Elongation factor 1-alpha 1 (human)
- Create:2017-04-15
- Modify:2025-01-18
Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis (PMID: 26593721, PMID: 26651998, PMID: 36123449, PMID: 36264623, PMID: 36638793). Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome (PMID: 26593721, PMID: 26651998, PMID: 36123449, PMID: 36264623, PMID: 36638793). The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation (PMID: 26593721, PMID: 26651998, PMID: 36123449, PMID: 36264623). Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (PMID: 17177976).
(Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection.
- Elongation factor 1-alpha 1
- EF-1-alpha-1
- EC 3.6.5.-
- Elongation factor Tu
- EF-Tu
- Eukaryotic elongation factor 1 A-1
- eEF1A-1
- Leukocyte receptor cluster member 7
- EF-Tu
- Elongation Factor Tu
- Eucaryotic Elongation Factor Tu
- Protein Synthesis Elongation Factor Tu
- eEF-Tu
>sp|P68104|EF1A1_HUMAN Elongation factor 1-alpha 1 (Run BLAST)
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
- Translational (tr)-type GTP-binding domain
- Translation elongation factor EFTu-like, domain 2
- Translation elongation factor EF1A, eukaryotic/archaeal
- Translation protein, beta-barrel domain superfamily
- Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
- P-loop containing nucleoside triphosphate hydrolase
- Tr-type G domain, conserved site
- Translation factor GTPase superfamily members
- GTP-eEF1A, C-terminal domain
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