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Ras-related protein Rab-21 (house mouse)

Protein
Encoding Gene
Dates
  • Create:
    2017-04-15
  • Modify:
    2025-01-21
Description
A Ras-related protein Rab-21 that is encoded in the genome of mouse.
Small GTPase involved in membrane trafficking control (PMID: 16754960, PMID: 18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (PMID: 16754960). As a result, may regulate cell adhesion and migration (PMID: 16754960). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PMID: 18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity).

1 Names and Identifiers

1.1 Synonyms

  • Ras-related protein Rab-21
  • Rab-12

1.2 Other Identifiers

1.2.1 RefSeq Accession

1.2.2 UniProt ID

1.2.3 PRO ID

1.2.4 GlyCosmos Protein

1.2.5 GlyGen Protein

1.2.6 STRING Protein ID

1.2.7 Wikidata

1.2.8 IntAct Protein

1.2.9 InterPro Protein

3 Sequence

>sp|P35282|RAB21_MOUSE Ras-related protein Rab-21 (Run BLAST)

MAAAGGGAAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDVTDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQAGAARRGVQIIDDEPQAQSSGGCCSSG

4 3D Structures

4.1 AlphaFold Structures

Highly accurate protein structure prediction with AlphaFold. Nature. 2021 Aug;596(7873):583-589. DOI:10.1038/s41586-021-03819-2. PMID:34265844; PMCID:PMC8371605

5 Domains

5.1 CDD Domains

5.2 InterPro Domains

6 Interactions and Pathways

6.1 Interactions

6.2 Pathways

7 Biochemical Reactions

8 Glycobiology

8.1 Glycosylation

2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

9 Literature

9.1 Consolidated References

10 Information Sources

  1. NCBI Protein
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  2. PubChem
  3. BioGRID
    LICENSE
    The MIT License (MIT); Copyright Mike Tyers Lab
    https://wiki.thebiogrid.org/doku.php/terms_and_conditions
  4. STRING: functional protein association networks
  5. GlyCosmos Glycoscience Portal
    LICENSE
    All copyrightable parts of the datasets in GlyCosmos are under the Creative Commons Attribution (CC BY 4.0) License.
    https://glycosmos.org/license
  6. GlyGen
  7. IntAct Molecular Interaction Database
    LICENSE
    Creative Commons Attribution 4.0 International (CC BY 4.0) License
    https://www.ebi.ac.uk/intact/about#license_privacy
  8. InterPro
    LICENSE
    All of the InterPro, Pfam, PRINTS and SFLD downloadable data provided on the InterPro website is freely available under CC0 1.0 Universal (CC0 1.0) Public Domain Dedication.
    https://www.ebi.ac.uk/interpro/about/license/
  9. NCBI Conserved Domains (CDD)
    LICENSE
    NCBI Website and Data Usage Policies and Disclaimers
    https://www.ncbi.nlm.nih.gov/home/about/policies/
  10. Protein Ontology
    LICENSE
    PRO is distributed under the Creative Commons CC-BY 4.0 license (https://creativecommons.org/licenses/by/4.0/).
  11. UniProt
    LICENSE
    We have chosen to apply the Creative Commons Attribution (CC BY 4.0, http://creativecommons.org/licenses/by/4.0/) License to all copyrightable parts of our databases.
    https://www.uniprot.org/help/license
  12. Wikidata
    RAB21, member RAS oncogene family
    https://www.wikidata.org/wiki/Q21986067
  13. AlphaFold DB
    LICENSE
    All of the data provided is freely available for both academic and commercial use under Creative Commons Attribution 4.0 (CC-BY 4.0) licence terms.
    https://alphafold.ebi.ac.uk/faq
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