export machinery of the cell. Possesses no intrinsic RNA-binding activity, but includes a C-terminal M1-binding domain. This domain is believed to allow recognition of RNPs bound to the protein M1. Since protein M1 is not available in large quantities before late stages of infection, such an indirect recognition mechanism probably ensures that genomic RNPs are not exported from the host nucleus until sufficient quantities of viral mRNA and progeny genomic RNA have been synthesized. Furthermore, the RNPs enter the host cytoplasm only when associated with the M1 protein that is necessary to guide them to the plasma membrane. May down-regulate viral RNA synthesis when overproduced.

1 Names and Identifiers

1.1 Synonyms

  • Nuclear export protein
  • NEP
  • Non-structural protein 2
  • NS2

1.2 Other Identifiers

1.2.1 UniProt ID

1.2.2 PRO ID

1.2.3 InterPro Protein

2 Sequence

>sp|P69262|NEP_I79A3 Nuclear export protein (Run BLAST)

MDSNTITSFQDILQRMSKMQLESSSVDLNGMITQFERLKIYRDSLGESVMRMGDLHSLQSRNATWREELSQKFEEIRWLIAECRNILTKTENSFEQITFLQALQLLLEVESEIRTFSFQLI

3 Domains

3.1 CDD Domains

3.2 InterPro Domains

4 Literature

4.1 Consolidated References

5 Patents

6 Information Sources

  1. NCBI Protein
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. InterPro
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    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  4. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  5. Protein Ontology
    LICENSE
    PRO is distributed under the Creative Commons CC-BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
  6. UniProt
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    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
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