Caspase-9 (human)
- Create:2017-04-15
- Modify:2025-01-17
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PMID: 36758105, PMID: 36758106).
Lacks activity is an dominant-negative inhibitor of caspase-9.
- Caspase-9
- CASP-9
- EC 3.4.22.62
- Apoptotic protease Mch-6
- Apoptotic protease-activating factor 3
- APAF-3
- ICE-like apoptotic protease 6
- ICE-LAP6
- Apoptotic Protease Activating Factor 3
- Caspase-9
- ICE-LAP6 Protein
- ICE-Like Apoptotic Protease 6
- Pro-Caspase-9
- Procaspase-9
>sp|P55211|CASP9_HUMAN Caspase-9 (Run BLAST)
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
- Peptidase C14, p20 domain
- CARD domain
- Peptidase C14, caspase non-catalytic subunit p10
- Death-like domain superfamily
- Peptidase C14, caspase domain
- Peptidase C14A, caspase catalytic domain
- Peptidase family C14A, His active site
- Caspase-like domain superfamily
- Peptidase family C14A, cysteine active site
- CASP9, CARD domain
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