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Neuroendocrine convertase 1 (Cook's mouse)

Protein
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-18
Description
Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.

1 Names and Identifiers

1.1 Synonyms

  • Neuroendocrine convertase 1
  • NEC 1
  • EC 3.4.21.93
  • Furin homolog
  • PC3
  • Prohormone convertase 1
  • Propeptide-processing protease
  • Proprotein convertase 1
  • PC1

1.1.1 MeSH Entry Terms

  • Neuroendocrine Convertase PC1
  • PC1 Endoprotease
  • PC1 Prohormone Convertase
  • PC3 Endoprotease
  • PC3 Prohormone Convertase
  • Prohormone Convertase 1
  • Prohormone Convertase 3
  • Prohormone Convertase, PC1
  • Proinsulin Convertase 1
  • Proprotein Convertase SPC3

1.2 Other Identifiers

1.2.1 UniProt ID

1.2.2 Enzyme Commission (EC) Number

1.2.3 GlyCosmos Protein

1.2.4 InterPro Protein

2 Sequence

>sp|P63240|NEC1_MUSCO Neuroendocrine convertase 1 (Run BLAST)

MEQRGWTLQCTAFAFFCVWCALSSVKAKRQFVNEWAAEIPGGQEAASAIAEELGYDLLGQIGSLENHYLFKHKSHPRRSRRSALHITKRLSDDDRVTWAEQQYEKERSKRSVQKDSALDLFNDPMWNQQWYLQDTRMTAALPKLDLHVIPVWEKGITGKGVVITVLDDGLEWNHTDIYANYDPEASYDFNDNDHDPFPRYDLTNENKHGTRCAGEIAMQANNHKCGVGVAYNSKVGGIRMLDGIVTDAIEASSIGFNPGHVDIYSASWGPNDDGKTVEGPGRLAQKAFEYGVKQGRQGKGSIFVWASGNGGRQGDNCDCDGYTDSIYTISISSASQQGLSPWYAEKCSSTLATSYSSGDYTDQRITSADLHNDCTETHTGTSASAPLAAGIFALALEANPNLTWRDMQHLVVWTSEYDPLASNPGWKKNGAGLMVNSRFGFGLLNAKALVDLADPRTWRNVPEKKECVVKDNNFEPRALKANGEVIVEIPTRACEGQENAIKSLEHVQFEATIEYSRRGDLHVTLTSAVGTSTVLLAERERDTSPNGFKNWDFMSVHTWGENPVGTWTLKITDMSGRMQNEGRIVNWKLILHGTSSQPEHMKQPRVYTSYNTVQNDRRGVEKMVNVVEKRPTQKSLNGNLLVPKNSSSSNVEGRRDEQVQGTPSKAMLRLLQSAFSKNALSKQSPKKSPSAKLSIPYESFYEALEKLNKPSKLEGSEDSLYSDYVDVFYNTKPYKHRDDRLLQALMDILNEEN

3 Domains

3.1 CDD Domains

3.2 InterPro Domains

4 Literature

4.1 Consolidated References

4.2 NLM Curated PubMed Citations

5 Patents

6 Classification

6.1 MeSH Tree

7 Information Sources

  1. NCBI Protein
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. Medical Subject Headings (MeSH)
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    https://www.nlm.nih.gov/copyright.html
  4. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  5. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  6. NCBI Conserved Domains (CDD)
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    https://www.ncbi.nlm.nih.gov/home/about/policies/
  7. UniProt
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    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
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